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Advances and perspectives in discovery and functional analysis of small secreted proteins in plants

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Horticulture research 2021年第1期8卷 1618-1631页

作者： Xiao-Li Hu Haiwei Lu Md Mahmudul Hassan jin Zhang Guoliang Yuan Paul E.Abraham Him K.Shrestha Manuel I.Villalobos Solis jin-Gui Chen Timothy j.Tschaplinski Mitchel j.Doktycz Gerald A.Tuskan Zong-Ming(Max)Cheng Xiaohan Yang Department of Plant Sciences University of TennesseeKnoxvilleTNUSA Biosciences Division Oak Ridge National LaboratoryOak RidgeTNUSA State Key Laboratory of Subtropical Silviculture School of Forestry and BiotechnologyZhejiang A&F UniversityHangzhouZhejiangChina The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTNUSA Department of Genome Science and Technology University of TennesseeKnoxvilleTNUSA College of Horticulture Nanjing Agricultural UniversityNanjingJiangsuChina

Small secreted proteins(SSPs)are less than 250 amino acids in length and are actively transported out of cells through conventional protein secretion pathways or unconventional protein secretion *** plants,SSPs have been found to play important roles in various processes,including plant growth and development,plant response to abiotic and biotic stresses,and beneficial plant–microbe *** the past 10 years,substantial progress has been made in the identification and functional characterization of SSPs in several plant species relevant to agriculture,bioenergy,and ***,there are potentially a lot of SSPs that have not been discovered in plant genomes,which is largely due to limitations of existing computational *** advances in genomics,transcriptomics,and proteomics research,as well as the development of new computational algorithms based on machine learning,provide unprecedented capabilities for genome-wide discovery of novel SSPs in *** this review,we summarize known SSPs and their functions in various plant *** we provide an update on the computational and experimental approaches that can be used to discover new ***,we discuss strategies for elucidating the biological functions of SSPs in plants.

关键词： species functional dating

轻型颅脑损伤:以CT为基础的管理策略——一种成本效益分析

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国际医学放射学杂志 2010年第2期 185-185页

作者： M.smits D.W.Dippel P.j.Nederkoorn H.M.Dekker P.E.Vos D.r.Kool 谢丽璇 Department of radiology Erasmus MC-University Medical Center RotterdamPO Box 20403000 CA RotterdamRotterdamthe Netherlands

目的对于所有需行CT检查的轻微颅脑外伤(MHI)病人,比较选择性运用CT检查策略的成本效益。材料与方法本研究得到了审查委员会批准,并且所有参与的病人都签

关键词：颅脑损伤病人所有成本效益策略神经外科手术 CT MHI

采集3个b值扩散加权成像评估选择性植入放射疗法对神经内分泌肝转移瘤的疗效

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国际医学放射学杂志 2014年第2期 192-192页

作者： G.M.Kukuk P.Mürtz F.Tr.ber.C.Meyer j.Ullrich j.Gieseke 林琳 Department of radiology University of Bonn SigmundFreud -Str25 53127 Bonn Germany

目的采集3个b值和ADC算法的扩散加权MrI评估选择性植入放射疗法(SIrT)对神经内分泌肝转移瘤的疗效。方法连续选择10例神经内分泌肝转移瘤的病人,在

关键词： MrI 扩散加权MrI 神经内分泌肿瘤肿瘤转移瘤放射性核素

一项激光诱导荧光内镜与标准电视内镜对Barrett食管早期瘤检测能力的随机、交叉研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 30-30页

作者： Kara M.A. smits M.E. rosmolen W.D. j.j.G.H.M. bergman 赵天智 Dept. of Gastroenterol. and Hepatol. Academic Medical Center Meibergdreef 9 1105 AZ Amsterdam Netherlands Dr.

