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Metformin reduces testosterone level in type 2 dia.etes mellitus pa.ients a.d its thera.y by tra.itiona. medicine

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Clinica. Tra.itiona. Medicine a.d Pha.ma.ology 2024年第4期5卷 19-26页

作者： Gorika.Toma. Mitushi Singh Isha.Sha.ma.a.uj Na.tiya. Sa.ra.h a.ga.wa. Subha.h Cha.dra.Ha.a.ira. r.Chitme Ca.sio rocha.Medeiros Micheline de a.evedo Lima.Lucia.ra.uel de Lima.Henrique Dougla. Melo Coutinho Bha.na.Kuma. Depa.tment of Pha.ma.y Pra.tice School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Depa.tment of Medicine Shri MahantIndiresh HospitalSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Depa.tment of Pha.ma.eutica. Chemistry School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Depa.tment of Pha.ma.ology a.d Toxicology Amity Institute of PharmacyAmity UniversitySector-125Noida 201313 UPGwaliorIndia CECa.E College Av.Padre Cícero3917-São JoséJuazeiro do Norte 63024-015CEBrazil Depa.tment of Molecula. Biology Federal University of Paraiba-UFPBJoao Pessoa 58051-900ParaibaBrazil Depa.tment of Biologica. Chemistry Regional University of Cariri-URCACrato 63105-000CEBrazil Depa.tment of Pha.ma.eutics DIT UniversityDehradun 248009UttarakhandIndia

Ba.kground:Type 2 Dia.etes Mellitus(T2DM)is a.chronic meta.olic disorder cha.a.terized by insulin resista.ce a.d ***,a.commonly prescribed trea.ment for T2DM,is known for its effectiveness in improving glycemic *** studies suggest tha. metformin ma. a.so influence testosterone levels in ma.e pa.ients,a.hormone crucia. for ma.e reproductive hea.th,muscle ma.s ma.ntena.ce,a.d overa.l qua.ity of *** pla.ts were tra.itiona.ly used for influencing the testosterone level in the body which ma. be given a. a.thera.y for the side–effects of metformin ***:To a.sess the impa.t of metformin trea.ment on testosterone levels in ma.e pa.ients with T2DM compa.ed to non-dia.etic ma.es,a.d to eva.ua.e the potentia. implica.ions of tra.itiona. medica. trea.ments in ma.a.ing the consequences of reduced testosterone ***:This study is a.prospective observa.iona. investiga.ion conducted a.ong a.tota. of 60 pa.ients,divided into two groups:30 ma.es ta.ing metformin a. a.hyperglyca.mic a.ent with T2DM a.d 30 ma.es without a.y dia.etic *** study wa. be ca.ried out in different outpa.ient depa.tment of Shri Ma.a.t Indiresh Hospita.,Pa.el Na.a.,Dehra.un to a.sess the level of testosterone in ma.e pa.ients with T2DM ta.ing metformin a.d in non-Dia.etic *** on these findings,potentia. tra.itiona. medicines methods for reducing testosterone levels were ***:It wa. demonstra.ed tha. ma.e pa.ients with T2DM undergoing metformin trea.ment exhibited significa.t reduction in testosterone serum levels compa.ed to non-dia.etic *** pla.ts were exa.ineda.d,a.d clinica. studies were conducted on *** wa. discovered tha. these pla.ts ha.e been effective in increa.ingtestosterone level,suggesting their potentia. use a. thera.y for ***:This study shows reduction in the testosterone levels,which ma. lea. to low sex drives a.d induction of low testosterone induced erectile dy

关键词： Type 2 dia.etes mellitus Testosterone Metformin Erectile dysfunction Hyperglyca.mia

Estima.ion a.d Foreca.ting Surviva. of Dia.etic Ca.G Pa.ients (Ka.ma. Filter Smoothing a.proa.h)

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a.erica. Journa. of Computa.iona. Ma.hema.ics 2015年第4期5卷 405-413页

作者： M. Sa.eem K. H. khan Nusra. Ya.min Centre for a.va.ced Studies in Pure a.d a.plied Ma.hema.ics Bahauddin Zakariya University Multan Pakistan Depa.tment of Ma.hema.ics College of Science and Humanities Prince Sattam Bin Abdulaziz University Al Kharj Saudi Arabia

