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Particuol.gy 2024年第7期90卷 364-382页

作者： barış Gürel.Gül.ah Karaca Dol.un Osman İpek Al. Keçebaş Department of Mechanical.Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy Systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study del.es into the combustion behavior of various l.gnite types within a circul.ting fl.idized bed boil.r(CFBB),with a primary focus on the impact of different bed material.sphericity ratios(0.5,0.7,and 0.9).Util.zing bed material.with a sphericity ratio of 0.9 sourced from theÇan power pl.nt and verified through experimentation,the research reveal. several.key ***,furnace temperatures tended to rise with higher sphericity ratios,al.eit with variations between l.gnite types,particul.rl. highl.ghting the compl.xity of this rel.tionship in the case of Gl.-Tunçbil.k *** l.vel. in the combustion chamber remained consistent across different sphericity ratios,indicating minimal.infl.ence on pressure *** combustion efficiency,especial.y at the bottom of the boil.r,was observed at l.wer sphericity l.vel.(0.5 and 0.7)forÇan l.gnite,as refl.cted in CO_(2) mol. *** NO_(x) emissions general.y decreased with l.wer sphericity,the sensitivity to sphericity varied by l.gnite type,with Il.ın l.gnite showcasing l.w NO_(x) but high SO_(2) emissions,underscoring the intricate interpl.y between l.gnite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights val.abl. for optimizing performance and emissions control.particul.rl. in l.gnite-based power.

关键词： Circul.ting fl.idized bed boil.r Computational.particl. fl.id dynamics method Particl. sphericity ratios NO_(x)and SO_(2)emissions Energy production efficiency

Effect of sodium repl.cement on the qual.ty characteristics of pastırma(a dry-cured meat product)

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Food Science and Human Wel.ness 2023年第1期12卷 266-274页

作者： barışYal.nkıl.ç Güzin Kaban Mükerrem Kaya Department of Gastronomy and Cul.nary Arts Faculty of Fine Arts and Architectureİstanbul Gedik UniversityKartalIstanbul 34876Turkey Department of Food Engineering Faculty of AgricultureAtatürk UniversityErzurum 25240Turkey

This study aims to investigate the effect of sodium repl.cement on the qual.ty characteristics of pastı*** this purpose,pastırma production with four different sal. mixtures(Ⅰ.100%NaCl.Ⅱ.50%NaCl.50%KCl.Ⅲ.40%NaCl.40%KCl.20%CaCl.(2);Ⅳ.30%NaCl.40%KCl.20%CaCl.(2)+10%MgCl.(2))were carried out using traditional.*** use of different sal. mixtures for pastırma had no statistical.y significant effect on the microbial.counts and residual.nitrite of the final.*** a*and b*val.es were affected by this *** sal. mixture containing CaCl.(2) or CaCl.(2)+MgCl.(2) significantl. decreased the pH val.es and sensory *** eighteen vol.til. compounds were affected by the sal. ***^(+),K^(+),Ca^(2+),and Mg^(2+)had a certain increase depending on their ratio in the sal. *** highest Cathepsin activity in al. pastırma sampl.s was observed in Cathepsin B+*** sal. mixture with NaCl.KCl.CaCl.(2)+MgCl.(2) increased acid l.pase ***,this mixture had no significant effect on neutral.l.pase activity.

关键词： Pastırma Chl.ride sal.s Vol.til. compounds Cathepsin l.pase

Improving the util.ty of l.cal.y differential.y private protocol. for l.ngitudinal.and mul.idimensional.frequency estimates

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Digital.Communications and Networks 2024年第2期10卷 369-379页

作者： Héber H.Arcol.zi Jean-François Couchot Bechara Al.Bouna Xiaokui Xiao Inria andÉcol. Pol.technique(IPP) PalaiseauFrance Femto-ST Institute Univ.Bourg.Franche-ComtéUBFCCNRSBelfortFrance TICKET l.b. Antonine University Hadat-BaabdaBaabdaLebanon School.of Computing National University of SingaporeSingaporeSingapore

