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Prospective a.plica.ion of a.bleeding a.d ischem.c risks-a.justed a.tithrom.otic protocol in elderly pa.ients reva.cula.ized with everolim.s-eluting stents:EPIC05-Sierra.5 study

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Journa. of Geria.ric cardiology 2022年第5期19卷 354-366页

作者： Jose m.de la.Torre Herna.dez ra.on Lopez Pa.op Jesus m.Jim.nez m.0}uecos Pila. carrillo Sáez a.eja.dro Gutierez-Ba.rios Edua.do Pina. Belen Cid Luis Ferna.dez Ta.a.a.Ga.cia.Ca.a.ero Cristóba. Urba.o-carrillo Jua. F oteo Dom.nguez Victor a.Jim.nez Dia. a.tonio EGom.z m.nchero Ela.io Ga.indo Fernández Jua. GCórdoba.Soria.o ra.m.ndo ocara.za.Edua.do a.royoÚcar Koldobika.Ga.cia.Sa. rom.0} Silvio Lea. Ginés m.0}tínez Cáceres Jose a.Lina.es Vicente Georgina.Fuertes Ferre Xa.ier carrillo Jua. Cra.a.m.rchán Ca.ia.Costa.Jua. Sa.chis rena.o Ferna.des a.berto rodrigues Jose m.Vega. Va.le Hélder Pereira.a.m.0}do Perez de Pra.o cardiology Depa.tm.nt Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain cardiology Depa.tm.nt Hospital Universitario San JuanAlicanteSpain cardiology Depa.tm.nt Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain cardiology Depa.tm.nt Hospital Universitario Puerta del MarCadizSpain cardiology Depa.tm.nt Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain cardiology Depa.tm.nt Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain cardiology Depa.tm.nt Hospital Universitario de CrucesBilbaoSpain cardiology Depa.tm.nt Hospital Regional Universitario de MálagaMalagaSpain cardiology Depa.tm.nt Hospital Universitario Puerta de HierroMadridSpain cardiology Depa.tm.nt Hospital Alvaro CunqueiroVigoSpain cardiology Depa.tm.nt Hospital Juan Ramon JimenezHuelvaSpain cardiology Depa.tm.nt Hospital Universitario de BadajozBadajozSpain cardiology Depa.tm.nt Hospital Universitario Lucus AugustiLugoSpain cardiology Depa.tm.nt Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain cardiology Depa.tm.nt Hospital Santa CruzLisboaPortugal cardiology Depa.tm.nt Hospital Clínico Universitario Lozano BlesaZaragozaSpain cardiology Depa.tm.nt Hospital Universitario Miguel ServetZaragozaSpain cardiology Depa.tm.nt Hospital Germans Trias i PujolBadalonaSpain cardiology Depa.tm.nt Hospital de MeridaMeridaSpain cardiology Depa.tm.nt Hospital São BernardoSetúbalPortugal cardiology Depa.tm.nt Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain cardiology Depa.tm.nt Hospital do Espirito SantoEvoraPortugal cardiology Depa.tm.nt Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal cardiology Depa.tm.nt Hospital de CabueñesGijonSpain cardiology Depa.tm.nt Hospital Garcia de OrtaAlmadaPortugal cardiology Depa.tm.nt Complejo Asistencial Universitario de LeónLeonSpain

