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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 42-43页

作者： Pollock B. Turner D. Stringer M.r. 牛新武 Department of Dermatol ogy Leeds General Infirmary Leeds LS1 3EX United Kingdom

BackgroundAcne affects 83- 95% of 16- year-oldsof both sexes, and many seek help from a clinician. Emerging problems with conventional acne treatments, specifically antibiotic resistance of Propionibacterium acnes and fears over th e safety and tolerance of oral isotretinoin, create a demand for novel treatment modalities in acne. Objectives To study the efficacy of aminolaevulinic acid- photodynamic therapy (ALA-PDT) in the treatment of acne and to identify the mode of acti on, looking specifically at the effects on surface numbers of P. acnes and on se bum excretion. Methods Ten patients (nine men and one woman, age range 16- 40 y ears) with mild to moderate acne on their backswere recruited. Each patient’s backwasmarkedwith four 30- cm2 areas of equal acne severity. Each site was then randomly allocated to either ALA-PDT treatment, light alone, ALAalone or an u ntreated control site. At baseline, numbers of inflammatory and noninflammatory acne lesions were counted, sebum excretionmeasured by Sebutapes (CuDerm, Dallas, TX, U.S.A.) and surface P. acnes swabs performed. ALA cream (20% in Unguentum Merck) was applied under occlusion to the ALA-PDT and ALA alone sites for 3 h . red light from a diode laser was then delivered to the ALA-PDT and light alo ne sites (635 nm, 25 mW cm- 2, 15 J cm- 2). Each patient was treated weekly fo r 3 weeks. At each visit acne lesion counts were performed and 3 weeks following the last treatment sebum excretion rates and P. acnes swabs were repeated. resu lts There was a statistically significant reduction in inflammatory acne lesion counts from baseline after the second treatment at the ALA-PDT site but not at any of the other sites. No statistically significant reduction in P. acnes numb ers or sebum excretion was demonstrated at any sites including the ALA-PDT sit e. Conclusions ALA-PDT is capable of clinically improving acne. An alternative mode of action for ALA-PDT other than direct damage to sebaceous glands or ph otodynamicki

关键词：寻常性痤疮光动力疗法氨基乙酰丙酸作用机制中度痤疮异维甲酸非炎性痤疮新型治疗方法临床改善封包

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肘部尺神经病变的短节段神经传导研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 32-33页

作者： Visser L.H. Beekman r. Franssen H. 赵正卿 Depts. neurol. Clin. neuro physiol. St. ElisabethHospitalP.O. Box 90151 5000 LC TilburgNetherlands Dr.

The aim of the study was to assess the diagnostic value of short-segment nerve conduction studies (NCS) at 2 cm intervals from 4 cm abov e to 4 cm below the medial epicondyle in a large group of patients with ulnar.ne uropathy at the elbow(Une). Furthermore, we wanted to compare electrodiagnostic and clinical findings. We evaluated 73 arms in 70 patients with Une and observed the following abnormalities on short segment NCS: focal conduction block (CB) i n 1, focal CB within creased latency change in 34, and increased latency change alone in 25. Short-segment NCS had an additional localizing value in 28 arms of the 37 patients (76%)with motor conduction velocity (MCV) slowing across the e lbow only or with nonlocalizing electrodiagnostic findings. The lesion was locat ed above the elbow in 32 arms (53%), at the epicondyle in 16 arms(27%), and be low the epicondyle in 12 (20%) of the 60 arms with focal CB or increased latenc y change on short-segment NCS. Patients with CB on routine and short-segment N CS had muscle weakness significantly more often than patients without CB. Thus, short-segment NCS are useful in localizing the lesion in patients with Une and CB on routine NCS and have additional diagnostic value in patients with MCV slow ing across the elbow or with nonlocalizing signs on routine nerve conduction stu dies. We recommend its use in all patients in whom Une is suspected.

