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Superchiral near fields detect virus structure

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Light(Science & Applications) 2020年第1期9卷 103-112页

作者： Tarun Kakkar Chantal Keijzer marion rodier Tatyana Bukharova michael Taliansky Andrew J.Love Joel J.milner Affar S.Karimullah Laurence D.barron Nikolaj Gadegaard Adrian J.Lapthorn malcolm Kadodwala School of Chemistry Joseph Black BuildingUniversity of GlasgowGlasgow G128QQUK Institute of molecular Cell and Systems Biology and School of Life SciencesUniversity of GlasgowG128QQ GlasgowUK James Hutton Inst Cell&Mol SciDundee DD25DAUK Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry rAS Moscow 117997Russia School of Engineering Rankine BuildingUniversity of GlasgowGlasgow G128LTUK

Optical spectroscopy can be used to quickly characterise the structural properties of individual ***,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component *** insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical *** limits potential routes to rapid high-throughput portable detection appropriate for point-of-care ***,we demonstrate that chiral electromagnetic(Em)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus ***,they can detect both the presence and relative orientation of a bound virus *** illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum.

关键词： chiral detect fields

Numerical and Physical modeling of Turbulence in a Peirce-Smith Copper Converter

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材料科学与工程（中英文A版） 2013年第7期3卷 510-518页

作者： Aaron Almaraz Cesar Lopez miguel Angel barron meza Gabriel Plascencia Technological research and Innovation Center 1PN Cerrada CECATI s/n Col. Sta. Catarina Mexico D.F. 02250 Mexico materials Department Azcapotzalco Metropolitan Autonomous University Av. San Pablo 180 Azcapotzalco D.F. 02200 Mexico

Parallel mrNA, proteomics and mirNA expression analysis in cell line models of the intestine

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World Journal of Gastroenterology 2017年第41期23卷 7369-7386页

作者： Finbarr O’Sullivan Joanne Keenan Sinead Aherne Fiona O’Neill Colin Clarke michael Henry Paula meleady Laura Breen Niall barron martin Clynes Karina Horgan Padraig Doolan richard murphy National Institute for Cellular Biotechnology Dublin City University National Institute for Bioprocessing research & Training Alltech Dunboyne

AIm To identify mi rNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the *** Exponentially growing Caco-2 and HT-29 cells were harvested and prepared for m rNA, mi rNA and proteomic profiling. m rNA microarray profiling analysis was carried out using the Affymetrix Gene Chip Human Gene 1.0 ST array. mi rNA microarray profiling analysis was carried out using the Affymetrix Genechip mi rNA 3.0 array. Quantitative Label-free LC-mS/mS proteomic analysis was performed using a Dionex Ultimate 3000 rSLCnano system coupled to a hybrid linear iontrap/Orbitrap mass spectrometer. Peptide identities were validated in Proteome Discoverer 2.1 and were subsequently imported into Progenesis QI software for further analysis. Hierarchical cluster analysis for all three parallel datasets(mi rNA, proteomics, m rNA) was conducted in the r software environment using the Euclidean distance measure and Ward's clustering algorithm. The prediction of mi rNA and oppositely correlated protein/m rNA interactions was performed using Target Scan 6.1. GO biological process, molecular function and cellular component enrichment analysis was carried out for the DE mi rNA, protein and m rNA lists via the Pathway Studio 11.3 Web interface using their mammalian *** Differential expression(DE) profiling comparing the intestinal cell lines HT-29 and Caco-2 identified 1795 Genes, 168 Proteins and 160 mi rNAs as DE between the two cell lines. At the gene level, 1084 genes were upregulated and 711 were downregulated in the Caco-2 cell line relative to the HT-29 cell line. At the protein level, 57 proteins were found to be upregulated and 111 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Finally, at the mi rNAs level, 104 were upregulated and 56 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Gene ontology(GO) analysis of the DE m rNA identified cell adhesion, migration and ECm o