Background: Light-induced fluorescence endoscopy (LIFE)-may improve the detection of high-grade dysplasia (HGD) and early stage cancer (EC) in Barrett’s esophagus (BE). The aim of this study was to compare LIFE with standard endoscopy (SE) in a randomized crossover study. Methods: Fifty patients with BE underwent SE and LIFE in a randomized sequence (4 to 6-week interval between procedures). The two procedures were performed by two different endoscopists who were blinded to the findings of the other examination. Targeted biopsy specimens were taken from detected lesions, followed by random biopsy specimens with a 2 cm interval, 4-quadrant protocol. Biopsy specimens were routinely evaluated and subsequently reviewed by a single, blinded expert GI pathologist. results: Targeted biopsy specimens had a sensitivity for the diagnosis of HGD/EC of 62%(8/13) for both techniques. The overall sensitivity (all biopsy specimens) was 85%for SE and 69%for LIFE (p = 0.69). All targeted biopsy specimens had a positive predictive value (PPV) for HGD/EC of 41%for SE and 28%for LIFE (p = 0.40); autofluorescence-targeted biopsy specimens had a PPV of 13%. False-positive lesions had a significantly higher rate of acute inflammation than random biopsy specimens. Conclusions: In this study, LIFE did not improve the detection of HGD or EC in patients with BE compared with SE.

关键词： Barrett 电视内镜交叉研究活检标本激光诱导荧光假阳性病变胃肠病异型增生诊断灵敏度早期癌变

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加拿大头部CT规则和新奥尔良标准对轻度脑损伤患者CT扫描的外部效度

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 3-3页

作者： smits M. Dippel D.W.j. De Haan G.G. M.G.M. Hunink 郭俊 Departments of radiology and Epidemiology and Biostatistics Erasmus MC-University Medical Centre PO Box 1738 3000 DR Rotterdam Netherlands.Dr.

Context: Two decision rules for indications of computed tomography (CT) in patients with minor head injury, the Canadian CT Head rule (CCHr) and the New Orleans Criteria (NOC), suggest that CT scanning may be restricted to patients with certain risk factors, which would lead to important reductions in the use of CT scans. Objective: To validate and compare these 2 published decision rules in Dutch patients with head injuries. Design, Setting, and Patients: A prospective multicenter study conducted between February 11, 2002, and August 31, 2004, in 4 university hospitals in the Netherlands of 3181 consecutive adult patients with minor head injury who presented with a Glasgow Coma Scale (GCS) score of 13 to 14 or with a GCS score of 15 and at least 1 risk factor. Main Outcome Measures: Primary outcome was any neurocranial traumatic finding on CT scan. Secondary outcomes were neurosurgical intervention and clinically important CT findings. Sensitivity and specificity were estimated for each outcome for the CCHr and the NOC, using both rules as originally derived and also as adapted to apply to an expanded patient population. results: Of 3181 patients with a GCS score of 13 to 15, neurosurgical intervention was performed in 17 patients (0.5%); neurocranial traumatic CT findings were present in 312 patients (9.8%). Sensitivity for neurosurgical intervention was 100%for both the CCHr and the NOC. The NOC had a higher sensitivity for neurocranial traumatic findings and for clinically important findings (97.7%-99.4%) than did the CCHr (83.4%-87.2%). Specificities were very low for the NOC (3.0%-5.6%) and higher for the CCHr (37.2%-39.7%). The estimated potential reduction in CT scans for patients with minor head injury would be 3.0%for the adapted NOC and 37.3%for the adapted CCHr. Conclusions: For patients with minor head injury and a GCS score of 13 to 15, the CCHr has a lower sensitivity than the NOC for neurocranial traumatic or clinically important CT findings, but wou

关键词：脑损伤新奥尔良美国患者 CT 解剖部位头部北美洲加拿大

HHV-6感染与凋落及细胞增殖 p53/bcl2/ras相互作用的调节机制

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德国医学 1996年第4期13卷 237-239页

作者： G.r.F.Krueger L.M.Buja j.rojo j.Lasch B.Koch N.Leyssens 阮幼冰 Institut fr Pathologie der Universitt zu Kln Joseph-StelzmannStr.9D-50924 KlnGermany 同济医科大学

人6型疱疹病毒(HHV-6)为1986年发现的一种亲淋巴的疱疹病毒,在各种增殖性及非增殖性疾病中起一定作用。

关键词：疱疹病毒感染细胞凋亡细胞增殖

维普期刊数据库

在非酒精性脂肪肝病人使用USPIO增强Mr成像无创性鉴别肝脂肪变性和脂性肝炎:概念证实性研究

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国际医学放射学杂志 2016年第3期 303-303页

作者： L.smits B.Coolen M.Panno j.runge jH W.Nijhof j.Verheij 陈惠娟 Department of Vascular Medicine Academic Medical Center