关键词：短节段尺神经神经传导内上髁潜伏期延长 medial 运动传导速度定位价值 conduction routine

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HIV相关毛囊综合征患者临床症状自发改善

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 31-32页

作者： Blasdale C. Turner r.J. Leonard N. 马慧群 Department of Dermatology Royal Victoria Infirmary Queen Victoria Road Newcastle upon Tyne NE1 4LP United Kingdom

Since 1991 infrequent reports have described a distinctive triad of nodulocystic acne, striking follicular spines and an eruption resembling pityriasis rubra pilaris (PrP) in HIV-positive patients. It has been suggested that this may represent a subtype of PrP, or alternatively that it should be viewed as a unique HIV-associated follicular occlusion triad. Clinical manifestations may be severe, and in several cases have been ultimately fatal, with death occurring due to complications of cutaneous sepsis. We describe a case demonstrating severe conglobate acne, follicular keratotic spines and histologically confirmed PrP in association with HIV infection. Clinical features and treatment modalities of previously reported cases are reviewed. Despite refusing all topical and systemic treatment our patient showed spontaneous remission of skin signs after 2 years.

关键词： HIV相关临床症状囊肿性痤疮聚合性痤疮毛发红糠疹角化性脓毒症外用药物皮肤症状非典型性

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静脉滴注免疫球蛋白治疗重症、难治性、复发性难辨梭状芽胞杆菌感染型腹泻

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 15-16页

作者： McPherson S. rees C.J. Ellis r. 张红凯 Department of Gastroenterology South Tyneside District HospitalHarton LaneSouth ShieldsNE34 0PLUnited Kingdom

PUrPOSE: Clostridium difficile diarrhea is common in elderly patients and leads to prolonged hospitalization. Patients with severe or recurrent Clostridium difficile diarrhea have poor antitoxin antibody responses. Intravenous immunoglobulin has been advocated in these patients. This study was designed to assess the response of patients with refractory, recurrent, or severe Clostridium difficile diarrhea to intravenous immunoglobulin. METHODS: retrospective review (November 2003-January 2005) of 14 patients with severe, refractory, recurrent Clostridium difficile diarrhea treated with intravenous immunoglobulin (Flebogamma, 150-400 mg/kg) from 264 Clostridium difficile toxin-positive patients. rESULTS: Median age was 79 (range, 54-91) years. Median length of symptoms before intravenous immunoglobulin was 29 (range, 3-90) days. Patients received a median of three (range, 1-5) courses of vancomycin or metronidazole before intravenous immunoglobulin. All had hypoalbuminemia (median, 22 g/l; range, 18-33) and raised C-reactive protein (median, 47 mg/l; range, 25-255) at time of infusion. The median white cell count was 15.3×109/liters (range, 4-24). Eight patients had evidence of pancolitis on abdominal imaging, suggesting severe Clostridium difficile diarrhea. All patients tolerated intravenous immunoglobulin without side effects. Nine (64 percent) responded with bowels normalizing in a median of ten (range, 2-26) days; one patient received two doses. One patient had a partial response from two doses but died two months later after a recurrence. The other four patients died of other causes within three weeks of infusion. CONCLUSIONS: Intravenous immunoglobulin may be effective for severe, refractory, or recurrent Clostridium difficile diarrhea after failed conventional treatment.

关键词：梭状芽胞杆菌免疫球蛋白感染型静脉滴注腹泻患者腹部影像学低蛋白血症抗毒梭菌白细胞计数

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应用肛门内肌电描记生物反馈物理疗法与联用肛门括约肌电刺激疗法早期治疗产后大便失禁的随机临床试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 17-18页

作者： Mahony r.T. Malone P.A. Nalty J. 朱晓明

The purpose of this study was to compare intra -anal electromyographic biofeedback alo ne with intra -anal bio-feedback that was augmented with ele ctrical stimulation of the anal sphincter in the treatment o f postpartum fecal in-continence.A secondary aim was to ex amine the impact of the treatment on continencerelated quality of *** symptomatic women were assigned ran domly to receive in-tra -anal electromyographic biofee dback or electrical stimulation of the anal sphincter on ce weekly for 12weeks and to perform daily pelvic floor exe rcises between *** response was eva luated with a symp-tom questionnaire to determine cont inence score,anal manometry,and endoanal ultrasound *** of life was assessed before and after tr eatment with a validated *** -four women co mpleted the treatment;52women(96%)had ultrasonic evidence of an extern al anal sphincter *** the tre atment,both groups demonstrated significant improvem ent in continence score(Pressures(Presting anal pressures did not alter *** of life improved after the completion o f physiotherapy,but there were no differences in outcome between intra -anal electromyographic biofeedback and electrical stimulation of the anal *** -anal elec tromyographic biofeed-back therapy was associated with imp roved continence and quality of life in women with altered fecal continence after *** addition of electrical stimulation of the anal sphincter did not enhance symptomatic outcome.

