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failure to rescue as a Quality Metric in Congenital Heart Surgeries in a High-Complexity Service Provider Institution located in a Middle-Income Country

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Congenital Heart Disease 2024年第2期19卷 207-218页

作者： Gustavo Cruz Santiago Pedroza Juan f.Vélez Jessica largo Juan f.Tejada Jorge H.Mejía-Mantilla Departamento de Anestesiología Fundación Valle del LiliCali760032Colombia Centro de Investigaciones Clínicas Fundación Valle del LiliCali760032Colombia Departamento de Cardiología Pediátrica Fundación Valle del LiliCali760032Colombia facultad de Medicina Universidad IcesiCali760031Colombia Unidad de Cuidado Intensivo Fundación Valle del LiliCali760032Colombia

Background:failure to rescue has been an effective quality metric in congenital heart ***,mor-bidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality *** aim to measure the complications,mortality,and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar ***:A retrospective observational study was conducted in a high-complexity service provider institution,in Cali,*** pediatric patients undergoing any congenital heart surgery between 2019 and 2022 were *** main outcomes evaluated in the study were complication,mortality,and failure to rescue *** and multivariate logistic regression analysis was performed with mortality as the outcome ***:We evaluated 308 congenital heart *** the outcomes,201(65%)complications occurred,23(7.5%)patients died,and the fTr of the entire cohort was 11.4%.The presence of a postoperative complication(Or 14.88,CI 3.06–268.37,p=0.009),age(Or 0.79,CI 0.57–0.96,p=0.068),and urgent/emergent surgery(Or 8.14,CI 2.97–28.66,pre the most significant variables in predicting ***:failure to rescue is an effective and comparable quality measure in healthcare institutions and is the major contributor to postoperative mortality in congenital heart *** our higher mortality and complication rate,we obtained a comparable failure to rescue rate to high-income countries’health institutions.

关键词： Congenital heart surgery complication mortality failure to rescue quality metric

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Pharmacovigilance guidelines for clinical application of Chinese patent medicines for mucosal administration

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Zhongguo Zhongyao Zazhi 2024年第16期49卷 4291-4297页

作者： Zhao X.-X. Hua H. li Y.-Y. Wang Z.-f. liu f.-M. Wei r.-l. Cui X. Yang S. Wang l.-X. Xie Y.-M. Institute of Basic research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China Graduate School Tianjin University of Traditional Chinese Medicine Tianjin 301617 China School and Hospital of Stomatology Peking University Beijing 100034 China

The group standard Pharmacovigilance guidelines for clinical application of Chinese patent medicines for mucosal administration was released on January 16, 2024, on the national group standards information platform by the Institute of Basic research in Clinical Medicine of China Academy of Chinese Medical Sciences and School and Hospital of Stomatology of Peking University, under the centralized management by the China Association of Chinese Medicine. The standard number is T / CACM 1563. 6-2024. It aims to propose key elements and specify technical methods for safety monitoring and reporting, signal identification, risk assessment, and risk control based on the Drug administration law of the People ' s republic of China (revised in 2019), which establishes normative pharmacovigilance guideline of Chinese patent medicine for mucosal administration that is in line with the characteristics of traditional Chinese Medicine (TCM) based on the pharmacovigilance content for clinical application of Chinese patent medicine for mucosal administration. The group standard has been discussed by internal and external experts through multiple rounds of consultation. It serves as a guiding document for stakeholders involved in pharmacovigilance activities, including pharmaceutical license holders, drug manufacturers, medical institutions, research institutes, and pharmaceutical trading enterprises. © 2024 Zhongguo Zhongyi Yanjiuyuan. All rights reserved.

关键词： Chinese patent medicines for mucosal administration group standard guideline pharmacovigilance traditional Chinese medicine

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Niche differentiation among facultative filter feeders: Insights from invasive Ponto-Caspian mysids

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Current Zoology 2024年第4期70卷 513-521页

作者： Péter Borza Varsha rani Csaba f.Vada Institute of Aquatic Ecology Centre for Ecological ResearchKarolina ut 29.1113 BudapestHungary Doctoral School of Biology Institute of BiologyEotvos Lorand UniversityPazmany Péter sétany 1/C1117 BudapestHungary

