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Proteins as nanomagnets and magnetoreceptors

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Zoological research 2024年第4期45卷 831-832页

作者： P.j.Hore Department of Chemistry University of OxfordUK

It is an appealing notion that a protein molecule could act as a nanomagnet.A genetically encodable biomolecule with a permanent magnetic moment at room temperature could have a range of applications:a magnetogenetic actuator,a magnetic tag for purifying and immobilizing enzymes,a contrast agent for magnetic resonance imaging,and a basis for a biomimetic magnetic sensing device,to name just a few.A magnetic protein could perhaps also function as the sensor in the magnetic compass that enables small songbirds to navigate the huge distances between their breeding and wintering *** though such possibilities may be,how realistic are they?

关键词： magnetic magnets enable

Surface engineering with ionic polymers on membranes for boron removal

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 61-69页

作者： Xiting Zhang Chenyi Fang j Paul Chen Sui Zhang Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117576Singapore Department of Civil and Environmental Engineering National University of SingaporeSingapore 119260Singapore College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

removal of boric acid from seawater and wastewater using reverse osmosis membrane technologies is imperative and yet remains inadequately addressed by current commercial *** research efforts performed post-modification of reverse osmosis membranes to enhance boron rejection,which is usually accompanied by substantial sacrifice in water *** study delves into the surface engineering of low-pressure reverse osmosis membranes,aiming to elevate boron removal efficiency while maintaining optimal salt rejection and water *** were modified by the self-polymerization and co-deposition of dopamine and polystyrene sulfonate at varying ratios and *** surfaces became smoother and more hydrophilic after *** optimum membrane exhibited a water permeability of 9.2±0.1 L·m^(-2)·h^(-1)·bar^(-1),NaCl rejection of 95.8%±0.3%,and boron rejection of 49.7%±0.1% and 99.6%±0.3% at neutral and alkaline pH,*** water permeability is reduced by less than 15%,while the boron rejection is 3.7 times higher compared to the blank *** research provides a promising avenue for enhancing boron removal in reverse osmosis membranes and addressing water quality concerns in the desalination process.

关键词： membrane low-pressure reverse osmosis boron surface engineering

removal of As(V)in the presence of Cr(VI)in contaminated water from the Bajio region of Mexico using ferrihydrite-functionalized graphene oxide(GOFH):A case study

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Emerging Contaminants 2024年第3期10卷 134-144页

作者： D.r.joya-Cardenas j.P.rodríguez-Caicedo M.A.Corona-rivera N.Saldana-robles C.E.Damian-Ascencio A.Saldana-robles Graduate Program in Biosciences University of GuanajuatoIrapuato36500Mexico Facultad de Ingenierías y Tecnologías Instituto XeriraUniversidad de SantanderBucaramanga680003Colombia Chemical Engineering Unit Academic Multidisciplinary Region Altiplano UAMRA.Autonomous University of San Luis PotosíMatehualaSan Luis Potosí78000Mexico Department of Agricultural Engineering University of GuanajuatoIrapuato36500Mexico Department of Mechanical Engineering University of GuanajuatoSalamanca36800Mexico Mechanical Engineering Department Virginia TechBlacksburgVA24061USA

The presence of heavy metals such as arsenic(As)and chromium(Cr)can be considered one of the most toxic heavy *** study aims to develop and evaluate a graphene oxide(GO)based material functionalized with ferrihydrite for the removal of As(V)in the presence of Cr(VI).The adsorbent ferrihydrite-functionalized graphene oxide(GOFH)was characterized by SEM,FTIr,XrD,XPS,surface charge,BET and *** adsorption capacities for As(V)and Cr(VI)were 160 and 66 mg g^(-1)respectively at pH 4 and 298 K,fitting the Langmuir *** binary systems,GOFH adsorbed As(V)with an adsorption capacity of 137 mg g^(-1)in the presence of 20 mg L^(-1)Cr(VI)at room *** analysis revealed an exothermic and spontaneous ***,GOFH effectively removed several coexisting anions from groundwater,including SO_(4)^(2-),CO_(3)^(2-)and Cl^(-).This work evidences the potential of GOFH for competitive adsorption of priority pollutants from complex *** GOFH material represents a technically and economically viable technology for application in groundwater decontamination,as it requires inexpensive precursors and ambient conditions during synthesis and operation.

关键词： Competition Ions Contamination Groundwater Adsorption capacity

Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

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Family Medicine and Community Health 2024年第S3期12卷 43-51页

作者： William B Ventres Leslie A Stone johanna F Shapiro Cynthia Haq jéssica r B Leao Donald E Nease jr Liz Grant Stewart W Mercer john C M Gillies Pablo González Blasco Maria Auxiliadora C De Benedetto Graziela Moreto Marcelo r Levites jennifer E DeVoe William r Phillips jane M Uygur Thomas r Egnew Colette S Stanley Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of Medicine University of Sao PauloSao PauloBrazil Family Medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOBrAMFA-Medical Education and Humanism Sao PauloBrazil Family Medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family Medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal Medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family Medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘reflective practice in action’,‘The doctor as drug—Balint groups’,‘Cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’May readers feel a deeper sense of their own therapeutic agency by reflecting on these essays.

关键词： illustration dimensions suffering

Bivariate Analysis of Pollutants Monthly Maxima in Mexico City Using Extreme Value Distributions and Copula

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journal of Environmental Protection 2024年第7期15卷 796-826页

作者： juan A. Vazquez-Morales Eliane r. rodrigues Hortensia j. reyes-Cervantes Facultad de Ciencias Fsico-Matemticas Benemrita Universidad Autnoma de Puebla Puebla Mexico Instituto de Matemticas Universidad Nacional Autnoma de Mxico Mexico City Mexico

In the present work, we are interested in studying the joint distributions of pairs of the monthly maxima of the pollutants used by the environmental authorities in Mexico City to classify the air quality in the metropolitan area. In order to obtain the joint distributions a copula will be considered. Since we are analyzing the monthly maxima, the extreme value distributions of Weibull and Fréchet are taken into account. Using these two distributions as marginal distributions in the copula a Bayesian inference was made in order to estimate the parameters of both distributions and also the association parameters appearing in the copula model. The pollutants taken into account are ozone, nitrogen dioxide, sulphur dioxide, carbon monoxide, and particulate matter with diameters smaller than 10 and 2.5 microns obtained from the Mexico City monitoring network. The estimation was performed by taking samples of the parameters generated through a Markov chain Monte Carlo algorithm implemented using the software OpenBugs. Once the algorithm is implemented it is applied to the pairs of pollutants where one of the coordinates of the pair is ozone and the other varies on the set of the remaining pollutants. Depending on the pollutant and the region where they were collected, different results were obtained. Hence, in some cases we have that the best model is that where we have a Fréchet distribution as the marginal distribution for the measurements of both pollutants and in others the most suitable model is the one assuming a Fréchet for ozone and a Weibull for the other pollutant. results show that, in the present case, the estimated association parameter is a good representation to the correlation parameters between the pair of pollutants analyzed. Additionally, it is a straightforward task to obtain these correlation parameters from the corresponding association parameters.

关键词： Copula Extreme Value Distribution Bayesian Inference Air Pollution Mexico City

Harnessing naturally occurring mutations for T-cell therapy:a potential new avenue to enhance treatment efficacy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1799-1801页

作者： Michael Hiltensperger jürgen ruland Kilian Schober Mikrobiologisches Institut-Klinische Mikrobiologie Immunologie und HygieneFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany Institute of Clinical Chemistry and Pathobiochemistry School of MedicineTechnical University of MunichMunichGermany TranslaTUM Center for Translational Cancer ResearchTechnical University of MunichMunichGermany German Cancer Consortium(DKTK) HeidelbergGermany German Center for Infection research(DZIF) partner site MunichMunichGermany FAU Profile Center Immunomedicine Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

In a recent study published in Nature,Garcia et *** a sophisticated approach to identify fitness-enhancing mutations for T cells that was inspired by cancer evolution.1 The identified CArD11-PIK3r3 gene fusion enhanced tumor rejection and persistence of engineered T cells in multiple tumor models and might have the potential to improve efficacy of adoptive T-cell therapies in cancer patients.

关键词： cancer potential

Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma

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Neural regeneration research 2024年第8期19卷 1637-1638页

作者： Pete A.Williams robert j.Casson Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden Ophthalmic research Laboratories Discipline of Ophthalmology and Visual SciencesUniversity of AdelaideAdelaideAustralia

Vision is arguably our most valued sense,yet approximately 340 million people globally suffer blindness or moderate visual impairment,highlighting the need to further develop and advance treatments for ophthalmic *** refers to a group of ocular disorders united by a clinically characteristic optic neuropathy with associated retinal ganglion cell loss.

关键词： metabolism glaucoma globally

The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring

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Neural regeneration research 2024年第2期19卷 399-400页

作者： Emilio j.Galván Angelica Zepeda Departamento de Farmacobiología CINVESTAV Unidad Sur CdMxMéxico、Centro de Investigaciones sobre el EnvejecimientoCIE-CinvestavCdMxMéxico Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoUNAMCdMxMéxico

Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.

关键词： prevalence activation impact

Optimizing pain management in elderly patients post-knee surgery:A novel collaborative strategy

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World journal of Clinical Cases 2024年第15期12卷 2475-2478页

作者： Abdulqadir j Nashwan Department of Nursing Hamad Medical CorporationDoha 3050Qatar

Total knee replacement,a common surgery among the elderly primarily necessitated by osteoarthritis,replaces the damaged knee joint with an artificial *** the aging population and the increasing prevalence of such surgeries,the article highlights the critical need for effective postoperative care *** editorial provides an overview of rehabilitation care for pain in elderly knee replacement patients,emphasizing the importance of a multimodal approach to postoperative ***,the article advocates for a patient-centered,comprehensive rehabilitation regimen that enhances recovery and quality of life in elderly patients undergoing knee replacement surgery.

关键词： Elderly Postoperative pain management rehabilitation care Multimodal pain strategy Total knee arthroplasty Enhanced recovery after surgery