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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural regeneration research 2025年第8期20卷 2373-2381页

作者： Lifang zhao Mingkai zhang Qimeng Li Xuemin wang Jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

A practical model for efficient anti-fatigue design and selection of metallic materials:Ⅰ.Model building and fatigue strength prediction

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Journal of Materials Science & Technology 2021年第11期70卷 233-249页

作者： r.Liu P.zhang z.J.zhang B.wang z.F.zhang Laboratory of Fatigue and Fracture for Materials Shi-changxu Innovation Center for Advanced MaterialsInstitute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China

The high cost and low efficiency of fatigue tests are bottleneck problem for the anti-fatigue design of metallic *** this problem,a theoretical fatigue model is proposed in this study,the possible applications have also been *** results would be introduced in two serial papers,in which the first paper focuses on the model building and the applications on fatigue strength prediction;the second paper put emphasis on the influencing factors of the model parameters and the applications on fatigue strength *** this first paper,a theoretical model is proposed considering both the strength and plastic restrictions of fatigue *** the model builds up a brief relationship among yield strength(Y),tensile strength(T)and fatigue strength(F),it is named as the Y-T-F *** the verification with fatigue strength data covering various kinds of metallic materials and loading conditions,this Y-T-F model exhibits both generality and *** the Y-T-F model,the efficient fatigue strength prediction could be conducted by brief linear fitting and calculation,just through yield strength,tensile strength and several known fatigue strength ***,through its deduced Y-F model,the analytical formula of fatigue strength continuously changing with materials strengthening can be obtained,as well as the maximum value of fatigue strength and corresponding critical yield *** summary,the Y-T-F model would be useful for reducing the fatigue tests,thus providing new possibilities on the efficient anti-fatigue design and selection of metallic materials.

关键词： Yield strength Tensile strength Plasticity Fatigue strength Anti-fatigue design

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Distinct dendritic α phase emerging on the surface of primary α phase in a compressed near-α titanium alloy

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Journal of Materials Science & Technology 2018年第4期34卷 666-669页

作者： z.Liu z.B.zhao J.r.Liu Q.J.wang r.Yang Institute of Metal research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China

The characteristic of the surface morphology of primary α phase was studied in a deformed near-α tita- nium alloy. Dendritic α phase emerged on the surfaces of primary α phase when the alloy was air-cooled in α ＋β phase field after deformation. The dendritic α grain has the same orientation with its original primary α grain. The formation of the dendritic α phase could be explained by interface instability in epi- taxial growth process of the primary α phase. The dislocations induced by deformation could facilitate the formation of dendritic α phase leading to the dendritic α phase and more obvious with the increase of strain. The growth of dendritic α phase was finally limited by the nucleation of second α phase with cooling.

关键词： Epitaxial growth Dendritic α phase Microstructure Interface instability Hot deformation

Survey of the mechanisms of power take-off(PTO)devices of wave energy converters

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Acta Mechanica Sinica 2020年第3期36卷 644-658页

作者： z.Liu r.zhang H.Xiao X.wang School of Engineering RMIT UniversityBundooraVIC 3083Australia

Ocean wave energy conversion as one of the renewable clean energy sources is attracting the research interests of many *** review introduces different types of power take-off(PTO)technology of wave energy *** novelty of this paper is to present advantages and disadvantages of the linear direct and indirect drive PTO devices for ocean wave energy *** designs and optimizations of PTO systems of ocean wave energy converters have been studied from reviewing the recently published *** novel mechanical designs of the PTO systems have been compared and investigated in order to increase the energy harvesting efficiency.

关键词： ocean wave energy

Analysis of local crystallographic orientation in an annealed Ti60 billet

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Journal of Materials Science & Technology 2019年第4期35卷 591-595页

作者： z.B.zhao z.Liu Q.J.wang J.r.Liu r.Yang Institute of Metal research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China

A heterogeneous microstructure in terms of local orientation distribution is often found in near-α titanium alloys. The presence of large regions with similar crystallographic orientation, called ‘macrozones',could drastically decrease the fatigue performance of titanium alloys. The present work reports on the crystallographic orientation of a near-α titanium alloy, Ti60, billet after annealing in an α+β phase *** texture was found to be weak, and no obvious macrozone was found in our measured zone where the variant selection is suppressed. Meanwhile, in-depth electron backscattered diffraction(EBSD) analysis was applied to evaluate the final microstructure, and the mechanisms by which they formed were analyzed.

关键词： Titanium alloys Microstructure Texture Heat treatment EBSD

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural regeneration research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Flat Band and η-Pairing States in a One-Dimensional MoiréHubbard Model

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Chinese Physics Letters 2024年第4期41卷 69-76页

作者：王冉宋智 College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387China School of Physics Nankai UniversityTianjin 300071China

A Moirésystem is formed when two periodic structures have a slightly mismatched period,resulting in unusual strongly correlated states in the presence of particle-particle *** periodic structures can arise from the intrinsic crystalline order and periodic external *** investigate a one-dimensional Hubbard model with periodic on-site potential of period n_(0),which is commensurate to the lattice *** large n_(0),the exact solution demonstrates that there is a midgap flat band with zero energy in the absence of Hubbard *** Moiréunit cell contributes two zero energy levels to the flat *** the presence of Hubbard interaction,the midgap physics is demonstrated to be well described by a uniform Hubbard chain in which the effective hopping and on-site interaction strength can be controlled by the amplitude and period of the external *** simulations are performed to demonstrate the correlated behaviors in the finite-sized Moiré Hubbard system,including the existence of an η-pairing state and bound pair *** finding provides a method to enhance the correlated effect by a spatially periodic external field.

关键词： oscillation interaction field

Tensile ductility and deformation mechanisms of a nanotwinned 316L austenitic stainless steel

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Journal of Materials Science & Technology 2020年第1期36卷 65-69页

作者： Y.z.zhang J.J.wang N.r.Tao Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China

A nanotwinned 316 L austenitic stainless steel was prepared by means of surface mechanical grinding *** recovery annealing,the density of dislocations decreases obviously while the average twin/matrix lamella thickness still keeps in the nanometer *** annealed nanotwinned sample exhibits a high tensile yield strength of 771 MPa and a considerate uniform elongation of 8%.TEM observations showed that accommodating more dislocations and secondary twinning inside the nanotwins contribute to the enhanced ductility and work hardening rate of the annealed nanotwinned sample.

关键词： Nanotwinned Stainless steel Ductility Deformation mechanism

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-ran Sun Hao-Ming Yuan Guo-Da zhang Chao wang Shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy