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molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

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Bone research 2018年第2期6卷 189-196页

作者： Julie E.pickett John m.Thompson Agnieszka Sadowska Christine Tkaczyk Bret r.Sellman Andrea minola Davide Corti Antonio Lanzavecchia Lloyd S.miller Daniel LJ Thorek Division of Nuclear.m.dicine and molecular Imaging Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineGaithersburgMDUSA Depar.m.nt of Orthopaedic Surgery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Depar.m.nt of Infectious Disease MedImmune LLCGaithersburgMDUSA Humabs Bio med SA BellinzonaSwitzerland Institute for research in Biomedicine Universitàdella Svizzera italianaBellinzonaSwitzerland Depar.m.nt of Dermatology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Division of Infectious Disease Department of MedicineJohns Hopkins University School of MedicineBaltimoreMDUSA Cancer.m.lecular and Functional Imaging Program Department of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21205USA

Discr.m.nating sterile inflammation fr.m.infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody（mAb） probe directed against the Gr.m.positive bacterial surface molecule lipoteichoic acid（LTA）. Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immuno PET imaging in an in vivo mouse model of prosthetic joint infection（PJI）. In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography（PET） with [^（18）F]FDG and [^（18）F]Na F as well as X-ray computed tomography（CT）, before being evaluated with the zirconium-89-labeled antibody specific for LTA（[^（89）Zr]SAC55）.The anti-LTA mAb exhibited specific binding in vitro to LTA-expressing bacteria. results fr.m.imaging showed that our.m.del could reliably simulate infection at the surgical site by bioluminescent imaging, conventional PET tracer imaging, and bone morphological changes by CT. One day following injection of both the radiolabeled anti-LTA and isotype control antibodies, the anti-LTA antibody demonstrated significantly greater（P 〈 0.05） uptake at S. aureus-infected prosthesis sites over either the same antibody at sterile prosthesis sites or of control non-specific antibody at infected prosthesis sites. Taken together, the radiolabeled anti-LTA mAb, [^（89）Zr]SAC55, may serve as a valuable diagnostic molecular imaging probe to help distinguish between sterile inflammation and infection in the setting of PJI. Future studies are needed to determine whether these findings will translate to human PJI.

关键词： Zr.m.lecularly specific detection bacterial lipoteichoic acid diagnosis prosthetic infection bone LTA SAC PET FDG tracer

Democratization of ecosystem services--a radical approach for assessing nature's benefits in the face of urbanization

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Ecosystem Health and Sustainability 2018年第5期4卷 2-18页

作者： melissa r.m.Hale Scott m.Beck Steward T.A.pickett Daniel L.Childers mary L.Cadenasso Louie rivers III Louise Swemmer Liesel Ebersohn Wayne Twine David N Bunn Depar.m.nt of Ecosystem Science and Sustainability Colorado State UniversityFort CollinsCOUSA School of Animal Plantand Environmental SciencesUniversity of the Witwatersr andJohannesburgSouth Africa Natural resource Ecology Lab Colorado State UniversityFort CollinsCOUSA Wits City Institute University of the WitwatersrandJohannesburgSouth Africa Cary Institute of Ecosystem Studies MillbrookNYUSA School of Sustainability Arizona State UniversityTempeAZUSA Depar.m.nt of Plant Sciences University of CaliforniaDavisCAUSA Depar.m.nt of Forestry and Environmental resources North Carolina State UniversityRaleighNCUSA South African National Parks Kruger National ParkPhalaborwaSouth Africa Centre for the Study of resilience University of PretoriaPretoriaSouth Africa Geography&Environmental management&Energy Studies University of Johannesburg

Objectives:(1)To evaluate how ecosystem services may be utilized to either reinforce or fracture the planning and development practices that emerged fr.m.segregation and eco-nomic exclusion;(2)To survey the current state of ecosystem service assessments and synthesize a growing number of recommendations fr.m.the literature for renovating ecosys-tem service ***:Utilizing current maps of ecosystem service distribution in Bushbuckridge Local municipality,South Africa,we considered how a democratized process of assessing ecosys-tem services will produce a more nuanced representation of diverse values in society and capture heterogeneity in ecosystem structure and ***:We propose interventions for assessing ecosystem services that are inclusive of a broad range of stakeholders'values and result in actual quantification of social and ecological *** demonstrate how to operationalize a pluralistic fr.m.work for ecosystem service ***:A democratized approach to ecosystem service assessments is a reimagined path to rescuing a poorly implemented concept and designing and managing future social-ecological systems that benefit people and support ecosystem *** is the responsi-bility of scientists who do ecosystem services research to embrace more complex,pluralistic fr.m.works so that sound and inclusive scientific information is utilized in decision-making.

