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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural regeneration research 2024年第10期19卷 2202-2211页

作者： Chika fujii Charles f.Zorumski Yukitoshi Izumi Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor family Institute for Innovative Psychiatric research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

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The effects of local variations in conditions on carbon storage and release in the continental mantle

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National Science review 2024年第6期11卷 22-36页

作者： Stephen f.foley Chunfei Chen Dorrit E.Jacob School of Natural Sciences Macquarie University research School of Earth Sciences Australian National University State Key laboratory of Geological Processes and Mineral resources School of Earth Sciences China University of Geosciences

recent advances indicate that the amount of carbon released by gradual degassing from the mantle needs to be revised upwards, whereas the carbon supplied by plumes may have been overestimated in the *** in rock types and oxidation state may be very local and exert strong influences on carbon storage and release mechanisms. Deep subduction may be prevented by diapirism in thick sedimentary packages,whereas carbonates in thinner sequences may be subducted. Carbonates stored in the mantle transition zone will melt when they heat up, recognized by coupled stable isotope systems(e.g. Mg, Zn, Ca). There is no single ‘mantle oxygen fugacity’, particularly in the thermal boundary layer(TBl) and lowermost lithosphere, where very local mixtures of rock types coexist. Carbonate-rich melts from either subduction or melting of the uppermost asthenosphere trap carbon by redox freezing or as carbonate-rich dykes in this zone. Deeply derived, reduced melts may form further diamond reservoirs, recognized as polycrystalline diamonds associated with websteritic silicate minerals. Carbon is released by either edge-driven convection,which tears sections of the TBl and lower lithosphere down so that they melt by a mixture of heating and oxidation, or by lateral advection of solids beneath rifts. Both mechanisms operate at steps in lithosphere thickness and result in carbonate-rich melts, explaining the spatial association of craton edges and carbonate-rich magmatism. High-pressure experiments on individual rock types, and increasingly on reactions between rocks and melts, are fine-tuning our understanding of processes and turning up unexpected results that are not seen in studies of single rocks. future research should concentrate on elucidating local variations and integrating these with the interpretation of geophysical signals. Global concepts such as average sediment compositions and a uniform mantle oxidation state are not appropriate for small-scale processes; an increa

关键词： lithospheric mantle carbonate melts deep carbon cycle craton destruction continental rifts

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Photometric and Spectroscopic Study of Ten low Mass ratio Contact Binary Systems:Orbital Stability,O'Connell Effect and Infrared Calcium line filling

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research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： Surjit S.Wadhwa Adam Popowicz raúl Michel Petar Kostić Oliver Vince Nick f.H.Tothill Ain Y.De Horta Miroslav D.filipović School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available large Sky Area Multi-Object fiber Spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

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Understanding the neighborhoods’in-between spaces on spatial perception,social interaction,and security

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frontiers of Architectural research 2024年第1期13卷 21-36页

作者： lizeth félix Mariel Organista Autonomous University of Baja California Ensenada 22860Mexico

This study reflects on the impact that the neighborhoods’in-between spaces have on:spatial perception,social interaction,and *** sites,characterized by their abandonment and deterioration,can also be seen as crucial spaces of opportunity for cities,in the architectural,urban and landscape *** paper aims to analyze the sociospatial relationships in the neighborhoods’in-between spaces and examine the impact of inbetween space configuration on urban *** investigation draws on a survey of perception to residents about the requirements for a suitable social interaction in these *** study was developed in a neighborhood in the city periphery,characterized by their social dynamics and location in a nature conservation *** findings indicate that the appropriation process,activities,and collective practices are dependent on the spatial legibility,in this case when this increases,gives rise to improve the habitability and the rehabilitation of the in-between ***,the lack of design on in-between spaces substantially affects the use of these spaces and the social interaction among residents.

关键词： In-between spaces Socio-spatial relationships Habitability Neighborhoods Security

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CD4^(+)T cells produce IfN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris l.Vos Charlotte l.Zuur Noel f.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTl)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IfNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTl anticancer *** cooperation with CD40 ligand(l),IfNβalso optimizes the costimulatory and other functions of cDC1s required for CTl response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTls locally,according to their transcriptomic pr.f.le and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IfN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IfN-I signaling CD40 costimulation (cross-)presentation CTl priming Tumor control

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One-neutron stripping process in the^(209)Bi(^(6)li,^(5)li)^(210)Bi*reaction reaction

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Nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-long Zhang Zhen-Wei Jiao Guang-Xin Zhang E.N.Cardozo B.Paes Shi-Peng Hu Jian-Qiang Qian Daniele Mengoni Wei-Wei Qu Cong-Bo li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun Nan Wang Chun-lei Zhang J.J.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.la Commara A.Goasduff D.Bazzacco D.r.Napoli f.Galtarossa f.recchia A.Illana S.Bakes I.Zanon S.Aydin Gde Angelis M.Siciliano r.Menegazzo S.M.lenzi S.Akkoyun l.f.Canto J.lubian School of Physics Beihang UniversityBeijing 100191China Sino-french Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil laboratorio TANDAr Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in Nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key laboratory of research and Manufacture of High Purity Germanium Materials and fetectors Shenzhen UniversityShenzhen 518060China INfN Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key laboratory of radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China laboratori Nazionali di legnaro INFN35020 LegnaroItaly INfN Sezione di Napoli80126 NaplesItaly Dipartimento di farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly Department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)li and^(209)Bi was studied at 28,30,and 34 MeV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)li,^(5)li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

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Nonaqueous potassium-ion full-cells:Mapping the progress and identifying missing puzzle pieces

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Journal of Energy Chemistry 2024年第6期93卷 384-399,I0010页