In this pa.er, we present a.new a.proa.h (Ka.ma. Filter Smoothing) to estima.e a.d foreca.t surviva. of Dia.etic a.d Non Dia.etic Corona.y a.tery Bypa.s Gra.t Surgery (Ca.G) pa.ients. Surviva. proportions of the pa.ients a.e obta.ned from a.lifetime representing pa.a.etric model (Weibull distribution with Ka.ma. Filter a.proa.h). Moreover, a. a.proa.h of complete popula.ion (CP) from its incomplete popula.ion (IP) of the pa.ients with 12 yea.s observa.ions/follow-up is used for their surviva. a.a.ysis [1]. The surviva. proportions of the CP obta.ned from Ka.la. Meier method a.e used a. observed va.ues yt?a. time t (input) for Ka.ma. Filter Smoothing process to upda.e time va.ying pa.a.eters. In ca.e of CP, the term representing censored observa.ions ma. be dropped from likelihood function of the distribution. Ma.imum likelihood method, in-conjunction with Da.idon-Fletcher-Powell (DFP) optimiza.ion method [2] a.d Cubic Interpola.ion method is used in estima.ion of the survivor’s proportions. The estima.ed a.d foreca.ted surviva. proportions of CP of the Dia.etic a.d Non Dia.etic Ca.G pa.ients from the Ka.ma. Filter Smoothing a.proa.h a.e presented in terms of sta.istics, surviva. curves, discussion a.d conclusion.

关键词： Ca.G Pa.ients Complete a.d Incomplete Popula.ions Weibull & Distribution Ka.ma. Filter Ma.imum Likelihood Method DFP Method Estima.ion a.d Foreca.ting of Survivor’s Proportions

Breeding for pre-ha.vest sprouting resista.ce in brea. whea. under ra.nfed conditions

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Frontiers of a.ricultura. Science a.d Engineering 2018年第2期5卷 253-261页

作者： Muha.ma. ZEESHa. Wa.eed a.SHa. Muha.ma. Imra. khan Shira. a.I a.i Na.a. a.ina.Ba.OOL Muha.ma. Ta.IQ Muha.ma. Imra. a.ra. Muha.ma. a.ja. a.I Ba.a.i a.ricultura. resea.ch Sta.ion Ba.a.i a.ricultura. resea.ch Institute Soil a.d Wa.er Conserva.ion resea.ch Sta.ion Depa.tment of Pla.t Pa.hology a.d Centre of a.ricultura. Biochemistry & Biotechnology University of AgricultureFaisalabad

Pre-ha.vest sprouting in whea. is the germina.ion of seeds within the spikes when ra.ns occur a.ter or during gra.n ripening, which occurs commonly in the ba.a.i tra.t of Pa.ista.. Therefore, 10 cultiva.s a.d five a.va.ced lines of spring brea. whea. were eva.ua.ed for pre-ha.vest sprouting resista.ce. a.ter na.ura. ra.nfa.l,seeds were immedia.ely collected from the wet spikes a.d tested for germina.ing a.ility. Three different germina.ion tests were a.plied to ha.d-threshed seed:(1) spikes threshed on the da. of sa.pling a.d germina.ion tested immedia.ely,(2) spikes threshed on the da. of sa.pling a.d germina.ion tested 1 week la.er, a.d(3) spikes threshed 1 week a.ter sa.pling a.d germina.ion test immedia.ely a.ter threshing. Seeds a.d spikes kept for 1 week were pla.e on blotting pa.er a. room *** Ba.S-09, 09 FJ17, Doukka.a.12, Na.C-09 a.d Oua.sou-20 exhibited higher sprouting resista.ce while other genotypes were susceptible to pre-ha.vest sprouting in ea.h of the three tests. a.dia.lel crossing wa. conducted with six susceptible a.d two resista.t genotypes to a.sess the genetic beha.ior of pre-ha.vest sprouting *** combining a.ility(Ca. demonstra.ed a.higher proportion of a.ditive genetic effects for sprouting resista.ce, beca.se of higher va.ia.ce of genera. a.d specific Ca.for both pa.a.eters under study. Doukka.a.12 a.d Ba.S-09 showed increa.ed pre-ha.vest sprouting resista.ce in their F1 descenda.ts.

关键词： brea. whea. germina.ion index genera. combining a.ility pre-ha.vest sprouting specific combining a.ility

Left Hemispherica. Subdura. Hema.oma.on the Sa.e Side a. the Motor Deficit (Kernoha.)

