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激光相变硬化可视化分析

光电子．激光 2001年第5期12卷 495-499页

作者：谢琼许振鄂华中科技大学激光技术国家重点实验室武汉430074

提出激光加工热响应的空间温度场可视化方法并对相变硬化进行分析。应用颜色映射原理 ,建立空间温度场数据点着色色彩与温度的对应关系 ,用可视化方法分析了光束功率密度和移动速度对空间温度分布及相变硬化带的影响。方法可以直观、形... 详细信息

提出激光加工热响应的空间温度场可视化方法并对相变硬化进行分析。应用颜色映射原理 ,建立空间温度场数据点着色色彩与温度的对应关系 ,用可视化方法分析了光束功率密度和移动速度对空间温度分布及相变硬化带的影响。方法可以直观、形象地显示温度场分布形态 ,预测相变硬化的深度和宽度。

关键词：密度分布温度场可视化相变硬化激光

Tracking Students’ Mental Engagement Using EEG Signals during an Interaction with a Virtual Learning Environment

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Journal of Intelligent Learning Systems and Applications 2019年第1期11卷 1-14页

作者： Asma Ben Khedher Imène Jraidi Claude Frasson Department of Computer Science and Operations research University of Montreal Montreal Canada

Monitoring students’ level of engagement during learning activities is an important challenge in the development of tutoring interventions. In this paper, we explore the feasibility of using electroencephalographic signals (EEG) as a tool to monitor the mental engagement index of novice medicine students during a reasoning process. More precisely, the objectives were first, to track students’ mental engagement evolution in order to investigate whether there were particular sections within the learning environment that aroused the highest engagement level among the students, and, if so, did these sections have an impact on learners’ performance. Experimental analyses showed the same trends in the different resolution phases as well as across the different regions of the environments. However, we noticed a higher engagement index during the treatment identification phase since it aroused more mental effort. Moreover statistically significant effects were found between mental engagement and students’ performance.

关键词： EEG Engagement Index Learners’ Performance Computer-Based Learning Environments

Water Quality from the Purification Unit of Thiakhar (Diourbel, Senegal) and Impact of Discharges from Treatment on Water resources

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Journal of Water resource and Protection 2013年第12期5卷 1186-1191页

作者： Cheikh Hamidou Kane Moustapha Diène Baba Sarr Department of Géology FST-UCAD University Cheikh Anta Diop of Dakar Dakar Senegal Laboratory of Geology IFAN University Cheikh Anta Diop of Dakar Dakar Senegal Laboratory of Mechanics and Modeling-Sciences of Engineering of Thies Thies Senegal

The installation of a purification unit since 2008 in the village of Thiakhar has improved the physico-chemical and bacteriological quality of the water supply. However about 55% of the raw water comes out of the unit as discharges (approximately 14 m3 per day) highly concentrated in fluoride and chloride ions. Based on historical samples, we find that the volumes of water consumed together with the volumes of water discharged are increasingly significant from year to year. The storage of waste water is carried out in a septic tank connected to a leaking cesspool sink. Significant excesses of these discharges are visible on the site and a flow of concentrate is observed creating a puddle of water that attracts birds and straying cattle. The study describes the following substantial impacts on the natural and human environment: 1) contamination of groundwater, 2) soil salinization 3), impact on flora and fauna, 4) impact on health. The study concludes by identifying measures to mitigate the negative impacts related to the discharges and by proposing alternative solution.

关键词： Drinking Water Treatment Quality Discharges Pollution Mitigation

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

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Translational neurodegeneration 2020年第1期9卷 39-54页

作者： Niccolo Candelise Matthias Schmitz Katrin Thüne Maria Cramm Alberto rabano Saima Zafar Erik Stoops Hugo Vanderstichele Anna Villar-Pique Franc Llorens Inga Zerr Department of neurology University Medicine Goettingen and the German Center for Neurodegenerative Diseases(DZNE)Robert-Koch-Stra?e 4037075 G?ttingenGermany Biomedical Engineering and Sciences Department School of Mechanical and Manufacturing Engineering(SMME)National University of Sciences and Technology(NUST)IslamabadPakistan Department of Experimental Diagnostic and Speciality MedicineUniversity of BolognaBolognaItaly Departamento de neuropatología y Banco de Tejidos(BT-CIEN) Fundación CIENInstituto de Salud Carlos III Centro Alzheimer Fundación Reina SofíacValderrebollo n°528031 MadridSpain ADx neuroSciences Technologiepark 4GhentBelgium CIBErneD(network center for biomedical research of neurodegenerative diseases) Institute Carlos IIIMadridSpain Bellvitge Biomedical research Institute(IDIBELL) Hospitalet de LlobregatBarcelonaSpain