关键词： Ecosystem services social-ecological systems heterogeneity landcover,pluralistic deliberative

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景观生态学:生态系统的空间异质性

生态学杂志 1999年第6期18卷 71-74页

作者： S.T.A.pickett m.L.Cadanasso Theinstitute of Ecosystems Studies Box ABMillbrookNY12545-0129USA

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经理人审计终极风险管理工具

毛管压力与pickett图一体化确定流动单元和储集层

丛书名：北京国家会计学院现代内部审计经典系列

2007年

作者：（英）K H. 斯宾塞·皮克特（K. H. Spencer pickett）（英）詹尼弗·m. 皮克特李秀莲曾嵘译

本书内容包括：为什么要审计？、广义的治理范畴、基本的风险概念、不同的审计方式、经理人的初步审计等。

ISBN: (数字)9787801697073

ISBN: (纸本)7801697073

本书内容包括：为什么要审计？、广义的治理范畴、基本的风险概念、不同的审计方式、经理人的初步审计等。

关键词：经济经济计划与管理审计

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国外油气地质信息 2003年第3期 98-104页

作者： r．Aguilera m．S．Aguilera 焦巧平杨艳凤唐红

本文介绍了如何在pickett图上绘出毛管压力常数、传输速度、孔喉半径以及自由水面以上高度线。综合利用这些属性可确定流动单元和储集层，并阐明了地质学、岩石物理学和油藏工程问的重要关系。流动(或水力)单元与储集层的概念在过去几... 详细信息

本文介绍了如何在pickett图上绘出毛管压力常数、传输速度、孔喉半径以及自由水面以上高度线。综合利用这些属性可确定流动单元和储集层，并阐明了地质学、岩石物理学和油藏工程问的重要关系。流动(或水力)单元与储集层的概念在过去几年里已相当成功地用于石油工业中，并取得了丰硕的成果。传输速度K／φ可用于许多确定流动单元的实例中。井问流动单元的关系有助于确定储集层和预测储层性能。研究表明，对传输速度K／φ为常数的地层，有效孔隙度与真电阻率的pickett交汇图为一系列相互平行的直线。直线的斜率与孔隙度指数m、含水饱和度指数n、和绝对渗透率方程中的常数有关。通过这些直线，可直接确定每一类流动单元在任意含水饱和度下的毛细管压力和孔喉半径。含水饱和度65％时的孔喉半径与Winland的r35值有很好的对应关系。以前发表的文献中没公开发表过此方法。画出K／φ常数曲线，可在pickett图上绘出完整的毛细管压力曲线，包括束缚水饱和度和非束缚水饱和度的区域。以前用于确定给定层段绝对渗透率的经验方法是假设含水饱和度为束缚水饱和度。本文介绍了一种确定绝对渗透率的方法，它适用于层段含可动水的情况。我们通过Cdorado东南部Sorrento地区的morrow砂岩资料和Dokoto北部Little Knife地区mission Canyon组的碳酸盐岩资料为例说明此技术的应用情况。我们认为，流动单元可通过单对数坐标的pickett图、毛细管压力、孔喉半径和Winland r35值一体化确定。

关键词：流动单元孔喉毛管压力储集层含水饱和度渗透率毛细管压力束缚水饱和度交汇地质学

用自然电位和电阻率测井曲线联合模拟和反演的方法估算地层水电阻率和阿尔奇胶结指数

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测井与射孔 2008年第1期11卷 48-55页

作者： Jesus m．Salazar 朱坤（译）不详中国石油大学北京

对地层水饱和度的了解是估算地层中原油的关键。另外，精确地估算渗透率对射孔层段、流体注入层段的选取以及预测产能都非常必要。当岩心测量可用时，对这两个岩石物理参数进行可靠性评估是可能的。然而，这样的测量总不可行，并且倘若... 详细信息

对地层水饱和度的了解是估算地层中原油的关键。另外，精确地估算渗透率对射孔层段、流体注入层段的选取以及预测产能都非常必要。当岩心测量可用时，对这两个岩石物理参数进行可靠性评估是可能的。然而，这样的测量总不可行，并且倘若可行的话，它们的可信度有时也令人质疑。本文描述了一种用来估算地层水电阻率（rw）和阿尔奇胶结指数（m）的新的反演方法。即在水层中联合使用裸眼井原始阵列感应电阻率测量和自然电位（SP）测井。在侵入剖面类似活塞的前提下，进行电阻率和自然电位测量结果的联合反演。在这样做的过程中，储集层被分成岩石物理层来说明地层纵向非均质性。反演结果为侵入地层和原始地层电阻率、侵入半径以及静自然电位（SSP）的值。通过假设薄膜和扩散电位是SSP的主要贡献者来预测地层水电阻率。阿尔奇或者双水公式使得对m值的估计成为可能。对于在碎屑地层中采集到的两组数据集，我们成功地应用了此联合预测方法。一组数据对应为高渗透率、低含盐浓度地层。第二组则为高渗透率、高含盐浓度地层。反演出的rw和m值与从pickett图中获得的值是一致的，由此则确认了预测的可信度。这些值被用来估算含油气地层的含水饱和度。对地层水饱和度的精确估算容许我们应用泥浆滤液侵入的物理特性来预测渗透率。通过逐步修正渗透率值和进行多重泥浆滤液反演模拟，我们匹配裸眼井电阻率测量结果，进而获得对绝对渗透率的预测。相对于大多数有希望层段中的初始估计，纵向非均质地层中预测出的渗透率值有所增加（在25％～85％之间）。本文中描述的方法对探井和评价井中（这里的岩心测量值可能不可用）的岩石物理分析是一种有效的方法。

关键词：自然电位电阻率模拟和反演地层水电阻率阿尔奇胶结指数

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钻井证实了雷达测绘的大气渗漏异常

国外石油动态 2007年第2期 16-21页

作者： Thomas C．Bailey James m．Grubb 高贵生（译）

本文将讨论三类大气渗漏异常（ASA）。pickett’s ridge是个随着生产而消失的始新世Yegua（8，500英尺）大气渗漏异常区，反映了地下聚集变化的相对情况。

关键词：异常区渗漏大气测绘雷达钻井始新世聚集