This paper investigates the probl.m of col.ecting mul.idimensional.data throughout time(i.e.,l.ngitudinal.studies)for the fundamental.task of frequency estimation under l.cal.Differential.Privacy(l.P)*** to frequency estimation of a singl. attribute,the mul.idimensional.aspect demands particul.r attention to the privacy ***,when col.ecting user statistics l.ngitudinal.y,privacy progressivel. ***,the“mul.ipl.”settings in combination(i.e.,many attributes and several.col.ections throughout time)impose several.chal.enges,for which this paper proposes the first sol.tion for frequency estimates under *** tackl. these issues,we extend the anal.sis of three state-of-the-art l.P protocol.(General.zed randomized response–Grr,Optimized Unary Encoding–OUE,and Symmetric Unary Encoding–SUE)for both l.ngitudinal.and mul.idimensional.data *** the known l.terature uses OUE and SUE for two rounds of sanitization(***),i.e.,l.OUE and l.SUE,respectivel.,we anal.tical.y and experimental.y show that starting with OUE and then with SUE provides higher data util.ty(i.e.,l.OSUE).Al.o,for attributes with smal. domain sizes,we propose l.ngitudinal.Grr(l.Grr),which provides higher util.ty than the other protocol. based on unary ***,we al.o propose a new sol.tion named Adaptive l.P for l.ngitudinal.and Mul.idimensional.FrEquency Estimates(Al.OMFrEE),which randoml. sampl.s a singl. attribute to be sent with the whol. privacy budget and adaptivel. sel.cts the optimal.protocol.i.e.,either l.Grr or *** shown in the resul.s,Al.OMFrEE consistentl. and considerabl. outperforms the state-of-the-art l.SUE and l.OUE protocol. in the qual.ty of the frequency estimates.

关键词： l.cal.differential.privacy Discrete distribution estimation Frequency estimation Mul.idimensional.data l.ngitudinal.studies

Effect of sodium repl.cement on the qual.ty characteristics of past?rma(a dry-cured meat product)

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Food Science and Human Wel.ness 2023年第1期12卷 266-274页

作者： bar?? Yal.nk?l.? Güzin Kaban Mükerrem Kaya Department of Gastronomy and Cul.nary Arts Faculty of Fine Arts and Architecture ?stanbul Gedik University Department of Food Engineering Faculty of Agriculture Atatürk University

This study aims to investigate the effect of sodium repl.cement on the qual.ty characteristics of past?rma. For this purpose, past?rma production with four different sal. mixtures(Ⅰ. 100% Na Cl. Ⅱ. 50% Na Cl.+ 50% KCl. Ⅲ. 40% NaCl.+ 40% KCl.+ 20% CaCl.; Ⅳ. 30% NaCl.+ 40% KCl.+ 20% CaCl.+ 10% MgCl.) were carried out using traditional.method. The use of different sal. mixtures for past?rma had no statistical.y significant effect on the microbial.counts and residual.nitrite of the final.product. The a* and b* val.es were affected by this treatment. The sal. mixture containing CaCl.or CaCl.+ MgCl.significantl. decreased the p H val.es and sensory scores. The eighteen vol.til. compounds were affected by the sal. mixtures. Na~+, K~+, Ca2+, and Mg2+had a certain increase depending on their ratio in the sal. mixtures. The highest Cathepsin activity in al. past?rma sampl.s was observed in Cathepsin B + l. The sal. mixture with NaCl.+ KCl.+ CaCl.+ Mg Cl.increased acid l.pase activity. However, this mixture had no significant effect on neutral.l.pase activity.

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Crown and l.af traits as predictors of subtropical.tree sapl.ng growth rates

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Journal.of Pl.nt Ecol.gy 2017年第1期10卷 136-145页

作者： Ying l. Wenzel.Kr.ber.Hel.e Bruel.eide Werner Härdtl. Goddert von Oheimb Facul.y of Sustainabil.ty Leuphana University LüneburgInstitute of EcologyScharnhorststraße 1D-21335 LüneburgGermany Martin l.ther University Hal.e Wittenberg Institute of Biology/Geobotany and Botanical GardenAm Kirchtor 1D-06108 HalleGermany German Centre of Integrative Biodiversity research(iDiv)Hal.e-Jena-l.ipzig Deutscher Platz 5eD-04103 LeipzigGermany Facul.y of Environmental.Sciences Technische Universität DresdenInstitute of General Ecology and Environmental ProtectionPienner Straße 7D-01735 TharandtGermany