The degree of dietary specialization has a fundamental impact on the ecological function and interactions of suspension *** niche differentiation by food particle size is common among obligate suspension feeders,its role is not evident in facultative *** this study,we aimed at providing new insights on the matter by focusing on sympatric mysid *** mysids use different mechanisms for raptorial and filter-feeding,they represent a more adequate model system than for example,the more extensively studied *** made morpholog-ical measurements on the 4 coexisting invasive Ponto-Caspian mysid species to determine the areas and mesh sizes of their *** also quantified their clearance rates on the microalga Cryptomonas *** a laboratory experiment to reveal how morphological differences manifest in their overall filtering *** found relatively small but consistent differences in the primary filter area among the species,indicating that morphological constraints due to the enclosed position of the setae might limit the possibility for *** primary filter mesh sizes were small in all 4 species(0.69-2.73μm)with moderate but consistent intraspecific differences,suggesting that the benefit of being able to capture small particles might outweigh the pressure for *** observed clearance rates were in accordance with the morphological characteristics of the species,highlighting that auxiliary filters(present in one of the species,limnomysis benedeni)are needed to increase filtering capacity *** study confirmed that food particle size can contribute to the niche differentiation of facultative filter feeders,but also indicated that they can tolerate a higher overlap than obligate *** observed differences were related to the habitat preferences and predatory potentials of the species,suggesting that complementarity among the different niche axes might further facilitate theircoexistence.

关键词： clearance rate coexistence filter area filtermesh size.

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Tuning the optoelectronic properties for small organic compounds as organic solar cell applications

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Optoelectronics letters 2024年第7期20卷 412-417页

作者： Hussein K.Mejbel lafy f.Al-Badry Department of Physics College of Education for Pure Science University of Thi-Qar Department of Physics College of Science University of Thi-Qar

recently, organic solar cells have attracted the attention of many researchers owing to flexibility, low cost, light weight and large-area applications, and significant improvement in the power conversion efficiency（PCE）. In this work, we designed chains from organic compounds as donors and replaced the core unit in each series with a variety of acceptors in order to enhance their optical and electronic characterization and performance for power conversion efficiencies in organic solar cells. We utilized density functional theory（DfT） and time-dependent density functional theory（TD-DfT） to investigate the geometry optimization by using the Gaussian 09 program. Both electronic and optical properties were determined, which involve the lowest unoccupied molecular orbital（lUMO） and the highest occupied molecular orbital（HOMO） levels, the band gap energy, maximum absorption wavelength(λ;max;), open circuit voltage(V;oc;), and light harvesting efficiency（lHE）. Our evaluation denotes that the small compounds suggested are predicted to exhibit the best performance compared to the first series（SC1）, like a lower band gap energy, a lower HOMO energy level, a greater absorption range, and a larger PCE.

关键词： A

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Clinical studies in COVID-related olfactory disorders:review of an institutional experience

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 129-136页

作者： Theresa Tharakan Dorina Kallogjeri Jay f.Piccirillo Department of Otolaryngology-Head and Neck Surgery Clinical Outcomes Research OfficeSchool of MedicineWashington University in St LouisSt LouisMissouriUSA

Objective:To share a single institutional experience with clinical research on COVID-related olfactory dysfunction(OD).Data Source/Method:Narrative review of published original data and ongoing clinical trials on COVID-related OD at Washington University from 2020 to ***:There were three new diagnostic-/patient-reported outcome measures developed and *** report five clinical trials of interventions for COVID-related olfactory disorders:combined Visual-Olfactory Training(VOlT)with patient-preferred scents versus standard olfactory training(VOlT trial),oral gabapentin versus placebo(Gabapentin for the relief of Acquired Chemosensory Experience trial),nasal theophylline irrigations versus placebo(Smell Changes and Efficacy of Nasal Theophylline trial),stellate ganglion block(single-arm),and mindfulness-based stress reduction(MBSr)versus lifestyle intervention(MBSr trial).Conclusions:Initial intervention trials for COVID-related OD have shown potential for improving subjective and objective olfactory ***,there remains no gold standard treatment that definitively outperforms placebo in controlled ***,continued investigation of novel therapeutic strategies for COVID-related OD is necessary to maximize olfactory outcomes for affected patients.

关键词： chemosensory disorders COVID olfactory dysfunction

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On the analytical solution of transient friction in channel flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： f.J.GArCíA-GArCíA P.fArI?AS-AlVArI?O Department of Naval & Industrial Engineering Polytechnic School of EngineeringUniversity of A Coru?a Campus Industrial de Ferrol Integraciones Técnicas de Seguridad S.A. Pol.Ind.Espíritu Santo

The transient friction in channel mean flows is the sum of two contributions,i.e., the underlying laminar flow(Ulf) and the purely turbulent component(PTC), and the contributions are analyzed separately by theoretical experiments. It is found that,the transient friction may be higher or remarkably lower than that in equal-reynolds number steady-state flows. The universal time constant for plane-parallel laminar flows is reported, and the role of the time constant in a turbulent mean flow is examined. It is shown that the time constant is related to the turbulence's frozen time. finally, a study of the logarithmic layer during the transient flow is accomplished, which shows that the logarithmic layer is destroyed.