关键词：电刺激疗法大便失禁生物反馈随机临床试验症状问卷骨盆底产后妇女生活质量超声扫描问卷调查

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THE　HEMOrHEOLOGY　CHANGE　IN ISCHEMIC　rEGION　BY　COrONArY　STENOSIS　AFTEr　LASEr　IrrADIATION　ON BLOOD

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Chinese Journal of Biomedical Engineering(English Edition) 1995年第3期4卷 164-164页

作者： Yang Jiqing Fan Yun Jian Zhong Zhang Feng Liu Qiang(Department of Biomedical Eng,The Fourth Military Medical University,Xi’an 710032, China)The hemorheologic change is one of the most important responses to He——ne laser irradiationon blood (LIB) for

ＴＨＥＨＥＭＯＲＨＥＯＬＯＧＹＣＨＡＮＧＥＩＮＩＳＣＨＥＭＩＣＲＥＧＩＯＮＢＹＣＯＲＯＮＡＲＹＳＴＥＮＯＳＩＳＡＦＴＥＲＬＡＳＥＲＩＲＲＡＤＩＡＴＩＯＮＯＮＢＬＯＯＤＴＨＥＨＥＭＯＲＨＥＯＬＯＧＹＣＨＡＮＧＥＩＮＩＳ... 详细信息

ＴＨＥＨＥＭＯＲＨＥＯＬＯＧＹＣＨＡＮＧＥＩＮＩＳＣＨＥＭＩＣＲＥＧＩＯＮＢＹＣＯＲＯＮＡＲＹＳＴＥＮＯＳＩＳＡＦＴＥＲＬＡＳＥＲＩＲＲＡＤＩＡＴＩＯＮＯＮＢＬＯＯＤＴＨＥＨＥＭＯＲＨＥＯＬＯＧＹＣＨＡＮＧＥＩＮＩＳＣＨＥＭＩＣＲＥＧＩＯＮＢＹＣＯＲ...

关键词： : Laser Coronary artery Hemorheology

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综合运用地球物理和土壤气剖面识别活动断层:以西班牙东北部比利牛斯山脉的阿梅尔(Amer)断层为例(Ⅱ)

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国际地震动态 2016年第4期37卷 7-21页

作者： m zarroca r linares j bach c roqué v moreno ll font c baixeras 杨江(译) 李营(校) grupo de geodinámica externa e hidrogeología dpto.de geologíaedicio ccuniversitat autònoma de barcelona08193 BellaterraBarcelonaSpain geodinámica xterna dpto.ciencias mbientalesuniversitat de girona17071 GironaSpain grupo de física de las radiaciones dpto.de física.edi cio ccuniversitat autònoma de barcelona08193 BellaterraBarcelonaSpain 中国地震局地震预测研究所不详

以与Amer断层近期活动相关的地貌和水文地质指标为基础,我们选择了两个站点开展地球物理和土壤气剖面探查（图2）.测量断面用我们工作的地点来命名：Pladela Font d’en Fàbregues剖面（图4）和ElMont剖面（图5）.选择的第1个剖面是因... 详细信息

以与Amer断层近期活动相关的地貌和水文地质指标为基础,我们选择了两个站点开展地球物理和土壤气剖面探查（图2）.测量断面用我们工作的地点来命名：Pladela Font d’en Fàbregues剖面（图4）和ElMont剖面（图5）.选择的第1个剖面是因为Amer区域内很多富含CO2的喷泉出现在其周围.

