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CDC7 inhibition impairs neuroendocr.ne transformation in lung and prostate tumors through MYC degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther redin Fathema Uddin Swanand rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter r.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu radhika A.Patel Colm Morrsey Sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas D.Socci richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.Chan Charles M.rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility Memorial Sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell Medical College new York NYUSA Present address:Swiss Institute for Experimental Cancer research(ISrEC) School of Life SciencesEPFLLausanneSwitzerland

neuroendocr.ne(ne)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and retinoblastoma Transcriptional Corepressor 1(rB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tumors during the initial steps of ne transformation,already after TP53/rB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed ne transdifferentiation and extended response to targeted therapy in in vivo models of ne transformation by inducing the proteasome-mediated degradation of the MYC Proto-Oncogen(MYC),implicated in stemness and histological *** overexpression of a degradation-resistant MYC isoform reestablished the ne transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat ne tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

肝红细胞生成性卟啉症:尿卟啉原脱羧酶基因错义突变与疾病的轻重及卟啉分泌类型

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 61-62页

作者： Armstrong D.K.B. Sharpe P.C. Chambers C.r. G.H. Elder 党倩丽 Dept. of Med. Biochem. and Immunol. University Hospital of Wales Univ. of Wales College of M edicine Heath Park Cardiff CF14 4XN United Kingdom

Hepatoerythropoietic porphyria (HEP) is an uncommon inherited cutaneo us porph yria, related to porphyria cutanea tarda, that results from severe uroporphyrino gen decarboxylase (UrOD) deficiency. It is characterized clinically by the onset in early childhood of severe lesions on sun-exposed skin. We describe a man a ged 38 years with an unusually mild form of the disease that started in his earl y teens. Our data confirm that homozygosity for the F46L mutation in the UrOD ge ne causes a mild form of HEP and show that this genotype may be associated with a unique urinary porphyrin excretion pattern in which pentacarboxylic porphyrin predominates.

关键词：卟啉症红细胞生成脱羧酶尿卟啉原错义突变纯合子数据显示五价

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继发于异常侧支的乳内动脉盗血综合征

世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 56-57页

作者： Lakkireddy D. r. Lanspa T. J. Mehta N. J. I. A. Khan 刘少伟 Division of Cardiology Creighton University Cardiac Center 3006Webster Street Omaha NE 68131 United States

A 53-year-old male who underwent three-vessel coronary artery bypass grafting had a left internal mammary artery(LIMA) graft to the left anterior descending artery(LAD) and saphenous venous grafts to right coronary artery(rCA) and left circumflex coronary artery. Four years after surgery, he developed exertion angina associated with upper body exercises and even deep breathing at times. Angiographic evaluation revealed an anomalous lateral internal thoracic artery with steal phenomenon documented by adenosine cardiolyte. Patient was successfully treated with transcutaneous steel coil embolization by closing the anomalous vessel. repeat stress electrocardiogram did not show any signs of ischemia. This case report emphasizes the variability in internal mammary artery(IMA)anatomy and the need to completely ligate all the branches of internal mammary artery intraoperatively.

关键词：盗血综合征乳内动脉心电图检测盗血现象劳累性心绞痛左旋支上肢运动成像显示胸廓内动脉隐静脉

Diurnal and Seasonal Variation of BTX in Ambient air of One Urban Site in Carmen City, Campeche, Mexico

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Journal of Environmental Protection 2013年第8期4卷 40-49页

作者： J. G. Cerón E. ramírez r. M. Cerón C. Carballo C. Aguilar U. López A. ramírez Y. Gracia D. Naal A. Campero J. Guerra E. Guevara Facultad de Ciencias Químicas Universidad Autónoma de Nuevo León (UANL) San Nicolás de los Garza Mexico Universidad Autónoma del Carmen Ciudad del Carmen Mexico