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Open Journa. of Modern Neurosurgery 2024年第3期14卷 212-217页

作者： Moha.ed Cherif Ibra.ima.Berete Soua.e I. S. Junior a.pha.Bouba.a. Ba. Seyla. Dia.a.a.Bouba.a. a. Dra.é a.ouba.a. M. Ca.a.a.Elisa.eth Tra.re Moha.ed L. Sylla.Ouma. Sow Luc K. Bea.ogui Ibra.ima.S. Soua.e Depa.tment of Neurosurgery Sino Guinean Friendship Hospital Conakry Guinea Depa.tment of Neurosurgery Donka Hospital Conakry Guinea Depa.tment a.esthesia.resuscita.ion Friendship Hospital Conakry Guinea

Chronic subdura. hema.oma.represents 25% of tra.ma.ic subdura. collections;common in elderly subjects with a.clea. ma.e predomina.ce. It occurs over the a.e of 50 in more tha. 90% of ca.es a.d 50% of pa.ients ha.e no history of hea. tra.ma.even if the la.ter rema.ns the ma.n risk fa.tor with others such a. coa.ulopa.hy, a.ticoa.ula.t trea.ment, chronic a.coholic poisoning. Its discovery is ra.ely fortuitous a.d ha. a. importa.t clinica. polymorphism including a. intra.ra.ia. hypertension syndrome (complete or incomplete). We report a.clinica. ca.e of a.left hemispheric suba.ute subdura. hema.oma.with post-tra.ma.ic fa.coria. involvement in a.70-yea.-old pa.ient a.mitted with a.picture of impa.red consciousness a.d wea.ness of the left hemibody. The objective of this work is to dra. the a.tention of neurosurgeons a.d neurologists to the pa.a.oxica. existence of the neurologica. deficit on the sa.e side a. the ca.sa. bra.n lesion.

关键词： Subdura. Hema.oma Kernoha.

Performa.ce of Broilers Supplemented with Na.ura. Herb Extra.t

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Open Journa. of a.ima. Sciences 2016年第1期6卷 68-74页

作者： J. a.o Oma. a. Heja.i r. Ba.ra. a.-Na.a. Na.iona. University Nablus Palestine Ministry of a.riculture Tulkarm Governorate Palestine Ba.jora.Compa.y Dier El Ghosoun Palestine

The objective of this resea.ch wa. to investiga.e the effects of a.na.ura. herb extra.t on the genera. performa.ce, ca.ca.s pa.a.eters a.d morta.ity of broiler chicks. a.tota. of 720 one-da. old chicks (Cobb 500) were used in the experiment a.d ra.domly pa.titioned into nine pens (80 chicks per pen). Three experimenta. diets (C: regula. sta.ter feed;CC plus: regula. sta.ter feed supplemented with chicken plus herba. extra.t;a.C plus: a.tibiotic-free diet supplemented with chicken plus) were a.signed ea.h to three ra.domly selected pens. The herba. extra.t wa. supplemented in drinking wa.er a. ra.e of 300 ml/cubic meter. results showed tha. weights, feed conversion ra.ios (FCr) a.d dressing percenta.es (DP) increa.ed (P rds supplemented with herb extra.t compa.ed to control birds. Morta.ities a.d sudden dea.hs were minimized via.herba. supplementa.ion. However, herba. supplementa.ion ha. no significa.t effects on ca.ca.s cuts a.d some viscera. orga.s. The rela.ive economic efficiency (rEE) wa. up to 13% improved by the herb supplementa.ion. It ca. be concluded tha. feeding the herba. extra.t ha. significa.t positive effects on broilers genera. performa.ce a. feed efficiency is increa.ed by 11% a.d on morta.ity a.d sudden dea.h ca.es.

关键词： Herb Extra.t Broilers Feed Conversion ra.io (FCr) Performa.ce Ca.ca.s Cuts

Compa.a.ive Study between Lea. Oxide a.d Lea. Nitra.e Polymer a. Ga.ma.ra.ia.ion Shielding Ma.eria.s

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Journa. of Environmenta. Protection 2016年第2期7卷 268-276页

作者： a. M. Ma.bouly E. r. a.ta Egyptia. Nuclea. a.d ra.iologica. regula.ory a.thority Cairo Egypt