关键词： 76D05 76D06 76f55 O361 transient flow transient friction unsteady channel flow

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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De león Yesica A lópez-Mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-De leon Xitlaly J González-leal raúl del Toro-Mijares Anna C rodríguez-Zúñiga Juan f Barrios-ruiz Victor Mingura-ledezma Perla r Colunga-Pedraza Olga G Cantú-rodríguez César H Gutiérrez-Aguirre luz Tarín-Arzaga Elías E González-lópez David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGrOUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NrM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and r with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NrM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

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A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa l.Starkie Elizabeth V.fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt David Gopurenko Matt N.Krosch francesca Strutt Karen f.Armstrong Hamish Patrick Mark K.Schutze Mark J.Blacket Department of Agriculture and fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ArMS)PCr assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ArMS-PCr colony molecular diagnostics pangolin tetra-primer

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Item-level Analysis of the revised Occupational Therapy fieldwork Performance Evaluation Applied in Practice

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Open Journal of Therapy and rehabilitation 2024年第2期12卷 145-159页

作者： Cynthia l. Sears Brad E. Egan Patricia f. Tomsic Craig A. Velozo Graduate College of Health Professions Occupational Therapy Program Hawai&#8217i Pacific University Honolulu HI USA College of Science and Health Occupational Therapy Program DePaul University Chicago IL USA Department of Occupational Therapy Wingate University Wingate NC USA College of Health Professions Department of Rehabilitation Sciences Division of Occupational Therapy Medical University of South Carolina Charleston SC USA

Competency-based assessments for healthcare professionals are critical for safe and effective client outcomes. rehabilitation clinical skill competency assessments must be validated and revised to produce safe and skilled practitioners. The revised American Occupational Therapy Association (AOTA) fieldwork Performance Evaluation (fWPE) instrument measures occupational therapy student performance to determine readiness for practice. The assessment includes thirty-seven competencies that address both profession specific clinical skills and general professional behavior skills. The objective of this study was to use rasch methods to explore the use of the revised fWPE in actual fieldwork practice and to determine the instrument’s psychometric properties when separating the item components into two distinct subdomains: General Health Professions Competences and Occupational Therapy-Specific Competencies. Internal construct validity and test reliability were analyzed using data from 149 occupational therapy students after completing their initial level II A fieldwork clinical internship. This study examined the item difficulty hierarchy, item fit, person-fit to model, person separation index, person separation reliability coefficient, strata, ceiling and floor effect, and unidimensionality of the fWPE instrument as a whole and as two separate domains. With the exception of not meeting the criteria for unidimensionality, the full fWPE instrument and the Occupational Therapy-Specific Competencies subdomain showed acceptable item-level psychometrics for reliability and precision. While the General Health Professions Competencies subdomain showed good item-level psychometrics, it was below the criterion for reliability and only separated the sample into two strata. results support the validity, reliability, and clinical use of the revised fWPE full instrument and the Occupational Therapy-Specific Competencies subdomain to measure entry-level clinical skill competencies in pr

关键词： rehabilitation Competency-Based Assessments Occupational Therapy Measurement rasch Analysis

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具有BCC或fCC晶体结构的固溶体高熵合金设计

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材料工程 2024年第1期52卷 16-26页

作者： HOrBAN V.f. 乌克兰国家科学院弗兰采维奇材料问题研究所乌克兰基辅03680

高熵合金最初报道于21世纪初期,该类合金具有较高的混合熵值,使其具有优异的热稳定性;较大的晶格畸变,产生了强烈固溶强化效果;较大的负焓值导致在晶粒内部形成团簇结构,有效阻碍了位错运动,进一步提高了合金强度。高熵合金独有的这些特... 详细信息

高熵合金最初报道于21世纪初期,该类合金具有较高的混合熵值,使其具有优异的热稳定性;较大的晶格畸变,产生了强烈固溶强化效果;较大的负焓值导致在晶粒内部形成团簇结构,有效阻碍了位错运动,进一步提高了合金强度。高熵合金独有的这些特性,使其在低温和高温条件下均有望表现出优异的物理性能和力学性能,引起了广泛的关注,研究报道呈爆发性增长。本文根据已有的BCC和fCC结构高熵合金物理-力学性能数据,分析了电子浓度、晶格常数、原子错配度、混合焓、硬度、弹性模量和归一化硬度等参数之间的关系,提出了BCC和fCC晶体结构的高熵合金弹性模量和硬度的经验计算公式,在此基础之上,综合考虑合金密度、塑性和服役工况等条件,提出了BCC和fCC结构的高熵合金成分设计方法。最后指出高熵合金的持久性能、大尺寸铸锭的成分和性能均匀性以及大尺寸合金锭的制备是高熵合金工程应用需解决的关键问题。

关键词：高熵合金电子浓度晶格常数晶格畸变混合焓硬度弹性模量归一化硬度

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