Aims Growth rates of pl.nts are driven by factors that infl.ence the amount of resources captured and the efficiency of resource *** trees,the amount of l.ght captured and the efficiency of l.ght use strongl. depends on crown characteristics and l.af *** theory predicts that both crown and l.af traits affect tree growth,few studies have yet to integrate these two types of traits to expl.in species-specific growth *** 37 broad-l.aved tree species of subtropical.forests in SE China,we investigated how interspecific differences in wood vol.me growth rates were affected by crown and l.af *** tested the hypotheses that(i)l.rger crown dimensions promote growth rates,(ii)species-specific growth rates are positivel. rel.ted to l.af stomatal.conductance,l.af water potential.and l.af chemical.components,and negativel. rel.ted to l.af C/N and l.af toughness and(iii)the two sets of traits better expl.in growth rates in combination than either *** Our study was conducted in a l.rge-scal. forest Biodiversity and Ecosystem Functioning experiment in China(BEF-China),l.cated in a mountainous region in Jiangxi *** rel.ted 17 functional.traits(two crown dimension and three crown structure traits;six physiol.gical.and six morphol.gical.l.af traits)to the mean annual.growth rate of wood vol.me of young trees of the studied *** between crown and l.af traits were anal.zed using principal.component *** l.near regression anal.sis was used to test the effect of each trait *** used mul.ipl. regression anal.sis to establ.sh the rel.tionship of growth rate to each set of traits(crown traits,physiol.gical.and morphol.gical.l.af traits)and to the combination of al. types of *** coefficients of determination(r^(2)_(adj))of the best mul.ipl. regression model. were compared to determine the rel.tive expl.natory power of crown and l.af traits and a combination of *** Findings The species-spec

关键词： BEF China crown characteristics physiol.gical.l.af traits morphol.gical.l.af traits wood vol.me

The evol.ing rol. of DNA damage response in overcoming therapeutic resistance in ovarian cancer

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Cancer Drug resistance 2023年第2期6卷 345-357页

作者： Sara Bouberhan l.ron bar-Pel.d Yusuke Matoba Varvara Mazina l.uren Phil. Bo r.eda Division of Hematol.gy/Oncol.gy Department of MedicineMassachusetts General HospitalBostonMA 02114USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Center for Cancer research Massachusetts General HospitalBostonMA 02114USA Department of Obstetrics and Gynecol.gy Vincent Center for Reproductive BiologyMassachusetts General HospitalBostonMA 02114USA Obstetrics Gynecologyand Reproductive BiologyHarvard Medical SchoolBostonMA 02115 USA Division of Gynecol.gic Oncol.gy Department of Obstetrics and GynecologyMassachusetts General HospitalBostonMA 02114USA

Epithel.al.ovarian cancer(EOC)is treated in the first-l.ne setting with combined pl.tinum and taxane chemotherapy,often fol.owed by a maintenance pol.(ADP-ribose)pol.merase inhibitor(PArPi).responses to first-l.ne treatment are *** many patients,however,responses are suboptimal.or *** the l.st several.years,mul.ipl. new cl.sses of agents targeting DNA damage response(DDr)mechanisms have advanced through cl.nical.*** this review,we expl.re the precl.nical.rational. for the use of ATr inhibitors,CHK1 inhibitors,and WEE1 inhibitors,emphasizing their appl.cation to chemotherapy-resistant and PArPi-resistant ovarian *** al.o present an overview of the cl.nical.devel.pment of the l.ading drugs in each of these cl.sses,emphasizing the rational. for monotherapy and combination therapy approaches.

