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Thermite assisted synthesis of ZrB2 and ZrB2-SiC through B4C reduction of ZrO2 and ZrSiO4 in air

Journal of Advanced Ceramics 2017年第2期6卷 139-148页

作者： r.V.KrISHNArAO r.sankarasubramanian Defence Metallurgical research Laboratory Kanchanbagh Hyderabad-500058 India

ZrB2 and ZrB2-SiC powders have been produced by reducing ZrO2 and ZrSiO4 with B4C without using any *** was added to the mixtures of (ZrO2+B4C) and (ZrSiO4+B4C).The reaction has been assisted by a floral thermite packed around the *** introducing elemental Si into (ZrO2+B4C) mixture,composite powders of ZrB2-SiC *** leaching out MgO with suitable HCl water solution,the product was analysed by X-ray diffraction (XrD) and scanning electron microscopy (SEM).The effect of Si,B4C,and Mg on the extent of formation of ZrB2,ZrB2-SiC,and other phases has been *** of nano-sized ZrB2 and ZrB2-SiC composite powders was *** adaptability of the process for bulk production was examined.

关键词： ZrB2 ZrO2 zircon (ZrSiO4) composites synthesis

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Computational structural mechanics Eastern economy ed.

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2001年

作者： S.rajasekaran G. sankarasubramanian.

来源：畅想之星图书光盘版（南... 评论

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Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions

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Bioactive Materials 2022年第8期7卷 61-75页

作者： Bo Liu Yunfan Kong Wen Shi Mitchell Kuss Ke Liao Guoku Hu Peng Xiao Jagadesan sankarasubramanian Chittibabu Guda Xinglong Wang Yuguo Lei Bin Duan Mary&Dick Holland regenerative Medicine Program and Division of Cardiology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNEUSA Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical CenterOmahaNEUSA Department of Genetics Cell Biology&AnatomyCollege of MedicineUniversity of Nebraska Medical CenterOmahaNEUSA Department of Pharmacology&Experimental Neuroscience College of MedicineUniversity of Nebraska Medical CenterOmahaNEUSA Department of Biomedical Engineering Huck Institutes of the Life SciencesSartorius Mammalian Cell Culture FacilityPennsylvania State UniversityUniversity ParkPAUSA Department of Surgery College of MedicineUniversity of Nebraska Medical CenterOmahaNEUSA Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNEUSA

Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health ***,especially those derived from mesenchymal stem cells(MSCs),are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural *** this study,we reported the differentiation of human adipose derived MSCs(hADMSCs)towards the Schwann cell(SC)phenotype(hADMSC-SCs)and then isolated exosomes from hADMSCs with and without differentiation(i.e.,dExo vs uExo).We assessed and compared the effects of uExo and dExo on antioxidative,angiogenic,anti-inflammatory,and axon growth promoting properties by using various peripheral nerve-related *** results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors,compared to hADMSCs without *** dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUVEC migration and *** to uExo,dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem ***,microrNA(mirNA)sequencing analysis revealed that exosomes and their parent cells shared some similarities in their mirNA profiles and exosomes displayed a distinct mirNA *** more mirNAs were identified in dExo than in *** upregulated mirNAs,like mirNA-132-3p and mirNA-199b-5p,were highly related to neuroprotection,anti-inflammation,and *** dExo can effectively modulate various peripheral nerve-related cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration.

关键词： Anti-oxidation Anti-inflammatory Axon growth Neural regeneration microrNA

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