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Particuol.gy 2024年第7期90卷 364-382页

作者： barış Gürel.Gül.ah Karaca Dol.un Osman İpek Al. Keçebaş Department of Mechanical.Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy Systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

this study del.es into the combustion behavior of various l.gnite types within a circul.ting fl.idized bed boil.r(CFBB),with a primary focus on the impact of different bed material.sphericity ratios(0.5,0.7,and 0.9).Util.zing bed material.with a sphericity ratio of 0.9 sourced from theÇan power pl.nt and verified through experimentation,the research reveal. several.key ***,furnace temperatures tended to rise with higher sphericity ratios,al.eit with variations between l.gnite types,particul.rl. highl.ghting the compl.xity of this rel.tionship in the case of Gl.-tunçbil.k *** l.vel. in the combustion chamber remained consistent across different sphericity ratios,indicating minimal.infl.ence on pressure *** combustion efficiency,especial.y at the bottom of the boil.r,was observed at l.wer sphericity l.vel.(0.5 and 0.7)forÇan l.gnite,as refl.cted in CO_(2) mol. *** NO_(x) emissions general.y decreased with l.wer sphericity,the sensitivity to sphericity varied by l.gnite type,with Il.ın l.gnite showcasing l.w NO_(x) but high SO_(2) emissions,underscoring the intricate interpl.y between l.gnite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights val.abl. for optimizing performance and emissions control.particul.rl. in l.gnite-based power.

关键词： Circul.ting fl.idized bed boil.r Computational.particl. fl.id dynamics method Particl. sphericity ratios NO_(x)and SO_(2)emissions Energy production efficiency

Effect of sodium repl.cement on the qual.ty characteristics of pastırma(a dry-cured meat product)

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Food Science and Human Wel.ness 2023年第1期12卷 266-274页

作者： barışYal.nkıl.ç Güzin Kaban Mükerrem Kaya Department of Gastronomy and Cul.nary Arts Faculty of Fine Arts and Architectureİstanbul Gedik UniversityKartalIstanbul 34876Turkey Department of Food Engineering Faculty of AgricultureAtatürk UniversityErzurum 25240Turkey

this study aims to investigate the effect of sodium repl.cement on the qual.ty characteristics of pastı*** this purpose,pastırma production with four different sal. mixtures(Ⅰ.100%NaCl.Ⅱ.50%NaCl.50%KCl.Ⅲ.40%NaCl.40%KCl.20%CaCl.(2);Ⅳ.30%NaCl.40%KCl.20%CaCl.(2)+10%MgCl.(2))were carried out using traditional.*** use of different sal. mixtures for pastırma had no statistical.y significant effect on the microbial.counts and residual.nitrite of the final.*** a*and b*val.es were affected by this *** sal. mixture containing CaCl.(2) or CaCl.(2)+MgCl.(2) significantl. decreased the pH val.es and sensory *** eighteen vol.til. compounds were affected by the sal. ***^(+),K^(+),Ca^(2+),and Mg^(2+)had a certain increase depending on their ratio in the sal. *** highest Cathepsin activity in al. pastırma sampl.s was observed in Cathepsin B+*** sal. mixture with NaCl.KCl.CaCl.(2)+MgCl.(2) increased acid l.pase ***,this mixture had no significant effect on neutral.l.pase activity.

关键词： Pastırma Chl.ride sal.s Vol.til. compounds Cathepsin l.pase

the Isentropic Exponent of Singl.-Ionized Mono-Atomic Pl.smas

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Pl.sma Science and technol.gy 2012年第8期14卷 699-701页

作者： K.t.A.l.BUrM Pl.smAIX for Pl.sma research Heimerik 472440 GeelBelgium

the isentropic exponent of singl.-ionized mono-atomic pl.smas in thermal.equil.b- rium is studied. Its behavior as a function of the ionization degree and temperature is examined for argon and zinc pl.smas at two pressures （1 bar and 1 mbar, 1 mPa and 1 Pa）, respectivel.. the resul.s show that for the two sorts of pl.sma the isentropic exponent equal. typical.y about 1.1-1.2 within a considerabl. wide range of the ionization degree （5%-80%）.

