检索结果-南通市图书馆

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Neural regeneration research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone regeneration

引用

NANO-MICrO LETTErS 2025年第1期17卷 1-51页

作者： Wang, Xiao zeng, Jia Gan, Donglin Ling, Kun He, Mingfang Li, Jianshu Lu, Yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

引用

Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian Li Wen Yi XiangHui Xue Jie zeng HaiLun Ye JianYuan Wang JinSong Chen Na Li TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment National Observation and research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inexact proximal gradient algorithm with random reshuffling for nonsmooth optimization

引用

Science China(Information Sciences) 2025年第1期 219-237页

作者： Xia JIANG Yanyan FANG Xianlin zeng Jian SUN Jie CHEN National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of Technology Beijing Institute of Technology Chongqing Innovation Center School of Electronic and Information Engineering Tongji University

Proximal gradient algorithms are popularly implemented to achieve convex optimization with nonsmooth regularization. Obtaining the exact solution of the proximal operator for nonsmooth regularization is challenging because errors exist in the computation of the gradient; consequently, the design and application of inexact proximal gradient algorithms have attracted considerable attention from researchers. This paper proposes computationally efficient basic and inexact proximal gradient descent algorithms with random reshuffling. The proposed stochastic algorithms take randomly reshuffled data to perform successive gradient descents and implement only one proximal operator after all data pass through. We prove the convergence results of the proposed proximal gradient algorithms under the sampling-without-replacement reshuffling *** computational errors exist in gradients and proximal operations, the proposed inexact proximal gradient algorithms can converge to an optimal solution neighborhood. Finally, we apply the proposed algorithms to compressed sensing and compare their efficiency with some popular algorithms.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Win-Win:Anthropogenic circularity for metal criticality and carbon neutrality

引用

Frontiers of Environmental Science & Engineering 2023年第2期17卷 111-122页

作者： Xianlai zeng State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China

resource depletion and environmental degradation have fueled a burgeoning discipline of anthropogenic circularity since the *** generally consists of waste reuse,remanufacturing,recycling,and *** economy and“zero-waste”cities are sweeping the globe in their current practices to address the world’s grand concerns linked to resources,the environment,and ***,metal criticality and carbon neutrality,which have become increasingly popular in recent years,denote the material's feature and state,*** goal of this article is to determine how circularity,criticality,and neutrality are *** anthropogenic circularity has the potential to expand the metal supply and,as a result,reduce metal *** barely accomplished 15%of its potential emission reduction by recycling iron,copper,and *** circularity has a lot of room to achieve a win-win objective,which is to reduce metal criticality while also achieving carbon neutrality in a near closed-loop *** barriers or challenges for conducting anthropogenic circularity are deriving from the inadequacy of life-cycle insight governance and the emergence of anthropogenic circularity *** flow analysis and life cycle assessment are the central methodologies to identify the hidden *** processing and smelting,as well as end-of-life management,are indicated as critical priority areas for enhancing anthropogenic circularity.

关键词： Anthropogenic circularity Material flow analysis Criticality Carbon neutrality Solid waste Circular economy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种ICEEMDAN-CNN-SVr滑坡位移组合预测模型

引用

三峡大学学报（自然科学版） 2025年第1期47卷 37-43页

作者：石化波王刚曾怀恩中煤湖北地质勘察基础工程有限公司武汉430070 中铁建城建交通发展有限公司江苏苏州215000 湖北长江三峡滑坡国家野外科学观测研究站湖北宜昌443002 三峡大学土木与建筑学院湖北宜昌443002

滑坡位移预测是滑坡早期预警系统的重要组成部分,针对位移分解程度与特征选取深入程度不够导致滑坡位移预测精度不高的问题,提出一种ICEEMDAN-CNN-SVr滑坡位移组合预测模型:为了解决位移分解程度不够的问题,该模型首先运用ICEEMDAN分解... 详细信息

