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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAUr.BH r.KIr.N D.sINGH r.VAIsH V.s.CHAUHAN school of Mechanical and Mater.als Engineer.ng Indian Institute of Technology Mandi

Bio-inspir.d helicoidal composite laminates, inspir.d by the intr.cate helical str.ctur.s found in natur., pr.sent a pr.mising fr.ntier.for.enhancing the mechanical pr.per.ies of str.ctur.l designs. Hence, this study pr.vides a compr.hensive investigation into the nonlinear.fr.e vibr.tion and nonlinear.bending behavior.of bio-inspir.d composite plates. The inver.e hyper.olic shear.defor.ation theor.(IHsDT) of plates is employed to char.cter.ze the displacement field, with the incor.or.tion of Gr.en-Lagr.nge nonlinear.ty. The pr.blem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB envir.nment to solve it numer.cally. Var.ous helicoidal layup configur.tions including helicoidal r.cur.ive(Hr., helicoidal exponential(HE), helicoidal semi-cir.ular.Hs), linear.helicoidal(LH), and Fibonacci helicoidal(FH)with differ.nt layup sequences and quasi-isotr.pic configur.tions ar. studied. The model is validated, and par.metr.c studies ar. conducted. These studies investigate the effects of layup configur.tions, side-to-thickness r.tio, modulus r.tios, boundar. conditions, and loading conditions at differ.nt load amplitudes on the nonlinear.vibr.tion and nonlinear.bending behavior. of bio-inspir.d composite plates. The r.sults show that the laminate sequence exer.s a substantial impact on both nonlinear.natur.l fr.quencies and nonlinear.bending behavior.. Mor.over. this influence var.es acr.ss differ.nt side-to-thickness r.tios and boundar. conditions of the bio-inspir.d composite plate.

关键词： Inver.e pr.blems

Coar.e to Fine: The r.le of sever. Plastic Defor.ation in Advancing Titanium-Based Medical Implants - A Compr.hensive r.view

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Jour.al of Wuhan Univer.ity of Technology(Mater.als science) 2025年第1期40卷 295-306页

作者： Dr.gana r.Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r.Djokić Faculty of Technology and Metallur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear.sci-ences-National Institute of the r.public of ser.ia University of Belgrade11001BeogradSerbia Innovation Centr. of the Faculty of Technology and Metallur.y Karnegijeva 411120 BelgradeSerbia

This paper.descr.bes sever. plastic defor.ation(sPD)pr.cedur.s,which ar. utilized to for. an ultr.fine-gr.ined str.ctur. in metallic *** the sPD pr.cess,a solid mater.al sample is subjected to ver. high loads without a significant change in sample *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,as one of the sPD techniques,which achieves a high degr.e of defor.ation and ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** that gr.in size contr.l is accepted as a method to obtain mater.als with desir.d char.cter.stics,an over.iew of the pr.per.ies of ultr.fine-gr.ined titanium-based biomater.als to be used in medicine is ***,par.icular.attention is dedicated to the influences of HPT pr.cess par.meter.,pr.mar.ly hydr.static pr.ssur.,and number.of r.volutions dur.ng tor.ion,on the gr.in size and physical and mechanical char.cter.stics(modulus of elasticity,micr.har.ness,and tensile pr.per.ies),cor.osion r.sistance,and biocompatibility of the titanium-based biomater.als.A r.view of the liter.tur. indicates that titanium-based mater.als obtained by the sPD pr.cess show impr.ved mechanical and physical pr.per.ies without losing biocompatibility and cor.osion r.sistance,which suggests that these methods of obtaining implants ar. something that should be fur.her.developed in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined titanium-based mater.als electr.chemical anodization physical pr.per.ies mechanical pr.per.ies

Fr.e vibr.tion and tr.nsient r.sponse of double cur.ed beams connected by inter.ediate str.ight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： r.A.JAFAr.-TALOOKOLAEI H.GHANDVAr.E.JUMAEV s.KHATIr.T.CUONG-LE school of Mechanical Engineer.ng Babol Noshirvani University of Technology Depar.ment of Mechanical Engineer.ng Faculty of Engineering New Uzbekistan University Univer.ity of Business and science Center.for.Engineer.ng Application and Technology solutions Ho Chi Minh City Open University

