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Vitamin E ameliorates aflatoxin-induced biochemical changes in the testis of mice

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Asian journal of Andrology 2001年第4期3卷 305-309页

作者： r.j.verma Anita Nair Department of Zoology University School of Sciences Gujarat University Ahmedabad-380 009 IndiaDepartment of Zoology University School of Sciences Gujarat University Ahmedabad-380 009 India

Aim: To assess the effect of aflatoxin on biochemical changes in the testis of mice and the possibility of ameliorationby vitamin E treatment. Methods: Adult male albino mice were orally administered with 25 or 50μg of aflatoxin/animal/day (750 or 1500 μg/kg body weight) for 45 days. The testis was isolated and processed for biochemical anal-ysis. results; There was a significant, dose-dependent reduction in DNA, rNA, protein, sialic acid contents andthe activities of succinic dehydrogenase, adenosine triphosphatase and alkaline phosphatase in the testis of aflatoxin-treated mice as compared to the vehicle control. However, the acid phosphatase activity was significantly increased inthe aflatoxin-treated mice. Vitamin E (2 mg/animal/day) treatment significantly ameliorated the aflatoxin-inducedchanges, except the acid and alkaline phosphatase activities in the high dose group. Conclusion; Vitamin E treat-ment ameliorates the aflatoxin-induced changes in the testis of mice. (Asian j Androl 2001 Dec; 3: 305 - 309)

关键词： aflatoxin vitamin E testis biochemical changes

Arsenic toxicity in mice and its possible amelioration

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journal of Environmental Sciences 2004年第3期16卷 447-453页

作者： r.j.verma Archana Vasu Abdul Alim Saiyed Department of Zoology Department of ZoologyDepartment of Zoology University School of SciencesGujarat UniversityAhmedabad 380009IndiaUniversity School of SciencesGujarat UniversityAhmedabad 380009IndiaUniversity School of SciencesGujarat UniversityAhmedabad 380009India

Oral administration of arsenic trioxide(3 and 6 mg/kg body weight/d) for 30 d caused, as compared with vehicle control, dose dependent significant reductions in body weight, absolute weight, protein, glycogen, as well as, total, dehydro and reduced ascorbic acid contents both in the liver and kidney of arsenic treated mice. Succinic dehydrogenase(SDH) and phosphorylase only in the liver activities were significantly reduced in a dose dependent manner. Acid phosphatase activity was significantly decreased in the liver of low dose arsenic treated animals; however, significant rise in its activity was observed in high dose group. As compared with vehicle control, treatment also caused significant dose dependent reductions in SDH, alkaline phosphatase and acid phosphatase activities in the kidney of mice. Vitamin E cotreatment as well as, 30 d withdrawal of arsenic trioxide treatment with or without vitamin E caused significant amelioration in arsenic induced toxicity in mice. Administration of vitamin E during withdrawal of treatment also caused significant amelioration as compared from only withdrawal of the treatment. It is concluded that vitamin E ameliorates arsenic induced toxicities in the liver and kidney of mice.

关键词： arsenic toxicity mice oral administration amelioration

Effect of papaya seed extract on microenvironment of cauda epididymis

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Asian journal of Andrology 2001年第2期3卷 143-146页

作者： r.j.verma N.j.Chinoy Department of Zoology University School of Sciences Gujarat University Ahmedabad 380009 IndiaDepartment of Zoology University School of Sciences Gujarat University Ahmedabad 380009 India

Aim: To evaluate the effect of aqueous Carica papaya seed extract on microenvironment of cauda ***: Adult male albino rats were intramuscularly administered with 0 (control) or 0.5 mg papaya seed ex-tract/kg body weight for 7 days. Cauda epididymal tubular content was collected by micropuncture technique; epididy-mal luminal fluid and sperm pellets were separately analyzed. results: The results revealed that the extract treat-ment caused significant reduction, as compared with control, in total protein and sialic acid contents in both epididymalfluid and sperm pellet. As compared with control, significantly lowered acid phosphatase activity was recorded in spermpellet but was higher in epididymal fluid after the treatment. The extract treatment also caused significant reduction inlevel of inorganic phosphorus in the epididymal fluid. Conclusion: It is concluded that the aqueous papaya seed ex-tract alters cauda epididymal microenvironment.

关键词： Carica papaya microenvironment epididymis spermatozoa protein sialic acid

Surface Modification Aspects for Improving Biomedical Properties in Implants:A review

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 213-241页

作者： j.Sharath Kumar rakesh Kumar rajeev verma Industrial and Production Department Dr B R Ambedkar National Institute of Technology JalandharJalandharPunjab144008India

The primary focus during surgery is to ensure successful implantation by achieving long-term and stable fixation of *** surgery is now more focused on the development of novel biomaterials intended to improve implant *** obtain a better understanding of metal implants,this article investigated the causes of material failures in certain cases and analysed a few case *** interaction between the implant and bone tissue was a crucial aspect of successful implantation,and this study explored the factors influencing this interaction as well as ways to improve *** modern approaches used for modifying implant surfaces were systematically illustrated and briefly *** spray coatings were often favoured because of their wide range of coating materials,but other substantial surface modifications(such as friction stir processing and laser surface texturing)were also used for a selection of ***,implant surfaces with desirable features,such as biocompatibility,antibacterial properties,corrosion resistance,and wear resistance,were essential for optimising implant *** systematic review's main aim is to provide exhaustive reference information and a broad overview to advance the production and design of orthopaedic implants.

关键词： Biomaterials Surface treatments Thermal spray coatings Antibacterial Biocompatibility Corrosion resistance Wear resistance

Facial Expression recognition with High response-Based Local Directional Pattern (Hr-LDP) Network

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Computers, Materials & Continua 2024年第2期78卷 2067-2086页

作者： Sherly Alphonse Harshit verma School of Computer Science and Engineering Vellore Institute of TechnologyChennaiIndia

Although lots of research has been done in recognizing facial expressions,there is still a need to increase the accuracy of facial expression recognition,particularly under uncontrolled *** use of Local Directional Patterns(LDP),which has good characteristics for emotion detection has yielded encouraging *** innova-tive end-to-end learnable High response-based Local Directional Pattern(Hr-LDP)network for facial emotion recognition is implemented by employing fixed convolutional filters in the proposed *** combining learnable convolutional layers with fixed-parameter Hr-LDP layers made up of eight Kirsch filters and derivable simulated gate functions,this network considerably minimizes the number of network *** cost of the parameters in our fully linked layers is up to 64 times lesser than those in currently used deep learning-based detection *** seven well-known databases,including jAFFE,CK+,MMI,SFEW,OULU-CASIA and MUG,the recognition rates for seven-class facial expression recognition are 99.36%,99.2%,97.8%,60.4%,91.1%and 90.1%,*** results demonstrate the advantage of the proposed work over cutting-edge techniques.

关键词： Emotion classification CNN network Hr-LDP

Fuzzy computational study on the generalized fractional smoking model with caputo gH-type derivatives

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International journal of Biomathematics 2024年第4期17卷 151-194页

作者： Lalchand verma ramakanta Mehert Department of Mathematics&Humanities S.V.National Institute of Technology Surat-395007India

This work considers a generalized fuzzy fractional smoking model with Caputo gHtypes fractional derivatives upon considering the case of uncertainty *** disease-free equilibrium point and stability of the equilibrium point have been discussed for the fuzzy nonlinear fractional smoking *** analytical proofs for the existence and uniqueness of the proposed model are concerned with the help of the fixed-point theorem,Banach contraction,and Schauder theorem.A robust double parametric approach with a generalized transform is used to study the behavior of the fuzzy fractional model in an uncertain context and obtain the convergence analysis of the study in a crisp ***,the obtained results of the proposed model have been validated with the runge-Kutta method of fourth order in crisp case(s=1,l=O).