BTX (benzene, ethylbenzene, toluene and p-xylene) and meteorological parameters were measured in ambient air of an urban site located in Carmen City, Campeche, Mexico. A total of 412 samples were collected for BTX and analyzed by Gas Chromatography with Flame Ionization Detection (GC-FID). Meteorological parameters were measured by a portable station. A marked diurnal variation was found for all measured BTX. The highest concentrations occurred during midday (13:00-14:30 h). A clear seasonal pattern was observed too for all compounds registering their highest levels during summer sampling period. Mean concentrations for benzene, ethylbenzene, toluene and p-xylene were: 5.42, 3.97, 11.24 and 8.32 ppbv, respectively. BTX abundance showed the following order: toluene > p-xylene > benzene > ethylbenzene. BTX maximum concentrations were found when winds blowed from E and ne. Important oil industry sources and avenues are located at these directions. These sources could contribute to the levels of BTX in this site.

关键词： BTX Carbonyls Volatile Organic Compounds Air Pollution Carmen City Mexico

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研究神经胶质细胞的新兴技术

神经损伤与功能重建 2020年第10期15卷 F0003-F0003页

作者： Hélène Hirbec Nicole Déglon Lynette C Foo Inbal Goshen Jaime Grutzendler Emilie Hangen Tirzah Kreisel Nathalie Linck Julien Muffat Sara regio Sybille rion Carole Escartin 杜一星 Institute for Functional Genomics(IGF) University of MontpellierCNRSINSERMMontpellierFrance Laboratory of neurotherapies and neuromodulation Department of Clinical NeuroscienceLausanne University HospitalUniversity of LausanneLausanneSwitzerland Laboratory of neurotherapies and neuromodulation Neuroscience Research CenterLausanne University Hospital and University of LausanneLausanneSwitzerland neuroimmunology and neurodegeneration Section The Neuroscience and Rare Diseases Discovery and Translational AreaF.Hoffman-La RocheBaselSwitzerland Edmond and Lily Safra Center for Brain Sciences The Hebrew University of JerusalemJerusalemIsrael Department of neurology Yale University School of MedicineNew HavenConnecticutUSA Department of neuroscience Yale University School of MedicineNew HavenConnecticutUSA Commissariatà l'Energie Atomique et aux Energies Alternatives Département de la Recherche FondamentaleInstitut de Biologie François JacobMIRCenFontenay-aux-RosesFrance Centre National de la recherche Scientifique Neurodegenerative Diseases LaboratoryUniversitéParis-SudUniversitéParis-SaclayUMR 9199Fontenay-aux-RosesFrance Program in neurosciences and Mental Health The Hospital for Sick Childrenand Department of Molecular GeneticsThe University of TorontoTorontoCanada 不详

大脑的发育、生理功能和病理与神经元和不同类型的神经胶质细胞(如星形胶质细胞、小胶质细胞、少突胶质细胞和少突胶质细胞的前体细胞等)之间的相互作用密切相关。研究脑功能及其功能障碍,除了神经元之外,还需要对不同类型的神经胶质细... 详细信息

大脑的发育、生理功能和病理与神经元和不同类型的神经胶质细胞(如星形胶质细胞、小胶质细胞、少突胶质细胞和少突胶质细胞的前体细胞等)之间的相互作用密切相关。研究脑功能及其功能障碍,除了神经元之外,还需要对不同类型的神经胶质细胞进行研究。近年来,多项技术突破使“神经胶质科学家”能够解决新的具有挑战性的生物学问题。这些技术发展使得以中/高含量工作流研究特定细胞类型的作用成为可能,并在保存完好的环境中对其相互作用进行精细的分析。本综述阐明了几种可能揭示神经胶质细胞在特定脑功能或疾病中作用的尖端实验方法。这些实验方法包括高级细胞培养,诱导多能干细胞(iPSC)衍生的人神经胶质细胞,病毒载体,原位胶质细胞成像,光学遗传学和化学遗传学方法,以及高内涵分子分析。本文还阐述了某些技术的临床转化,通过特定的脑成像方法以监控患者的神经胶质细胞。本文亦讨论了每种技术的优点,缺陷和未来发展,并提供了选定的示例以说明现在如何可以解决特定的“胶质生物学”问题。