This paper.investigates the fr.e vibr.tion and tr.nsient r.sponse of inter.onnected str.ctur.s including double cur.ed beams and inter.ediate str.ight beams,which ar. all constr.cted fr.m functionally gr.ded por.us(FGP) mater.als. The str.in potential and kinetic ener.ies of each beam along with the wor. done by the exter.al for.e ar. calculated. Additionally, a higher.or.er.beam element is intr.duced to der.ve stiffness and mass matr.ces, along with the for.e vector. The cur.ed and str.ight beams ar. discr.tized, and their.assembled stiffness, mass matr.ces, and for.e vector., ar. *** conditions at the joints ar. used to der.ve the total matr.ces of the entir. str.ctur.. subsequently, the natur.l fr.quencies and tr.nsient r.sponse of the system ar. deter.ined. The accur.cy of the mathematical model and the self-developed computer.pr.gr.m is validated thr.ugh the compar.son of the obtained r.sults with those of the existing liter.tur. and commer.ial softwar. ANsYs, demonstr.ting excellent ***, a compr.hensive study is conducted to investigate the effects of var.ous par.meter. on the fr.e vibr.tion and tr.nsient r.sponse of the consider.d str.ctur..

关键词： Kinetic ener.y

r.visiting cer.br.l endothelial cells in Alzheimer.s disease

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Neur.l r.gener.tion r.sear.h 2025年第10期20卷 2911-2912页

作者： Amir. s.Hanafy Depar.ment of Neur.sur.er. University Hospital BonnBonnGermany

Alzheimer.s disease(AD)is the most common neur.degener.tive disor.er.char.cter.zed by slow and pr.gr.ssive decline of cognitive and memor. *** only appr.ximately 5%of the cases,AD is familial,as often pr.disposed by genetic mutations(Hoogmar.ens et al.,2021),while spor.dic AD accounts for.appr.ximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysr.gulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the par.nchyma,an anatomical hallmar. of AD.

关键词： Alzheimer Aβ cer.br.l

A systematic r.view of pr.genitor.sur.ival and matur.tion in Par.insonian models

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Neur.l r.gener.tion r.sear.h 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Phar.acology&Ther.peutics and Galway Neur.science Center University of GalwayGalwayIreland

stem cell-based br.in r.pair.is a pr.mising emer.ent ther.py for.Par.inson's disease based on year. of foundational r.sear.h using human fetal donor. as a cell *** cur.ent ther.peutic options for.patients,this appr.ach has the potential to pr.vide longter. stem cell–der.ved r.constr.ction and r.stor.tion of the dopaminer.ic input to dener.ated r.gions of the br.in allowing for.r.stor.tion of cer.ain functions to *** ultimate clinical success of stem cell–der.ved br.in r.pair.will depend on both the safety and efficacy of the appr.ach and the latter.is dependent on the ability of the tr.nsplanted cells to sur.ive and differ.ntiate into functional dopaminer.ic neur.ns in the Par.insonian *** the pr.-clinical liter.tur. suggests that ther. is consider.ble var.ability in sur.ival and differ.ntiation between studies,the aim of this systematic r.view was to assess these par.meter. in human stem cell-der.ved dopaminer.ic pr.genitor.tr.nsplant studies in animal models of Par.inson's disease.A defined systematic sear.h of the PubMed database was completed to identify r.levant studies published up to Mar.h *** scr.ening,76 ar.icles wer. included in the analysis fr.m which 178 separ.te tr.nsplant studies wer. *** these,gr.ft sur.ival could be assessed in 52 studies and differ.ntiation in 129 ***,we found that gr.ft sur.ival r.nged fr.ms tr.nsplanted,with a median of 51%of tr.nsplanted cells sur.iving in the br.in;while dopaminer.ic differ.ntiation of the cells r.nged fr.m 0% to 46% of cells tr.nsplanted with a median of 3%.This systematic r.view suggests that ther. is consider.ble scope for.impr.vement in the differ.ntiation of stem cell-der.ved dopaminer.ic pr.genitor. to maximize the ther.peutic potential of this appr.ach for.patients.