摘要目的 (a)研究超顺磁性氧化铁(USPIO)增强MrI在非酒精性脂肪肝的合适扫描时间和剂量;(b)评估在非酒精性脂肪肝中肝脏对于USPIO的摄取是否会降低;(c)研究USPIO增强Mr成像对于诊断非酒精性脂肪肝和单纯性肝脂肪变性的准确性。材料与方... 详细信息

摘要目的 (a)研究超顺磁性氧化铁(USPIO)增强MrI在非酒精性脂肪肝的合适扫描时间和剂量;(b)评估在非酒精性脂肪肝中肝脏对于USPIO的摄取是否会降低;(c)研究USPIO增强Mr成像对于诊断非酒精性脂肪肝和单纯性肝脂肪变性的准确性。材料与方法该前瞻性的研究得到了当地伦理委员会的批准,所有病人均签署知情同意书。在注射USPIO时和之后72 h采集量化的肝脏r2*Mr影像,被试对

关键词：非酒精性脂肪肝病肝脏 USPIO 肝脂肪变性 Mr

MrI评估经放射性栓塞治疗后的钬166聚左旋乳酸微球在体内的生物学分布

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国际医学放射学杂志 2013年第3期 292-292页

作者： G.H.van de Maat P.r.Seevinck M.Elschot M.L.j.smits H.deLeeuw A.D.van het Schip 宾锋利 Image Sciences Institute University Medical Center Utrecht

目的为了证实MrI评估经放射性栓塞治疗后钬-聚左旋乳酸-微球(Ho-PLLA-MS)在肝内的生物学分布的可行性,以评估所吸收的辐射剂量。方法在I期研究中有15例病人经钬166(166Ho)、聚(左旋乳酸)装载的微球(Ho-PLLA-MS,平均484mg;范围是408～593... 详细信息

目的为了证实MrI评估经放射性栓塞治疗后钬-聚左旋乳酸-微球(Ho-PLLA-MS)在肝内的生物学分布的可行性,以评估所吸收的辐射剂量。方法在I期研究中有15例病人经钬166(166Ho)、聚(左旋乳酸)装载的微球(Ho-PLLA-MS,平均484mg;范围是408～593mg)治疗。多回波梯度回波Mr影像采集自被构建的r2*图。肝内Ho-PLLA-MS的量可通过使用Ho-PLLA-MS的r2*弛豫效能来测定,并与给药量对比。用定量的单光子发射计算机体层摄影(SPECT)与MrI来对全肝吸收的辐射剂量进行比较。结果 r2*图很详细地显示Ho-PLLA-MS的沉积。MrI检测到肝内Ho-PLLA-MS的平均总量为431mg(236～666mg)或给药量的(89±19)%(相关系数r=0.7,PrI和SPECT来评估全肝平均吸收的辐射剂量有很好的相关性(相关系数r=0.927,PrI评估经钬166放射性栓塞治疗后的放射量是可行的。其在体内的生物学分布可详细显现且可能进行定量测量。要点①放射性栓塞被越来越多地用于治疗不能手术切除的原发性或转移性肝肿瘤。②MrI评估经钬166放射性栓塞治疗后肝内微球的生物学分布是可行的。③MrI能用短成像时间对肝内的钬166微球定量。④MrI可以评估经钬166放射性栓塞治疗后全肝吸收的辐射剂量。

关键词：放射性栓塞治疗钬 MrI 放射量测定生物学分布

乳腺病变的Mr扩散加权成像:不同脂肪抑制技术对定量和可重复性的影响

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国际医学放射学杂志 2014年第6期 609-609页

作者： P.Mürtz M.Tsesarskiy A.Kowal F.Tr.ber.j.Gieseke W.A.Willinek 杨君 Department of radiology University of BonnSigmund-Freud-Straβe 2553105 BonnGermany

摘要目的评价对乳腺病变进行Mr扩散加权成像时,采用不同脂肪抑制技术对定量测定和结果可重复性的影响。方法 25例不同类型乳腺病变病人接受了临床1.5 T Mr

关键词：脂肪抑制技术加权成像可重复性乳腺病变 Mr