滑坡位移预测是滑坡早期预警系统的重要组成部分,针对位移分解程度与特征选取深入程度不够导致滑坡位移预测精度不高的问题,提出一种ICEEMDAN-CNN-SVr滑坡位移组合预测模型:为了解决位移分解程度不够的问题,该模型首先运用ICEEMDAN分解模型对滑坡位移曲线进行分解,将平滑性较好且具有递增趋势的IMF曲线作为趋势项位移,将其他具有波动趋势的IMF曲线总和重构为周期项位移;为了解决特征选取深入程度不够的问题,针对不同位移特性进行了特征变量选取,通过二维平铺与CNN特征提取得到特征变量更深层次的信息,将提取到的特征信息输入SVr预测模型中实现对趋势项位移与周期项位移的精准预测.以典型堆积层滑坡———八字门滑坡为例,选取ZG110与ZG111监测点2007年1月—2012年9月典型变形阶段水平位移数据进行研究,结果表明:ZG110与ZG111监测点预测评价指标r2,ErMSE,EMAE分别为0.9951、0.9989、5.7489、2.7532,4.5091、1.8529,预测效果良好;将模型预测结果与EEMDCNN-SVr预测模型及CNN-SVr预测模型结果作对比,相较其他预测模型,新模型的预测精度有所提升.

关键词：八字门滑坡 ICEEMDAN分解特征提取 CNN-SVr模型对比分析

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

response of bacteria in the deep-sea sediments and the Antarctic soils to carbohydrates: Effects on ectoenzyme activity and bacterial community

引用

Journal of Environmental Sciences 2010年第11期22卷 1779-1785页

作者： Xiang zeng School of Life Sciences Xiamen University Xiamen 361005 China. Key Laboratory of Marine Biogenetic resources Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China School of Life Sciences and Biotechnology Shanghai Jiaotong University Shanghai 200240 China

The response of bacteria to various carbohydrates in the deep-sea sediments and the Antarctic soils was investigated using cellulose, chitin, and olive oil. It was found that the carbohydrates significantly increased the corresponding specific ectoenzyme activity （β- glucosidase, β-N-acetylglucosaminidase, lipase） in the samples from deep-sea sediments. In the case of Antarctic soil samples, the cellulose or olive oil amendments had minor or no effect on β-glucosidase or lipase activity, except the chitin which stimulated β- N-acetylglucosaminidase production. The responses of the bacteria in the deep-sea sediment sample WP02-3 and the Antarctic soil sample CC-TY2 towards the chitin amendment were further analyzed. Chitin amendments were shown to stimulate the ectoenzyme activity in all the tested sediments and the soils. The bacterial response before and after the carbohydrates amendments were compared by denaturing gradient gel electrophoresis and quantitative competitive polymerase chain reaction. Significant changes were found in the structure and density of the bacterial community in the deep sea sediments as compared to the Antarctic soil sample, where the effects were relatively lower. There was no change in the bacterial population in both studied samples in response to carbohydrates amendments. These data indicate that the bacterial communities in the oligotrophic deep-sea sediments are more dynamic than that in the Antarctic soils as they respond to the nutrient sources efficiently by regulation of ectoenzyme activity and/or changing community structure.

关键词： deep-sea sediments Antarctic soils amending cellulose chitin olive oil ectoenzyme activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aflatoxin B1： Toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni

引用

Insect Science 2013年第3期20卷 318-328页

作者： ren Sen zeng Zhimou Wen Guodong Niu r. Berenbaum State Key Laboratory of Conservation and Utilization of Subtropical Agricultural Bio-resources South China Agricultural University Guangzhou China Department of Entomology University of Illinois Urbana Department of Cell and Developmental Biology University of Illinois Urbana Illinois United States