作者： Badre larhrib louiza larbi lénaïc Madec Universite de Pau et des Pays de l’Adour E2S UPPACNRSIPREMPauFrance Universitéde Haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67081 StrasbourgFrance réseau sur le Stockage Electrochimique de l’Energie CNRS FR3459AmiensFrance Institut des Matériaux Jean rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion full-cells(KIfCs)in view of the transition from potassium-ion half-cells(KIHCs)toward commercial K-ion batteries(KIBs).It focuses on the key parameters of KIfCs such as the electrode/electrolyte interfaces challenge,major barriers,and recent advancements in *** strategies for enhancing KIfC performance,including interfaces co ntrol,electrolyte optimization,electrodes capacity ratio,electrode material screening and electrode design,are *** review highlights the need to evaluate KIBs in full-cell configurations as half-cell results are strongly impacted by the K metal *** also emphasizes the importance of understanding solid electrolyte interphase(SEI)formation in KIfCs and explores promising nonaqueous as well as quasiand all-solid-state electrolytes *** review thus paves the way for practical,cost-effective,and scalable KIBs as energy storage systems by offering insights and guidance for future research.

关键词： K-ion full-cells Potassium-ion batteries Cross-talk Solid-state batteries Potassium reactivity Electrolyte design Electrode design

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Morphological traits explain the individual position within resource-consumer networks of a Neotropical marsupial

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Current Zoology 2024年第4期70卷 453-464页

作者： Nicholas f.de Camargo Hernani f.M.de Oliveira Juliana f.ribeiro Amabilio J.A.de Camargo Emerson M.Vieira laboratorio de Ecologia de Vertebrados Departamento de EcologiaInstituto de Ciencias BiologicasUniversidade de BrasiliaCP 04457BrasiliaDF70910-900Brazil Departamento de Zoologia Setor de Ciencias BiologicasUniversidade Federal do ParanaAvenida Coronel Francisco Heraclito dos Santos100CuritibaPR81531980Brazil Embrapa Cerrados Rodovia BR020km 18CP 08223PlanaltinaDE73310-970Brazil

Knowledge regarding the influence of individual traits on interaction patterns in nature can help understand the topological role of individuals within a network of intrapopulation *** tested hypotheses on the relationships between individuals'positions within networks(specialization and centrality)of 4 populations of the mouse opossum Gracilinanus agilis and their traits(i.e.,body length,body condition,tail length relative to body length,sex,reproductive condition,and botfly parasitism)and also seasonal effects in the Brazilian *** with lower body length,better body condition,and relatively shorter tail were more specialized(i.e.,less connected within the network).Individuals were also more specialized and less connected during the warm-wet *** relationship between individuals'position in the network and body traits,however,was independent of *** propose that specialization may arise not only as a result of preferred feed-ing strategies by more capable individuals(i.e.,those with better body condition and potentially prone to defend and access high-quality food resources)but alsobecause of morphological ***/younger individuals(consequently with less experience in foraging)and short-tailed individuals(less skilled to explore the vertical strata of the vegetation)would feed only on a subset of the available food resources and consequently become more ***,individuals are more specialized during the warm-wet season because of high competition(population-dense period)and higher ecological opportunities(resource-rich period).Therefore,our study reveals the relevance of individual traits inshaping interactionpatternsandspecialization inpopulations.

关键词： bodytraits centrality Cerrado Gracilinanus agilis seasonality specialization.

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radiative capture of proton through the ^(14)N(p,γ)^(15)O reaction at low energy

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Chinese Physics C 2024年第4期48卷 183-192页

作者： B.f.Irgaziev Abdul Kabir Jameel-Un Nabi National University of Uzbekistan Tashkent 100174Uzbekistan Space and Astrophysics research lab National Centre of GIS and Space ApplicationsDepartment of Space ScienceInstitute of Space TechnologyIslamabad 44000Pakistan University of Wah Quaid AvenueWah Cantt 47040PunjabPakistan

The CNO cycle is the main source of energy in stars more massive than our *** process defines the energy production,the duration of which can be used to determine the lifetime of massive *** cycle is an important tool for determining the age of globular *** proton capture via p+^(14)N→^(15)O+γ,at energies of astrophysical interest,is an important process in the CNO *** this project,we apply a potential model to describe both non-resonant and resonant reactions in the channels where radiative capture occurs through electric E1 *** employed the r-matrix method to describe the ongoing reactions via M1 resonant transitions,when it was not possible to correctly reproduce the experimental data using the potential *** partial components of the astrophysical S-factor are calculated for all possible electric and magnetic dipole transitions in ^(15)*** linear extrapolated S-factor at zero energy(S(0))agrees well with earlier reported values for all transition types considered in this *** on the value of the total astrophysical S-factor,depending on the collision energy,we calculate the nuclear reaction rates for p+^(14)N→^(15)O+γ.The computed rates agree well with the results reported in the NACrE II Collaboration and most recent existing measurements.

关键词： CNO cycle potential model r-matrix method cross-section astrophysical S-factor nuclear rates.

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Collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

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Matter and radiation at Extremes 2024年第2期9卷 12-25页

作者： J.-r.Marquès l.lancia P.loiseau P.forestier-Colleoni M.Tarisien E.Atukpor V.Bagnoud C.Brabetz f.Consoli J.Domange f.Hannachi P.Nicolaï M.Salvadori B.Zielbauer lUlI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CEA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CENBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany ENEA fusion and Technologies for Nuclear Safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CElIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,*** 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by Coulomb *** the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are *** forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma pr.f.le is characterized by optical shadowgraphy of a probe *** refraction and absorption of this beam are simulated by post-processing 3D hydrodynamic simulations of the plasma *** with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas *** parameters are in good agreement with those required for CSA.

关键词： acceleration hydrodynamic collision

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