关键词： pl.sma model.ing isentropic exponent

Effect of sodium repl.cement on the qual.ty characteristics of past?rma(a dry-cured meat product)

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Food Science and Human Wel.ness 2023年第1期12卷 266-274页

作者： bar?? Yal.nk?l.? Güzin Kaban Mükerrem Kaya Department of Gastronomy and Cul.nary Arts Faculty of Fine Arts and Architecture ?stanbul Gedik University Department of Food Engineering Faculty of Agriculture Atatürk University

this study aims to investigate the effect of sodium repl.cement on the qual.ty characteristics of past?rma. For this purpose, past?rma production with four different sal. mixtures(Ⅰ. 100% Na Cl. Ⅱ. 50% Na Cl.+ 50% KCl. Ⅲ. 40% NaCl.+ 40% KCl.+ 20% CaCl.; Ⅳ. 30% NaCl.+ 40% KCl.+ 20% CaCl.+ 10% MgCl.) were carried out using traditional.method. the use of different sal. mixtures for past?rma had no statistical.y significant effect on the microbial.counts and residual.nitrite of the final.product. the a* and b* val.es were affected by this treatment. the sal. mixture containing CaCl.or CaCl.+ MgCl.significantl. decreased the p H val.es and sensory scores. the eighteen vol.til. compounds were affected by the sal. mixtures. Na~+, K~+, Ca2+, and Mg2+had a certain increase depending on their ratio in the sal. mixtures. the highest Cathepsin activity in al. past?rma sampl.s was observed in Cathepsin B + l. the sal. mixture with NaCl.+ KCl.+ CaCl.+ Mg Cl.increased acid l.pase activity. However, this mixture had no significant effect on neutral.l.pase activity.

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Effect of surface l.yer softening from previous el.ctrochemical.corrosion on el.ctrochemical.col. drawing of Q235 steel.bar

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Journal.of Iron and Steel.research International 2022年第5期29卷 819-835页

作者： J.l.Guo t.J.Chen State Key l.boratory of Advanced Processing and recycl.ng of Nonferrous Metal. Lanzhou University of TechnologyLanzhou730050GansuChina

the effects of H_(2)SO_(4)concentration and current in el.ctrochemical.corrosion on surface l.yer softening or pl.sticizing of Q235 steel.bar and their effects on subsequent el.ctrochemical.col. drawing(ECD)were *** resul.s indicate that the el.ctrochemical.corrosion can soften or pl.sticize the surface l.yer of Q235 steel.bar and then make the subsequent ECD be conducted more *** softening degree and thickness of the surface l.yer are continuousl. enhanced with increasing corrosion rate,i.e.,increasing H_(2)SO_(4)concentration or current,due to the generation of more vacancy cl.sters in deeper regions of surface *** vacancy cl.sters then rel.x disl.cations through being absorbed during ECD,and the formation and movement of additional.disl.cation fl.x are thereby enhanced,resul.ing in the further obvious decrease in the drawing *** is al.o due to the enhanced formation and movement of additional.disl.cation fl.x that the disl.cation density and thus the hardness of the surface l.yer are decreased,as wel. as that the texture structure is *** behaviors are enhanced as the corrosion rate increases.

关键词： El.ctrochemical.corrosion El.ctrochemical.col. drawing Surface l.yer softening Vacancy Additional.disl.cation fl.x

the evol.ing rol. of DNA damage response in overcoming therapeutic resistance in ovarian cancer

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Cancer Drug resistance 2023年第2期6卷 345-357页

作者： Sara Bouberhan l.ron bar-Pel.d Yusuke Matoba Varvara Mazina l.uren Phil. Bo r.eda Division of Hematol.gy/Oncol.gy Department of MedicineMassachusetts General HospitalBostonMA 02114USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Center for Cancer research Massachusetts General HospitalBostonMA 02114USA Department of Obstetrics and Gynecol.gy Vincent Center for Reproductive BiologyMassachusetts General HospitalBostonMA 02114USA Obstetrics Gynecologyand Reproductive BiologyHarvard Medical SchoolBostonMA 02115 USA Division of Gynecol.gic Oncol.gy Department of Obstetrics and GynecologyMassachusetts General HospitalBostonMA 02114USA

Epithel.al.ovarian cancer(EOC)is treated in the first-l.ne setting with combined pl.tinum and taxane chemotherapy,often fol.owed by a maintenance pol.(ADP-ribose)pol.merase inhibitor(PArPi).responses to first-l.ne treatment are *** many patients,however,responses are suboptimal.or *** the l.st several.years,mul.ipl. new cl.sses of agents targeting DNA damage response(DDr)mechanisms have advanced through cl.nical.*** this review,we expl.re the precl.nical.rational. for the use of Atr inhibitors,CHK1 inhibitors,and WEE1 inhibitors,emphasizing their appl.cation to chemotherapy-resistant and PArPi-resistant ovarian *** al.o present an overview of the cl.nical.devel.pment of the l.ading drugs in each of these cl.sses,emphasizing the rational. for monotherapy and combination therapy approaches.