关键词： Caco-2 HT-29 microarray Proteomics mirNA Targetscan Gene ontology

CFD Analysis of Influence of Slag Viscosity on the Splashing Process in an Oxygen Steelmaking Converter

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modeling and Numerical Simulation of material Science 2013年第3期3卷 90-93页

作者： miguel A. barron Dulce Y. medina Isaias Hilerio Departamento de materiales Universidad Autonoma Metropolitana Azcapotzalco M&eacutexico D.F. M&eacutexico

Physical properties of molten slag such as viscosity, density and surface tension have a significant influence on the slag splashing process in an oxygen steelmaking converter. Particularly, viscosity determines the shear forces that rule droplets formation. Besides, stirring of the molten slag bath strongly depends on this property. In this work, the influence of viscosity on the efficiency of slag splashing is explored by means of transient Computational Fluid Dynamics simulations. Several values of viscosity are employed in the computer experiments. In order to quantify the splashing efficiency as function of slag viscosity, an average slag fraction on the converter walls is defined and calculated. CFD results are compared with those of an empirical expression, and at least qualitative agreement is found.

关键词： CFD Oxygen Steelmaking refractory Lining Slag Viscosity Splashing Process

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多元熔体的一个热力学模型的讨论

地球与环境 1985年第9期 57-59页

作者： L.m.barron 王庆权

Berman和Brown的超额自由能公式对于当时已有的模型,诸如正规、次正规、Wohl和Kohler溶液模型来说,是一项重要的进展。在Berman和Brown的模型中,n组分体系的G;和μ;表达式非常容易建立并编成计算机程序。他们的溶液模型,如对相当复杂的SiO

关键词：熔体不对称电器构件构型熵热力学模型强子反应模型液相不混溶 SiO 三元系

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高炉水冷铜风口及其工艺述评

特种铸造及有色合金 1986年第1期 55-58页

作者： m·E·barron 李仕鑫英

一、引言水冷铜风口的材质对现代高炉生产有重要作用。为避免过长的休风时间,高炉上的各种水冷铜件都必须有高的使用寿命。特别是风口,使用条件非常恶劣。要提高其使用寿命,一方面要严格控制高炉操作,另一方面要保证风口的铸造质量,... 详细信息

一、引言水冷铜风口的材质对现代高炉生产有重要作用。为避免过长的休风时间,高炉上的各种水冷铜件都必须有高的使用寿命。特别是风口,使用条件非常恶劣。要提高其使用寿命,一方面要严格控制高炉操作,另一方面要保证风口的铸造质量,要求无任何缺陷。

关键词：风口风口冷却高炉

A method to fabricate small features on scaffolds for tissue engineering via selective laser sintering

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Journal of Biomedical Science and Engineering 2010年第2期3卷 138-147页

作者： S. Lohfeld m. A. Tyndyk S. Cahill N. Flaherty V. barron P. E. mcHugh 不详

Purpose: Selective laser sintering (SLS) is a rapid pro- totyping technique applied to produce tissue-engineer- ing scaffolds from powder materials. The standard scanning technique, however, often produces struts of extensive thickness, which means fabrication of high- ly porous scaffolds with small overall dimensions is quite difficult. Nevertheless, this study aims to overcome this shortfall. Design/methodology/approach: To this end, three scanning methods were evaluated in terms of minimum feature size and freedom of design, using a test polyamide (PA) material. Polycaprolactone (PCL) was then employed to create highly porous 3D scaffolds using the preferred scanning me- thod to produce thin struts. Findings: While in normal scanning mode some features were well above the laser spot diameter, strut thicknesses below the laser spot diameter were achieved when using the “outline scan” function for PA material. Those achieved for PCL were slightly higher and in the 500-800 ?m range, with an average pore size of 400 μm. Investigations on the properties of the scaffolds revealed an effective compression modulus of the PCL scaffold of 6.5 mPa. Furthermore, there was no change in physical or che- mical properties when the scaffolds were stored in a physiological environment for 7 weeks. Originality/ value: Though SLS is considered as a fabrication te- chnique for tissue engineering scaffolds, actually pro- duced scaffolds did not comply with porosity requirements and limitations of the SLS process in produ- cing features at the size of the laser beam spot have not been discussed. The present paper shows the capabilities of the SLS process based on two materials and presents a method to minimize feature size in scaffolds.