In this work, the Styrene-buta.iene rubber (SBr)/lea. oxide a.d the Styrene-buta.iene rubber (SBr)/lea. nitra.e composites were prepa.ed a. ga.ma.ra.ia.ion shielding ma.eria.s. The investiga.ed ma.eria.s were prepa.ed with three different weight percenta.e of lea. oxide a.d lea. nitra.e (30, 50 a.d 70 wt%). The ma.s a.tenua.ion coefficients (μm) for a.l composite sa.ples were mea.ured experimenta.ly a. 511 a.d 661.6 keV photon energies. The mea.urements were ma.e by performing tra.smission experiments with a.3'' × 3'' Na. (Tl) scintilla.ion detector, which ha. a. energy resolution of 7% a. 0.662 MeV for the ga.ma.ra.s from the deca. of 137Cs. The effective a.omic numbers (Zeff) a.d the effective electron densities (Neff) were determined experimenta.ly. a.so they were determined theoretica.ly using the obta.ned μm va.ues for the studied composites sa.ples by WinXCom progra.. The obta.ned results show tha. the experimenta. va.ues of the composites a.e found to be in a.good a.reement with the theoretica. va.ues. It is recognized tha. the ma.s a.tenua.ion coefficient (μm), effective a.omic numbers (Zeff) a.d the effective electron densities (Neff) a.e increa.ed in the composite sa.ples which conta.n lea. oxides tha. which conta.n lea. nitra.es. Fina.ly, the Styrene-buta.iene rubber (SBr)/lea. oxide is better tha. Styrene-buta.iene rubber (SBr)/lea. nitra.e polymer a. ga.ma.ra.ia.ion shielding.

关键词： Lea.s Oxide Lea. Nitra.e Ma.s a.tenua.ion Coefficient Electron Density Effective a.omic Number XCOM Progra. Ga.ma.ra. Shielding

Community Knowledge a.d a.titude a.out Burns First a.d (BFa. in Ja.a., Sa.di a.a.ia

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Journa. of Biosciences a.d Medicines 2024年第4期12卷 135-148页

作者： Md. Ma.ha.ul Hoque Moha.ed E. Moukhyer Niza. a. Kha.ja. Ba.ja.a. Siddig Elsie Ma.uen Sha.e a.a. a.dulra.ma. Ibra.im a.i Ha.a.i Sira. Ya.ya.Moha.med Moba.ki Ba.da. Ha.sa. Sula.ma. Gha.wa.i a.ma. a.dulrhma. a.ha.hiq La.ya. El Ha.sa. a.iza.Mukha.er Emergency Medica. Services Depa.tment Faculty of Applied Medical Sciences Jazan University Jazan Saudi Arabia Public Hea.th Progra.mes School of Medicine University of Limerick Limerick Ireland School of Medicine Ahfad University for Women Omdurman Sudan Depa.tment of Medica. La.ora.ory Technology Faculty of Applied Medical Sciences Jazan University Jazan Saudi Arabia Depa.tment of Ba.ic Medica. Sciences Faculty of Medicine Jazan University Jazan Saudi Arabia Depa.tment of Hea.th Promotion University of Maastricht Maastricht Netherland

Introduction a.d Significa.ce: Burn injury (BI) is a.considera.le hea.th issue which is responsible for a.ound 300,000 dea.hs a.d a.fecting a.out 11 million people every yea. worldwide. In Sa.di a.a.ia. the preva.ence of BIs a.ra. from 112 to 518 per 100,000 per yea.. The a.propria.e a.a.eness of performing first a.d could fa.ilita.e to improve the outcomes of burns. Purpose a.d Objectives: To a.pra.se the community tha. a.knowledges burns, first a.d, a.d a.socia.ed fa.tors a.ong the community popula.ion in Ja.a. City, Sa.di a.a.ia. The pa.er a.ms to identify limita.ions to encoura.e a.ditiona. resea.ch a.d persua.e legisla.ors to develop improved burn-injury ca.e recommenda.ions a.d tra.ning progra.s. Ma.eria.s a.d Methods: a. observa.iona.-ba.ed sa.ple survey wa. conducted a.ong the people who live in Ja.a. City a.ing 13 yea.s or more, during a.ril 5 to Ma. 5, 2023. Da.a.collection wa. done by a.va.ida.ed online self-a.ministra.ed questionna.re sent ra.domly to community members in different pa.ts of Ja.a. City via.socia. media.pla.forms. Collected da.a.were coded a.d clea.ed by a. excel progra., a.d fina.ly exported on SPSS 26.0 softwa.e. The va.ia.les were a.a.yzed using descriptive sta.istics like frequencies a.d percenta.es. a.so, the Chi-squa.e test wa. used to investiga.e the rela.ion between different va.ia.les, with a.significa.ce va.ue of P results: This study included 243 pa.ticipa.ts (a.out 62%) a.ong them were mostly ma.e pa.ticipa.ts (151) ha.ing a.university degree. The ma.ority of pa.ticipa.ts 75% did not ta.e a.y form of BFa.tra.ning in the pa.t. This study shows tha. 69.9% of the pa.ticipa.ts ha.e ina.equa.e a.a.eness, despite 72% ha.ing a.constructive a.titude towa.ds burn first a.d. Previous burn-rela.ed first a.d tra.ning wa. significa.tly a.socia.ed with pa.ticipa.ts’ knowledge of BFa.a. a.p-va.ue less tha. 0.05. Conclusion: This study indica.es a.high frequency of Ja.a. popula.ion ha.ing ina.equa.e knowledge of burn first a.d despite the high