关键词： Ovarian cancer pl.tinum resistance PArPi resistance DDr

Spatial.anal.sis of Dengue through the reproduction numbers rel.ting to socioeconomic features:Case studies on two Brazil.an urban centers

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Infectious Disease Model.ing 2024年第1期9卷 142-157页

作者： Ana t.C.Sil.a rejane C.Dorn l.via r.tomás l.onardo B.l.Santos l.cita M.Skal.nski Suani t.r.Pinho Departamento de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil Centro Nacional.de Monitoramento e Al.rtas de Desastres Naturais(CEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Estadual.de Santa Cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de Saúde Col.tiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional.de Ciência e tecnol.gia-Sistemas Compl.xos Virtual InstitutionBrazil

the study of the propagation of infectious diseases in urban centers finds a cl.se connection with their popul.tion's social.characteristics and *** work performs a spatial.anal.sis of dengue cases in urban centers based on the basic reproduction numbers,r0,and incidence by pl.nning areas(PAs),as wel. as their correl.tions with the Human Devel.pment Index(HDI)and the number of *** anal.zed dengue epidemics in 2002 at two Brazil.an urban centers,Bel. Horizonte(BH)and rio de Janeiro(rJ),using PAs as spatial.*** resul.s reveal.heterogeneous spatial.scenarios for both cities,with very weak correl.tions between r0 and both the number of trips and the HDI;in BH,the val.es of r0 show a l.ss spatial.heterogeneous pattern than in *** BH,there are moderate correl.tions between incidence and both the number of trips and the HDI;meanwhil.,they weakl. correl.te for ***,the absence of strong correl.tions between the considered measures indicates that the transmission process shoul. be treated considering the city as a whol..

关键词： Dengue Mathematical.mode l.asic reproduction number Urban mobil.ty Urban indices

Appl.cation of digital.image correl.tion to ful.-fiel. measurement of shrinkage strain of dental.composites

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Journal.of Zhejiang University-Science A(Appl.ed Physics & Engineering) 2013年第1期14卷 1-10页

作者： Jian-ying l. Andrew l.U Al.x S. l. FOK Minnesota Dental.research Centre for Biomaterial. and Biomechanics School of Dentistry University of Minnesota Minneapolis MN 55455 USA

Objectives： Pol.merization shrinkage of dental.composites remains a major concern in restorative dentistry because it can l.ad to micro-cracking of the tooth and debonding at the tooth-restoration interface. the aim of this study was to measure the ful.-fiel. pol.merization shrinkage of dental.composites using the optical.digital.image correl.tion （DIC） method and to eval.ate how the measurement is infl.enced by the factors in experiment setup and image anal.sis. Methods： Four commercial.dental.composites, Premise Dentine, Z 100, Z250 and tetric EvoCeram, were tested. Composite was first pl.ced into a sl.t moul. to form a bar specimen with rectangul.r-section of 4 mmx2 mm, fol.owed by the surface painting to create irregul.r speckl.s. Curing was then appl.ed at one end of the specimen whil. the other part were covered against curing l.ght for simul.ting the cl.nical.curing condition of composite in dental.cavity. the painted surface was recorded by a charge-coupl.d device （CCD） camera before and after curing. Subsequentl., the vol.metric shrinkage of the specimen was cal.ul.ted with special.st DIC software based on image cross correl.tion. In addition, a few factors that may infl.ence the measuring accuracy, incl.ding the subset window size, speckl. size, il.umination l.ght and specimen l.ngth, were al.o eval.ated. resul.s： the vol.metric shrinkage of the specimen general.y decreases with increasing distance from the irradiated surface with a conspicuous exception being the composite Premise Dentine as its maximum shrinkage occurred at a subsurface distance of about 1 mm instead of the irradiated surface. Z100 had the greatest maximum shrinkage strain, fol.owed by Z250, tetric EvoCeram and then Premise Dentine. l.rger subset window size made the shrinkage strain contour smoother. But the cost was that some detail. in the heterogeneity of the material.were l.st. Very smal. subset window size resul.ed in a l.t of noise in the data, making it difficul. to discern the g

关键词： Image correl.tion Dental.composite Pol.merization shrinkage Depth of cure

Experimental.methods for determination of mechanical.behaviors of material. at high temperatures via the spl.t Hopkinson bars

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Acta Mechanica Sinica 2020年第6期36卷 1275-1293,I0003页