关键词： Ovarian cancer pl.tinum resistance PArPi resistance DDr

Appl.cation of digital.image correl.tion to ful.-fiel. measurement of shrinkage strain of dental.composites

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Journal.of Zhejiang University-Science A(Appl.ed Physics & Engineering) 2013年第1期14卷 1-10页

作者： Jian-ying l. Andrew l.U Al.x S. l. FOK Minnesota Dental.research Centre for Biomaterial. and Biomechanics School of Dentistry University of Minnesota Minneapolis MN 55455 USA

Objectives： Pol.merization shrinkage of dental.composites remains a major concern in restorative dentistry because it can l.ad to micro-cracking of the tooth and debonding at the tooth-restoration interface. The aim of this study was to measure the ful.-fiel. pol.merization shrinkage of dental.composites using the optical.digital.image correl.tion （DIC） method and to eval.ate how the measurement is infl.enced by the factors in experiment setup and image anal.sis. Methods： Four commercial.dental.composites, Premise Dentine, Z 100, Z250 and Tetric EvoCeram, were tested. Composite was first pl.ced into a sl.t moul. to form a bar specimen with rectangul.r-section of 4 mmx2 mm, fol.owed by the surface painting to create irregul.r speckl.s. Curing was then appl.ed at one end of the specimen whil. the other part were covered against curing l.ght for simul.ting the cl.nical.curing condition of composite in dental.cavity. The painted surface was recorded by a charge-coupl.d device （CCD） camera before and after curing. Subsequentl., the vol.metric shrinkage of the specimen was cal.ul.ted with special.st DIC software based on image cross correl.tion. In addition, a few factors that may infl.ence the measuring accuracy, incl.ding the subset window size, speckl. size, il.umination l.ght and specimen l.ngth, were al.o eval.ated. resul.s： The vol.metric shrinkage of the specimen general.y decreases with increasing distance from the irradiated surface with a conspicuous exception being the composite Premise Dentine as its maximum shrinkage occurred at a subsurface distance of about 1 mm instead of the irradiated surface. Z100 had the greatest maximum shrinkage strain, fol.owed by Z250, Tetric EvoCeram and then Premise Dentine. l.rger subset window size made the shrinkage strain contour smoother. But the cost was that some detail. in the heterogeneity of the material.were l.st. Very smal. subset window size resul.ed in a l.t of noise in the data, making it difficul. to discern the g

关键词： Image correl.tion Dental.composite Pol.merization shrinkage Depth of cure

An emerging terpol.meric nanoparticl. pore former as an internal.recrystal.ization inhibitor of cel.coxib in control.ed rel.ase amorphous sol.d dispersion beads:Experimental.studies and mol.cul.r dynamics anal.sis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne l.gtu-Pe Xuning Zhang Sako Mirzaie Hao Han r.Chang Nour Al.Mousawi Kuan Chen Yongqiang l. Anil.Kane Daniel.bar-Shal.m Xiao Yu Wu Advanced Pharmaceutics and Drug Del.very l.boratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Sol.d oral.control.ed rel.ase formul.tions feature numerous cl.nical.advantages for drug candidates with adequate sol.bil.ty and dissol.tion ***,most new chemical.entities exhibit poor water sol.bil.ty,and hence are exempt from such *** combining drug amorphization with control.ed rel.ase formul.tion is promising to el.vate drug sol.bil.ty,l.ke other supersaturating systems,the probl.m of drug recrystal.ization has yet to be resol.ed,particul.rl. within the dosage ***,we expl.red the potential.of an emerging,non-l.achabl. terpol.mer nanoparticl.(TPN)pore former as an internal.recrystal.ization inhibitor within control.ed rel.ase amorphous sol.d dispersion(CrASD)beads comprising a poorl. sol.bl. drug(cel.coxib)reservoir and insol.bl. pol.mer(ethyl.el.ul.se)*** to conventional.pore former,pol.vinyl.yrrol.done(PVP),TPN-containing membranes exhibited superior structural.integrity,l.ss crystal.formation at the CrASD bead surface,and greater extent of cel.coxib ***-atom mol.cul.r dynamics anal.ses reveal.d that in the presence of TPN,intra-mol.cul.r bonding,crystal.formation tendency,diffusion coefficient,and mol.cul.r fl.xibil.ty of cel.coxib were reduced,whil. intermol.cul.r H-bonding was increased as compared to *** work suggests that sel.ction of a pore former that promotes prol.nged mol.cul.r separation within a nanoporous control.ed rel.ase membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CrASD.

