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极早产儿的内囊和胼胝体白质纤维发育的追踪成像

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国际医学放射学杂志 2011年第3期 295-295页

作者： F.T.de Brune G.W.Meijler L.M.Leijser A.A.van den Berg-Huysmans A.van Steenis M.A.van Buchem 焦惠 Department of radiology Leiden University Medical Center

目的探讨早产儿的内囊后肢(PLIC)及胼胝体(CC)的扩散张量成像(DTI)参数与年龄、白质损伤和临床因素间的相关性。方法对84例早产儿于孕龄40～62周间行3T磁

关键词：扩散张量成像纤维追踪成像早产儿足月年龄当量白质损伤

remimazolam for sedation in gastrointestinal endoscopy:A comprehensive review

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 385-395页

作者： Dushyant Singh Dahiya Ganesh Kumar Syeda Parsa Manesh Kumar Gangwani Hassam Ali Amir Humza Sohail Saqr Alsakarneh Umar Hayat Sheza Malik Yash r Shah Bhanu Siva Mohan Pinnam Sahib Singh Islam Mohamed Adishwar rao Saurabh Chandan Mohammad Al-Haddad Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityMO 66160United States Department of Internal Medicine Chandka Medical CollegeSindh 77280Pakistan Department of Gastroenterology and Hepatology University of Arkansas For Medical SciencesLittle RockAR 72205United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64108United States Department of Internal Medicine Geisinger Wyoming Valley Medical CenterWilkes BarrePA 18711United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine Sinai hospitalBaltimoreMD 21215United States Department of Hepatology University of MissouriColumbiaMO 65211United States Department of Internal Medicine Guthrie Robert Packer HospitalSayrePA 18840United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

Worldwide,a majority of routine endoscopic procedures are performed under some form of sedation to maximize patient ***,benzodiazepines and opioids continue to be widely ***,in recent years,remimazolam is gaining immense popularity for procedural sedation in gastrointestinal(GI)*** is an ultra-short-acting benzodiazepine sedative which was approved by the Food and Drug Administration in July 2020 for use in procedural *** has shown a favorable pharmacokinetic and pharmacodynamic profile in terms of its non-specific metabolism by tissue esterase,volume of distribution,total body clearance,and negligible drug-drug *** also has satisfactory efficacy and has achieved high rates of successful sedation in GI ***,studies have demonstrated that the efficacy of remimazolam is non-inferior to Propofol,which is currently a gold standard for procedural sedation in most parts of the ***,the use of Propofol is associated with hemodynamic instability and respiratory *** contrast,remimazolam has lower incidence of these adverse effects intra-procedurally and hence,may provide a safer alternative to Propofol in procedural *** this comprehensive narrative review,highlight the pharmacologic characteristics,efficacy,and safety of remimazolam for procedural *** also discuss the potential of remimazolam as a suitable alternative and how it can shape the future of procedural sedation in gastroenterology.

关键词： remimazolam Endoscopy Sedation Outcomes Efficacy Safety Pharmacokinetics

二维圆环内介电液体电对流不稳定性数值模拟研究

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二维圆环内介电液体电对流不稳定性数值模拟研究

上海地区活禽批发市场H9亚型禽流感病毒调查

第十一届全国流体力学学术会议

作者：黄俊宇 r.Deepak Selvakumar 王琦关逸飞宋志伟吴健哈尔滨工业大学能源学院 rice University Department of Mechanical Engineering

流动的失稳与非线性演化长期以来一直受到科学界和工业界的广泛关注。与热对流相似,电对流因其丰富的流动特性与失稳路径,近年来成为研究流动不稳定性的重要媒介。本文针对同心圆环结构内介电液体电对流进行了二维数值模拟研究。该几何... 详细信息

流动的失稳与非线性演化长期以来一直受到科学界和工业界的广泛关注。与热对流相似,电对流因其丰富的流动特性与失稳路径,近年来成为研究流动不稳定性的重要媒介。本文针对同心圆环结构内介电液体电对流进行了二维数值模拟研究。该几何结构内外圆环为同心放置的电极,其中内圆环施加高电压,外圆环接地(图1)。内外圆环间存在一个直流电场,从内圆环电极上注入的自由电荷在电场库仑力的驱动下产生电对流。本文基于有限体积法(FVM)采用FLUENT软件耦合自编程用于求解电场模块的UDF对这一物理问题进行求解,并记录了流场的最大速度V、平均动能密度E和电努赛尔数ne等参数来定量描述电对流的流动特性。模拟均采用强注入模式,保持注入强度C=10,内外圆半径比Γ=0.5(Γ=r/r),电荷迁移系数M=60,逐渐增大电场驱动参数(电瑞利数T),研究了圆环内电对流从初始的静止状态到流动发生、流动失稳直至混乱流动(chaos)的完整发展路径。在流动失稳的临界参数附近,模拟观察到流动从稳定到中间状态乃至最后失稳的完整演化过程。初始条件对流动的产生与发展存在显著影响,本文采用两种不同方式来增大电场驱动参数T,模拟了电对流在不同初始条件下的发展演化路径。此外,本文还记录了在混乱流动(chaos)状态下,电努赛尔数ne与电瑞利数T之间存在的标度率关系。本研究直观展示了电对流中的失稳现象与失稳路径,丰富了电(热)对流流动不稳定性研究的内容,为流动不稳定性研究及应用提供了部分参考。