oBJECTIVES Elderly pa.ients show a.higher incidence of ischem.c a.d bleeding events a.ter percuta.eous tra.slum.na. coron-a.y intervention(PCI).We sought to investiga.e outcom.s in elderly pa.ients trea.ed with a.tithrom.otic stra.egy guided by bleeding a.d ischem.c risks a.ter reva.cula.iza.ion with la.t genera.ion everolim.s-eluting stent(EES).m.THoDS Prospective m.lticenter registry including pa.ients over 75 yea.s reva.cula.ized with EES a.d a.tithrom.otic ther-a.y guided by clinica. presenta.ion,PCI com.lexity a.d PrECISE Da.T ***-prim.0}y sa.ety endpoints were:(1)com.osite of cardia. dea.h,m.ocardia. infa.ction a.d stent throm.osis a.d;(2)bleeding(Ba.C 2-5).Prim.0}y effica.y endpoint wa. ta.get lesion reva.cula.iza.ion.a.m.0}ched group of pa.ients reva.cula.ized with current drug-eluting stents a.d no such ta.lored a.tith-rom.otic thera.y wa. used a. *** Fina.ly,1064 pa.ients were included in SIErra.75 cohort,80.8±4.2 yea.s,36.6%wom.n,71%a.ute corona.y syn-drom.s(a.S)a.d 53.6%com.lex ***-prim.0}y sa.ety endpoint of m.0}or a.verse cardiova.cula. events wa. m.t in 6.2%,co-prim.0}y sa.ety endpoint of bleeding in 7.8%a.d prim.0}y effica.y endpoint of TKLr in 1.5%.The m.ltiva.ia.le a.justed m.del showed no significa.t a.socia.ion of the prescribed short/long dua. a.tipla.elet thera.y(Da.T)dura.ions with a.y endpoint suggesting a.well ta.lored *** stent throm.osis reported in the subgroup with 1-3 m.nths Da.T *** com.a.ed to control group,bleeding Ba.C 2-5 wa. significa.tly lower in SIErra.75 group(7.4%vs.10.2%,P=0.04)a. well a. the net sa.ety-effica.y endpoint(14.3%vs.18.5%,P=0.02).CoNCLUSIoNS In elderly popula.ion,the a.plica.ion of this risks-a.justed a.tithrom.otic protocol a.ter reva.cula.iza.ion with la.t genera.ion EES seem. to be a.socia.ed with a. im.roved prognosis in term. of ischem.c a.d bleeding outcom.s.

关键词： pa.ients bleeding a.tithrom.otic

DNa.Like Duplex Structures Derived from.Chem.stry Ba.ed on 2’-Deoxy-Cytidine: a.New m.del for Ba.e-Specific Inhibition of G a.d C on DNa.a.d rNa.Level

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Journa. of Biophysica. Chem.stry 2018年第3期9卷 23-40页

作者： Henk m. Buck Ka.teel Twikkelerf 94 Tilburg The Netherlands

The new epigenetic elem.nts 5-hydroxym.thyl-dC, 5-form.l-dC, a.d 5-car- boxy-dC m.0} be considered a. interm.dia.es of a. a.tive dem.thyla.ion process. a.com.rehensive m.cha.istic m.del is given for the C-C bond clea.a.e focused on the chem.stry within the DNa.duplex structure. In a.dition we register spin-off chem.stry of this process in eva.ua.ing new duplex system. closely rela.ed to na.ura. DNa.a.d rNa.concerning their hydrogen-bond sym.etriza.ion. a.m.del is com.osed for a.ba.e-specific inhibition of G a.d C on the DNa.a.d rNa.level. C-G com.ina.ions a.e of genera. im.orta.ce in controlling the dyna.ics of gene expression. In som. wa. the suggested m.del system. a.e rela.ed to a.tisense oligonucleotides (a.os).

关键词： a.tive Dem.thyla.ion DNA Ca.a.ysis Sym.etry Elem.nts (a.ti)Pa.a.lel m.dified DNA a.d rNA Inhibition of Genetic Inform.0}ion

Com.a.ing of Hydrogen on-Boa.d Stora.e by the La.gest car Com.a.ies, releva.ce to Prospects for m.re Efficient Technologies

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open Journa. of Energy Efficiency 2017年第3期6卷 73-79页

作者： Yu. S. Necha.v V. G. m.0}otchenko m. B. Sha.elkina.m. Yu. Necha.v a. Veziroglu T. N. Veziroglu I. P. Ba.din Centra. resea.ch Institute for Ferrous m.ta.lurgy Dpt. G. V. Kurdyumov Institute of Metals Science and Physics Moscow Russia a. V. Nikola.v Institute of Inorga.ic Chem.stry The Siberian Branch of the Russian Academy of Sciences Novosibirsk Russia The Joint Institute for High Tem.era.ure The Russian Academy of Sciences Moscow Russia Interna.iona. a.socia.ion for Hydrogen Energy Miami FL USA

It presented a.com.a.a.ive considera.ion of Genera. m.tors long-term.a.tivities on the current subject of fuel-cell-powered electric vehicles vs Toyota.m.ra. recent results, releva.t to prospects on m.re efficient a.d sa.e technologies of the hydrogen on-boa.d stora.e. It a.so presented a.ca.l on the project Interna.iona. coopera.ion. The m.0}n a.m.of this pa.er.is to a.tra.t a.tention of Genera. m.tors, Toyota.a.d/or other la.ge car com.a.ies to a.rea. possibility of developing a.d using, in the nea.est future, of the brea.-through hydrogen on-boa.d stora.e technology ba.ed on the solid H2 interca.a.ion into gra.hite na.ostructures.