Background: α-Synuclein is a small soluble protein,whose physiological function in the healthy brain is poorly *** inclusions of α-synuclein,referred to as Lewy bodies(LBs),are pathological hallmarks ofαsynucleinopathies,such as Parkinson’s disease(PD)or dementia with Lewy bodies(DLB).Main body:Understanding of the molecular basis as well as the factors or conditions promoting α-synuclein misfolding and aggregation is an important step towards the comprehension of pathological mechanism ofαsynucleinopathies and for the development of efficient therapeutic *** on the conversion and aggregation mechanism of α-synuclein,novel diagnostic tests,such as protein misfolding seeded conversion assays,*** real-time quaking-induced conversion(rT-QuIC),had been *** diagnostics, α-synuclein rT-QuIC exhibits a specificity between 82 and 100%while the sensitivity varies between 70 and 100%among different *** addition,the α-synuclein rT-QuIC can be used to study the α-synuclein-seeding-characteristics of different α-synucleinopathies and to differentiate between DLB and ***:The variable diagnostic accuracy of current α-synuclein rT-QuIC occurs due to different protocols,cohorts and material etc..An impact of micro-environmental factors on the α-synuclein aggregation and conversion process and the occurrence and detection of differential misfolded α-synuclein types or strains might underpin the clinical heterogeneity of α-synucleinopathies.

关键词： rT-QuIC α-Synucleinopathies Protein misfolding Protein strains

Survey of Staphylococcus aureus in a general pediatric population and focus on isolates with three clinically relevant toxin-encoding genes

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World Journal of Pediatrics 2018年第1期14卷 35-43页

作者： Anne Filleron Sarah Beauregard-Birba Thibault Mura Fabien Aujoulat Anne Laure Michon Michel rodière Tu Anh Tran Eric Jeziorski Hélène Marchandin Department of Pediatrics Nimes University HospitalNimesFrance INSErM U1183 Team3Immune Regulationand Micr obiotaMedical University of Montpellier NimesNimesFrance Laboratory ofBacter iology Montpellier University HospitalMontpellierFrance Department of Medical Information Montpellier UniversityHospitalMontpellierFrance Montpellier University UMR5569HydroSciencesMontpellierPharmacy University of MontpellierMontpellierFrance Division of Pediatric Infectious Diseases Departmentof P ediatricsMontpellier University HospitalMontpellierFrance Department of Micr obiology Nimes University HospitalNimesFrance

Background In children, surveys on Staphylococcus aureus have focused on specific infections, situations or strains but no study has so far given an overview on S. aureus isolation without any selection. Here, we describe the overall bacteriologi-cal and clinical characteristics of S. aureus isolation in children, with a special focus on isolates harbouringtst,sea, and/or luk-PV genes, respectively, encoding the three clinically relevant toxins: toxic shock syndrome toxin-1, enterotoxin A and Panton–Valentine leukocidin. Methods Data associated with S. aureus isolation were reviewed: isolation site, infection status,tst,sea andluk-PV genes, antimicrobial susceptibility pattern,agr typing. results Three hundred and seventy-seven isolates retrieved from 328 children during S. aureus infection (55.2%) or colo-nisation (44.8%) were ***,sea and luk-PV genes were amplified in 14.3, 9.5 and 5.8% of the isolates, respectively. These isolates were significantly more frequently retrieved during infection (69.1%) than colonisation but differences were observed according to isolation site. Methicillin-resistance was found in 7.2% of the isolates, 78% of which harboured ≥ 1 of the targeted toxin-encoding genes. Conclusions This first comprehensive study of S. aureus in children showed S. aureus to be mainly retrieved during infection and a high rate of colonisation, not limited to the nasopharynx. Predominant infections were skin and soft tissue infections wheretst was most frequently ***-PV was most commonly detected during bone and joint infections. Isolates harbouring targeted toxin-encoding genes were significantly associated with infections but a quarter of children were asymp-tomatic carriers representing a reservoir for dissemination of isolates with virulence potency.