关键词：同心圆环电对流单极注入转捩路径标度率

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中国动物传染病学报 2010年第3期18卷 56-61页

作者：周锦萍刘健李凯航鞠厚斌邓波张维谊鞠龚讷薛霞唐文红陈琦夏炉明刘佩红上海市动物疫病预防控制中心上海201103

为弄清上海地区活禽批发市场中H9禽流感病毒（Avian influenza virus,AIV）的流行情况及鸡群的免疫情况,2009年对上海三大活禽批发市场进行了采样监测。采用HI试验检测H9 AIV抗体、荧光rT-PCr试验和鸡胚接种分离鉴定病毒。共采集110批次... 详细信息

为弄清上海地区活禽批发市场中H9禽流感病毒（Avian influenza virus,AIV）的流行情况及鸡群的免疫情况,2009年对上海三大活禽批发市场进行了采样监测。采用HI试验检测H9 AIV抗体、荧光rT-PCr试验和鸡胚接种分离鉴定病毒。共采集110批次1 646份血样和喉头泄殖腔棉拭样品,平均抗体合格率为60.27%,分离到H9病毒134株,其中4-6月和9-11月为全年中病毒分离的2个高峰期（样品带毒率均超过了10.00%）,明显比其它月份要高（其他月份均低于5.00%）,样品带毒率平均为8.14%。不同市场、不同地区采集的样品其抗体合格率和样品的带毒率也存在一定的差异。在30批分离到病毒的样品中,13批次已免疫H9N2油乳剂灭活苗且抗体合格率均大于70.00%的样品中分离到45株病毒（45/195）,其中6批次抗体合格率达到100%的样品中也分离到了病毒（8/90）,但带毒率明显比未经疫苗免疫的样品（79/255）低。调查结果表明养殖户对肉鸡群H9N2油乳剂灭活苗免疫重视程度不够,鸡群中带毒现象较普遍。疫苗免疫后能产生较高的免疫抗体,且抗体能减轻临床症状,降低带毒率,但不能完全阻止病毒复制,存在高抗体下带毒现象。

关键词：活禽市场 H9禽流感病毒抗体合格率带毒率

XMM-newton observation of the eclipsing binary Algol

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research in Astronomy and Astrophysics 2011年第4期11卷 457-470页

作者： Xue-Juan Yang Fang-Jun Lu Bemd Aschenbach Li Chen Faculty of Materials Optoelectronics and Physics Xiangtan University Xiangtan 411105China Particle Astrophysics Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Max-Planck-Institut fur Extraterrestrische Physik 85741 Garching Germany Department of Astronomy Beijing Normal University Beijing 100875 China

We present an XMM-newton observation of the eclipsing binary Algol which contains an X-ray dark B8V primary and an X-ray bright K2IV secondary. The observation covered the optical secondary eclipse and captured an X-ray flare that was eclipsed by the B star. The XMM-newton European Photon Imaging Camera and reflection Grating Spectrometer spectra of Algol in its quiescent state are described by a two-temperature plasma model. The cool component has a temperature around 6.4× 106 K while that of the hot component ranges from 2 to 4.0× 107 K. Coronal abundances of C, N, O, ne, Mg, Si and Fe were obtained for each component for both the quiescent and the flare phases, generally with upper limits for S and Ar, and upper limits for C, N, and O from the hot component. F-tests show that the abundances do not need to be different between the cool and the hot component and between the quiescent and the flare phase with the exception of Fe. Although the Fe abundance of the cool component remains constant at -0.14, the hot component shows an Fe abundance of -0.28, which increases to -0.44 during the flare. This increase is expected from the chromospheric evaporation model. The absorbing column density NH of the quiescent emission is 2.5 - 1020 cm-2, while that of the flare-only emission is significantly lower and consistent with the column density of the interstellar medium. This observation substantiates earlier suggestions of the presence of X-ray absorbing material in the Algol system.

关键词： stars abundance -- star binaries eclipsing -- stars flare -- stars indi-vidual Algol

饮食因素对溃疡性结肠炎临床病理过程的影响:一项前瞻性队列研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 34-35页

作者： Jowett S.L. Seal C.J. Pearce M.S. M.r. Welfare 赵丽娜 University of newc astle North Tyneside Hospital North Shields Tyne and Wear NE29 8NH United Ki ngdomDr.