关键词：神经胶质细胞少突胶质细胞小胶质细胞星形胶质细胞脑功能细胞培养细胞类型脑成像

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鼻气管鸟疫杆菌中国株的初步鉴定

鼻气管鸟疫杆菌中国株的初步鉴定

Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

中国畜牧兽医学会禽病学会分会第十次学术研讨会

作者：陈小玲宋程罗廷荣宋敏训 Terry T Bragg r Blackall P.J. 北京市农林科学院畜牧兽医研究所广西大学山东家禽研究所澳大利亚昆士兰大学微生物学和寄生虫学系南非Bloemfontein大学微生物学和寄生虫学系澳大利亚昆士兰州动物研究所

通过形态特性检验,常规生化试验,API-20ne生化试剂盒检验、PCr检验和血清学检验从疑似副鸡嗜血杆菌的野外分离株中鉴定出2株鼻气管鸟疫杆菌。

关键词：鼻气管鸟疫杆菌鉴定

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： robert B. Mitchell Daren D. redfearn Kenneth P. Vogel Terry J. Klopfenstein Galen Erickson P. Stephen Baenziger Bruce E. Anderson Mary E. Drewnoski Jay Parsons Steven D. Masterson Marty r. Schmer Virginia L. Jin USDA-ArS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural Economics University of Nebraska-Lincoln Lincoln NE USA USDA-ArS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, ne, USA. Each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

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2004年深圳市重点医学专科中期评估分析

中华医学科研管理杂志 2006年第4期19卷 227-229页

作者：许四虎张丹韩铁光周丽萍李江波付林骆新娥隋丽颖黄华丽罗晓琼深圳市卫生局 518020 深圳市孙逸仙心血管医院深圳市第二人民医院深圳市人民医院北京大学深圳医院

目的了解深圳市重点医学专科中期建设情况并据此制订下一步的发展战略目标。方法根据《深圳市重点医学专科(实验室)评估指标体系(试行)》(该体系有19个Ⅱ级指标,总分值1 000分),分别从学科管理、人才建设、学科影响力、科技优势、教学... 详细信息

目的了解深圳市重点医学专科中期建设情况并据此制订下一步的发展战略目标。方法根据《深圳市重点医学专科(实验室)评估指标体系(试行)》(该体系有19个Ⅱ级指标,总分值1 000分),分别从学科管理、人才建设、学科影响力、科技优势、教学培训、学科条件和医疗质量7个方面对已建设了2年的34个深圳市重点医学专科和实验室进行了中期评估。结果得分在700以上(A组)、600～699分(B组)、500～599分(C组)、400～499分(D组)及400分以下(E组)的重点医学专科分别为2个、12个、15个、4个和1个；其中,A组和B组的重点医学专科取得了满意的建设结果,但D组和E组没有达标,C组还需进行整改,有望在后半个建设周期内达标。结论按上述指标体系对现有的重点医学专科建设进行中期评估是可行的。评估结果可以为重点医学专科发展战略目标的制订提供科学的指导意见。

关键词：重点医学专科中期评估

无症状受试者中冠状动脉钙化进展的危险因素:动脉粥样硬化多种族研究(MESA)的结果

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世界核心医学期刊文摘(心脏病学分册) 2007年第9期 45-45页

作者： Kronmal r.A. McClelland r.L. Detrano r. 孙凯 Collaborative Health Studies Coordinating Center Department of Biostatistics University of Washington 6200 NE 74th St SeattleWA 98115 United States

背景:动脉粥样硬化多种族研究(MESA)提供了机会,在大规模基于社区的无临床心血管疾病证据的人群中,研究传统心血管危险因素与冠状动脉钙化(CAC)发生及进展间关系。方法和结果:对5756例参与者进行平

关键词：冠状动脉危险因素 CAC MESA 危险隐患动脉硬化动脉粥样硬化人种种族