关键词： Colonisation Infection Pediatric Staphylococcus aureus Toxins

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-α inhibition

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Acta Pharmaceutica Sinica B 2020年第6期10卷 1061-1072页

作者： Yishan Ye Laure ricard Lama Siblany Nicolas Stocker Frédéric De Vassoigne Eolia Brissot Baptiste Lamarthée Arsène Mekinian Mohamad Mohty Béatrice Gaugler Florent Malard Sorbonne Université INSERMCentre de Recherche Saint-Antoine(CRSA)Paris F-75012France Bone Marrow Transplantation Center the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China AP-HP Hôpital Saint-AntoineService d’Hématologie Clinique et Thérapie CellulaireParis F-75012France AP-HP Hôpital Saint-AntoineService de Médecine Interne et de l'Inflammation-(DHU i2B)Paris F-75012France

Arsenic trioxide(As2O3)is recently found to have therapeutic potential in systemic sclerosis(SSc),a life-threatening multi-system fibrosing autoimmune disease with type I interferon(IFN-I)*** activated plasmacytoid dendritic cells(pDCs)are responsible for IFN-I secretion and are closely related with fibrosis establishment in *** this study,we showed that high concentrations of As2O3 induced apoptosis of pDCs via mitochondrial pathway with increased BAX/BCL-2 ratio,while independent of reactive oxygen species ***,at clinical relevant concentrations,As2O3 preferentially inhibited IFN-αsecretion as compared to other cytokines such as TNF-α,probably due to potent down-regulation of the total protein and mrNA expression,as well as phosphorylation of the interferon regulatory factor7(IrF7).In addition,As2O3 induced a suppressive phenotype,and in combination with cytokine inhibition,it down-regulated pDCs’capacity to induce CD4+T cell proliferation,Thl/Th22 polarization,and B cell differentiation towards ***,chronically activated pDCs from SSc patients were not resistant to the selective IFN-αinhibition,and regulatory phenotype induced by ***,our data suggest that As2O3 could target pDCs and exert its treatment efficacy in SSc,and more autoimmune disorders with IFN-I signature.

关键词： Arsenic trioxide Plasmacytoid dendritic cell Immunotherapy Systemic sclerosis IFN-I

neurocognitive Variety in neurotypical Environments: The Source of “Deficit” in Autism

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Journal of Behavioral and Brain Science 2019年第6期9卷 246-272页

作者： Mylène Legault Jean-Nicolas Bourdon Pierre Poirier Department of Philosophy Université du Québec à Montréal Montréal Canada Institut des Sciences Cognitives Université du Québec à Montréal Montréal Canada Institut de rechercheset études Féministes Université du Québec à Montréal Montréal Canada

As recent developments in autism research offer alternative explanations to the mainstream options, it can now be argued that the so-called cognitive deficits in the social domain associated with autism have been mischaracterized or, at least, oversimplified. We will use predictive models within a 4E (i.e., embodied, embedded, enactive and extended) conception of cognition to address the question of cognitive impairment in psychiatrics and autism. Such models force us to reassess what “cognitive deficit” means by integrating the environment not only in its usual sense (evo-developmental), but by understanding all cognitive performances as embedded in environments (or fields of affordances) that shape and sustain them. By adopting a predictive 4E perspective, we aim to show that the “cognitive deficits” associated with autism are in fact mismatches between environmental resources and the particular form of neurological functioning of autistic people (neurodiversity), brought about by the fact that the cultural niches that set up the relevant fields of affordances are structured by and for.neurotypicals. This mismatch leads to epistemic injustices, both testimonial and hermeneutic, that feed back into research on autism and clinical approaches, thereby making the “deficits” appear based on individual shortcomings. In this context, autism interventions should partly focus on the development of social policies aimed at modifying those aspects of cultural niches that make environments unsuitable for the full development of all individuals.

