检索结果-南通市图书馆

Modifying metabolic and immune hallmarks of cancer by a copper complex

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Chengyan Chu Yunhua Zhang Chengyuan Qian Xiuzhi Yang Yicun Shang Zijian guo Xiaoyong Wang State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University

Metabolic adaptation of cancer cells is a key tactic for maintaining their tumorigenicity and viability in the tumor immune microenvironment （TIME）.Concurrent modulation on the metabolic pathway and immune system could change the living condition of cancer cells and potentiate the efficacy of anticancer drugs.A copper complex （DDCu） was designed to influence the energy metabolism of cancer cells and reshape the *** restrained the production and transportation of lactate by inhibiting the expression of lactate dehydrogenase and monocarboxylate transporter 4,thereby altering the metabolic pathway of cancer cells and improving the acidic tumor ***,DDCu was reduced to Cu+by cellular glutathione to react with lipoylated proteins of the tricarboxylic acid cycle and destabilize the Fe–S cluster proteins,leading to the aggregation of dihydrolipoamide S-acetyltransferase and cuproptosis in cancer ***,DDCu promoted the polarization of macrophages from the M2 to M1 phenotype,activated CD4+and CD8+T cells,and reversed the *** a result,DDCu inhibited the tumor growth through a synergy between metabolic regulation and immunomodulation.

关键词：

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia guo Zhaoyang Zeng Can guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular rNAs(circrNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circrNAs remain elusive. In this study, we identified a novel circrNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circrNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

关键词：

Advances and applications in single-cell and spatial genomics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Jingjing Wang Fang Ye Haoxi Chai Yujia Jiang Teng Wang Xia ran Qimin Xia Ziye Xu Yuting Fu guodong Zhang Hanyu Wu guoji guo Hongshan guo Yijun ruan Yongcheng Wang Dong Xing Xun Xu Zemin Zhang Beijing Advanced Innovation Center for Genomics (ICG) Peking University Guangdong Provincial Key Laboratory of Genome read and Write BGI Research Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Life Sciences Institute and The Second Affiliated Hospital Zhejiang University BGI research Biomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences Peking University Academy for Advanced Interdisciplinary Studies Peking University Institute of Hematology Zhejiang University Department of Laboratory Medicine of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Center for Stem Cell and regenerative Medicine Zhejiang University School of Medicine Zhejiang Provincial Key Lab for Tissue Engineering and regenerative Medicine Dr.Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine

The applications of single-cell and spatial technologies in recent times have revolutionized the present understanding of cellular states and the cellular heterogeneity inherent in complex biological systems. These advancements offer unprecedented resolution in the examination of the functional genomics of individual cells and their spatial context within tissues. In this review, we have comprehensively discussed the historical development and recent progress in the field of single-cell and spatial genomics. We have reviewed the breakthroughs in single-cell multi-omics technologies, spatial genomics methods, and the computational strategies employed toward the analyses of singlecell atlas data. Furthermore, we have highlighted the advances made in constructing cellular atlases and their clinical applications,particularly in the context of disease. Finally, we have discussed the emerging trends, challenges, and opportunities in this rapidly evolving field.

关键词：

Laser image refractive index sensor based on the combination of a coreless optical fiber and a digital camera

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年第2期 65-68页

作者： guo Jingzhong LAN Feng CHEN Xiang LIU Haifeng Xi'an Institute of Space radio Technology Key Laboratory of Optoelectronic Sensor and Sensing Network Technology College of Electronic Information and Optical Engineering Nankai University

As a laser passes through a scattering medium,the light interacts with the irregular reflections within the medium,resulting in light scattering and the formation of *** this paper,an image sensor based on the combination of a coreless optical fiber and a digital camera is proposed for liquid refractive index sensing *** coreless fiber is used as a sensing unit,and the change in the speckle pattern is measured using the digital correlation method to detect the magnitude of the liquid's refractive *** experimental results indicate that the laser image sensing technique is capable of effectively distinguishing liquid samples with refractive indices ranging from 1.332 8 to1.390 8,with a sensing sensitivity of-1.306 ***,the laser image sensing technique,with its advantages of high experimental reproducibility,simple system design,remote over-control,holds great research significance and potential application in laser communication and sensor integration.

