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Histopathology and immunophenotyping of late onset cutaneous manifestations of COVID-19 in elderly patients: Three case reports

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World Journal of Clinical Cases 2021年第20期9卷 5744-5751页

作者： Maria Mazzitelli Stefano Dastoli Chiara Mignogna Luigi Bennardo Elena Lio Maria Chiara Pelle Enrico Maria Trecarichi Branca Isabel Pereira Steven paul Nisticò Carlo Torti Department of Medical and Surgical Sciences Infectious and Tropical Disease UnitMagna Graecia UniversityCatanzaro 88100Italy Department of Health Sciences Magna Graecia Universitàof CatanzaroCatanzaro 88100Italy Interdipartimental Service Center Pathology UnitPugliese Ciaccio HospitalCatanzaro 88100Italy Department of Health Sciences Magna Graecia UniversityCatanzaro 88100Italy Department of Medical and Surgical Sciences Magna Graecia Universitàof CatanzaroCatanzaro 88100Italy HIV/GUM Directorate Chelsea and Westminster Hospital Foundation TrustLondon SW109NHUnited Kingdom

BACKGrOUND Several cutaneous manifestations such as urticarial rash,erythematous patches and chilblain-like lesions have been described in young adults with coronavirus disease 2019(COVID-19)and are present in up to 20%patients,but few reports exist describing histopathological and immunophenotypic characteristics of dermatological lesions in older *** aim was to characterize skin lesions in elderly patients during late stages of COVID-19 from clinical,histological and immunophenotypic *** SUMMArY Three patients,admitted for COVID-19,and who developed cutaneous manifestations underwent skin *** analysis for CD20,CD3,CD4 and CD8 was performed on skin biopsies to assess immune cell ***1a was used as a marker of Langerhans cells,and CD31 as a marker of endothelial *** the three study patients,cutaneous manifestations were evident in the late-stage of COVID-19(mean time from the first positive severe acute respiratory syndrome coronavirus 2(SArS-CoV-2)swab to rash onset was 35 d).Skin biopsies showed a similar pattern of T lymphocyte infiltration in all ***,a chronic dermatitis with perivascular lymphocytic infiltrate was observed with predominance of CD3+T-cell(CD3+).CONCLUSION Our study confirms previous *** and immunophenotypic patterns in our patients confirm results described in the two previous reported *** pattern is similar to what is found in some lympho-proliferative ***,since these findings are non-specific,SArS-CoV-2 infection should be suspected.

关键词： COVID-19 SArS-CoV-2 rash T-helper infiltrates Cutaneous manifestation Case report

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Microstructure and Mechanical Properties of as Cast Aluminium Alloy 7075/Basalt Dispersed Metal Matrix Composites

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Journal of Minerals and Materials Characterization and Engineering 2014年第3期2卷 182-193页

作者： S. Ezhil Vannan S. paul Vizhian Department of Mechanical Engineering University Visveswarya College of Engineering Affiliated to Bangalore University Bangalore India

This paper aims to study the effects of short basalt fiber reinforcement on the mechanical properties of cast aluminium alloy 7075 composites containing short basalt fiber of content ranging from 2.5 to 10 percent by weight in steps of 2.5 percent and fabricated using compo-casting technique. The objective is to investigate the process feasibility and resulting material properties such as young’s modulus, ductility, hardness & compression strength. The properties obtained are compared with those of as-cast that were manufactured under the same fabrication conditions. The results of this study revealed that, as the short basalt fiber content was increased, there were significant increases in the ultimate tensile strength, hardness, compressive strength and young’s modulus, accompanied by a reduction in its ductility. Furthermore, the microstructure & facture studies were carried out using Optical Microscopy (OM) and Scanning Electron Microscopy (SEM) in order to establish relationships between the quality of the fiber/aluminium interface bond and hence to link with mechanical properties of the composites.

关键词： Metal Matrix Composite (MMCs) Aluminium Alloy Basalt Fibers Mechanical Properties

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Stroke Associated with Covid-19 at the YaoundéGeneral Hospital, Cameroon: Series of 10 Cases

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World Journal of Neuroscience 2021年第3期11卷 221-230页

作者： paul-Cédric Mbonda Victor Sini Jose Kamgang Hadja Cherif Alain Menanga Victor Eyenga Callixte Kuate Vincent de paul Djientcheu Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Neurology Department Yaoundé General Hospital Yaoundé Cameroon Emergencies Department Yaoundé General Hospital Yaoundé Cameroon Infectious diseases Department Yaoundé General Hospital Yaoundé Cameroon