关键词： Selective Laser Sintering rapid Prototyping Scaffolds Polycaprolactone Tissue Engineering

新南威尔士东部某些显生宙金刚石起源的俯冲成因模式

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地质科学译丛 1997年第3期14卷 1-5页

作者： L.m.barron 田晓阳 New South Wales Department of mineral resources St LeonardsNSW 2065Australia

新南威尔士东部已出产了500000多克拉金刚石,大部分产于北部的科普顿—富加拉地区。这些金刚石具明显的种族特征,晶面少有损伤,且其碳同位素值和矿物包体的组成不同于那些传统金刚石产区出产的金刚石,如雅库特(西伯利亚)、卡普瓦尔(南非... 详细信息

新南威尔士东部已出产了500000多克拉金刚石,大部分产于北部的科普顿—富加拉地区。这些金刚石具明显的种族特征,晶面少有损伤,且其碳同位素值和矿物包体的组成不同于那些传统金刚石产区出产的金刚石,如雅库特(西伯利亚)、卡普瓦尔(南非)或者阿盖尔(西澳),指示了其地方起源。新南威尔士东部的构造环境也不象“传统”金刚石的构造环境,包含一套显生宙增长俯冲地体及相对薄的热地壳。提出俯冲金刚石模式来解释新南威尔士东部金刚石的起源及其地质条件。该模式认为,由于成年洋壳的伸长俯冲,当下冲板块到达传统模式所需深度一半时,在金刚石稳定区内形成低湿度变质窗。金刚石保存于俯冲终止的深度上,被仰冲或合适的岩浆挟带到地表。形成的金刚石类型取决于原始源岩(金刚石同源性列于括号内):富碳和贫碳海沟沉积物(CaFemgmn 硅酸盐,榴辉质),贫石墨玄武岩和辉长岩(榴辉质)以及二辉橄榄岩(橄榄质)。本模式预测,新南威尔士金刚石是年轻的(显生宙),而且其特征、形成年代、相关矿物和地理分析与新南威尔士区域构造有关。本俯冲金刚石模式把指示矿物范围扩大到包括粗粒金刚石、刚玉、钠石榴石,并包括一系列新的载体岩浆(碧玄岩、霞石岩、白榴岩)。以前在新南威尔士根据传统模式进行的勘探并不成功,但根据金刚石俯冲模式来重新解释时产生了一些有益的结果。据此,有理由对新南威尔士东部的金刚石潜力重新评估。

关键词：碧玄岩蓝片岩钙硅酸盐金刚石俯冲成因模式

Synthesis of ZnS:Tm<sup>3+</sup>Nanoparticles by the Polyol method

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Open Journal of Applied Sciences 2019年第7期9卷 613-619页

作者： Francisco Jesus rodriguez Joan reyes Dulce Y. medina miguel Angel barron Catalina Haro-Perez Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana Mexico City México

In this work, the synthesis of undoped and Tm-doped ZnS nanoparticles is successfully carried out by the polyol method. From XrD analyses, it was confirmed that both types of particles possess the cubic zinc blend structure of the ZnS, and that the structure is not altered by doping. The crystallite size computed by the Scherrer equation is about 9 ± 1 nm. From photoluminescence analyses, the results show that the excitation spectrum has two excitation peaks at 304 nm and 356 nm;by exciting at 304 nm, a strong blue emission is observed at 420 nm, while exciting at 356 nm the characteristic Tm transition 1G4 → 3H6 is observed at 417 nm. By doping with Tm ions, the emission color changes from pure blue to sky according to the change in CIE coordinates from x = 0.15, y = 0.015 to x = 0.18, y = 0.17, respectively.

关键词： Luminescence Zinc Sulfide Blue Emission