关键词： 4E Cognition Predictive Processing Cognitive Deficit Autism Epistemic Injustice

Detrital Mode and Geochemistry of the Shurijeh Formation (Late Jurassic-Early Cretaceous) in the Central and Western Parts of the Intracontinental Kopet-Dagh Basin, ne Iran: Implications for Provenance, Tectonic Setting and Weathering Processes

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Acta Geologica Sinica(English Edition) 2013年第4期87卷 1058-1080页

作者： M. MOrTAZAVI r. MOUSSAVI-HArAMI A. MAHBOUBI Department of Geology Faculty of science Ferdowsi University of Mashhad

Petrographical and geochemical methods were combined to investigate the provenance, geodynamic and weathering history of the Shurijeh sandstones, Kopet-Dagh Basin. The point-counting method and XrF technique are used for modal and geochemical analyses. Based on petrographical examinations, it seems that the Shurijeh sandstones are mainly deposited in the craton interior and recycled orogen belts. In addition to petrographical investigation, geochemical analyses （major oxides and trace elements） of Late Jurassic-Early Cretaceous rocks reveal that the sedimentation processes are performed in a passive continental margin. Such interpretation is supported with geodynamic and paleogeographical studies of the Kopeh-Dagh basin during this time. The geochemical investigations suggested that the composition of probable source rocks mostly was acidic-intermediate with minor mafic igneous rocks. Based on the above, Paleo-Tethys remnants and their collision-related granitoids, in the south and west of Mashhad, may have been the source area for these rocks. CIA values, which range from 63.8 to 94.9 in samples, are suggesting a moderate to relatively high degree of alteration （weathering） in the source area. Therefore, petrographical and paleogeographical studies of siliciclastic rocks can be used for the provenance, tectonic setting and paleoweathering studies in the source area.

关键词： petrography geochemistry tectonic setting provenance weathering processes ShurijehFormation

Dental pulp stem cells as a promising model to study imprinting diseases

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International Journal of Oral Science 2022年第2期14卷 174-181页

作者： Eloïse Giabicani Aurélie Pham Céline Sélénou Marie-Laure Sobrier Caroline Andrique Julie Lesieur Agnès Linglart Anne Poliard Cather.ne Chaussain Ir.ne netchine Universitéde Paris URP2496Laboratoire Pathologiesimagerie et biothérapies oro-facialesMontrougeFrance INSErM UMRS_938 Centre de Recherche Saint AntoineParisFrance APHP Hôpital de BicêtreEndocrinologie et Diabétologie de l’EnfantCentre de Référence des Maladies Rares du Métabolisme du Calcium et du PhosphateLe Kremlin-BicêtreFrance APHP Hôpital BretonneauCentre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate et FHU DDS-netParisFrance Sorbonne Université INSERMUMRS_938APHPHôpital Armand TrousseauExplorations Fonctionnelles EndocriniennesParisFrance

Parental imprinting is an epigenetic process leading to monoallelic expression of certain genes depending on their parental *** diseases are characterized by growth and metabolic issues starting from birth to *** are mainly due to methylation defects in imprinting control region that drive the abnormal expression of imprinted *** currently lack relevant animal or cellular models to unravel the pathophysiology of growth failure in these *** aimed to characterize the methylation of imprinting regions in dental pulp stem cells and during their differentiation in osteogenic cells(involved in growth regulation)to assess the interest of this cells in modeling imprinting *** collected dental pulp stem cells from five controls and four patients(three with Silver-russell syndrome and one with Beckwith-Wiedemann syndrome).Methylation analysis of imprinting control regions involved in these syndromes showed a normal profile in controls and the imprinting defect in *** results were maintained in dental pulp stem cells cultured under osteogenic ***,we confirmed the same pattern in six other loci involved in imprinting diseases in *** also confirmed monoallelic expression of H19(an imprinted gene)in controls and its biallelic expression in one *** imprinting control regions methylation analysis shows the strong potential of dental pulp stem cells in modeling imprinting diseases,in which imprinting regions are preserved in culture and during osteogenic *** will allow to perform in vitro functional and therapeutic tests in cells derived from dental pulp stem cells and generate other cell-types.

关键词： pulp maintained fir