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2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理

中华精神科杂志 2019年第1期52卷 5-49页

作者： Lakshmi N Yatham Sidney H Kennedy sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham rej Serge Beaulieu Martin Alda Glenda MaeQueen roumen V Milev Arun ravindran Claire O'Donovan Diane Mclntosh raymond W Lam Gustavo Vazquez Flavio Kapczinski roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph r Calabrese Eduard Vieta Gin Malhi robert M Post Michael Berk 胡晨(译) 王刚(译) 加拿大卑诗省温哥华市英属哥伦比亚大学精神病学系加拿大金斯敦皇后大学精神病学与心理学系加拿大卑诗省温哥华英属哥伦比亚大学人口与公共卫生学院日本福冈九州大学神经精神学系巴西圣保罗大学精神病学系美国斯坦福大学精神病学和行为科学系双相障碍和抑郁症研究组美国俄亥俄州克利夫兰凯斯西储大学医院医疗中心精神科西班牙巴塞罗那大学神经科学研究所双相障碍科澳大利亚悉尼大学精神病学系美国乔治华盛顿大学精神病学系澳大利亚迪肯大学医学院IMPACT策略研究中心加拿大多伦多大学精神病学系首都医科大学附属北京安定医院美国密歇根州密歇根大学精神病学系美国明尼阿波利斯明尼苏达大学精神病学系加拿大汉密尔顿麦克马斯特大学精神病学和行为神经科学系加拿大伦敦市西方大学精神病学和妇产科系加拿大蒙特利尔麦吉尔大学精神病学系加拿大新州哈利法克斯达尔豪西大学精神病学系加拿大卡尔加里大学精神病学系

加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(Inter... 详细信息

加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。

关键词：治疗指南双相障碍焦虑障碍疾病管理心境障碍加拿大学会国际

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Investigation of Support Vector Machine To Assess Cardiac Arrhythmia

Investigation of Support Vector Machine To Assess Cardiac Ar...

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International Conference on Advances in Computer and Electrical Engineering(ICACEE’2012);International Conference on Electronics Engineering & Its Applications(ICEEA’2012);International Conference on Trends in Mechanical and Production Engineering(ICTMPE’2012);International Conference on Agriculture Technology and Food Sciences(ICATFS’2012);International Conference on Chemical,Environment and Civil engineering(ICCECE’2012);International Conference on Literature,Management and Education(ICLME’2012)

作者： r Ganesh Kumar Y S Kumaraswamy Department of Computer Science & Engineering Sathyabama Universit Department of MCA (VTU) Dayananda Sagar College of Engineering

Cardiac Arrhythmia is irregular heartbeat caused by irregular rhythms. The heartbeat is either slowed down or increased causing irregular rhythm. Electrocardiogram （ECG） is used to assess the heart arrhythmia. Different types of arrhythmia which are relevant to diagnosis of heart disease are accurately detected using ECG. Automatic assessment of arrhythmia from ECG is widely researched. Features in the form of rr interval extracted from the ECG and used for classifying the arrhythmia. In this paper, a new approach for cardiac arrhythmia classification is proposed. The proposed method incorporates Support Vector Machine （SVM） approach with Polynomial kernel and radial Basis Function （rBF）. First, the features are extracted from the time series ECG data using Discrete Cosine Transform （DCT） and the distance between rr wave computed. Experiments were conducted using MIT-BIH arrhythmia database.

关键词： Cardiac Arrhythmia Electrocardiogram (ECG) rr interval Discrete Cosine Transform (DCT) Support Vector Machine (SVM).

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Correlative Analysis of Data and Functions of Neuronal Synapse

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Journal of Behavioral and Brain Science 2013年第2期3卷 276-287页

作者： T. r. Gopalakrishnan Nair A. Baby Jerald research Associate—rIIC Neuroscience Research Group Dayananda Sagar Institutions ARAMCO Endowed Chair—Technology PMU Alkhobar KSA Vice President—rIIC Dayananda Sagar Institutions ARAMCO Endowed Chair—Technology PMU Alkhobar KSA

Until recently, the synaptic transmission and excitatory amino acid transporters activation of neurons are very well discussed in the previous studies and are considered to be the two distinct features of Synapse. It is also found that a large number of interactions take place in the domain of ionic exchanges and protein interactions in synapses. It is evolutionary to have destined to release of Neurotransmitters to conduct an impulse to the other consecutive neurons, which forms the most important characteristic of synapse. From the popular perspective, it has been identified that detailed theoretical closer correlation of data produced through various studies about synapse can unravel many mysteries related to functions of synapse. Hence, this research paper tries to concentrate on a selected group of prominent characteristics and properties of synapse and also highlights some noteworthy discoveries, emphasizing the influential capabilities of them in the thought process and improving the knowledge of the field. It also highlights the expressive properties and forms of synapse brought out through the evidences available in sparse to dense data in a correlational way.

