检索结果-南通市图书馆

FIrST-OrDer AND SEcOND-OrDer, cHAOS-FrEE, FINITE DIFFerENcE scHEMES FOr FISHer EQUATION

在线全文

学校读者我要写书评

暂无评论

Journal of computational Mathematics 2001年第5期19卷 519-530页

作者： geng Sun Hua-mo Wu Li-er Wang Institute of Mathematics Academy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China LSEc ICMSECAcademy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China

Presents a study which constructed a class of finite difference schemes for Fisher partial differential equation. Properties of solutions for logistic equation; construction of high fidelity algorithms; Numerical meth... 详细信息

关键词： reaction-diffusion equation fidelity algorithm

recent advances in tertiary amine Lewis base-promoted cycloadditions of allenoates

在线全文

学校读者我要写书评

暂无评论

chinese chemical Letters 2022年第5期33卷 2372-2382页

作者： Manman Song Jing Zhao er-Qing Li college of chemistry Green Catalysis CenterZhengzhou UniversityZhengzhou 450001China Xuchang Environmental Monitoring center Xuchang 461000China

Lewis base-catalyzed annulations of allenoates have been one of the most powerful synthetic strategies for the synthesis of various valuable cycles,especially in the preparation of biologically active natural products and ***,the effective Lewis bases mainly include tertiary phosphine,NHc and tertiary amine catalysts,among those catalysis,tertiary amine Lewis bases have proven to be effective catalysts for a range of synthetic *** the past decades,tremendous progress in-volving tertiary amines-promoted cycloaddition of allenoates has been made in the chemoselective con-struction of valuable *** review describes a comprehensive and updated summary of tertiary amine Lewis base-promoted annulation reactions of *** reactivities,chemoselectivties and detailed reaction mechanisms will be highlighted in this review.

关键词： Lewis base Tertiary amine Annualtion Allenoates Olefin

Sintering behavior and properties of Sic/Si_3N_4 composite

在线全文

学校读者我要写书评

暂无评论

rare Metals 2015年第2期34卷 95-100页

作者： Yong Jiang Lan-er Wu Wen-Zhou Sun school of Materials science and Engineering Beifang University of Nationalities

Sic/Si_3N_4 composite was pressureless sintered using self-propagating high-temperature combustion synthesis a-Si_3N_4 powder and appropriate amount of b-Sic powder. Both of the sintering additive systems were used,which were YAN（Y_2O_3–Al_2O_3–AlN） and YN（Y_2O_3–AlN）.The influences of b-Sic content on sintering behavior of Sic/Si_3N_4 composite were investigated. The results show that the density, shrinkage, bending strength, hardness, and fracture toughness of the samples with two sintering additive systems increase first with the increase of the contents of b-Sic and then decrease even when b-Sic contents continually increase. The tendency of weight loss of the samples is opposite. The b-Sic content of the samples with the best mechanical properties is different in two systems. For YAN system, the best mechanical properties of the samples are gained when b-Sic content reaches 10 %, while as for YN system it is 5 %. The properties of YN samples are superior to YAN samples. J phase（2Y_2O_3 ·Si_2N_2O） forms in YN system easily. A small amount of M phase（Y_2O_3·Si_3N_4） is observed in YAN system.

关键词： SHS powder β-SIc Sic/Si_3N_4 composite Sintering behavior Properties

Action of ZDY101 on passive avoidance test and brain M-receptor density after intracranial co-injection of Aβ plus ibotenic acid

在线全文

学校读者我要写书评

暂无评论

Nuclear science and Techniques 2001年第4期12卷 250-255页

作者： HUYa－er XIAZong－Qin 等 researchLaboratoryofcellregulation ShanghaiSecondMedicalUniversityShanghai200025