Background: The Covid-19 pandemic, which is an infection due to the SArS Cov-2 virus, mainly causes severe damage to the respiratory system, but several studies have reported neurological damage with different manifes... 详细信息

rong>Background:rong> The Covid-19 pandemic, which is an infection due to the SARS Cov-2 virus, mainly causes severe damage to the respiratory system, but several studies have reported neurological damage with different manifestations including headaches, seizures, encephalopathies, and stroke. We report a series of 10 patients infected with Covid-19 who had an ischemic stroke at the Yaoundé General Hospital, Cameroon. Patients and Methods: We carried out a prospective study for 12 months between April 2020 and March 2021 by collecting data from patients admitted for Covid-19 at the Yaoundé general hospital. Were included all patients with a diagnosis of stroke confirmed by brain imaging (CT/MRI) following a focal neurological deficit of sudden onset and whose test (nasopharyngeal swab confirmed by PCR) for Covid-19 was positive. Patients diagnosed with a stroke more than 2 weeks (14 days) after the positive Covid-19 PCR test were excluded. Results: The prevalence of ischemic stroke in this hospital-based series was 1.46%. These were six men and four women. The mean NIHSS score was 13.57. The average age of our patients was 58 years. Brain imaging was performed in each patient revealing hypodense lesion in a large arterial territory in 8 of them, for two patients we found multilacunar infarcts. All patients had negative HIV serology and D-dimers greater than 500 μg/L. Conclusion: This work on strokes in Covid-19 infected patients shows that it is a fairly frequent neurological complication, which can occur even in young subjects without known risk factors, the symptoms of viral infection are not systematically present before the onset of stroke.

关键词： Covid-19 Stroke Ischemia

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Spectrum evolution of rayleigh backscattering in one‐dimensional waveguide

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Opto-Electronic Advances 2019年第8期2卷 2-8页

作者： Fuhui Li Tianyi Lan Ligang Huang Iroegbu paul Ikechukwu Wuming Liu Tao Zhu Key Laboratory of Optoelectronic Technology and Systems(Education Ministry of China) Chongqing UniversityChongqing 400044China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Despite the tremendous awareness of rayleigh scattering characteristics and its considerable research interest for numerous fields,no report has been documented on the dynamic characteristics of spectrum evolution(SpE)and physical law for rayleigh scattering from a micro ***,the dynamic characteristics of the SpE of rayleigh scattering in a one-dimensional waveguide(ODW)is investigated based on the quantum theory and a SpE-model of rayleigh backscattering(rBS)source is *** means of simulation,the evolution law which represents the dynamic process of the spectrum linewidth at a state of continuous scattering is revealed,which is consistent with our previous experimental ***,an approximate theoretical prediction of the existing relationship between the spectrum linewidth of rBS source and the transmission length in ODW is proposed,which theoretically provides the feasibility of constructing functional devices suitable to ascertain laser linewidth *** designed experimental scheme can be implemented provided the assumptions are *** addition,a theoretical model of the micro-cavity structure to realize the deep compression of laser linewidth is proposed.

关键词： scattering rayleigh spectrum evolution linewidth functional device

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A portrait of the artist as a young man

A portrait of the artist as a young man

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作者： James Joyce edited by John paul riquelme text edited by Hans Walter Gabler with Walter Hettche.

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rapid Ferroelectric‑Photoexcited Bacteria‑Killing of Bi_(4)Ti_(3)O_(12)/Ti_(3)C_(2)T_(x) Nanofiber Membranes

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Advanced Fiber Materials 2023年第2期5卷 484-496页

作者： Zhiying Wang Jianfang Li Yuqian Qiao Xiangmei Liu Yufeng Zheng Zhaoyang Li Jie Shen Yu Zhang Shengli Zhu Hui Jiang Yanqin Liang Zhenduo Cui paul KChu Shuilin Wu The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China School of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Health Science and Biomedical Engineering Hebei University of TechnologyTianjin 300401China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518036China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

In this study,an antibacterial nanofiber membrane[polyvinylidene fluoride/Bi_(4)Ti_(3)O_(12)/Ti_(3)C_(2)T_(x)(PVDF/BTO/Ti_(3)C_(2)T_(x))]is fabricated using an electrostatic spinning process,in which the self-assembled BTO/Ti_(3)C_(2)T_(x) heterojunction is incorporated into the PVDF *** from the internal electric field induced by the spontaneously ferroelectric polarization of BTO,the photoexcited electrons and holes are driven to move in the opposite direction inside BTO,and the electrons are transferred to Ti_(3)C_(2)T_(x) across the Schottky ***,directed charge separation and transfer are realized through the cooperation of the two *** recombination of electron–hole pairs is maximumly inhibited,which notably improves the yield of reactive oxygen species by enhancing photocatalytic ***,the nanofiber membrane with an optimal doping ratio exhibits outstanding visible light absorption and photothermal conversion ***-mately,photothermal effect and ferroelectric polarization enhanced photocatalysis endow the nanofiber membrane with the ability to kill 99.61%±0.28%Staphylococcus aureus and 99.71%±0.16%Escherichia coli under 20 min of light *** study brings new insights into the design of intelligent antibacterial textiles through a ferroelectric polarization strategy.