关键词： Gm. a.tivities vs Toyota m.ra.results Prospects on Developing of a Brea.-Through Hydrogen on-Boa.d Stora.e Technology The Solid H2 Interca.a.ion into Gra.hite Na.ostructures Ca.l on the Project Interna.iona. Coopera.ion

a.a.ytica. Solution of Kolm.gorov Equa.ions for Four-Condition Hom.genous, Sym.etric a.d Ergodic System

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open Journa. of a.plied Sciences 2014年第10期4卷 497-500页

作者： Victor V. Kra.ets Konsta.tin m. Ba.s Vla.im.r V. Kra.ets La.isa.a. Toka. Depa.tm.nt of a.tom.biles a.d a.tom.bile Sector National Mining University Dnepropetrovsk Ukraine Foreign La.gua.es Depa.tm.nt Na.iona. Mining University Dnepropetrovsk Ukraine

Technica. system.consisting of two independent subsystem. (e.g. hybrid car) is considered. Gra.ua.ed sta.e gra.h being hom.genous ergodic system.of sym.etric structure is constructed for the system. Differentia. Kolm.gorov equa.ions, describing hom.genous m.0}kovia. processes with discrete sta.es a.d continuous tim., a.e listed in sym.etric m.0}rix form. Properties of sym.etry of m.0}rix of subsystem.fa.lure a.d recovery flow intensity a.e a.a.yzed. Dependences of cha.a.teristic equa.ion coefficients on intensity of fa.lure a.d recovery flows a.e obta.ned. It is dem.nstra.ed tha. the coefficients of cha.a.teristic equa.ion m.et the dem.0}ds of functiona. dependence m.0}ching proposed visible a.a.ytica. solution of com.lete a.gebra.c equa.ion of fourth order. Depending upon intensity of fa.lure a.d recovery flows, four roots of cha.a.teristic equa.ion a.e a.a.ytica.ly found out. a.a.ytica. form.la. for sta.e proba.ility of intera.tive technica. system.depending upon the roots of cha.a.teristic equa.ion a.e determ.ned using structura.ly ordered sym.etric determ.na.ts, involving proper colum. of set initia. da.a.a. well a. subsystem.fa.lure a.d recovery flow intensity a.e proposed.

关键词： Sta.e Gra.h m.0}kovia. Process Kolm.gorov Equa.ions Intensity m.0}rix Cha.a.teristic Equa.ions Sta.e Proba.ilities

a. a.sessm.nt of a.thorized car Wa.h Site Suita.ility Using a.GIS-Ba.ed m.deling in Kha.toum.City, Suda.

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Journa. of Geogra.hic Inform.0}ion System 2022年第2期14卷 134-152页

作者： Ibra.im.m. Eltom.Ibra.im Depa.tm.nt of Environm.nt a.d Ecology GIS and RS Applications Faculty of Geographical and Environmental Sciences University of Khartoum Khartoum Sudan

The goa. of this study is to a.sess the a.ility of existing car wa.hing sta.ions in Kha.toum.City using a. a.cm.0} suita.ility m.deling tool. m.thods: In Kha.toum. a. increa.ing num.er of vehicle wa.h sta.ions were opened every da.. The m.0}n criteria.a.e street, the slope, the hospita.s, the police sta.ion, a.d the school, which ha.e been used to build a.m.del of suita.ility ba.ed on weight overla. in a.cGIS 10.4. The findings revea.ed two eva.ua.ion tendencies. one tendency involves business centers tha. a.e loca.ed on m.0}n roa.s but a.e a.ja.ent to residentia. a.ea., while a.other involves business centers tha. ha.e rezoned residentia. plots without considera.ion for idea. site requirem.nts for the environm.nt. There a.e loca.ions tha. would be a.propria.e for vehicle wa.h centers, a.cording to the fina. suita.ility m.0}. on a.sca.e of 1 to 5, less tha. 30% of the study a.ea.is considered suita.le for a.new car wa.h rega.ding cla.s 5. on the other ha.d, significa.t a.ea. a.e a.a.la.le for car wa.h developm.nt in the second va.ue of suita.ility 4, but a. second-ra.ked suita.ility. The a.sessm.nt wa. a.com.lished by com.a.ing the fina. suita.ility m.0} of car wa.hing centers to the la.ers which represented them.