The aim of this study was to establish a model by single injection of Aβ1-40+IA into rat brain basal ganglion and examine the effect of ZDY101, an active component of a Yin tonic from chinese traditional medicinal herb. The results showed that the amnestic effect of co-injection of Aβ and IA lasted for at least 2 months. At same time, the total M-receptor density in model brain was significantly lower than blank control, indicating the change is profound enough for long term pathological studies or drug screening. It can be clearly seen that the decreased brain M-receptor density caused by Aβ was significantly increased by ZDY101. Such an elevation effect was significantly correlated with dose of ZDY101 when the dose was examined in a certain reasonable range. It can also he clearly seen that such an elevation of M-cholinergic receptor density was significantly correlated with the improvement of memory which indicated that the increase of M-cholinergic receptor density was an important factor in improving the memory of such animal model.

关键词：放射医学 Alzeimer病动物模型

challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics

在线全文

学校读者我要写书评

暂无评论

cellular & Molecular Immunology 2020年第5期17卷 451-461页

作者： Heliang Li Phei er Saw erwei Song guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and gene regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan school of Medicine Sun Yatsen University74 Zhongshan Road IIGuangzhou 510080China guangzhou regenerative Medicine and Health guangdong Laboratory Guangzhou 510005China

Bispecific antibodies(bsAbs)refer to a large family of molecules that recognize two different epitopes or *** a series of challenges,especially immunogenicity and chain mispairing issues,once hindered the development of bsAbs,they have been gradually overcome with the help of rapidly developing technologies in the past 5 *** the meantime,an increasing number of bsAb platforms have been designed to satisfy different clinical ***,numerous preclinical and clinical trials are underway,portraying a promising future for bsAb-based cancer ***,bsAb drugs still face enormous challenges in their application as cancer therapeutics,including tumor heterogeneity and mutational burden,intractable tumor microenvironment(TME),insufficient costimulatory signals to activate T cells,the necessity for continuous injection,fatal systemic side effects,and off-target toxicities to adjacent normal ***,we provide several strategies as solutions to these issues,which comprise generating multispecific bsAbs,discovering neoantigens,combining bsAbs with other anticancer therapies,exploiting natural killer(NK)-cell-based bsAbs and producing bsAbs in *** this review,we mainly discuss previous and current challenges in bsAb development and underscore corresponding strategies,with a brief introduction of several typical bsAb formats.

关键词： Bispecific antibodies(bsAbs) Tumor microenvironment(TME) Tumor immunotherapy Monoclonal antibodies(mAbs)

Improving effect on forming quality and accuracy using a polyurethane board positioning/resetting the discrete steel pad in multi-point forming

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2019年第4期26卷 447-459页

作者： er-hu Qu Ming-zhe Li rui Li college of Materials science and Engineering Jilin University roll Forging Institute Jilin University changchun ruiguang Technology co. Ltd.

To improve the quality of multi-point die forming, a new approach using discrete steel pads was proposed. The formability of three different multi-point die forming processes was analyzed through numerical simulation and experiments. Numerical simulation and experimental results showed that the use of discrete steel pads in the multi-point forming process can substantially improve the stress–strain state on the plate and suppress dimple, straight-edge, and wrinkle defects. This analysis verified that the use of discrete steel pads in a multi-point forming process can effectively improve the quality and accuracy with which sheet metal is formed.

关键词： multi-point forming dimple wrinkle numerical simulation forming accuracy

Effects of co-administration of methanol leaf extract of catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 475-477页

作者： Ohadoma sc Michael HU Department of Pharmacology and Toxicology Madonna UniversityElele Rivers StateNigeria