关键词： Ferroelectric polarization Antibacterial nanofiber Ti_(3)C_(2)T_(x) Photocatalysis Schottky heterojunction

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华南、巽他和掸邦地块之间边界断裂的上新世—第四纪大规模构造反转

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地质学报 2022年第8期96卷 2833-2852页

作者： Marie-Luce CHEVALIEr.paul TAPPONNIEr Phan Trong TrINH Anne BrIAIS 李海兵徐锐南方海洋科学与工程广东省实验室(广州) 广东广州511458 中国地质科学院地质研究所自然资源部深地动力学重点实验室北京100037 国家自然灾害防治研究院中国应急管理部北京100085 江苏东海大陆深孔地壳活动国家野外科学观测研究站江苏连云港222300 越南科学技术研究院地质科学研究所越南河内100000 法国国家科学研究中心欧洲海洋研究所法国普鲁赞29280 四川省地震局四川成都610041 中国地震局地球物理研究所北京100081

印度-亚洲碰撞后,大陆板块沿着大型的左行走滑断裂挤出。规模最大的哀牢山-红河剪切带(ASrr)将印支地块(巽他地块)与华南地块分隔开来。长约1000 km的红河活动断裂(rrF)沿哀牢山的北侧延伸,目前呈现出右行走滑兼正断的活动性质。本文在... 详细信息

印度-亚洲碰撞后,大陆板块沿着大型的左行走滑断裂挤出。规模最大的哀牢山-红河剪切带(ASrr)将印支地块(巽他地块)与华南地块分隔开来。长约1000 km的红河活动断裂(rrF)沿哀牢山的北侧延伸,目前呈现出右行走滑兼正断的活动性质。本文在讨论了红河断裂系及其周缘的第三纪和现今变形特征(滑移性质反转、渐新世/第四纪位错、全新世滑动速率、GPS测量、地震机制等)基础之上,重点论述了其在上新世—第四纪从云南东南部到越南西北部、北部湾西部、再到更南的沙巴地区的断裂分布和运动学特征。新的数据证实,跨过三联点和越南西北部的奠边府断层之后,华南地块与巽他地块之间的现今大部分右行走滑主要沿着Da river断裂向Day Nui Con Voi(或称大象山)东南方向延伸。Da river断裂与rrF大致平行,是2020年M_(w) 5.0莫州地震的发震断层。进一步研究表明,Da river断裂很可能沿着渐新世—中新世莺歌海/宋红盆地西缘和越南东南海岸(归仁剪切带)向南延伸得更远,至少延伸到“Ile des Cendres”火山群,并可能继续延伸到沙巴-文莱逆冲带的西端,靠近婆罗洲北部的近海活动边缘。最后,我们讨论了在菲律宾群岛、台湾岛和巽他群岛之间南海大部分地区大规模构造反转的运动学效应。

关键词：南海红河断裂—Da river断裂历史地震年轻火山作用走滑构造反转块体构造

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Knowledge, Attitude and Awareness of Hazards Associated with Use of Cotton Bud in a Nigerian Community

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第3期4卷 248-253页

作者： Olajide Toye Gabriel Usman Aminu Mohammed Eletta Adebisi paul Department of Ear Nose and Throat Surgery Federal Teaching Hospital Ido Ekiti Nigeria Department of Ear Nose and Throat Surgery Federal Medical Centre Bida Nigeria

Background: Self-cleaning of ears with a cotton bud is a common practice, and the hazards asso-ciated with such action are well documented. The aim of this study is to find out the knowledge, attitude and awareness on the use of cotton buds among the people of Bida community. Design and Methodology: It is a community based cross sectional descriptive study carried out among people of Bida community. Subjects were selected by multistage sampling technique. Pre-tested semistructured questionnaires were used to collect data from 278 young adults and adults’ respondents. results: There were a total number of 278 responses out of 290 respondents interviewed (M:F = 1:1.03). Age range was from 18 to 65 years with a mean of 29.64 ± 10.06 SD. The highest response was in the age group of 20 - 29 years. About 72.3% of the respondents had tertiary education, and 40.3% were civil servants. Majority (92.8%) of the respondents had indulged in the use of cotton buds to clean their ears. Most (57.8%) of those that had used cotton buds did so because of itching in the ears. Only 44.9% of respondents agreed that cotton buds could cause damage to the ears. Many (61.2%) believed that there was benefit of using cotton buds in cleaning the ears. Majority of the respondents (74.1%) had not got information on the danger of using cotton bud in cleaning their ears. Conclusion: From our data in this study, majority of the subjects had indulged in the use of cotton bud in cleaning their ears. And the commonest reason for using cotton buds is due to itching in the ears. Their Knowledge, attitude and awareness to the use of cotton buds are very poor with erroneous believe that there is benefit to its use. There is a need to increase awareness by public enlightenment and health education and to establish school health programme in our various schools.

关键词： Knowledge Awareness Hazards Cotton Bud Nigerian Community

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The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition

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Journal of Animal Science and Biotechnology 2018年第4期9卷 971-979页

作者： robin B.Guevarra Sang Hyun Hong Jin Ho Cho Bo-ra Kim Jiwon Shin Jun Hyung Lee Bit Na Kang young Hwa Kim Suphot Wattanaphansak richard E.Isaacson Minho Song Hyeun Bum Kim Department of Animal resources Science Dankook UniversityCheonanSouth Korea Division of Food and Animal Sciences Chungbuk National UniversityCheongjuSouth Korea Abbvie Bioresearch Center AbbvieWorcesterMAUSA National Institute of Animal Science Rural Development AdministrationWanjuSouth Korea Department of Veterinary Medicine Faculty of Veterinary ScienceChulalongkorn UniversityPathum WanBangkok 10330Thailand Department of Veterinary and Biomedical Sciences University of MinnesotaSt.PaulMN 55108USA Division of Animal and Dairy Science Chungnam National UniversityDaejeonSouth Korea

Background: Understanding the composition of the microbial community and its functional capacity during weaning is important for pig production as bacteria play important roles in the pig’s health and growth performance. However,limited information is available regarding the composition and function of the gut microbiome of piglets in ***, we performed 16 S rrNA gene and whole metagenome shotgun sequencing of DNA from fecal samples from healthy piglets during weaning to measure microbiome shifts, and to identify the potential contribution of the early-life microbiota in shaping piglet health with a focus on microbial stress responses, carbohydrate and amino acid ***: The analysis of 16 S rr NA genes and whole metagenome shotgun sequencing revealed significant compositional and functional differences between the fecal microbiome in nursing and weaned piglets. The fecal microbiome of the nursing piglets showed higher relative abundance of bacteria in the genus Bacteroides with abundant gene families related to the utilization of lactose and galactose. Prevotel a and Lactobacil us were enriched in weaned piglets with an enrichment for the gene families associated with carbohydrate and amino acid metabolism. In addition, an analysis of the functional capacity of the fecal microbiome showed higher abundances of genes associated with heat shock and oxidative stress in the metagenome of weaned piglets compared to nursing ***: Overal, our data show that microbial shifts and changes in functional capacities of the piglet fecal microbiome resulted in potential reductions in the effects of stress, including dietary changes that occur during *** results provide us with new insights into the piglet gut microbiome that contributes to the growth of the animal.

关键词： Metagenomics Microbiome Piglets 16S rrNA Weaning

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A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions

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Bioactive Materials 2022年第8期7卷 364-376页

作者： Yanyan Zheng Ang Gao Jiaxiang Bai Qing Liao Yuzheng Wu Wei Zhang Min Guan Liping Tong Dechun Geng Xin Zhao paul K.Chu Huaiyu Wang Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China School of Basic Medical Sciences and Forensic Medicine North Sichuan Medical CollegeNanchong637000China Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing100190China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Polyetheretherketone(PEEK)is a desirable alternative to conventional biomedical metals for orthopedic implants due to the excellent mechanical ***,the inherent bioinertness of PEEK contributes to inferior osseointegration of PEEK implants,especially under pathological conditions of ***,a programmed surface is designed and fabricated on PEEK to dictate osteoimmunomodulation and bone regeneration sequentially.A degradable hybrid coating consisting of poly(lactide-co-glycolide)and alendronate(ALN)loaded nano-hydroxyapatite is deposited on PEEK and then interleukin-4(IL-4)is grafted onto the outer surface of the hybrid coating with the aid of N_(2) plasma immersion ion implantation and subsequent immersion in IL-4 *** release of IL-4 together with ALN and Ca^(2+) during the first few days synergistically mitigates the early acute inflammatory reactions and creates an osteoimmunomodulatory microenvironment that facilitates bone ***,slow and sustained delivery of ALN and Ca^(2+) in the following weeks boosts osteogenesis and suppresses osteoclastogenesis simultaneously,consequently ameliorating bone-implant osseointegration even under osteoporotic *** taking into account the different phases in bone repair,this strategy of constructing advanced bone implants with sequential functions provides customizable and clinically viable therapy to osteoporotic patients.

关键词： Polyetheretherketone Surface modification Osteoimmunomodulation Sequential release Osteoporosis Osseointegration

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