关键词：

同方期刊数据库

2D free-standing ultra-large ferromagnetic nanosheets via a topotactic transformation strategy

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Haofeng Sun Minghao Wang Wenjie Li Yang Liu Xinyu Sun Wenjie Wang Yuqiao guo Yi Xie Changzheng Wu Key Laboratory of Precision and Intelligent Chemistry University of Science&Technology of China National Synchrotron radiation Laboratory University of Science and Technology of China

Considerable progress has been made in synthesizing two-dimensional （2D） materials by exfoliating layered ***,for tremendous non-layered inorganic materials,especially magnet solids,usually with closely packed bulk phases by strong chemical bonds,it is challenging to obtain their high-quality 2D ***,we highlighted a new structure of free-standing ferromagnetic nanosheets featuring （111） *** magnet,Fe3O4,its inversed spinel crystalline has limited abilities to exfoliate into 2D forms and rarely exists as free-standing nanosheets owing to aggregation induced by magnetic *** realized a breakthrough in achieving free-standing ferromagnetic nanosheets with dramatically surpassing size limitations via topotactic conversion from layered *** Fe3O4nanosheets exhibited a maximum width of 60μm while only～4 nm thick,prominently exposing （111） facets.2D Fe3O4behaved anisotropic magnetism,which displayed a 4.6 emu g-1moment（H=500 Oe） in the （111） plane but 2.1 emu g-1out of the （111） plane,indicating a （111） in-plane easy *** anticipated our topotactic conversion strategy would inspire the creation of 2D non-layered materials and enrich the 2D materials family.

关键词：

回应性制度赋能:新时代基层党员领导干部政治能力建设的制度分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

河北学刊 2025年第1期45卷 47-54页

作者：卢爱国广西师范大学马克思主义理论与区域实践研究中心广西师范大学马克思主义学院

党的事业,根基在基层,关键在干部。随着中国特色社会主义进入新时代,发展阶段的升级、主要矛盾的转化、奋斗目标的转向以及发展环境的不确定性,给基层政治接续有效带来了新挑战,基层党员领导干部政治能力建设成为新时代中国基层政治接... 详细信息

党的事业,根基在基层,关键在干部。随着中国特色社会主义进入新时代,发展阶段的升级、主要矛盾的转化、奋斗目标的转向以及发展环境的不确定性,给基层政治接续有效带来了新挑战,基层党员领导干部政治能力建设成为新时代中国基层政治接续有效的核心议题。从“政党回应、制度赋能与有效政治”的分析框架透视,新时代基层党员领导干部政治能力建设,实际上是党回应时代环境、时代使命和时代需求的变化,坚持和完善党的政治能力建设制度,创新制度赋能的组织实践和自我实践,提高基层党员领导干部政治能力,实现基层有效政治的政治行动。新时代新征程应以基层政治的有效性为导向,持续加强基层党员领导干部政治能力提升的制度建设,积极构建“内外双生、多层复合”的均衡性制度框架。

关键词：新时代基层党员领导干部政治能力回应性制度赋能有效政治

维普期刊数据库

The low-latitude sodium layer:comparative data from lidar observations at Hainan,China and São Paulo,Brazil

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2025年第1期9卷 39-53页

作者： Fang Wu Jing Jiao guoTao Yang LiFang Du ZhengKuan Liu Haoran Zheng JiXin guo ShaoHua Gong YaJun Zhu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China China-Brazil Joint Laboratory for Space Weather NSSC/INPESão Josédos Campos 12227-010Brazil School of Physics and Electronics Engineering Hainan Normal UniversityHaikou 571158China

Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude *** sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s *** paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the *** low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in ***,maximal Na density over Brazil is greater than that over *** variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before *** variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain *** suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.

关键词： metallic sodium layer seasonal variation nocturnal variation lidar

维普期刊数据库

Enhancing anion conductivity in a highly alkali-stable eta topologic Cu(Ⅰ) framework via strong electrostatic repulsion

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xiaolu Wang Shaohui guo Chao Suo Fuqiang Zhang Junhao Wang Wenjing Wang Daqiang Yuan Linfeng Liang Xianming Zhang College of Chemistry Taiyuan University of Technology Institute of Crystalline Materials Shanxi University School of Chemistry and Materials Science Shanxi Normal University State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Metal-organic frameworks （MOFs） based on anion exchange membranes （AEMs） have garnered considerable interest,particularly for their potential to enhance ion conductivity by pre-introducing anions into *** approach is recognized as straightforward and effective for improving ion ***,developing high-performance AEMs is limited by the inherent instability and low resistance of *** study presents a novel 1,3,5-triazineμ3-bridged neutral Cu（I） framework,designated SXU-120 （where SXU represents Shanxi University）.This framework is synthesized using melamine,a widely available industrial product,as the starting material,achieving a high space-time yield exceeding 1.1 kg *** organic ligands and metal ions in SXU-120 are 3-connected,forming a rare eta topology with the point symbol 8～***-120 exhibits exceptional stability,even in a 10 M KOH solution,due to its high density of uncoordinated–NH2and carbonyl ***,the framework’s unique one-dimensional channels,characterized by their electronegativity,interact electrostatically with OH-ions,thereby accelerating OH-ion transfer along these ***,the OH-conductivity of this material reaches an impressive 0.49 S cm-1at 90°C under full humidity for 100 h,representing the highest OH-conductivity reported for MOF-based conductors to *** properties make SXU-120 a promising candidate for efficient AEM materials in next-generation industrial applications.

关键词：

Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Lu Gan Yi Yang Bin Zhao Kai Yu Kehua guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(Hrs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, Hr [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend rast, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, Hr [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values rved associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

关键词：