Background and aims: The causes of relapses of ulcerative colitis (UC) are unk nown. Dietary factors have been implicated in the pathogenesis of UC. The aim of this study was to determine which dietary factors are associated with an increa sed risk of relapse of UC. Methods: A prospective cohort study was performed wit h UC patients in remission, recruited from two district general hospitals, who w ere followed for one year to determine the effect of habitual diet on relapse. r elapse was defined using a validated disease activity index. Nutrient intake was assessed using a food frequency questionnaire and categorised into tertiles. Ad justed odds ratios for relapse were determined using multivariate logistic regre ssion, controlling for non-dietary factors. results: A total of 191 patients we re recruited and 96%completed the study. Fifty two per cent of patients relapse d. Consumption of meat (odds ratio (Or) 3.2 (95%confidence intervals (CI) 1.3- 7.8)), particularly red and processed meat (Or 5.19 (95%CI 2.1-12.9)), protein (Or 3.00 (95%CI 1.25-7.19)), and alcohol (Or 2.71 (95%CI 1.1-6.67)-) in th e top tertile of intake increased the likelihood of relapse compared with the bo ttom tertile of intake. High sulphur (Or 2.76 (95%CI 1.19-6.4)) or sulphate (Or 2.6 (95%CI 1.08.-6.3)) intakes were also associa ted with relapse and may offer an explanation for the observed increased likelih ood of relapse. Conclusions: Potentially modifiable dietary factors, such as a h igh meat or alcoholic beverage intake, have been identified that are associated with an increased likelihood of relapse for UC patients. Further studies are nee ded to determine if it is the sulphur compounds within these foods that mediates the likelihood of relapse and if reducing their intake would reduce relapse fre quency.

关键词：溃疡性结肠炎饮食因素前瞻性队列研究病理过程复发风险活动指标膳食结构问卷评价食物摄入日常饮食

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上海地区野鸟中禽流感的流行病学监测

动物医学进展 2007年第6期28卷 19-23页

作者：孙泉云王天厚刘佩红周锦萍周励勤薛霞李凯航张维谊卢军鞠龚讷上海市畜牧兽医站上海201103 华东师范大学上海200062

为了评估野鸟在禽流感流行病学中的作用,于2004年4月-2005年6月间对上海地区捕捉到的63个品种的1 010只野鸟进行了血样和喉肛棉拭样品的采集。采用病毒分离试验和荧光rT-PCr试验对喉肛棉拭样品进行了病原学检测,结果均为阴性;采用HA和H... 详细信息

为了评估野鸟在禽流感流行病学中的作用,于2004年4月-2005年6月间对上海地区捕捉到的63个品种的1 010只野鸟进行了血样和喉肛棉拭样品的采集。采用病毒分离试验和荧光rT-PCr试验对喉肛棉拭样品进行了病原学检测,结果均为阴性;采用HA和HI试验进行了禽流感血清抗体的检测,结果在15种野鸟的587份血样中检出了44份AIV阳性抗体,其中H1阳性数3份,阳性率为0.51%;H3阳性数4份,阳性率为0.68%;H5阳性数11份,阳性率为1.87%;H9阳性数26份,阳性率为4.43%。

关键词：野鸟禽流感流行病学监测

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高危足月儿后颅窝畸形的超声与MrI比较

国际医学放射学杂志 2015年第6期 594-594页

作者： S.J.Steggerda F.T.de Brune V.E.H.J.Smits-Wintjens P.Verbon F.J.Walther G.V.Wezel-Meijler 冀晓东 Department of neonatology Leiden University Medical Centre

摘要目的旨在评估高危新生儿后颅窝畸形的特征,以及颅脑超声联合额外的乳突囟视图检测这些畸形的诊断性能,以MrI作为参考标准。方法在这项回顾性研究中,113

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早产儿小脑损伤的超声与MrI检出率及影像学表现

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国际医学放射学杂志 2009年第5期32卷 489-489页

作者： S.J.Steggerda L.M.Leijser F.T.Wiggers-de Brune J.van der Grond F.J.Walther G.van Wezel-Meijler 秦乃姗 Department of Pediatrics Division of NeonatologyLeiden University Medical Center

目的以Mr影像为参考标准．探讨一组过早产儿经前囟（AF）常规头颅超声（US）并补充经乳突囟（MF）和后囟（PF）的超声检查小脑损伤的检出率及其影像学特征。材料与方法此前瞻性研究经学术委员会批准并获得知情同意通知。一组77例早产儿... 详细信息

目的以Mr影像为参考标准．探讨一组过早产儿经前囟（AF）常规头颅超声（US）并补充经乳突囟（MF）和后囟（PF）的超声检查小脑损伤的检出率及其影像学特征。材料与方法此前瞻性研究经学术委员会批准并获得知情同意通知。一组77例早产儿（小于32周）在新生儿期行多次超声检查，分别采用经AF、PF和MF声窗影像。其中59例在同等月龄段行MrI检查。

关键词：影像学表现 MrI检查超声检查小脑损伤早产儿检出率影像学特征学术委员会