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利比城石棉暴露工人:回顾性鉴定和X线摄影改变进程

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国际医学放射学杂志 2010年第4期 389-389页

作者： T.C.Larson C.A.Meyer V.Kapil J.W.Gurney r.D.Tarver C.B.Black 高飞 Division of Health Studies Agency for Toxic Substances and Disease Registry4770 Buford Hwy NEMS F57AtlantaGA 30341USA

目的评估石棉暴露下病人的早期胸膜和(或)肺实质的异常及确定与病变进展的有关因素。材料与方法此研究经伦理委员会通过并获得知情同意书。收集1955年

关键词：工人工资劳动者胸膜斑肺实质石棉保温材料

立体数字化钼靶成像:提高特异度和降低召回率的前瞻性临床实验研究

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国际医学放射学杂志 2013年第2期 160-160页

作者： C. J. D' Orsi D.J. Getty r.M. Pickett I.Sechopoulos M. S. newell 郭凌飞 Department of radiology and Imaging Sciences Emory University School of Medicine 1701 Upper Gate Dr NE Suite C1104 Atlanta GA 30322

目的在对具有乳腺癌高发风险的人群筛查中,比较立体数字化钼靶成像(DM)与标准DM对癌症的检出率和病人召回率的差异。材料与方法于2004年9月—2007年12月进行的本项前瞻性研究符合HIPAA法案,筛查实验经过伦理委员会的同意,所有参加该试... 详细信息

目的在对具有乳腺癌高发风险的人群筛查中,比较立体数字化钼靶成像(DM)与标准DM对癌症的检出率和病人召回率的差异。材料与方法于2004年9月—2007年12月进行的本项前瞻性研究符合HIPAA法案,筛查实验经过伦理委员会的同意,所有参加该试验的具有乳腺癌高发风险的女性病人(如有乳腺癌病史或直系亲属有乳腺癌)均签订知情同意书。获得共779例病人(年龄32～91岁,平均58.6岁)的1298次检查可供分析的数据集。采用配对研究设计,每例参与本实验的病人均为自身进行对照。在一次检查中病人接受立体DM与标准DM检查,所获得的影像学表现由2名有经验的放射科医生独立进行判读,使用乳腺成像报告与数据系统(BI-rADS)进行评估(分为0、1、2级)。对所有病人的一个或更多的确定的形态学发现都进行召回性的规范诊断评价。针对这些结果都进行1年以上的随访观察或活检来确定病例的真实性。结果与DM比较,立体DM对癌症的检测具有更高的特异度[91.2%(共1167/1279次检查出现异常)∶87.8%(共1123/1279次检查出现异常);P=0.0024]和准确度[90.9%(共准确诊断1180/1298次)∶87.4%(共准确诊断1135/1298次);P=0.0023]。在癌症检测的敏感度方面,立体DM(68.4%,13/19例)与标准DM(63.2%,12/19例)的差异无统计学意义(P>0.99)。在病人的召回率方面,立体DM为9.6%(1298例病人中召回125例),DM为12.9%(1298例病人中召回168例)(P=0.0018)。结论与DM比较,立体DM可以显著提高癌症检测的特异性,并且可以保持比较高的敏感性。立体DM与DM相比,可以显著降低病人的召回率。

关键词：召回率病人 DM 钼靶特异度

EGFr Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: results from “ErBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François ramée Jean-Luc raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis roger Faroux Marie-Aude Coulon Philippe Deguiral Kar.ne Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier régional Universitaire (CHrU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Cather.ne de Sienne Nantes France CrLCC Eugène Marquis Rennes France ICO rené Gauducheau Nantes France Centre CArIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ArMOr Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFr) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCrC). With the objective of improving patient selection, “ErBITUX-OUEST” study aimed at analyzing EGFr status in a large cohort of mCrC patients who received cetuximab without preliminary EGFr screening, and assessing the correlation between EGFr status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFr status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFr-positive and EGFr-non-detected (or considered as negative with at least one test) patients were compared. results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFr-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. regarding results from FDA approved test only, neither objective response rate (Orr), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFr.negative and EGFr-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of Orr (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCrC patients selection for Cetuximab treatment based on EGFr expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFr Expression

前瞻性和回顾性心电门控冠状动脉64层CT成像:影像质量和病人放射剂量的对照性研究

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国际医学放射学杂志 2008年第5期31卷 400-400页

作者： W.P. Shuman K.r. Branch J.M. May L.M. Mitsumori D.W. Lockhart T.J.Dubinsky 邱建星（译）唐光健（校） Department of radiology University of Washington School of Medicine 1959 NE Pacific St Seattle WA 98195USA. 不详

目的比较一组接受前瞻性心电门控64层CT冠状动脉成像病人及另一组接受回顾性心电门控64层CT冠状动脉病人的成像质量及病人放射剂量。方法本研究依从HIPAA法案并得到了机构审查委员会的批准。由于设计是回顾性研究故不需要知情同意。2位... 详细信息