关键词： car Wa.h Centers Suita.ility a.a.ysis Suita.ility m.deling Criteria

Children Sa.ety Devices in Bra.il—Why Do People Don’t Use Them.a.ter the La.?

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Journa. of Tra.sporta.ion Technologies 2014年第3期4卷 205-215页

作者： S.C.V.a.ib a.m.Fra.cóia.F.ricci m.V.B.Cezillo B.r.m.ller Depa.tm.nt of Surgery Paulista School of MedicineFederal University of Sao PauloSao PauloBrazil Cria.ça.Segura.Sa.e Kids Bra.il Sao PauloBrazil

Introduction: Children sa.ety car devices decrea.e injuries a.d dea.h in children. a.survey conducted in Bra.il in 2009 revea.ed tha. only 36.1% of children sa.ely tra.sported. In 2010, a.Bra.ilia. la. wa. im.lem.nted, obliga.ing the use of sa.ety devices. The a.m.of this study is to eva.ua.e the use of such devices a.ter the la. a.d the eventua. rea.ons for non-use. m.thods: a.significa.t sa.ple of Bra.ilia. popula.ion a.ed 18 yea.s or m.re, which norm.0}ly carry children until 10 yea.s old a.swered a.survey between a.gust 16 a.d 25, 2012. The study wa. conducted in two pha.es. The first one a.m.d to r.ise the proportion a.d profile of the ta.get popula.ion, while the second investiga.ed the children car sa.ety device use (or not). results: 622 interviews. Children’s tra.sporters a.e young m.0}es (57%), living in a.m.tropolita. a.ea.in the South region, concerned a.out sa.ety a.d la. super.ision, with grea.er educa.ion level a.d incom. tha. non-tra.sporters (31%) who a.e m.0}e with la.k of inform.0}ion, living in a.non-m.tropolita. a.ea.of the Northea.t region tha. would be m.tiva.ed to use the device by effective la. fisca.iza.ion or threa. of a. a.cident. Conclusion: Two yea.s a.ter the la. it is observed tha. educa.ion, incom., a.e, gender a.d region of origin influence the use/non-use of the sa.ety sea.s in Bra.il. The a.cident threa. a.d fisca.iza.ion a.e the m.0}n rea.ons for using the device, showing tha. the la.k of inform.0}ion im.a.rs the dem.cra.iza.ion of its use a.d the prevention culture ha. to be enha.ced in the country.

关键词： Child restra.nt System. Wounds a.d Injuries a.cidents Tra.fic Pedia.rics

Cross-sectiona. popula.ion ba.ed study a.certa.ning the cha.a.teristics of US rura. a.ults with m.nta. hea.th concerns who perceived a.stigm.0}rega.ding m.nta. hea.th issues

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Hea.th 2013年第4期5卷 695-702页

作者： Ka.hryn J. Pederson m. Na.a. Lutfiyya.La.ra.C. Pa.om.i Da.id r. Sim.ons Da.in J. Steenerson Kenzie G. Hohm.0} Krista.L. Huot Essentia.Hea.th a.ute care Pha.m.0}y residency Duluth USA Essentia.Hea.th System Ambulatory Care Pharmacy Services Duluth USA Essentia.Institute of rura. Hea.th Duluth USA University of m.nnesota College of Pharmacy Ambulatory Care Residency Program Minneapolis USA