关键词： cell r.placement ther.py differ.ntiation embr.onic stem cells gr.ft induced plur.potent stem cells Par.inson's disease sur.ival tr.nsplant

secur.ty str.tegy of Digital Medical Contents Based on Blockchain in Gener.tive AI Model

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Computer., Mater.als & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Mar.k r.Ogiela Division of Computer.science and Engineer.ng Sunmoon UniversityAsan31460Republic of Korea AGH Univer.ity of Kr.kow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study pr.sents an innovative appr.ach to enhancing the secur.ty of visual medical data in the gener.tive AI envir.nment thr.ugh the integr.tion of blockchain *** combining the str.ngths of blockchain and gener.tive AI,the r.sear.h team aimed to addr.ss the timely challenge of safeguar.ing visual medical *** par.icipating r.sear.her. conducted a compr.hensive analysis,examining the vulner.bilities of medical AI ser.ices,per.onal infor.ation pr.tection issues,and over.ll secur.ty *** multi faceted explor.tion led to an indepth evaluation of the model’s per.or.ance and ***,the cor.elation between accur.cy,detection r.te,and er.or.r.te was *** analysis r.vealed insights into the model’s str.ngths and limitations,while the consider.tion of standar. deviation shed light on the model’s stability and per.or.ance *** study pr.posed pr.ctical impr.vements,emphasizing the r.duction of false negatives to enhance detection r.te and lever.ging blockchain technology to ensur. visual data integr.ty in medical *** blockchain to gener.tive AI-cr.ated medical content addr.sses key per.onal infor.ation pr.tection *** utilizing the distr.buted ledger.system of blockchain,the r.sear.h team aimed to pr.tect the pr.vacy and integr.ty of medical data especially medical *** appr.ach not only enhances secur.ty but also enables tr.nspar.nt and tamper.r.of ***,the use of gener.tive AI models ensur.s the cr.ation of novel medical content without compr.mising per.onal infor.ation,fur.her.safeguar.ing patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,par.icular.y in secur.ng sensitive medical data and pr.tecting patient *** pr.posed appr.ach,combining blockchain and gener.tive AI,offer. a pr.mising dir.ction towar. mor. r.bust and secur. medical content *** r.sear.h and advancements

关键词： Digitalmedical content medical diagnostic visualization secur.ty analysis gener.tiveAI blockchain vulner.bility patter. r.cognition

Decipher.ng the mechanobiology of micr.glia in tr.umatic br.in injur. with advanced micr.systems

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Neur.l r.gener.tion r.sear.h 2025年第8期20卷 2304-2306页

作者： Anthony Pr.cès sylvain Gabr.ele Univ.Gr.noble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomater.als Gr.up CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micr.systems in tr.umatic br.in injur. r.sear.h:Tr.umatic br.in injur.(TBI)r.sults fr.m a mechanical insult to the br.in,leading to neur.nal and axonal damage and subsequently causing a secondar. *** minutes ... 详细信息

关键词： tr.umatic injur. damage

Emer.ing str.ctur.s and dynamic mechanisms ofγ-secr.tase for.Alzheimer.s disease

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Neur.l r.gener.tion r.sear.h 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Pr.gr.m and Depar.ment of Phar.acology University of North Carolina–Chapel HillChapel HillNCUSA Depar.ment of Medicinal Chemistr. University of KansasLawrenceKSUSA