关键词： Caputo fractional derivative triangular fuzzy number smoking model q-HAShTM convergence analysis

Dynamics of some new solutions to the coupled DSW equations traveling horizontally on the seabed

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journal of Ocean Engineering and Science 2024年第2期9卷 154-163页

作者： raj Kumar ravi Shankar verma Department of Mathematics Faculty of Engineering&TechnologyVeer Bahadur Singh Purvanchal UniversityJaunpur 222003India

The system of(1+1)-coupled Drinfel’d-Sokolov-Wilson equations describes the surface gravity waves travelling horizontally on the *** objective of the present research is to construct a new variety of analytical solutions for the *** invariants are derived with the aid of Killing form by using the optimal algebra classification via Lie symmetry *** invariant solutions involve time,space variables,and arbitrary *** adequate constraints on arbitrary constants,solutions are represented graphically to make them more applicable in designing sea *** behavior of solutions shows asymptotic,bell-shaped,bright and dark soliton,bright soliton,parabolic,bright and kink,kink,and periodic *** constructed results are novel as the reported results[26,28,29,30,33,38,42,49]can be deduced from the results derived in this *** remaining solutions derived in this study,are absolutely different from the earlier *** this study,the physical character of analytical solutions of the system could aid coastal engineers in creating models of beaches and ports.

关键词： Coupled Drinfel’d-Sokolov-Wilson model Invariants Killing form Optimal sub algebra Lie symmetry reductions

Evaluation of slope stability through rock mass classification and kinematic analysis of some major slopes along NH-1A from ramban to Banihal, North Western Himalayas

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journal of rock Mechanics and Geotechnical Engineering 2024年第1期16卷 167-182页

作者： Amit jaiswal A.K.verma T.N.Singh Department of Civil and Environmental Engineering Indian Institute of Technology PatnaPatna801106India

The network of Himalayan roadways and highways connects some remote regions of valleys or hill slopes,which is vital for India’s socio-economic *** to natural and artificial factors,frequency of slope instabilities along the networks has been increasing over last few *** of stability of natural and artificial slopes due to construction of these connecting road networks is significant in safely executing these roads throughout the *** rock mass classification methods are generally used to assess the strength and deformability of rock *** study assesses slope stability along the NH-1A of ramban district of North Western *** structurally and non-structurally controlled rock mass classification systems have been applied to assess the stability conditions of 14 *** evaluating the stability of these slopes,kinematic analysis was performed along with geological strength index(GSI),rock mass rating(rMr),continuous slope mass rating(CoSMr),slope mass rating(SMr),and Q-slope in the present *** SMr gives three slopes as completely unstable while CoSMr suggests four slopes as completely *** stability of all slopes was also analyzed using a design chart under dynamic and static conditions by slope stability rating(SSr)for the factor of safety(FoS)of 1.2 and 1 respectively.Q-slope with probability of failure(PoF)1%gives two slopes as stable *** slope angle has been determined based on the Q-slope safe angle equation and SSr design chart based on the *** value ranges given by different empirical classifications were rMr(37-74),GSI(27.3-58.5),SMr(11-59),and CoSMr(3.39-74.56).Good relationship was found among rMr&SSr and rMr&GSI with correlation coefficient(r 2)value of 0.815 and 0.6866,***,a comparative stability of all these slopes based on the above classification has been performed to identify the most critical slope along this road.

关键词： rock mass classification Kinematic analysis Slope stability Himalayan road Static and dynamic conditions

Advancements in nanotechnology for the delivery of phytochemicals

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journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： Divya Chauhan Pavan K.Yadav Nazneen Sultana Arun Agarwal Saurabh verma Manish K.Chourasia jiaur r.Gayen Division of Pharmaceutics and Pharmacokinetics Central Drug Research InstituteCouncil of Scientific and Industrial ResearchLucknow 226031Uttar PradeshIndia Academy of Scientific and Innovative research Ghaziabad 201002Uttar PradeshIndia

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Phytochemical Bioavailability Drug delivery system Phytosome Plant extracts