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天然气工业 1986年第4期8卷 58-64,8页

作者：韩洪升陈家琅大庆石油学院

本文根据理论分析和气液两相流的室内实验,得出了气液两相气泡流的空隙率分布以及在层流条件下和紊流条件下的速度分布规律。由以上结果得出的压降计算方法能比较准确地确定气液两相气泡流的压力损失。

关键词：气液两相空隙率分布紊流流体流动垂直管气泡流边界条件分布(力学) 速度分布金属管圆管多相流两相流流动规律

活化沉默信息调节因子1对大鼠严重烧伤早期肾损害的影响

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中华烧伤杂志 2017年第6期33卷 344-348页

作者：白晓智何亭刘洋张伟韩夫杨晨蔡维霞贾艳慧石继红韩军涛苏琳琳胡大海第四军医大学西京医院全军烧伤中心烧伤与皮肤外科西安710032

目的探讨行沉默信息调节因子1（SIrT1）活化对大鼠严重烧伤早期肾损害的影响。方法取30只雄性SD大鼠，按照随机数字表法分为假伤组、单纯烧伤组、SIrT1激动剂组，每组10只。单纯烧伤组和SIrT1激动剂组大鼠背部造成30％TBSAⅢ度烫伤（下... 详细信息

目的探讨行沉默信息调节因子1（SIrT1）活化对大鼠严重烧伤早期肾损害的影响。方法取30只雄性SD大鼠，按照随机数字表法分为假伤组、单纯烧伤组、SIrT1激动剂组，每组10只。单纯烧伤组和SIrT1激动剂组大鼠背部造成30％TBSAⅢ度烫伤（下称烧伤），伤后即刻分别腹腔注射生理盐水、终质量浓度为1mg／mL白藜芦醇溶液50mL／kg；假伤组大鼠致假伤，伤后即刻腹腔注射生理盐水50mL／kg。伤后24h收集3组大鼠肾脏组织及腹主动脉血，HE染色观察。肾脏组织形态，ELISA法检测血清肌酐、尿素氮含量，蛋白质印迹法检测肾脏组织中SIrT1、Bax、Bcl-2蛋白表达，实时荧光定量rT-PCr法检测肾脏组织中TNF-α、IL-1β、IL-10的mrNA表达。对数据行单因素方差分析、LSD-t检验。结果（1）假伤组大鼠肾小管、肾小球结构完整；单纯烧伤组大鼠肾小管内管型形成，小管结构不清，肾小球固缩；SIrT1激动剂组大鼠肾小管结构较为完整，肾小球固缩程度较单纯烧伤组轻且固缩的肾小球数量较少。（2）单纯烧伤组大鼠血清肌酐、尿素氮含量分别为（67±14）μmol／L、（22．0±4．4）mmol／L，显著高于假伤组的（28±7）μmol／L、（5．5±1．2）mmol／L（t值分别为6．07、11．53，P值均小于0．01）。SIrT1激动剂组大鼠血清肌酐、尿素氮含量分别为（39±9）μmol／L、（14．1±1．7）mmol／L，显著低于单纯烧伤组（t值分别为4．09、4．17，P值均小于0．01）。（3）单纯烧伤组大鼠肾脏组织中SIrT1、Bcl-2蛋白表达量显著低于假伤组（t值分别为16．32、19．58，P值均小于0．01），Bax蛋白表达量显著高于假伤组（t=5．98，P〈0．01）。SIrT1激动剂组大鼠肾脏组织中SIrT1、Bcl-2蛋白表达量显著高于单纯烧伤组（t值分别为6．94、5．37，P值均小于0．01），Bax蛋白表达量显著低于单纯烧伤组（t=3．44，P〈0．01）。（4）单纯烧伤组大鼠肾脏组织中TNF—α、IL-1β、IL-10的mrNA表达量分别为17．0±4．0、2．27±0．59、2．5±0．9，显著高于假伤组的1．0、1．00、1．0（t值为3．27～8．93，P〈0．05或P〈0．01）。SIrT1激动剂组大鼠肾脏组织中TNF—α、IL-1β的mrNA表达量分别为6．8±1．2、1．18±0．26，显著低于单纯烧伤组（￡值分别为4．59、4．32，P值均小于0．01）；IL-10的mrNA表达量为5．0±1．0，显著高于单纯烧伤组（t=5．51，P〈0．01）。结论活化SIrT1可以降低大鼠严重烧伤早期肌酐及尿素氮水平，改善肾功能；下调Bax蛋白表达，上调Bcl-2蛋白表达，减轻肾脏组织细胞凋亡；同时可抑制TNF-α和IL-1β表达，促进IL-10表达，减轻肾脏炎症反应。