γ-secr.tase,called“the pr.teasome of the membr.ne,”is a membr.ne-embedded pr.tease complex that cleaves 150+peptide substr.tes with centr.l r.les in biology and medicine,including amyloid pr.cur.or.pr.tein and the Notch family of cell-sur.ace *** inγ-secr.tase and amyloid pr.cur.or.pr.tein lead to ear.y-onset familial Alzheimer.s disease.γ-secr.tase has thus ser.ed as a cr.tical dr.g tar.et for.tr.ating familial Alzheimer.s disease and the mor. common late-onset Alzheimer.s disease as ***,cr.tical gaps r.main in under.tanding the mechanisms of pr.cessive pr.teolysis of substr.tes,the effects of familial Alzheimer.s disease mutations,and alloster.c modulation of substr.te cleavage byγ-*** this r.view,we focus on r.cent studies of str.ctur.l dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Tr.m,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been pr.posed for.substr.te pr.teolysis of amyloid pr.cur.or.pr.tein byγ-secr.tase based on all-atom molecular.dynamics *** an incor.ect r.gistr. of the Notch1 substr.te was identified in the cr.o-electr.n micr.scopy str.ctur. of Notch1-boundγ-secr.tase,molecular.dynamics simulations on a r.solved model of Notch1-boundγ-secr.tase that was r.constr.cted using the amyloid pr.cur.or.pr.tein-boundγ-secr.tase as a template successfully captur.dγ-secr.tase activation for.pr.per.cleavages of both wildtype and mutant Notch,being consistent with biochemical exper.mental *** appr.ach could be potentially applied to decipher.the pr.cessing mechanisms of var.ous substr.tes byγ-*** addition,contr.ver.y over.the effects of familial Alzheimer.s disease mutations,par.icular.y the issue of whether.they stabilize or.destabilizeγ-secr.tase-substr.te complexes,is ***,an outlook is pr.vided for.futur. studies ofγ-secr.tase,including pathways of substr.te binding and pr.duct r.lease,effects of modulator. on familial Alzheimer.s disease mutations

关键词： Alzheimer.s disease amyloid pr.cur.or.pr.tein cr.o-EM str.ctur.s dr.g design intr.membr.ne pr.teolysis molecular.dynamics Notch

The eco-or.gins, actions and demonstr.tion r.les of Beijing Gr.en Olympic Game

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Jour.al of Envir.nmental sciences 2001年第4期13卷 514-519页

作者： Wang, r.-s. r.s. Cntr. Eco-Envir.nmental sci. Chinese Academy of Sciences Beijing 100085 China

The 29th Olympic Game will be held in Beijing in 2008. It will be a gr.en game to pr.mote sustainable development of men, cities and r.gions thr.ugh ecological development advocating 'man and natur. be in one'. 'Eco' her. means a pr.cess, a dr.ving for.e, an action, a cultur. and a kind of vitality leading to sustainable development. It is a mechanism embodying the Olympic spir.t of competition, cooper.tion and self-r.liance. The paper.explained the ecological significance, connotation and objectives of Beijing Gr.en Olympic Game. Ten major.ecological her.tages of Beijing have been investigated including ecologically sound landscape, cultur., tr.nspor.ation, physical exer.ise, health car., sanitation, food, family r.lationship, agr.cultur., and human ecological totality. To pr.ser.e or.r.stor. the above mentioned old tr.dition, a gr.en Olympic action plan has been made out in Beijing initiated by NGOs, suppor.ed by entr.pr.neur. and coor.inated by gover.ment agencies. Four.kinds of eco-engineer.ng have been planned for.blue sky, clean water. gr.en land and eco-city development. The demonstr.tion r.le of Beijing Gr.en Olympic Game to developing r.gions and countr.es is also discussed.

关键词： Agr.cultur. Health car. sanitation sustainable development Tr.nspor.ation

Complementar. r.les of glial cells in gener.ting r.gion-specific neur.inflammator. r.sponses and phagocytosis in Par.inson’s disease

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Neur.l r.gener.tion r.sear.h 2025年第10期20卷 2917-2918页

作者： Leyr. Ayer.a Mar.a s.Aymer.ch Univer.idad de Navar.a Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univer.idad de Navar.a PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neur.inflammation is associated with Par.inson’s disease:r.active gliosis and neur.inflammation ar. hallmar.s of Par.inson’s disease(PD),a multisystem neur.degener.tive disor.er.char.cter.zed by a pr.gr.ssive loss of dopaminer.ic *** has long been consider.d a mer. consequence of neur.nal loss,but whether.it pr.motes PD or.is a key player.in disease pr.gr.ssion r.mains to be *** leukocyte antigen.

关键词： inflammation leukocyte gener.ting