Trichoplusia ni caterpillars are polyphagous foliage-feeders and rarely likely to encounter aflatoxin B1 （AFB1）, a mycotoxin produced by Aspergillus flavus and A. parasiticus, in their host plants. To determine how T. ni copes with AFB 1, we evaluated the toxicity ofAFB 1 to T. ni caterpillars at different developmental stages and found that AFB 1 tolerance significantly increases with larval development. Diet incorporation of AFB 1 at 1μg/g completely inhibited larval growth and pupation of newly hatched larvae, but 3μg/g AFB 1 did not have apparent toxic effects on larval growth and pupation of caterpillars that first consume this compound 10 days after hatching. Piperonyl butoxide, a general inhibitor of cytochrome P450 monooxygenases （P450s）, reduced the toxicity of AFB 1, suggesting that AFB1 is bioactivated in T. ni and this bioactivation is mediated by P450s. Some plant allelochemicals, including flavonoids such as fiavones, furanocoumarins such as xanthotoxin and imperatorin, and furanochromones such as visnagin, that induce P450s in other lepidopteran larvae ameliorated AFBI toxicity, suggesting that P450s are also involved in AFB 1 detoxification in T. ni.

关键词： aflatoxin allelochemical bioactivation cytochrome P450 monooxygenase,flavone Helicoverpa zea imperatorin mycotoxin piperonyl butoxide Trichoplusia ni,visnagin xanthotoxin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On generalized extending modules

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第6期8卷 939-945页

作者： zeng Qing-yi Department of Mathematics Zhejiang University Hangzhou 310027 China Department of Mathematics Shaoguan University Shaoguan 512005 China

A module Mis called generalized extending if for any submodule N of M, there is a direct summand K of M such that N≤K and KIN is singular. Any extending module and any singular module are generalized extending. Any homomorphic image of a generalized extending module is generalized extending. Any direct sum of a singular （uniform） module and a semi-simple module is generalized extending. A ring r is a right Co-H-ring if and only if all right r modules are generalized extending modules.

关键词： Generalized extending modules Singular Co-H-rings

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Temporal Variations in Soil CO_2 Efflux Under Diferent Land Use Types in the Black Soil Zone of Northeast China

引用

Pedosphere 2013年第5期23卷 636-650页

作者： HAN Xiao-zeng LI Hai-Bo W. r. HOrWATH National Field research Station of Agro-Ecosystem in Hailun Northeast Institute of Geography and Agro-ecology Chinese Academy of Sciences College of Plant Sciences Jilin University of Agricultural Science and Technology Department of Land Air and Water Resources University of California

The quantification of soil CO2 effiux is crucial for better understanding the interactions between driving variables and C losses from black soils in Northeast China and for assessing the function of black soil as a net source or sink of atmospheric CO2 depending upon land use. This study investigated responses of soil CO2 effiux variability to soil temperature interactions with different soil moisture levels under various land use types including grassland, bare land, and arable （maize, soybean, and wheat） land in the black soil zone of Northeast China. The soil CO2 effiuxes with and without live roots, defined as the total CO2 efftux （FtS） and the root-free CO2 ei^lux （FrfS）, respectively, were measured from April 2009 to May 2010 using a static closed chamber technique with gas chromatography. The seasonal soil CO2 fluxes tended to increase from the beginning of the measurements until they peaked in summer and then declined afterwards. The mean seasonal FtS ranged from 20.3=h7.8 to 58.1~21.3 mg CO2-C m-2 h-1 for all land use types and decreased in the order of soybean land ~ grassland 〉 maize land ~ wheat land ） bare land, while the corresponding values of FrfS were relatively lower, ranging from 20.3~7.8 to 42.3~21.3 mg CO2-C m-2 h-1. The annual cumulative FtS was in the range of 107-315 g CO2-C m-2 across all land uses types. The seasonM CO2 effiuxes were significantly （P 〈： 0.001） sensitive to soil temperature at 10 cm depth and were responsible for up to 62% of the CO2 effiux variability. Correspondingly, the temperature coefficient Q10 values varied from 2.1 to 4.5 for the seasonal FtS and 2.2 to 3.9 for the FrfS during the growing season. Soil temperature interacting with soil moisture accounted for a significant fraction of the CO2 flux variability for FtS （up to 61%） and FrfS （up to 67%） via a well-defined multiple regression model, indicating that temperature sensitivity of C02 flux can be mediated by water availability, especially under water stress.

关键词： interaction root soil moisture temperature sensitivity water stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：