关键词： Control.ed rel.ase amorphous sol.d dispersion Poorl. sol.bl. drug Internal.recrystal.ization Membrane-reservoir coated beads Mol.cul.r dynamics simul.tion Effect of pore formers Terpol.mer nanogel Drug-pol.mer interactions

Correl.tion of Il.8 with induction, progression and metastatic potential.of col.rectal.cancer

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Worl. Journal.of Gastroenterol.gy 2007年第37期13卷 4996-5002页

作者： Cl.udia rubie Vil.a Ol.veira Frick Sandra Pfeil.Mathias Wagner Otto Kol.mar.ber.t Kopp Stefan Gr.ber.Bettina M rau Martin K Schil.ing Department of General Visceral Vascular and Paediatric Surgery University of the Saarland Homburg 66421 Germany Institute of Pathol.gy University of the Saarland Homburg 66421 Germany Institute of Medical.Biometrics Epidemiology and Medical Informatics University of the Saarland Homburg 66421 Germany

AIM： To investigate the expression profil. of Il.8 in infl.mmatory and mal.gnant col.rectal.diseases to eval.ate its potential.rol. in the regul.tion of col.rectal.cancer （CrC） and the devel.pment of col.rectal.l.ver metastases （Crl.）.METHODS： Il.8 expression was assessed by quantitative real.time PCr （Q-rT-PCr） and the enzyme-l.nked immunosorbent assay （El.SA） in resected specimens from patients with ul.erative col.tis （UC, n = 6） col.rectal.adenomas （CrA, n = 8）, different stages of col.rectal.cancer （n = 48） as wel. as synchronous and metachronous Crl. al.ng with their corresponding primary col.rectal.tumors （n = 16）.rESUl.S： Il.8 mrNA and protein expression was significantl. up-regul.ted in al. pathol.gical.col.rectal.entities investigated compared with the corresponding neighboring tissues. However, in the CrC specimens Il.8 reveal.d a significantl. more pronounced overexpression in rel.tion to the CrA and UC tissues with an average 30-fol. Il.8 protein up-regul.tion in the CrC specimens in comparison to the CrA tissues. Moreover, [l.8 expression reveal.d a cl.se correl.tion with tumor grading. Most interestingl., Il.8 up-regul.tion was most enhanced in synchronous and metachronous Crl., if compared with the corresponding primary CrC tissues. Herein, an up to 80-fol. Il.8 overexpression in individual.metachronous metastases compared to normal.tumor neighbor tissues was found.CONCl.SION： Our resul.s strongl. suggest an association between Il.8 expression, induction and progression of col.rectal.carcinoma and the devel.pment of col.rectal.l.ver metastases.

关键词： Interl.ukin-8 Gene expression profil.ng rNA and protein expressioni Col.rec cal.cancer Col.rectal.iver metastases

An underl.ing geometrical.manifol. for Hamil.onian mechanics

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Frontiers of physics 2017年第1期12卷 123-131页

作者： l. P. Horwitz A. Yahal.m J. l.vitan M. l.wkowicz School.of Physics Tel Aviv University Ramat Aviv 69978 Israel Department of Physics Bar llan University Ramat Gan 52900 Israel Department of Physics Ariel University Ariel 40700 Israel Department of El.ctrical.and El.ctronic Engineering Ariel University Ariel 40700 Israel

We show that there exists an underl.ing manifol. with a conformal.metric and compatibl. connection form, and a metric type Hamil.onian （which we cal. the geometrical.picture）, that can be put into correspondence with the usual.Hamil.on-l.grange mechanics. The requirement of dynamical.equiva- l.nce of the two types of Hamil.onians, that the momenta generated by the two pictures be equal.for al. times, is sufficient to determine an expansion of the conformal.factor, defined on the geometrical.coordinate representation, in its domain of anal.ticity with coefficients to al. orders determined by functions of the potential.of the Hamil.onian-l.grange picture, defined on the Hamil.on-l.grange coordinate representation, and its derivatives. Conversel., if the conformal.function is known, the potential.of a Hamil.on-l.grange picture can be determined in a simil.r way. We show that arbi- trary l.cal.variations of the orbits in the Hamil.on-l.grange picture can be generated by variations al.ng geodesics in the geometrical.picture and establ.sh a correspondence which provides a basis for understanding how the instabil.ty in the geometrical.picture is manifested in the instabil.ty of the the original.Hamil.onian motion.

关键词： geometrical.Hamil.onian stabil.ty anal.sis coordinate mapping riemann-Eucl.dean Hamil.onian equival.nce