关键词：活动断层地球物理土壤气剖面综合运用东北部西班牙山脉

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兽用喹诺酮类药物——奥比沙星

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畜禽业 2003年第3期14卷 28-29页

作者：戴述诚李名芳刘亚楠广东省天宝生物制药有限公司广东广州510650 广州白云山中药厂广东省医药保健品工程技术研究开发中心

本文简述了奥比沙星的体外抗菌活性、药物动力学参数、用药剂量规定、生物利用度及休药期等,并与恩诺沙星和单诺沙星一一作了比较。

关键词：奥比沙星兽用喹诺酮类药物抗菌活性药物动力学参数剂量休药期药物残留

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Experiments and simulations of isochorically heated warm dense carbon foam at the Texas Petawatt Laser

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Matter and radiation at Extremes 2021年第1期6卷 21-30页

作者： r.roycroft P.A.Bradley E.McCary B.Bowers H.Smith G.M.Dyer B.J.Albright S.Blouin P.Hakel H.J.Quevedo E.L.Vold L.Yin B.M.Hegelich The University of Texas at Austin AustinTexas 78712USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA SLAC National Accelerator Laboratory Menlo ParkCalifornia 94025USA

An experimental and simulation study of warm dense carbon foams at ambient density(ne∼10^(21) cm^(−3))is *** study of isochorically heated foams is motivated by their potential application in carbon-atmosphere white-dwarf envelopes,where there are modeling uncertainties due to the equation of *** foams are heated on an approximately picosecond time scale with a laser-accelerated proton *** cooling and expansion of the heated foams can be modeled with appropriately initialized radiation-hydrodynamics codes;xrAGE code is used in this *** primary experimental diagnostic is the streaked optical pyrometer,which images a narrow band of radiation from the rear surface of the heated *** are xrAGE modeling results for both solid aluminum targets and carbonized resorcinol-formaldehyde foam targets,showing that the foam appears to cool slowly on the pyrometer because of partial *** that simulations of cooling foam are processed properly,it is necessary to account for finite optical depth in the photosphere calculation,and the methods for performing that calculation are presented in depth.

关键词： heated carbon transparency

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家禽红螨(鸡皮刺螨)的意义及防治

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养禽与禽病防治 2024年第4期 25-40页

作者： O.A.E.Sparagano D.r.George D.WJ.Harrington A.Giangaspero 刘红(校对) Faculty of Health and Life Sciences Northumbria UniversityNewcastle upon Tyne NE18STUnited Kingdom Poultry Division Chr.Hansen A/S2970 HorsholmDenmark Dipartimento di Scienze Agrarie degli Alimenti e dell'AmbienteUniversita di Foggia71121Italy 默沙东动物保健品(上海)有限公司

家禽红螨(鸡皮刺螨)严重威胁世界各地的家禽生产和母鸡健康。鸡皮刺螨不但逐渐被认为是疫病重要的载体,而且有越来越多的报告显示其还可攻击包括人类在内的其他宿主,可见这种害虫对经济的影响变得越来越严重。随着世界各地的家禽生产逐... 详细信息

家禽红螨(鸡皮刺螨)严重威胁世界各地的家禽生产和母鸡健康。鸡皮刺螨不但逐渐被认为是疫病重要的载体,而且有越来越多的报告显示其还可攻击包括人类在内的其他宿主,可见这种害虫对经济的影响变得越来越严重。随着世界各地的家禽生产逐渐脱离传统的笼养方式,鸡皮刺螨在禽群中的影响将变得更加普遍,防控将变得更加困难。尽管已有耐药性和治疗失败的报告,但鸡皮刺螨的防治仍以合成杀螨剂为主。目前在鸡皮刺螨及螨虫管理的专项研究报告中已经提出一些替代防治措施。尽管许多替代防治措施仍处于商业化前期阶段,但仍有部分措施已经逐渐进入市场。本综述汇集了日益扩充的鸡皮刺螨的研究,并评估了其当前和未来可供选择的防控措施。得出的结论是,鸡皮刺螨防治的重大进展最有可能来自综合防控的措施,将最新的研究融入到现有的和新型的防治策略中,这种融合将改进的监测和建模相结合,更好地为治疗和干预该病提供信息支持。

关键词：鸡母鸡体外寄生虫兽医害虫防治

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