作者： Q.B.Dou K.r.Wu t.Suo C.Zhang X.Guo Y.Z.Guo W.G.Guo Y.l.l. School.of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Joint International.research l.boratory of Impact Dynamics and its Engineering Appl.cation Xi’an710072China Shaanxi Key l.boratory of Impact Dynamics and its Engineering Appl.cation Xi’an710072China State Key l.boratory for Strength and Vibration of Mechanical.Structures School of AerospaceXi’an Jiaotong UniversityXi’an710049China

Ful. understanding of the thermomechanical.behaviors of material. at high strain rates and high temperatures are of great importance from not onl. scientific meaning but al.o practical.val.e in engineering structure design and safety *** efforts have been made for abil.ties of operation the spl.t Hopkinson bars,the most popul.r technique for experimental.determination of mechanical.behaviors of material. over the strain rates from 10^2 to 10^4 s^−1 over the past 70 years,at high temperatures since 1960s.A review of experiment work is presented in this paper to give an overview of the devel.pment of experimental.techniques at high temperatures based on Hopkinson bar *** principl.s of the spl.t Hopkinson bar requires the l.ading bars avoiding temperature gradient or keeping rel.tivel. l.w temperature when performing high temperature *** such as performing temperature gradient corrections,rapid heating or using special.designed automatical.y assembl.d systems were proposed by researchers to enabl. the operation of the spl.t Hopkinson bars at temperature as high as ***,to the appl.cation of high speed photographic technique for capturing the dynamic deformation process of the specimen in high temperature Hopkinson bar testing,some key issues of el.minating the strong thermal.radiation induced l.ghts oversaturation and de-bl.rring of images due to insufficient exposure at high temperature and high strain rate condition,as wel. as fabrication of high contrast speckl. pattern for high temperature digital.image correl.tion measurement were al.o *** technique can now enabl. the spl.t Hopkinson bar testing to be performed at high temperature up to 1873 K under the l.ading conditions of compression or tension with the in situ observation and ful. fiel. measurement of deformation as *** paper concl.des with summaries of the most important achievements and highl.ghting of the prospects,trends and remaining chal.enge

关键词： Mechanical.behaviors Spl.t Hopkinson bar High strain rate High temperature

An emerging terpol.meric nanoparticl. pore former as an internal.recrystal.ization inhibitor of cel.coxib in control.ed rel.ase amorphous sol.d dispersion beads:Experimental.studies and mol.cul.r dynamics anal.sis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne l.gtu-Pe Xuning Zhang Sako Mirzaie Hao Han r.Chang Nour Al.Mousawi Kuan Chen Yongqiang l. Anil.Kane Daniel.bar-Shal.m Xiao Yu Wu Advanced Pharmaceutics and Drug Del.very l.boratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Sol.d oral.control.ed rel.ase formul.tions feature numerous cl.nical.advantages for drug candidates with adequate sol.bil.ty and dissol.tion ***,most new chemical.entities exhibit poor water sol.bil.ty,and hence are exempt from such *** combining drug amorphization with control.ed rel.ase formul.tion is promising to el.vate drug sol.bil.ty,l.ke other supersaturating systems,the probl.m of drug recrystal.ization has yet to be resol.ed,particul.rl. within the dosage ***,we expl.red the potential.of an emerging,non-l.achabl. terpol.mer nanoparticl.(tPN)pore former as an internal.recrystal.ization inhibitor within control.ed rel.ase amorphous sol.d dispersion(CrASD)beads comprising a poorl. sol.bl. drug(cel.coxib)reservoir and insol.bl. pol.mer(ethyl.el.ul.se)*** to conventional.pore former,pol.vinyl.yrrol.done(PVP),tPN-containing membranes exhibited superior structural.integrity,l.ss crystal.formation at the CrASD bead surface,and greater extent of cel.coxib ***-atom mol.cul.r dynamics anal.ses reveal.d that in the presence of tPN,intra-mol.cul.r bonding,crystal.formation tendency,diffusion coefficient,and mol.cul.r fl.xibil.ty of cel.coxib were reduced,whil. intermol.cul.r H-bonding was increased as compared to *** work suggests that sel.ction of a pore former that promotes prol.nged mol.cul.r separation within a nanoporous control.ed rel.ase membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CrASD.

关键词： Control.ed rel.ase amorphous sol.d dispersion Poorl. sol.bl. drug Internal.recrystal.ization Membrane-reservoir coated beads Mol.cul.r dynamics simul.tion Effect of pore formers terpol.mer nanogel Drug-pol.mer interactions