目的比较一组接受前瞻性心电门控64层CT冠状动脉成像病人及另一组接受回顾性心电门控64层CT冠状动脉病人的成像质量及病人放射剂量。方法本研究依从HIPAA法案并得到了机构审查委员会的批准。由于设计是回顾性研究故不需要知情同意。2位独立阅片者分别对100例病人心脏CT成像（每组各50例）的冠状动脉进行分段影像质量评分和综合评分。计算观察者间偏差。记录对应实际扫描Z轴长度的病人放射剂量，以Z轴长度为12cm的典型心脏计算标准化剂量。结果2组病例的临床特征及CT参数匹配良好。

关键词：回顾性心电门控冠状动脉病放射剂量 CT成像影像质量 64层CT 冠状动脉成像质量评分

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Two different molecular mechanisms underlying progester.ne neuroprotection against ischemic brain damage

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南京医科大学学报(自然科学版) 2008年第10期 1355-1355页

作者： Cai, W. Y. Zhu, Y. Furuya, K. Li, Z. Sokabe, M. Chen, L. Nanjing Med Univ, Lab reprod Med, Dept Physiol, Nanjing 210029, Jiangsu, Peoples r China. Nagoya Univ, Grad Sch Med, Dept Physiol, Nagoya, Aichi 4668550, Japan. JST, ICOrP SOrST Cell Mechanosensing, Nagoya, Aichi 4668550, Japan. Natl Inst Physiol Sci, Dept Mol Physiol, Okazaki, Aichi 4448585, Japan.

Herein, we show that a single injection of P4(4 mg/kg) at 1 h or 48 h, but not 96 h, before middle cerebral artery occlusion (MCAO) produces significant protective effects against the ischemia-induced neuronal death and the deficits in spatial cognition and UP induction. The present study focused on the molecular mechanisms underlying the neuroprotection exerted by P4 administration at I h and 48 h pre-MCAO, termed acute and delayed P4-neuroprotection, respectively. Pharmacology suggested that P4-receptor(P4r) cascading to a Src-ErK1/2 signaling mediated the delayed P4-neuroprotection. To support this, it was observed by anti-phosph-ErK1/2 immunoblots that a single injection of P4 triggered a P4r-mediated persistent increase in ErK1/2 phosphorylation and their nuclear translocation for 48 h. In contrast, the acute P4-neuroprotection did not depend on the P4r-mediated Src-ErK1/2 signaling. Instead, the acute P4-administration attenuated the NMDA-induced rise in the intracellular calcium concentration([Ca2+] (i) ) that may be a primary cause for MCAO-induced neuronal injury. This effect seemed to be exerted by an antagonism of sigma(1) receptor since the sigma(1) receptor antagonist ne100 perfectly mimicked the acute P4-neuroprotection and also attenuated the NM- DA-incluced [Ca2+] (i), increase. These findings suggest that the P4 neuroprotection involves two independent processes depending on the timing of P4 administration before MCAO: an acute protection by antagonizing sigma (1) receptor to inhibit NMDAr-Ca2+ influx and a delayed one by an activation of P4r-mediated SrcErK signaling pathway. (C) 2008 Elsevier Ltd. All rights reserved.

关键词： progester.ne(P4) middle cerebral artery occlusion(MCAO) extracellular receptor kinase(ErK) NMDA receptor (NMDAr) sigma1 (sigma (1) ) receptor cerebral-artery occlusion long-term potentiation methyl-d-aspartate preconditioning-induced activation cerebellar purkinje-cells hippocampal ca1 region rat hippocampus protein-kinase nmda receptor tyrosine phosphorylation

Fungal diversity notes 367-490:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2016年第5期80卷 1-270页