关键词： Synapse Synapse Formation Synapse Gap Synaptic Transmission Synaptic Plasticity Synapse Proteins Functions

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Microwave Assisted Synthesis of Guar Gum Grafted Acrylic Acid/Nanoclay Superabsorbent Composites and Its Use in Crystal Violet Dye Absorption

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Green and Sustainable Chemistry 2016年第1期6卷 11-25页

作者： S. B. Shruthi Chandan Bhat S. P. Bhaskar G. Preethi r. r. N. Sailaja Chemical Engineering Department Dayananda Sagar College of Engineering Kumaraswamy Layout Bengaluru India resource Efficient Process Technology Application The Energy and Resources Institute Bengaluru India

Natural gums can be tailored and used for the removal of toxic dyes like crystal violet via grafting techniques. However, grafting via microwave irradiation showed both higher yield and fast reaction kinetics as compared to conventional grafting. Silane modified nanoclay has been used to prepare acrylic acid grafted guar gum nanocomposites via microwave irradiation technique. The grafting was confirmed via infrared spectroscopy while XrD diffractograms suggested exfoliation of modified nanoclay in guar gum grafted acrylic acid. The reaction kinetic parameters have been optimized. The effect of nanoclay on swelling characteristics has been examined. The sensitivity of pH on swelling capabilities has also been assessed. The efficiency of the superabsorbent nanocomposite on the absorption of crystal violet dye has been studied. The superabsorbent nanocomposite loaded with 1.75% modified nanocaly was found to be optimal concentration for the removal of crystal violet dye.

关键词： Microwave Guar Gum Superabsorbent Nanocomposites Dye Absorption

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Microstructure and dry sliding wear behavior of Cu-Sn alloy reinforced with multiwalled carbon nanotubes

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Transactions of Nonferrous Metals Society of China 2016年第7期26卷 1755-1764页

作者： H.M.MALLIKArJUNA K.T.KASHYAP P.G.KOPPAD C.S.rAMESH r.KESHAVAMUrTHY Advanced Composites research Centre (ACrC) P E S Institute of Technology Department of Mechanical Engineering GEC Department of Mechanical Engineering Atria Institute of Technology research and Development Rapsri Engineering Products Company Ltd. Department of Mechanical Engineering Alliance College of Engineering and Design Alliance University Department of Mechanical Engineering Dayananda Sagar College of Engineering

Multiwalled carbon nanotubes （MWCNTs） reinforced Cu-Sn alloy based nanocomposite was developed by powder metallurgy route. The mass fraction of CNTs was varied from 0 to 2% in a step of 0.5%. The developed nanocomposites were subjected to density, hardness, electrical conductivity, and friction and wear tests. The results reveal that the density of nanocomposite decreases with the increase of the mass fraction of CNTs. A significant improvement in the hardness is noticed in the nanocomposite with the addition of CNTs. The developed nanocomposites show low coefficient of friction and improved wear resistance when compared with unreinforced alloy. At an applied load of 5 N, the coefficient of friction and wear loss of 2%CNTs reinforced Cu-Sn alloy nanocomposite decrease by 72% and 68%, respectively, compared with those of Cu-Sn alloy. The wear mechanisms of worn surfaces of the composites are reported. In addition, the electrical conductivity reduces with the increase of the content of CNTs.

关键词： Cu-Sn alloy carbon nanotube nanocomposites powder metallurgy microstructure sliding wear

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Effect of carbon nanotube and silicon carbide on microstructure and dry sliding wear behavior of copper hybrid nanocomposites

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Transactions of Nonferrous Metals Society of China 2016年第12期26卷 3170-3182页

作者： H.M.MALLIKArJUNA C.S.rAMESH P.G.KOPPAD r.KESHAVAMUrTHY K.T.KASHYAP Advanced Composites research Centre P E S Institute of Technology Department of Mechanical Engineering Government Engineering College Department of Mechanical Engineering Alliance College of Engineering & DesignAlliance University Department of Mechanical Engineering CMR Institute of Technology Department of Mechanical Engineering Dayananda Sagar College of Engineering Department of Mechanical Engineering School of Engineering and TechnologyJain University

Microstructure and tribological properties of copper-based hybrid nanocomposites reinforced with copper coatedmultiwalled carbon nanotubes (MWCNTs) and silicon carbide (SiC) were studied. Carbon nanotube was varied from 1% to 4% withsilicon carbide content being fixed at 4%. The synthesis of copper hybrid nanocomposites involves ball milling, cold pressing andsintering followed by hot pressing. The developed hybrid nanocomposites were subjected to density, grain size, and hardness *** tribological performances of the nanocomposites were assessed by carrying out dry sliding wear tests using pin-on-steel disctribometer at different loads. A significant decrease in grain size was observed for the developed hybrid composites when comparedwith pure copper. An improvement of 80% in the micro-hardness of the hybrid nanocomposite has been recorded for 4% carbonnanotubes reinforced hybrid composites when compared with pure copper. An increase in content of CNTs in the hybridnanocomposites results in lowering of the friction coefficient and wear rates of hybrid nanocomposites.

关键词： copper carbon nanotubes (CNTs) SiC microhardness wear mechanisms nanocomposite

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Biomethanisation of Municipal Solid Waste by Anaerobic Fungi Co-culture with Methanogens： An Approach to Energy recovery

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Journal of Environmental Science and Engineering 2010年第6期4卷 60-66页

作者： N.r. Chandra Shekar reddy H.K. ramaraju Quality ＆ Environment Volvo India Private Limited Bangalore 562122 Karnataka India Civil ＆ Environnemental Engineering Department Dayananda Sagar College of Engineering Kumara Swamy Layout Bangalore560078 Karnataka India

In nature, cellulose, lignocellulose and lignin are major sources of plant biomass; their recycling is indispensable for global carbon cycle. The major portion of the municipal solid waste consists of lignocellulose. The incineration of organic fraction of municipal solid waste （OFMSW） with high moisture content and low calorific value is not environmentally, techno-commercially viable option for energy recovery. Optimization of biomethanisation process is aim to maximize organic waste stabilization at short digestion period with higher energy recovery. The biomethanisation studies, demonstrate co-digestion of substrates improves CH4 yield due to nutrients balance. Fungi are low sensitive to environment, thrive in acidic environment and produces required multi-enzyme, attach to cell envelope and hydrolyze the substrate for energy recovery. Fermentation of cellulose by the monoculture results in the formation of H2, CO2, formate, acetate, lactate, succinate, and ethanol. In co-cultures with Methanobacterium, H2 and formate reduction indicates it＇s utilized in CH4 production. Engineered co-culture of microorganisms is essential for the heterogeneous complex organic substrate degradation for extraction of unutilized energy fraction of biomass, as potential source of energy.

关键词： MSW anaerobic fungi cellulose degradation enzymes

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Spectro-Structural Characterization of Chalcogenide Films Containing Cd, Te and Se

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Journal of Minerals and Materials Characterization and Engineering 2011年第11期10卷 1051-1060页

作者： T.M. rajakumar C. Sanjeeviraja r. Chandramani Department of Physics Alagappa University Karaikudi-630 003 India Department of Physics Bharathiar University Coimbatore India Department of Physics Dayananda Sagar College of Engineering Bangalore-560 078 India

Chalcogenide films find many applications in electronics as memory device, laser writer & xerography. To tailor the property to the requirement, various compositions of Cd, Te and Se have been deposited and characterized optically. Films have been deposited by thermal evaporation as well as by electron beam evaporation. Thermal analysis such as TGA, DTA and DSC has been carried out before deposition to ensure the composition. Dependence of Eg on the composition has been justified from (T% data) Transmittance measurements. Drastic changes in optical property due to annealing in the range 200°C to 400°C have been investigated.

关键词： Chalcogenide Eg TGA DTA DSC XrD Transmittance Annealing

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什哈拉姆住宅

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世界建筑导报 2020年第3期35卷 58-58页

作者： Jino Sam(摄影) Siddharth(摄影) Akash Sharma(摄影) sagar Kudtarkar(摄影) 无不详 Wallmakers

该建筑位于特里凡得琅(Trivandrum)一座安静的山顶上,是这片丛林中的最高点。墙壁计划取材于当地,可以简陋但要能遮蔽刺眼的光芒,于是便有了倾斜的废料墙。

关键词：特里凡得琅丛林中最高点

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基于拉曼光谱技术检测菠菜的毒死蜱残留

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食品安全质量检测学报 2014年第3期5卷 -页

作者：徐田锋彭彦昆李永玉 DHAKA Lsagar 翟晨中国农业大学工学院国家农产品加工技术装备研发分中心北京100083

目的基于拉曼光谱技术初步探讨菠菜表面有机磷农药毒死蜱的快速、无损检测新方法。方法利用本研究自行搭建的拉曼光谱检测系统获取残留不同浓度毒死蜱农药的菠菜光谱曲线,通过SG-5点平滑减小曲线噪声,基于最小二乘法的10次多项式拟合法... 详细信息

目的基于拉曼光谱技术初步探讨菠菜表面有机磷农药毒死蜱的快速、无损检测新方法。方法利用本研究自行搭建的拉曼光谱检测系统获取残留不同浓度毒死蜱农药的菠菜光谱曲线,通过SG-5点平滑减小曲线噪声,基于最小二乘法的10次多项式拟合法剔除菠菜荧光背景,并对含有不同浓度毒死蜱农药的菠菜样品拉曼图谱进行比较分析。结果特征归属为P=S振动的632 cm-1处的拉曼信号可识别菠菜表面毒死蜱农药残留,其检测限为400 mg/kg,而且拉曼特征波峰的相对强度与菠菜表面农药残留浓度存在较好的线性关系,其相关系数为r2=0.92。结论拉曼光谱技术有望实现叶片类蔬菜的农药残留的快速、无损、定量检测。

关键词：菠菜毒死蜱拉曼光谱快速无损

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