Objective:To investigate the interacting effects of co-administration of methanol leaf extract of catharanthus roseus（***） on the hypoglycemic activity of metformin as well as glibenclamide using experimental ***:Phytochemical analysis as well as acute toxicity and lethality(LD50) test were carried out on its methanol leaf *** alloxan model for experimental induction of diabetes in rats was *** groups comprising five rats each were ***Ⅱ,ⅢandⅣreceived 250 mg/kg of extract,100 mg/kg of metformin and 1 mg/kg of glibenclamide respectively,while V and VI were administered metformin-extract and glibenclamide-extract combinations respectively at doses as *** I served as negative control and received only distilled *** administration was done once daily for seven days. Fasting blood glucose was determined at 2,12,24,72 and 168 h using a ***-way ANOVA with post-hoc tests was used to assess for significant difference due to administration of drug alone and with co-administration of drug and ***:The LD50 was 2 121.32 mg/kg. The phytochemical studies indicated the presence of saponins,tannins,alkaloids,phlotatannins, flavonoids,triterpenoids,reducing sugars,anthraquinones and *** medicaments significantly reduced blood glucose levels when compared with control alone（Pghest percentage reduction in blood glucose（64.86%） exhibited by metformin-extract ***:The leaf extract of *** significandy increases the hypoglycemic effect of metformin.

关键词： catharanthus roseus Hypoglycemic activity Metformin glibenclamide co-administration

Nonseparating Independent Sets and Maximum genus of graphs

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2022年第3期38卷 719-728页

作者： chao YANg Han rEN er-ling WEI center of Intelligent computing and Applied Statistics School of MathematicsPhysics and StatisticsShanghai University of Engineering ScienceShanghai 201620China school of Mathematical sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of PMMP Shanghai 200241China school of Mathematics Renmin University of ChinaBeijing 100872China

A subset I of vertices of an undirected connected graph g is a nonseparating independent set(NSIS)if no two vertices of I are adjacent and g􀀀I is *** Z(g)denote the cardinality of a maximum NSIS of g.A nonseparating independent set containing Z(g)vertices is called the maximum nonseparating independent *** this paper,we firstly give an upper bound for Z(g)of regular graphs and determine Z(g)for some types of circular ***,we show a relationship between Z(g)and the maximum genus M(g)of a general ***,an important formula is provided to compute Z(g),i.e.,Z(g)=Σx∈I dI(x)+2(M(g-I)-γM(g))+(ξ(g-I)-ξ(g));where I is the maximum nonseparating independent set and ξ(g)is the Betti deficiency(Xuong,1979)of g.

关键词： nonseparating independent sets maximum genus graph embedding decycling set

Human Activity recognition in a realistic and Multiview Environment Based on Two-Dimensional convolutional Neural Network

在线全文

学校读者我要写书评

暂无评论

Journal of Artificial Intelligence and Technology 2023年第3期3卷 100-107页

作者： Ashish KhareArati Kushwaha om Prakash Department of Electronics and communication University of AllahabadAllahabadIndia Department of computer science HNB Garhwal UniversitySrinagarIndia

recognition of human activity based on convolutional neural network(cNN)has received the interest of researchers in recent years due to its significant improvement in accuracy.A large number of algorithms based on the deep learning approach have been proposed for activity recognition ***,with the increasing advancements in technologies having limited computational resources,it needs to design an efficient deep learning-based approaches with improved utilization of computational *** paper presents a simple and efficient 2-dimensional cNN(2-D cNN)architecture with very small-size convolutional kernel for human activity *** merit of the proposed cNN architecture over standard deep learning architectures is fewer trainable parameters and lesser memory requirement which enables it to train the proposed cNN architecture on low gPU memory-based devices and also works well with smaller as well as larger size *** proposed approach consists of mainly four stages:namely(1)creation of dataset and data augmentation,(2)designing 2-D cNN architecture,(3)the proposed 2-D cNN architecture trained from scratch up to optimum stage,and(4)evaluation of the trained 2-D cNN *** illustrate the effectiveness of the proposed architecture several extensive experiments are conducted on three publicly available datasets,namely IXMAS,YouTube,and UcF101 *** results of the proposed method and its comparison with other state-of-the-art methods demonstrate the usefulness of the proposed method.

关键词： computational resources convolutional neural network gPU memory human activity recognition softmax classifier training parameters