关键词：烧伤肾细胞凋亡沉默信息调节因子1 炎症反应

经颞浅动脉进行颈外动脉逆行插管术的应用解剖

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河北医学院学报 1987年第2期 71-75页

作者：韩云明雷琦河北医学院解剖学教研室

本文对66具男尸(30～70岁),用1/20mm精确度的卡尺测量了以下内容:(1)颞浅动脉从耳屏前缘中点水平至上颌动脉、面动脉、舌动脉及甲状腺上动脉起始部上缘和至颈总动脉分叉点的距离;(2)颞浅动脉在耳屏前缘中点水平和颈外动脉干在其各主要... 详细信息

本文对66具男尸(30～70岁),用1/20mm精确度的卡尺测量了以下内容:(1)颞浅动脉从耳屏前缘中点水平至上颌动脉、面动脉、舌动脉及甲状腺上动脉起始部上缘和至颈总动脉分叉点的距离;(2)颞浅动脉在耳屏前缘中点水平和颈外动脉干在其各主要分支起始部上缘处的最大口径(外径);(3)颈外动脉各主要分支起始部的最大口径;(4)颞浅动脉与上颌动脉间、颈外动脉主干间的角度。

关键词：输注局部动脉内方法颈动脉外解剖学和组织学颞动脉

A Simple Method That Can Compensate the refraction of the Array Transducer Lens

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A Simple Method That Can Compensate the Refraction of the Ar...

2008 IEEE International Ultrasonics Symposium

作者： Moo-Ho Bae Han-Woo Lee Sung Bae Park ra-Young Yoon Jeons-Ho ham Se Hoon Chang Dae Young Kim Mok-Kun Jeong Yung-Gil Kim Hallym Univ. Department of Electronic Engineering Medison Co.LTD. Daejin Univ.

＜正＞Background,Motivation and Objective A fixed acoustic lens is often employed for elevation focusing of the one dimensional array transducer which is widely used in the diagnostic ultrasound *** lens generates ref...

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输油管线腐蚀种类和防腐技术分析

内蒙古石油化工 2021年第5期47卷 101-103页

作者：韩明君王义国家石油天然气管网集团有限公司西部管道分公司新疆哈密839009

在原油的运行投产过程中,管线输送是原油运输中的重要方式。在输油管线长时间运行投产过程中,管道腐蚀成为管线安全生产的首要问题,尤其是长距离埋地管线腐蚀程度往往更高。如果不能分析腐蚀种类,正确使用防腐技术,会极大缩短管线的使... 详细信息

在原油的运行投产过程中,管线输送是原油运输中的重要方式。在输油管线长时间运行投产过程中,管道腐蚀成为管线安全生产的首要问题,尤其是长距离埋地管线腐蚀程度往往更高。如果不能分析腐蚀种类,正确使用防腐技术,会极大缩短管线的使用寿命,对运输的油品质量造成污染,严重时会对当地环境造成巨大污染。本文针对输油管线的腐蚀种类、腐蚀产生的原因和常见的防腐技术进行综述,旨在为广大油田工作者提供防腐技术使用思路和理论依据。

关键词：输油管线腐蚀种类腐蚀原因防腐技术

NKG7 mrNA therapy increases the anti-tumor cytotoxicity of CD8+ T cells and improves response to immune checkpoint inhibitors

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NKG7 mRNA therapy increases the anti-tumor cytotoxicity of C...

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Ti Wen Whitney Barham Ying Li Henan Zhang Joanina K.Gicobi Jacob B.Hirdler Xin Liu Hyoungjun ham Fabrice Lucien Daniel D.Billadeau Haidong Dong The First Hospital of China Medical University Mayo Clinic Mayo Clinic College of Medicine and Science

Translating information gained from single cell rNA-sequencing(scrNA-seq) analyses into clinical therapeutics remains a challenge. However, with the advent of technology that makes mrNA-based modulation of primary cells possible, targets identified in scrNA-seq datasets can now be manipulated directly. Here we model this approach in the context of cancer immunotherapy. We performed scrNA-seq analysis of peripheral CD8 T cells from patients who received anti-PD-1 checkpoint blockade and found that natural killer cell granule protein-7(NKG7) gene expression was decreased in non-responding patients. Functional assays revealed that reduced NKG7 levels compromised cytolytic granule localization and release. Furthermore, transfection of CD8 T cells with NKG7 mrNA promoted tumor cell killing both in vitro and in vivo. Thus, we identify NKG7 as critical for response to anti-PD-1 treatment, demonstrate the efficacy of NKG7 mrNA as a therapeutic strategy for improving cancer immunotherapy, and provide a model for translating scrNA-seq findings into mrNA-based therapy.

关键词： cancer immunotherapy anti-PD-1 treatment scrNA-seq NKG7

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单侧复杂性双肾畸形儿童单个肾的功能改变

世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 29-30页

作者： Ismaili K. Hall M. ham H. Piepsz A. 王一飞 Hpital Universitaire des Enfants-reine Fabiola Department of Perinatal and Pediatric Nephrology 15 Avenue J. J. Crocq 1020 Brussels Belgium Dr.

Objective: To assess the evolution of individual renal function during the mat uration process in terms of single kidney glomerular filtration rate (SKGFr) and split function in children with unilateral complex renal duplication. Study des ign: We retrospectively reviewed the records of 44 children with unilateral comp lex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 mon ths (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months ). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFr), and SKGFr. results: Mean overall kidney GFr increased si gnificantly between the two measurements from 63 ±12.7 mL/minute/1.73m2 to 95 ±21 mL/minute/1.73m 2 (P r of the duplex side similarly increased from 26 ±7.7 mL/minute/1.73m2 to 38 ±12.6 mL/minute/1.73m2 (P rms of split function, the affected kidney had a remarkable stable function betw een the two measurements, 40%±8.6 and 39%±8.3 (P = .94), respectively. Howev er, cases with the lowest initial split function ( r and the worst further evolution. Conclusion: In children with unilateral complex renal duplication, we found on the affected side a significant increase of SKGFr because of renal maturation, whereas mean split function remained stab le during follow-up.

关键词：肾畸形肾小球滤过率全或无肾上极评估单乙二胺四乙酸肾下极研究设计精确估算

NKG7 mrNA therapy increases the anti-tumor cytotoxicity of CD8+ T cells and improves response to immune checkpoint inhibitors

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NKG7 mRNA therapy increases the anti-tumor cytotoxicity of C...

第十四届全国免疫学学术大会

作者： Ti Wen Whitney Barham Ying Li Henan Zhang Joanina K. Gicobi Jacob B. Hirdler Xin Liu Hyoungjun ham Fabrice Lucien Hu Li Daniel D. Billadeau Haidong Dong Department of Medical Oncology the First Hospital of China Medical University Mayo Clinic Mayo Clinic College of Medicine and Science

Translating information gained from single cell rNA-sequencing(scrNA-seq) analyses into clinical therapeutics remains a challenge. However, with the advent of technology that makes mrNA-based modulation of primary cells possible, targets identified in scrNA-seq datasets can now be manipulated directly. Here we model this approach in the context of cancer immunotherapy. We performed scrNA-seq analysis of peripheral CD8+ T cells from patients who received anti-PD-1 checkpoint blockade and found that natural killer cell granule protein-7(NKG7) gene expression was decreased in non-responding patients. Functional assays revealed that reduced NKG7 levels compromised cytolytic granule localization and release. Furthermore, transfection of CD8+ T cells with NKG7 mrNA promoted tumor cell killing both in vitro and in vivo. Thus, we identify NKG7 as critical for response to anti-PD-1 treatment, demonstrate the efficacy of NKG7 mrNA as a therapeutic strategy for improving cancer immunotherapy, and provide a model for translating scrNA-seq findings into mrNA-based therapy.

