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Luteolin attenuates diabetic nephropathy via inhibition of metalloenzymes in rats

Asian Pacific Journal of Tropical biomedicine 2023年第12期13卷 507-520,I0002,I0003页

作者： r.b.daude rajendra bhadane J.S.Shah Department of Pharmacy Government PolytechnicJalgaon-425001MaharashtraIndia Structural bioinformatics Laboratory Faculty of Science and EngineeringBiochemistryAbo Akademi UniversityFI-20520 TurkuFinland Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringPharmacyÅbo Akademi UniversityFI-20520 TurkuFinland Institute of biomedicine Research Unit for Infection and ImmunityUniversity of TurkuFI-20520 TurkuFinland Department of Pharmacology Institute of PharmacyNirma UniversityAhmedabad-382481GujratIndia

Objective:To investigate the renoprotective effects of luteolin on diabetes in ***:One week after administration of streptozotocin 55 mg/kg intraperitoneally,rats were given 25,50,and 75 mg/kg/day of luteolin orally for another eight *** the end of the experiment,body weight,blood glucose level,biochemical parameters for renal function(serum creatinine,blood urea nitrogen,uric acid,serum albumin,and total protein),kidney histology,matrix metalloproteinase(MMP)-2,MMP-9,and histone deacetylase 2(HDAC-2)expression,and malondialdehyde,myeloperoxidase,and hydroxyproline content in renal tissue were *** glucose-induced damage using NrK-52E cell line was studied to evaluate cell viability and metalloenzyme ***,in silico studies including docking and molecular dynamics simulations were ***:MMP-2,MMP-9,and HDAC-2 expressions were significantly increased in high glucose-induced NrK-52E cells and the renal tissue of diabetic ***,these changes were reversed by luteolin at the administered ***,luteolin significantly reduced oxidative stress,inflammation,and fibrosis,as well as improved biochemical parameters in diabetic ***,luteolin at the examined doses markedly alleviated diabetes-induced histopathological changes in renal ***:Luteolin effectively attenuates streptozotocin-induced diabetic nephropathy in rats by inhibiting MMP-2,MMP-9,and HDAC-2 expression,and reducing oxidative stress and inflammation.

关键词： MMPs HDAC-2 Luteolin NrK-52E Diabetic nephropathy Docking Molecular dynamic simulations

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