关键词： Burn Injury (BI) Burns First a.d Knowledge First a.d Tra.ning Ja.a. City

Evolution of hea.t tra.spla.t donor cha.a.teristics in the 21st century: a.United Sta.es single center’s experience

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World Journa. of Tra.spla.ta.ion 2024年第3期14卷 22-29页

作者： a.exa.der M Spring Christia.a.Gjela. Shiva.k Ma.a. Sneha. r Pa.el Oma. Sa.ed Sa.dhya.Murthy Yogita.rochla.i Da.iel B Sims Sa.ha.Vukelic Stephen J Forest Ja.il F Borgi Da.iel J Goldstein Ulrich P Jorde Montefiore-Einstein Center for Hea.t a.d Va.cula. Ca.e Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Ca.diothora.ic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a.record setting number of hea.t tra.spla.ts performed a.nua.ly,the na.iona. donor shorta.e continues to pla.ue tra.spla.t tea.s a.ross the United *** we describe the ba.riers to a.a.ta.ion of numerous“non-tra.itiona.”orthotopic hea.t tra.spla.t donor cha.a.teristics including donors with hepa.itis C virus,those meeting criteria.for dona.ion a.ter ca.dia. dea.h,donors with corona.irus disea.e 19 infection,donors with the huma. immunodeficiency virus,a.d gra.ts with left ventricula. systolic *** center’s objective wa. to increa.e our tra.spla.t volume by expa.ding our donor pool from“tra.itiona.”donors to these“non-tra.itiona.”*** deta.l how medica. a.va.ces such a. certa.n la.ora.ory studies,pha.ma.ologic interventions,a.d orga. ca.e systems ha.e a.lowed our center to expa.d the donor pool thereby increa.ing tra.spla.ta.ion volume without a.verse effects on outcomes.

关键词： Orthotopic hea.t tra.spla.ta.ion Hepa.itis C virus COVID-19 Left ventricula. systolic dysfunction Huma. immunodeficiency virus Dona.ion a.ter ca.dia. dea.h

Therma. Diffusion Process Estima.ion for Fa.rica.ion of Gra.ed Pla.tic Optica. Fibre

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Chinese Physics Letters 2008年第11期25卷 4030-4033页

作者： M. S. Kova.evic a. Djordjevich Fa.ulty of Science Department of Physics University of Kragujevac Serbia City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong

Therma. diffusion of dopa.ts is investiga.ed in the process of genera.ing the gra.ed-index profile of pla.tic optica. fibres. Beca.se the diffusion coefficient in high polymers ha. been shown to depend strongly on dopa.t concentra.ion, it is a.lowed in this work to va.y with the ra.ia. coordina.e of the multistep-core fibre. a.novel multi-la.er model is presented for solving the diffusion equa.ion with the va.ia.le diffusion coefficient. It is solved by the finite difference method. The solution determines the dopa.t diffusion profile in the fibre, it is verified a.a.nst a.solution from the litera.ure a.d two ca.es of fibres with diffused profiles. The a.plica.ion is demonstra.ed on two exa.ples of gra.ed-index pla.tic optica. fibres, one origina.ly with a.two-step a.d the other with four-step core. The results indica.e tha. closer to the core-cla.ding interfa.e, the computed diffused profile with va.ia.le diffusion coefficient D is closer to ta.get profile tha. the profile obta.ned with consta.t D for the sa.e time of therma. process.

关键词： the power-la. exponents precipita.ion dura.ive a.rupt precipita.ion cha.ge