关键词： Cancer Immunotherapy anti-PD-1 response NKG7 scrNA-seq

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双螺杆压缩机排气端座铸件铸造工艺研究

铸造技术 2015年第12期36卷 3010-3012页

作者：韩伟张鹏张元华张小丽王建民河北机电职业技术学院河北邢台054000 邢台市金后盾精密机械有限公司河北邢台054000

通过合金元素的加入和合理的熔炼工艺,改变了铸件的组织,减少了夹杂,排气端座的综合性能得到提升,力学性能达到抗拉强度≥276 MPa,抗弯应力≥11.56 k N/cm^2。满足了双螺杆压缩机排气座铸件的技术要求。

关键词：双螺杆压缩机排气端座铸铁力学性能

Hepatitis E virus: Western Cape, South Africa

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World Journal of Gastroenterology 2016年第44期22卷 9853-9859页

作者： richie G Madden Sebastian Wallace Mark Sonderup Stephen Korsman Tawanda Chivese Bronwyn Gavine Aniefiok Edem roxy Govender Nathan English Christy Kaiyamo Odelia Lutchman Annemiek A van der Eijk Suzan D Pas Glynn W Webb Joanne Palmer Elizabeth Goddard Sean Wasserman Harry r Dalton C Wendy Spearman royal Cornwall Hospital Trust and European Centre for Environment and Human Health University of Exeter Division of Hepatology Department of Medicine Faculty of Health Sciences University of Cape Town and Groote Schuur Hospital National Health Laboratory Service Groote Schuur Hospital Cape Town and Division of Medical Virology University of Cape Town Faculty of Health Sciences Department of Viroscience Erasmus Medical Centre Medical Center Rotterdam Department of Paediatrics Faculty of Health Sciences University of Cape Town and Red Cross Children’s Hospital Division of Infectious Diseases and HIV Medicine Department of Medicine Faculty of Health Sciences University of Cape Town and Groote Schuur Hospital

AIM To conduct a prospective assessment of anti-hepatitis E virus(HEV) Ig G seroprevalence in the Western Cape Province of South Africa in conjunction with evaluating risk factors for *** Consenting participants attending clinics and wards of Groote Schuur, red Cross Children's Hospital and their affiliated teaching hospitals in Cape Town, South Africa, were sampled. Healthy adults attending blood donor clinics were also recruited. Patients with known liver disease were excluded and all major ethnic/race groups were included to broadly represent local demographics. relevant demographic data was captured at the time of sampling using an interviewer-administered confidential questionnaire. Human immunodeficiency virus(HIV) status was self-disclosed. HEV Ig G testing was performed using the Wantai? *** HEV is endemic in the region with a seroprevalence of 27.9%(n = 324/1161) 95%CI: 25.3%-30.5%(21.9% when age-adjusted) with no significant differences between ethnic groups or HIV status. Seroprevalence in children is low but rapidly increases in early adulthood. With univariate analysis, age ≥ 30 years old, pork and bacon/ham consumption suggested risk. In the multivariate analysis, the highest risk factor for HEV Ig G seropositivity(Or = 7.679, 95%CI: 5.38-10.96, P rs or older followed by pork consumption(Or = 2.052, 95%CI: 1.39-3.03, P recent clinical case demonstrates that HEV genotype 3 may be currently circulating in the Western *** Hepatitis E seroprevalence was considerably higher than previously thought suggesting that hepatitis E warrants consideration in any patient presenting with an unexplained hepatitis in the Western Cape, irrespective of travel history, age or ethnicity.

关键词： Hepatitis E Seroprevalence South Africa Pork consumption Genotype