作者： Kevin D.Hyde Sinang Hongsanan rajesh Jeewon D.Jayarama Bhat Eric H.C.McKenzie E.B.Gareth Jones rungtiwa Phookamsak Hiran A.Ariyawansa Saranyaphat Boonmee Qi Zhao Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Supharat Banmai Putarak Chomnunti Bao-Kai Cui Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Nimali Ide Silva Asha J.Dissanayake Mingkwan Doilom Anusha H.Ekanayaka Tatiana Baptista Gibertoni Aristóteles Góes-neto Shi-Ke Huang Subashini C.Jayasiri ruvishika S.Jayawardena Sirinapa Konta Hyang Burm Lee Wen-Jing Li Chuan-Gen Lin Jian-Kui Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Patinjareveettil Manimohan Ausana Mapook Tuula Niskanen Chada Norphanphoun Moslem Papizadeh rekhani H.Perera Chayanard Phukhamsakda Christian richter AndréL.C.Mde A.Santiago E.ricardo Drechsler-Santos Indunil C.Senanayake Kazuaki Tanaka T.M.D.S.Tennakoon Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Benjarong Thongbai Alfredo Vizzini Dhanushka N.Wanasinghe Nalin N.Wijayawardene Hai-Xia Wu Jing Yang Xiang-Yu Zeng Huang Zhang Jin-Feng Zhang Timur S.Bulgakov Erio Camporesi Ali H.Bahkali Mohammad A.Amoozegar Lidia Silva Araujo-neta Joseph F.Ammirati Abhishek Baghela r.P.Bhatt Dimitar Bojantchev Bart Buyck Gladstone Alves da Silva Catarina Letícia Ferreira de Lima rafael JoséVilela de Oliveira Carlos Alberto Fragoso de Souza Yu-Cheng Dai Bálint Dima Tham Thi Duong Enrico Ercole Fernando Mafalda-Freire Aniket Ghosh Akira Hashimoto Sutakorn Kamolhan Ji-Chuan Kang Samantha C.Karunarathna Paul M.Kirk Ilkka Kytovuori Angela Lantieri Kare Liimatainen Zuo-Yi Liu Xing-Zhong Liu robert Lücking Gianfranco Medardi Peter E.Mortimer Thi Thuong Thuong Nguyen Itthayakorn Promputtha K.N.Anil raj Mateus A.reck Saisamorn Lumyong Seyed Abolhassan Shahzadeh-Fazeli Marc Stadler Mohammad reza Soudi Hong-Yan Su Takumasa Takahashi Narumon Tangthirasunun Priyanka Uniyal Yong Wang Ting-Chi Wen Jian-Chu Xu Zhong-Kai Zhang Yong-Chang Zhao Jun-Liang Zhou Lin Zhu Institute of Biotechnology and Germplasm resources Key Lab of Southwestern Crop Gene Resources and Germplasm Innovation Ministry of AgricultureYunnan Provincial Key Laboratory of Agricultural BiotechnologyYunnan Academy of Agricultural SciencesKunming 650223YunnanPeople’s Republic of China Key Laboratory of Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal research Mae Fah Luang University333 M.1T.ThasudMuangChiang Rai 57100Thailand State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori 036-8561Japan The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 ChomeMorioka 020-8550Japan Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesXiaohe DistrictGuiyang CityGuizhou Province 550006People’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025GuizhouPeople’s Republic of China Department of Botany Goa UniversityTaleigãoGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Centre of Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Department of Microbial Drugs Helmholtz Centre for Infection Res

This is a continuity of a series of taxonomic papers where materials are examined,described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates on their *** addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets(rDNA,TEF-a,rBP2 and b-Tubulin)to infer phylogenetic relationships and substantiate systematic position of taxa within appropriate *** new species or combinations are being proposed,we apply an integrative approach(morphological and molecular data as well as ecological features wherever applicable).Notes on 125 fungal taxa are compiled in this paper,including eight new genera,101 new species,two new combinations,one neotype,four reference specimens,new host or distribution records for eight species and one alternative *** new genera introduced in this paper are Alloarthopyrenia,Arundellina,Camarosporioides,neomassaria,neomassarina,neotruncatella,Paracapsulospora and *** new species are Alfaria spartii,Alloarthopyrenia italica,Anthostomella ravenna,***,Arthrinium paraphaeospermum,Arundellina typhae,Aspergillus koreanus,Asterina cynometrae,Bertiella ellipsoidea,Blastophorum aquaticum,Cainia globosa,Camarosporioides phragmitis,Ceramothyrium menglunense,Chaetosphaer.nema achilleae,Chlamydotubeufia helicospora,Ciliochorella phanericola,Clavulinopsis aurantiaca,Colletotrichum insertae,Comoclathris italica,Coronophora myricoides,Cortinarius fulvescentoideus,***,***,***,Cunninghamella gigacellularis,Cyathus pyristriatus,Cytospora cotini,Dematiopleospora alliariae,***,Diaporthe aseana,***,Distoseptispora multiseptata,***,***,Dothiora buxi,Emericellopsis persica,Gloniopsis calami,Helicoma guttulatum,Helvella floriforma,***,Hermatomyces subiculosa,Ju

关键词： Ascomycota Basidiomycota Dothideomycetes Mortierellomycotina Mucoromycotina Pezizomycetes Phylogeny Taxonomy new genus new species new host records

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular.neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza r Al-Bayati Leonardo renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot rodrigo rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts romain Bourcier romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano ryoo Yamamoto Adrienne Weeks Elena A Cora rotem Sivan-Hoffmann roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-neto Ajay K Wakhloo Barbara Voetsch Eytan raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug neurology RadiologyBoston Medical CenterBostonMassachusettsUSA neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA neurology National Hospital Organization Osaka National HospitalOsakaJapan neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan neurology Alexandria UniversityAlexandriaEgypt radiology Boston Medical CenterBostonMassachusettsUSA Department of neurology Xinqiao HospitalChongqingChina neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance neurology Hospital Geral de FortalezaFortalezaBrazil Interventional neuroradiology Hospital Geral de FortalezaFortalezaBrazil neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional neurovascular Unit University Hospital CareggiFirenzeToscanaItaly neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional neuroradiology Lahore General HospitalLahorePakistan neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of radiology Beaumont HospitalDublinIreland neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional neuroradiology Institut National de NeurologieTunisTunisia neurology Boston Medical CenterBostonMassachusettsUSA neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,prelative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid