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Millimetric devices for nerve stimulation:a promising path towards miniaturization

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Neural regeneration research 2024年第8期19卷 1702-1706页

作者： ryan M.Dorrian Anna v.Leonard Antonio Lauto Spinal Cord Injury research Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerve stimulation is a rapidly developing field,demonstrating positive outcomes across several *** potential benefits,current nerve stimulation devices are large,complicated,and are powered via implanted pulse *** facto rs necessitate invasive surgical implantation and limit potential *** nerve stimulation devices to millimetric sizes would make these interventions less invasive and facilitate broader therapeutic ***,device miniaturization presents a serious engineering *** review presents significant advancements from several groups that have overcome this challenge and developed millimetricsized nerve stimulation *** are based on antennas,mini-coils,magneto-electric and optoelectronic materials,or receive ultrasound *** highlight key design elements,findings from pilot studies,and present several considerations for future applications of these devices.

关键词： biomedical engineering deep brain stimulation electrical engineering electrical stimulation neuromodulation peripheral nerve stimulation

Effects of temperature on the mechanical properties of Ti6Al4v powder compacts prepared by magnetic pulse compaction

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rare Metals 2010年第3期29卷 302-307页

作者： LI mini YU Haiping LI Chunfeng School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

The effects of temperature （0-500°C） on the compressive strength,hardness,average relative density,and microstructure of Ti6Al4v powder green compacts prepared by magnetic pulse compaction were *** results show that with increasing heating temperature,the compressive strength first increases and then decreases with the maximum value of 976.74 Mpa at 400°*** average relative density and hardness constantly increase,and their values reach 96.11% and HrA 69.8 at 500°C,*** increase of partial welding is found among the junctions of particles inside the compacts; there is no obvious grain growth inside the compacts within the temperature range.

关键词： powder metallurgy powder compaction magnetic pulse compaction heating temperature relative density electromagnetic forming

KOH activated carbon derived from biomass-banana fibers as an efficient negative electrode in high performance asymmetric supercapacitor

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Journal of Energy Chemistry 2017年第1期26卷 56-62页

作者： ChaitraK vinny r T Sivaraman p Narendra reddy Chunyan Hu Krishna venkatesh vivek C S Nagaraju N Kathyayini N Department of Nanobiosciences Centre for Emerging TechnologiesJain Global CampusJain UniversityJakkasandra postKanakapura TalukRamanagara DistrictBangalore Rural 562112 KarnatakaIndia Naval Materials research Laboratory DRDOAmbernathThane 421506India Department of Chemistry St.Joseph’s College P.G.Centre.46Langford RoadShanthinagarBangaloreKarnataka 560027India research resource Centre Visveswaraya Technological UniversityBelagaviIndia College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China National Engineering research Center for Dyeing and Finishing of Textiles Donghua UniversityShanghai 201620China

Here we demonstrate the fabrication, electrochemical performance and application of an asymmetric supercapacitor (AS) device constructed with ss-Ni(OH)(2)/MWCNTs as positive electrode and KOH activated honeycomb-like porous carbon (K-pC) derived from banana fibers as negative electrode. Initially, the electrochemical performance of hydrothermally synthesized ss-Ni(OH)(2)/MWCNTs nanocomposite and K-pC was studied in a three-electrode system using 1 M KOH. These materials exhibited a specific capacitance (Cs) of 1327 Fig and 324 F/g respectively at a scan rate of 10 mv/s. Further, the AS device i.e., ss-Ni(OH)(2)/MWCNTs// K-pC in 1 M KOH solution, demonstrated a Cs of 156 F/g at scan rate of 10 mv/s in a broad cell voltage of 0-2.2 v. The device demonstrated a good rate capability by maintaining a Cs of 59 F/g even at high current density (25 A/g). The device also offered high energy density of 63 Wh/kg with maximum power density of 5.2 kW/kg. The AS device exhibited excellent cycle life with 100% capacitance retention at 5000th cycle at a high current density of 25 A/g. Two AS devices connected in series were employed for powering a pair of LEDs of different colors and also a mini fan. (C) 2016 Science press and Dalian Institute of Chemical physics, Chinese Academy of Sciences. published by Elsevier B.v. and Science press. All rights reserved.

关键词： Asymmetric supercapacitor device Activated porous carbon High energy density Cyclability power source

The Basic Components of Software-hardware System for Modeling and Control of the Toroidal plasma by Epsilon-Nets on Heterogeneous mini-Supercomputers

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Communications in Computational physics 2018年第6期24卷 1-26页

作者： Fedor S.Zaitsev Alexei G.Shishkin Andrei A.Lukianitsa Egor p.Suchkov Sergei v.Stepanov Fedor A.Anikeev Scientific research Institute of System Development Russian Academy of SciencesNakhimovsky prosp.26 b.1117218MoscowRussia Moscow State University Department of Computational Mathematics and CyberneticsLenin’s Hills119991MoscowRussia.

A significant step towards the comprehensive solution of the important new fundamental control problems of high-temperature plasma of toroidal configuration is made by utilizing heterogeneous mini-supercomputers of NIISI rAS(Scientific research Institute of System Development,russian Academy of Science).The basic components of hardware and software modeling system and automatic real-time plasma feedback control are developed and *** system is named HASp CS(hardware-Software plasma Control System).It is based on a fundamentally new,more accurate and reliable control algorithm using a solution with a given accuracy of a number of inverse diagnostic problems by ∈-*** possibility of an application of the proposed technique during discharge time to provide feedback control of the boundary and internal plasma parameters is *** is shown that the complex allows investigating the processes in currently operated and designed fusion devices and solving problems of fusion application for energy *** recommendations to the engineering implementation of plasma control systems are *** directions for further research are formulated.

关键词： Control problem ∈-net plasma tokamak modeling

Behavioral and physiological flexibility are used by birds to manage energy and support investment in the early stages of reproduction

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Current Zoology 2010年第6期56卷 767-792页

作者： Franois vZINA Katrina G. SALvANTE Département de Biologie chimie et géographieGroupe de recherche sur les environnements nordiques BORASUniversité du Québec à Rimouski Department of Biological Sciences Simon Fraser University

Interest in phenotypic flexibility has increased dramatically over the last decade, but flexibility during reproduction has received relatively little attention from avian scientists, despite its possible impact on fitness. Because most avian species maintain atrophied reproductive organs when not active, reproduction in birds requires major tissue remodeling in preparation for breeding. Females undergo rapid （days） recrudescence and regression of their reproductive organs at each breeding attempt, while males grow their organs ahead of time at a much slower rate （weeks） and may maintain them at maximal size throughout the breeding season. reproduction is associated with significant metabolic costs. Egg production leads to a 22%-27% increase in resting metabolic rate （rMr） over non-reproductive values. This is partly due to the activity of the oviduct, an organ that may allow females to adjust reproductive investment by modulating egg size and quality. In males, gonadal recrudescence may lead to a 30% increase in rMr, but the data are inconsistent and general conclusions regarding energetic costs of reproduction in males will require more research. recent studies on captive female zebra finches describe the impacts of these costs on daily energy budgets and highlight the strategies used by birds to maintain their investment in reproduction when energy is limited. Whenever possible, birds use behavioral flexibility as a first means of saving energy. Decreasing locomotor activity saves energy during challenges such as egg production or exposure to cold temperatures and is an efficient way to buffer variation in individual daily energy budgets. However, when behavioral flexibility is not possible, birds must rely on flexibility at the physiological level to meet energy demands. In zebra finches breeding in the cold, this results in a reduced pace of laying, likely due to down-regulation of both reproductive and non-reproductive function, allowing females to defend mini

关键词： phenotypic plasticity phenotypic flexibility BMr Energy budget Organ Egg size physiological tradeoff Fitness

A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov Natalia v.Naryzhnaya Sergey v.popov Alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming pei vyacheslav v.ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of physiology and pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/r)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

Dimensions of emotional distress among Brazilian workers in a COvID-19 reference hospital:A factor analytical study

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World Journal of psychiatry 2022年第6期12卷 843-859页

作者： Marcos O Carvalho-Alves vitor A petrilli-Mazon Andre r Brunoni Andre Malbergier pedro Fukuti Guilherme v polanczyk Euripedes C Miguel Felipe Corchs Yuan-pang Wang Department of psychiatry School of MedicineUniversity of Sao PauloSao Paulo 05403-010Brazil program in Neuroscience and Behavior Department of Experimental PsychologyInstitute of PsychologyUniversity of Sao PauloSao Paulo 01060-970Brazil Department and Institute of psychiatry University of Sao PauloSao Paulo 05403-010Brazil

BACKGrOUND The coronavirus disease 2019(COvID-19)pandemic is an unprecedented challenge for public health and has caused the loss of millions of lives *** workers play a key role in averting the collapse of the health system,but the mental health of many has deteriorated during the *** studies have been devoted to identifying the needs of workers on frontline *** To investigate dimensions of common emotional symptoms and associated predictors among Brazilian workers in a COvID-19 reference *** This is an observational study of the mental health of professionals in a COvID-19 hospital in the city of São *** invited all hospital employees to respond to an online survey between July and August 2020,during the first peak of the *** of 1000 participants who completed the survey were analyzed(83.9%were women and 34.3%were aged 30 to 40).Hospital workers selfreported the presence of symptoms of depression,anxiety,trauma-related stress,and burnout through the patient Health Questionnaire-9,the Generalized Anxiety Disorder-7,the Impact of Event Scale-revised and the mini-Z Burnout Assessment *** were assembled and subjected to exploratory factor analysis to reveal workers’core emotional *** linear regression models were subsequently carried out to estimate the likelihood of dimensions of distress using questions on personal motivation,threatening events,and institutional *** Around one in three participants in our sample scored above the threshold of depression,anxiety,post-traumatic stress disorder,and *** factor analysis revealed a three-factor structure that explained 58%of the total data *** distressing emotional domains were avoidance and re-experience,depression-anxiety,and sleep *** analysis revealed that institutional support was a significant protective factor for each of these dimensions(βrange=-0.41 to-0.20,pver,partici

关键词： COvID-19 pandemics Health personnel Mental health psychological distress Occupational medicine

Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury

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Neural regeneration research 2021年第2期16卷 357-361页

作者： rustem r.Islamov Farid v.Bashirov Mikhail E.Sokolov Andrei A.Izmailov Filip O.Fadeev vage A.Markosyan Maria A.Davleeva Olga v.Zubkova Maxim M.Smarov Denis Yu.Logunov Boris S.Naroditskyi Ilnur I.Salafutdinov Albert A.rizvanov ramil G.Turaev Kazan State Medical University KazanRussia Gamaleya research Institute of Epidemiology and Microbiology MoscowRussia Kazan Federal University KazanRussia The republican Blood Center of the ministry of Health of the republic of Tatarstan KazanRussia

We previously demonstrated that gene-modified umbilical cord blood mononuclear cells overexpressing a combination of recombinant neurotrophic factors are a promising therapeutic approach for cell-mediated gene therapy for neurodegenerative diseases,neurotrauma,and *** this study,using a mini pig model of spinal cord injury,we proposed for the first time the use of gene-modified leucoconcentrate prepared from peripheral blood in the plastic blood bag for personalized ex vivo gene *** obtained from mini pig peripheral blood was transduced with a chimeric adenoviral vector(Ad5/35 F)that carried an enhanced green fluorescent protein(EGFp)reporter gene in the plastic blood *** day after blood donation,the mini pigs were subjected to moderate SCI and four hours post-surgery they were intravenously autoinfused with gene-modified leucoconcentrate.A week after gene-modified leucoconcentrate therapy,fluorescent microscopy revealed EGFp-expressing leucocytes in spinal cord at the site of contusion *** the spleen the groups of EGFp-positive cells located in the lymphoid follicles were *** vitro flow cytometry and fluorescent microscopy studies of the gene-modified leucoconcentrate samples also confirmed the production of EGFp by ***,the efficacy of leucocytes transduction in the plastic blood bag and their migratory potential suggest their use for temporary production of recombinant biologically active molecules to correct certain pathological *** paper presents a proof-of-concept of simple,safe and effective approach for personalized ex vivo gene therapy based on gene-modified leucoconcentrate *** animal protocols were approved by the Kazan State Medical University Animal Care and Use Committee(approval No.5)on May 27,2014.

关键词： chimeric Ad5/35F virus enhanced green fluorescent protein gene-modified leucoconcentrate mini pig peripheral blood personalized ex vivo gene therapy plastic blood bag spinal cord injury

Differences between delusional disorder and schizophrenia:A mini narrative review

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World Journal of psychiatry 2022年第5期12卷 683-692页

作者： Alexandre González-rodríguez Mary v Seeman Department of Mental Health Mutua Terrassa University HospitalUniversity of BarcelonaBarcelona 08280Spain Department of psychiatry University of TorontoToronto M5P 3L6OntarioCanada

psychotic syndromes are divided into affective and non-affective *** among the non-affective forms,substantial differences *** aim of this relatively brief review is to synthesize what is known about the differences between two non-affective psychoses,schizophrenia and delusional disorder(DD),with respect to clinical,epidemiological,sociodemographic,and treatment response characteristics.A pubMed literature search revealed the following:in schizophrenia,hallucinations,negative symptoms and cognitive symptoms are *** are rare in *** to schizophrenia patients,individuals with DD maintain relatively good function,and their delusions are believable;many are beliefs that are widely held in the general *** are generally similar in these two forms of psychosis,with the exception that antidepressants are used more frequently in DD and,for acute treatment,effective antipsychotic doses are lower in DD than in *** is with the hope that the contrasts between these two conditions will aid in the provision of safe and effective treatment for both that this review has been conducted.

关键词： Non-affective psychosis Delusional disorder Schizophrenia Epidemiology Symptoms Treatment response