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Structural changes in the obese brain

Neural regeneration research 2024年第12期19卷 2561-2562页

作者： Anna r.r.Da conceicao Marcelo N.N.vieira Fernanda G.De Felice D’Or Institute for research and Education Rio de JaneiroBrazil Institute of Medical Biochemistry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for Neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).

关键词： diseases consequences prevalence

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Computerized geochemical modeling of burial diagenesis of the Eocene turbidite reservoir elements：Urucutuca Formation,Espirito Santo Basin,southeastern Brazil passive margin

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Journal of Palaeogeography 2018年第4期7卷 363-377页

作者： Marcos Antonio Klunk Sudipta Dasgupta r.mmulo vieira conceicao Institute of Isotope Geology Federal University of Rio Grande do SulPorto AlegreBrazil Department of Earth Sciences Indian Institute of Technology (IIT) BombayMumbai India

The computerized geochemical modeling, a useful tool to understand the diagenetic processes influencing the quality of hydrocarbon reservoirs, is performed by using different modules of computer codes based on the thermodynamic and chemical kinetic principles and their associated parameters. As observed in the reservoir lithofacies deposited from the marine sediment-gravity flows, a case study of diagenesis is presented here from the Espírito Santo Basin in southeastern Brazil. The study uses the Geochemist＇s Workbench（GWB～（TM））, PHrEEQC～（TM） and TOUGHrEACT～（TM） computation packages. The comparison of performances of these packages demonstrates the convergence of results from the software-based geochemical modeling with the petrographic observation of dissolution, albitization, kaolinization, and the precipitation of calcite and dolomite. Moreover, with limited data points, e.g., the sedimentary petrographic data acquired from limited number of boreholes, the computer simulation establishes itself to be a powerful quantitative method estimating the degree and type of diagenetic alteration of turbidite reservoir bodies in contact with a source of saline-water influx associated with salt ***, using the limited petrographic data points, the geochemical computer-simulation method can even be utilized and extrapolated for areas where similar geological context is interpreted but no borehole data are available. Hence, porosity of turbidite reservoir lithofacies can be predicted in relation to the spatial distribution of dissolution, kaolinization, and albitization of feldspars and authigenic carbonate precipitation.

关键词： Sandstone diagenesis Computerized diagenetic modeling Turbidite reservoir GWB PHrEEQC TOUGHrEACT

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Pressure- and Urea-Induced Denaturation of Bovine Serum Albumin: Considerations about Protein Heterogeneity

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Open Journal of Biophysics 2012年第1期2卷 4-14页

作者： Douglas ricardo Norberto Joelma Mauricio vieira Ancelmo rabelo de Souza Jose Ailton conceicao Bispo Carlos Francisco Sampaio Bonafe 不详

Urea denatures proteins at different concentrations, depending on the experimental conditions and the protein. We in-vestigated the pressure-induced denaturation of bovine serum albumin (BSA) in the presence of subdenaturing concen-trations of urea based on a two-state equilibrium. Pressure-induced denaturation was enhanced at urea concentrations ([U]) of 3.5 M to 8.0 M, with the free energy of denaturation at atmospheric pressure ranging from +5.0 to –2.5 kJ/mol of BSA. The m values appeared to be biphasic, with m1 and m2 of 0.92 and 2.35 kJ mol–1?M–1, respectively. Plots of versus ln[U] yielded values of u, the apparent stoichiometric coefficient, of 1.68 and 6.67 mol of urea/mol of BSA for m1 and m2, respectively. These values were compared with the m and u values of other monomeric proteins reported in or calculated from the literature. The very low values of u systematically observed for proteins were suggestive of heterogeneity in the free energy of denaturation. Thus, a u value of 140 mol of urea/mol of BSA may indicate the existence of a heterogeneous molecular population with respect to the free energy of dena-turation.

关键词： Apparent Stoichiometric Coefficient Bovine Serum Albumin High Pressure-Induced Denaturation Protein Heterogeneity Urea-Induced Denaturation

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Intense Exercise in the Quality of Life of Breast Cancer Survivors:A Meta-Analysis

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Journal of Cancer Therapy 2019年第12期10卷 895-907页

作者： Paulo Francisco de Almeida Neto Erenice conceicao de Almeida Barbosa Karoline Queiroz Martins Almeida de Araujo Tatianny de Macedo Cesario Brunna rafaella do Carmo Silva Thiago Gil vieira de Figueiredo Lima Nelson Carvas Junior Ana Carla Gomes Canario Federal University of rio Grande do Norte UFRNNatalRNBrazil Brazilian Society of Clinical Oncology SBOCSao PauloSPBrazil Mauricio of Nassau University Center UNINASSANatalRNBrazil Institute of Medical Assistance to the state public servant IAMSPESao PauloSPBrazil Federal University of Paraíba UFPBJoao PessoaPBBrazil

The treatment of breast cancer (BC) leaves emotional and functional sequels affecting the quality of life (QOL) of the survivors. We aim to investigate, intense exercises in the rehabilitation of BC survivors. Using the systematic search model in the PubMed databases;Lilacs Bireme and Scielo. Meta-Analysis used the Meta package implemented in software r (version 3.3.2) p rticles, and after reading in the Integra, we excluded 27 texts being included in the meta-analysis only 2. In the QOL, the heterogeneity in the emotional function showed a difference of 75%, in the social function 36% and in the physics 32%. Using intense exercises in BC survivors during rehabilitation improves overall QOL, muscle structure, and preserves functional capacity.

关键词： Breast Cancer High-Intensity Exercises High-Intensity Intermittent Exercise Women’s Health

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Pressure- and Urea-Induced Denaturation of Bovine Serum Albumin: Considerations about Protein Heterogeneity

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Open Journal of Biophysics（生物物理学期刊） 2012年第1期

作者： Douglas ricardo Norberto Joelma Mauricio vieira Ancelmo rabelo de Souza Jose Ailton conceicao Bispo Carlos Francisco Sampaio Bonafe

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