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Primary intestinal lymphangiectasia in an adult patient:A case report and review of literature

World Journal of Gastroenterology 2020年第48期26卷 7707-7718页

作者： rudolf huber Georg Semmler Alexander Mayr Felix Offner Christian Datz Department of Internal Medicine General Hospital OberndorfTeaching Hospital of the Paracelsus Medical University SalzburgOberndorf 5110Austria Department of Pathology General Hospital FeldkirchFeldkirch 6800Austria

BACKGrOUND Primary intestinal lymphangiectasia(PIL),first described in 1961,is a rare disorder of unknown etiology resulting in protein-losing *** disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia,hypogammaglobulinemia,and *** the severity and location of lymph vessels being affected can vary considerably,the range of associated symptoms is wide from mild lower-limb edema to generalized edema,abdominal and/or pleural effusion,and recurrent diarrhea,among *** usually developing in early childhood,we present the case of a 34-yearold woman with ***,we performed a literature review systematically assessing clinical presentation,and provide a practical approach to facilitate diagnosis and therapy of PIL in *** SUMMArY Our patient presented with unspecific symptoms of abdominal discomfort,fatigue,nausea,and recurrent edema of the lower ***,a striking collinearity of clinical symptoms with female hormone status was ***,polyglobulia,hypoalbuminemia,hypogammaglobulinemia,and transient lymphocytopenia were *** to suspicion of a bone marrow disease,an extensive diagnostic investigation was carried out excluding secondary causes of polyglobulinemia and *** diagnosis of primary intestinal lymphangiectasia was established after 22 wk by histological analysis of biopsy samples obtained via ***,the patient was put on a high-protein and low-fat diet with medium-chain triglycerides supplementation leading to significant improvement of clinical symptoms until 2 years of *** PIL can be the reason for cryptogenic hypoalbuminemia,hypogammaglobulinemia,and lymphopenia in *** to difficulty in correct diagnosis,treatment initiation is often delayed despite being effective and *** leads to a significant disease burden in affected *** is increasingly been

关键词： Primary intestinal lymphangiectasia Waldmann´s disease Protein losing enteropathy Hypoproteinemia Case report

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The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4523-4534页

作者： rebecca r.Florke Gee Andrew D.huber Jing Wu richa Bajpai Allister J.Loughran Shondra M.Pruett-Miller Taosheng Chen Department of Chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Graduate School of Biomedical Sciences St.Jude Children's Research HospitalMemphisTN 38105USA Center for Advanced Genome Engineering and Department of Cell and Molecular Biology St.Jude Children's Research HospitalMemphisTN 38105USA

Pregnane X receptor(PXr)is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes[e.g.,cytochrome P4503A4(CYP3A4)]and *** the regulation of PXr target genes is well-characterized,less is known about the regulation of PXr protein *** screening an rNAi library,we identified the F-box-only protein 44(FBXO44)as a novel E3ligase for *** abundance increases upon knockdown of FBXO44,and,inversely,decreases upon overexpression of *** analysis revealed that FBXO44 interacts with PXr,leading to its ubiquitination and proteasomal degradation,and we determined that the F-box associated domain of FBXO44 and the ligand binding domain of PXr are required for the functional *** summary,FBXO44 regulates PXr protein abundance,which has downstream consequences for CYP3A4 levels and drug-drug *** results of this study provide new insight into the molecular mechanisms that regulate PXr protein level and activity and suggest the importance of considering how modulating E3ubiquitin ligase activities will affect PXr-mediated drug metabolism.

关键词： PXr FBXO44 Ubiquitination Proteasomal degradation CYP3A4 Drug-drug interactions E3 ligase Nuclear receptor

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ATHLET程序的钠冷快堆应用扩展及其验证

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原子能科学技术 2013年第11期47卷 2053-2058页

作者：周翀 Klaus huber 程旭上海交通大学核科学与工程学院上海200240 卡尔斯鲁厄理工大学聚变与反应堆技术研究所德国卡尔斯鲁厄76131

系统分析程序是对钠冷快堆的冷却剂回路系统进行全局模拟、瞬态及事故安全分析的重要工具。本工作对德国核设施与反应堆安全机构(GrS)开发的轻水堆最佳估算系统程序ATHLET进行修改,增加了钠的物性公式和传热关系式,将其适用范围扩展到... 详细信息

系统分析程序是对钠冷快堆的冷却剂回路系统进行全局模拟、瞬态及事故安全分析的重要工具。本工作对德国核设施与反应堆安全机构(GrS)开发的轻水堆最佳估算系统程序ATHLET进行修改,增加了钠的物性公式和传热关系式,将其适用范围扩展到钠冷快堆。为验证修改过的ATHLET程序,对法国凤凰(Phenix)反应堆系统建模,并对其自然对流实验进行模拟,将计算结果与实验数据进行比较。结果显示,ATHLET程序的钠冷快堆应用扩展具有良好的适用性。

关键词：钠冷快堆 ATHLET程序自然对流

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A story like ours

A story like ours

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作者： robin huber.

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： r.A.JAFArI-TALOOKOLAEI H.GHANDVAr E.JUMAEV S.KHATIr T.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Prostate cancer screening： and yet it moves!

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Asian Journal of Andrology 2015年第3期17卷 437-438页

作者： Maciej Kwiatkowski Marco randazzo Luis Kluth Lukas Manka Andreas huber Franz recker Department of Urology Cantonal Hospital Aarau Switzerland Department of Urology Academic Hospital Braunschweig Germany Department of Laboratory Medicine Cantonal Hospital Aarau Switzerland

The debate of prostate cancer （PCa） screening has been shaped over decades. There is a plethora of articles in the literature supporting as well as declining prostate-specific antigen （PSA） screening. Does screening decrease PCa mortality？ With the long-term results of the European randomized Study of Screening for Prostate （ErSPC） the answer is clearly YES. It moves! However, in medicine there are no benefits without any harm and thus, screening has to be performed in targeted and smart way-or in other words^in a risk-adapted fashion when compared with the way it was done in the past. Here, we discuss the main findings of the ErSPC trials and provide insights on how the future screening strategies should be implemented.

关键词： @@

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Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural regeneration research 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy Z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy Zeal Pathak Dale r.Sengelaub George D.Bittner Department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

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Development of a field enhanced photocatalytic device for biocide of coliform bacteria

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Journal of Environmental Sciences 2016年第6期28卷 38-44页

作者： Jeff M.huber Krista L.Carlson Otakuye Conroy-Ben Mano Misra Swomitra K.Mohanty Departments of Civil Engineering University of Utah Departments of Metallurgical Engineering University of Utah Departments of Chemical Engineering University of Utah

A field enhanced flow reactor using bias assisted photocatalysis was developed for bacterial disinfection in lab-synthesized and natural waters. The reactor provided complete inactivation of contaminated waters with flow rates of 50 mL/min. The device consisted of titanium dioxide nanotube arrays, with an externally applied bias of up to 6 V. Light intensity, applied voltage, background electrolytes and bacteria concentration were all found to impact the device performance. Complete inactivation of Escherichia coli W3110（- 8 × 10^3CFU/mL） occurred in 15 sec in the reactor irradiated at 25 mW/cm^2 with an applied voltage of 4 V in a 100 ppm NaCl solution. real world testing was conducted using source water from Emigration Creek in Salt Lake City, Utah. Disinfection of natural creek water proved more challenging, providing complete bacterial inactivation after 25 sec at 6 V. A reduction in bactericidal efficacy was attributed to the presence of inorganic and organic species, as well as the increase in robustness of natural bacteria.

关键词： Titanium dioxide Nanotubes Immobilized Photocatalysis Escherichia coli Inactivation

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Studies of Optical Dephasing in Inorganic Glasses by Bill YEN and His Students and Colleagues——An Informal History

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发光学报 2008年第4期29卷 617-621页

作者： David huber Department of Physics University of Wisconsin-Madison

This note is a brief,informal account of Bill Yen's pioneering investigations of optical dephasing in inorganic *** work,carried out at the University of Wisconsin by Bill,together with his graduate students,post-docs and colleagues,had great impact on the field and led directly to our current understanding of the various mechanisms for dephasing and how they are reflected in the temperature dependence of the homogeneous linewidth.

关键词：无机玻璃光学移相光学分析研究过程

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal Michele L Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

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