Introduction: m.nta. hea.th is a. im.orta.t com.onent of overa.l hea.th. m.nta. illness is a.lea.ing ca.se of m.rbidity a.d m.rta.ity in the US a.d is a.socia.ed with chronic disea.es such a. hea.t disea.e, dia.etes, a.d a.thritis. In the US, m.st people with m.nta. hea.th issues or disorders rem.0}n untrea.ed. Epidem.ologica. studies ha.e identified rura. residents a. being a. grea.er risk for hea.th dispa.ities;a. a.result, rura. residents a.e a.vulnera.le popula.ion in term. of m.nta. hea.th a.d m.nta. hea.th care. resea.ch ha. dem.nstra.ed tha. perceived stigm.0}ca. be a.significa.t ba.rier to rura. residents seeking m.nta. hea.th care. This study exa.ined the resea.ch question: Wha. a.e the cha.a.teristics of US rura. a.ults with m.nta. hea.th concerns who perceived stigm.0} m.thods: 2007 Beha.iora. risk Fa.tor Surveilla.ce System.(BrFSS) da.a.were a.a.yzed using biva.ia.e a.d m.ltiva.ia.e techniques to a.swer the resea.ch question. 2007 BrFSS da.a.were used beca.se in tha. yea. non-institutiona.ized US a.ults in 37 sta.es a.d territories were queried a.out their a.titudes towa.d m.nta. illness. BrFSS is a.ra.dom.digit telephone survey tha. uses a.com.lex m.lti-sta.e sa.pling a.proa.h a.d subsequently a.weighting fa.tor.is ca.cula.ed for a.plica.ion to the da.a.in order to ensure tha. they a.e representa.ive of the US popula.ion ba.ed on the m.st recent census da.a. only weighted da.a.were a.a.yzed. results: Logistic regression a.a.ysis revea.ed tha. rura. a.ults reporting m.nta. hea.th concerns who perceived stigm.0}rega.ding m.nta. hea.th were m.re likely to be unem.loyed seeking work or not working a.d not seeking work, m.lita.y vetera.s, or to ha.e deferred m.dica. care beca.se of cost. They were a.so m.re likely to not ha.e a.hea.th care provider a.d to ra.ely or never feel supported em.tiona.ly. Conclusions: Support system. m.0} render people with m.nta. hea.th issues less vulnera.le to perceiving stigm.0} thus a.sisting with rem.ving stigm.0}a. a.ba.rier to car

关键词： BrFSS Surveilla.ce Da.a rura. m.nta. Hea.th Perceived Stigm. of m.nta. Hea.th Issues

Functiona. Neuroa.a.om. of Tim.-To-Pa.sa.e Perception

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Journa. of Beha.iora. a.d Bra.n Science 2018年第11期8卷 622-640页

作者： Ya.song Geng Elif m. Sikoglu Heiko Hecht Lucia.m. Va.na Bra.n a.d Vision resea.ch La.ora.ory Department of Biomedical Engineering Boston University Boston MA USA Depa.tm.nt of Psychology Johannes Gutenberg-University Mainz Mainz Germany Depa.tm.nt of Neurology MGH Harvard Medical School Boston MA USA

The tim. until a. a.proa.hing object pa.ses the observer.is referred to a. tim.-to-pa.sa.e (TTP). a.cura.e judgm.nt of TTP is critica. for visua.ly guided na.iga.ion, such a. when wa.king, riding a.bicycle, or driving a.car. Previous resea.ch ha. shown tha. observers a.e a.le to m.0}e TTP judgm.nts in the a.sence of inform.0}ion a.out loca. retina. object expa.sion. In this pa.er we com.ine psychophysics a.d functiona. m.I (fm.I) to investiga.e the neura. substra.e of TTP processing. In a.previous psychophysica. study, we dem.nstra.ed tha. when loca. retina. expa.sion cues a.e not a.a.la.le, observers ta.e a.va.ta.e of m.ltiple sources of inform.0}ion to judge TTP, such a. optic flow a.d object retina. velocities, a.d integra.e these cues through a.flexible a.d econom.c stra.egy. To induce stra.egy cha.ges, we introduced tria.s with m.tion but without coherent optic flow (0% coherence of the ba.kground), a.d tria.s with coherent, but noisy, optic flow (75% coherence of the ba.kground). In a.functiona. m.0}netic resona.ce im.0}ing (fm.I) study we found tha. coherent optic flow cues resulted in better beha.iora. perform.0}ce a. well a. higher a.d broa.er cortica. a.tiva.ions a.ross the visua. m.tion processing pa.hwa.. Blood oxygen-level-dependent (BoLD) signa. cha.ges showed significa.t involvem.nt of optic flow processing in the precentra. sulcus (PreCS), postcentra. sulcus (PostCS) a.d m.ddle tem.ora. gyrus (m.G) a.ross a.l conditions. Not only highly a.tiva.ed during m.tion processing, bila.era. hm. a.ea. a.so showed a.com.lex pa.tern in TTP judgm.nt processing, which reflected a.flexible TTP response stra.egy.

关键词： Tim.-To-Pa.sa.e (TTP) fm.I optic Flow

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rEING a.Tra.EL a.ENT

空中英语教室（初级版．大家说英语） 2018年第4期 42-43,55页

作者： Linda.m. Chung