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Acute and subacute oral toxicity study on the flavonoid rich fraction of Monodora tenuifolia seed in albino rats

Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 194-202页

作者： r.phael chukwuma ekeanyanwu Obioma Uzoma Njoku Department of Biochemistry Faculty of SciencesImo State University OwerriImo StateNigeria Department of Biochemistry Faculty of Biological SciencesUniversity of Nigeria NsukkaEnugu StateNigeria

Objective:To investigate the effects of the flavonoid rich fraction of Monodora tenuifolia seed on the haematology,histopathology and liver profile of Wistar albino ***:Toxicity study was investigated on the flavonoid rich fraction of Monodora tenuifolia in rats administered different concentrations orally for 28 d using standard laboratory ***:The LD_(50)of the flavonoid rich fraction was found to be above 5000 mg/kg body weight in mice observed for 48 *** the Day 14,biochemical markers of liver injury such as serum alanine aminotransferase,and aspartate aminotransferase decreased significantly(Prum alkaline phosphatase increased non-significantly(P>0.05).There was non-significant(P>0.05)effect observed across the groups in the levels of serum total protein,albumin,globulin,urea and *** result of histological examination showed various degrees of peribiliary hepatitis after the Day 14 which fizzled out after the Day ***:The result therefore suggests that the seed extract is potentially safe.

关键词： Monodora tenuifolia Toxicity Haematological parameters Biochemical parameters Histology

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Flavonoid-rich fraction of the Monodora tenuifolia seed extract attenuates behavioural alterations and oxidative damage in forced-swim stressed rats

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Chinese Journal of Natural Medicines 2015年第3期13卷 183-191页

作者： ekeanyanwu r.phael chukwuma NJOKU Obioma Uzoma Department of Biochemistry Faculty of Medicine Imo State University Owerri Department of Biochemistry Faculty of Biological Sciences University of Nigeria Nsukka

The antidepressant effects of the flavonoid-rieh fraction of Monodora tenuifolia seed extract were examined by assess- ing the extent of attenuation of behavioural alterations and oxidative damage in the rats that were stressed by forced swim test. Com- pared with the model control group, the altered behavioural parameters were attenuated significantly （P 〈 0.05） in the group treated with the flavonoid-rich fraction （100 and 200 mg·kg^-1）, comparable to the group treated with the standard drug, fluoxetine （10 mg·kg^-1）. The flavonoid-rich fraction and fluoxetine improved significantly （P 〈 0.05） the activities of the antioxidant enzymes such as superoxide dismutase and catalase as well as other biochemical parameters such as reduced glutathione, protein, and nitrite in the brain of the stressed rats. These results suggested that the flavonoid-rich fraction of Monodora tenuifolia seed extract exerted the antidepres- sant-like effects which could be useful in the management of stress induced disease.

关键词： Monodora tenuifolia Antidepressant Forced swim test Depression Oxidative damage

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