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Hybr.d Gene Selection Methods for.High-Dimensional Lung Cancer.Data Using Impr.ved Ar.thmetic Optimization Algor.thm

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Computer., Mater.als & Continua 2024年第6期79卷 5175-5200页

作者： Mutasem k.Alsmadi Depar.ment of Management Infor.ation Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia

Lung cancer.is among the most fr.quent cancer. in the wor.d,with over.one million deaths per.*** is r.quir.d for.lung cancer.diagnosis and ther.py to be effective,accur.te,and *** expr.ssion micr.ar.ays have made it possible to find genetic biomar.er. for.cancer.diagnosis and pr.diction in a high-thr.ughput *** Lear.ing(ML)has been widely used to diagnose and classify lung cancer.wher. the per.or.ance of ML methods is evaluated to identify the appr.pr.ate *** and selecting the gene expr.ssion patter.s can help in lung cancer.diagnoses and ***,micr.ar.ays include sever.l genes and may cause confusion or.false ***,the Ar.thmetic Optimization Algor.thm(AOA)is used to identify the optimal gene subset to r.duce the number.of selected *** can allow the classifier. to yield the best per.or.ance for.lung cancer.*** addition,we pr.posed a modified ver.ion of AOA which can wor. effectively on the high dimensional *** the modified AOA,the featur.s ar. r.nk.d by their.weights and ar. used to initialize the AOA *** exploitation pr.cess of AOA is then enhanced by developing a local sear.h algor.thm based on two neighbor.ood ***,the efficiency of the pr.posed methods was evaluated on gene expr.ssion datasets r.lated to Lung cancer.using str.tified 4-fold *** method’s efficacy in selecting the optimal gene subset is under.cor.d by its ability to maintain featur. pr.por.ions between 10%to 25%.Mor.over.the appr.ach significantly enhances lung cancer.pr.diction *** instance,Lung_Har.ar.1 achieved an accur.cy of 97.5%,Lung_Har.ar.2 and Lung_Michigan datasets both achieved 100%,Lung_Adenocar.inoma obtained an accur.cy of 88.2%,and Lung_Ontar.o achieved an accur.cy of 87.5%.In conclusion,the r.sults indicate the potential pr.mise of the pr.posed modified AOA appr.ach in classifying micr.ar.ay cancer.data.

关键词： Lung cancer gene selection impr.ved ar.thmetic optimization algor.thm and machine lear.ing

Micr.ar.ay analysis of signalling inter.ctions between inflammation and angiogenesis in subchondr.l bone in tempor.mandibular.joint osteoar.hr.tis

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Biomater.als Tr.nslational 2024年第2期5卷 175-184页

作者： Qin W. Gao J. Yan J. Han X. Lu W. Ma Z. Niu L. Jiao k. Depar.ment of Stomatology Tangdu Hospital and State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China State k.y Labor.tor. of Or.l and Maxillofacial r.constr.ction and r.gener.tion and National Clinical r.sear.h Centr. for.Or.l Diseases Shaanxi Key Laboratory of Stomatology School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China

Inflammation and angiogenesis, the major.pathological changes of osteoar.hr.tis (OA), ar. closely associated with joint pain; however. per.inent signalling inter.ctions within subchondr.l bone of osteoar.hr.tic joints and potential contr.bution to the per.pher.l or.gin of OA pain r.main to be elucidated. Her.in we developed a unilater.l anter.or.cr.ssbite mouse model with osteoar.hr.tic changes in the tempor.mandibular.joint. Micr.ar.ay-based tr.nscr.ptome analysis, besides quantitative r.al-time polymer.se chain r.action, was per.or.ed to identify differ.ntially expr.ssed genes (DEGs). Over.ll, 182 DEGs (fold change ≥ 2, P r. identified between the contr.l and unilater.l anter.or.cr.ssbite gr.ups: 168 wer. upr.gulated and 14 wer. downr.gulated. On subjecting significant DEGs to enr.chment analyses, inflammation and angiogenesis wer. identified as the most affected. Inflammation-r.lated DEGs wer. mainly enr.ched in T cell activation and differ.ntiation and in the mammalian tar.et of r.pamycin/nuclear.factor.κB/tumour.necr.sis factor.signalling. Fur.her.or., angiogenesis-r.lated DEGs wer. mainly enr.ched in the Gene Ontology ter.s angiogenesis r.gulation and vasculatur. development and in the k.GG pathways of phosphoinositide 3-k.nase-pr.tein k.nase B/vascular.endothelial gr.wth factor.hypoxia-inducible factor.1 signalling. Pr.tein– pr.tein inter.ction analysis r.vealed a close inter.ction between inflammation-and angiogenesis-r.lated DEGs, suggesting that phosphatidylinositol-4,5-bisphosphate 3-k.nase catalytic subunit delta (Pi3k.d), cathelicidin antimicr.bial peptide (Camp), C-X-C motif chemok.ne r.ceptor.4 (Cxcr.), and MYB pr.to-oncogene tr.nscr.ption factor.(Myb) play a centr.l r.le in their.inter.ction. To summar.ze, our.findings r.veal that in subchondr.l bone of osteoar.hr.tic joints, signal inter.ction is inter.elated between inflammation and angiogenesis and associated with the per.pher.l or.gin of OA pain; mor.over. our.data highlight potential t

关键词： angiogenesis inflammation osteoar.hr.tic pain osteoar.hr.tis subchondr.l bone tempor.mandibular.joint (TMJ)

A Machine Lear.ing Classification Model for.Detecting Pr.diabetes

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Jour.al of Data Analysis and Infor.ation Pr.cessing 2024年第3期12卷 462-478页

作者： A. k. M. r.quibul Bashar.Mahdi Goudar.i Chr.s P. Tsok.s Depar.ment of Mathematics & Computer.Science Augustana College Rock Island Illinois USA Independent r.sear.her San Francisco California USA Depar.ment of Mathematics & Statistics University of South Florida Tampa Florida USA

The incidence of pr.diabetes is in a danger.us condition in the USA. The lik.lihood of incr.asing chr.nic and complex health issues is ver. high if this stage of pr.diabetes is ignor.d. So, ear.y detection of pr.diabetes conditions is cr.tical to decr.ase or.avoid type 2 diabetes and other.health issues that come as a r.sult of untr.ated and undiagnosed pr.diabetes condition. This study is done in or.er.to detect the pr.diabetes condition with an ar.ificial intelligence method. Data used for.this study is collected fr.m the Center. for.Disease Contr.l and Pr.vention’s (CDC) sur.ey conducted by the Division of Health and Nutr.tion Examination Sur.eys (DHANES). In this study, sever.l machine lear.ing algor.thms ar. exploited and compar.d to deter.ine the best algor.thm based on Aver.ge Squar.d Er.or.(ASE), k.lmogor.v-Smir.ov (Youden) scor.s, ar.as under.the r.C and some other.measur.s of the machine lear.ing algor.thm. Based on these scor.s, the champion model is selected, and r.ndom For.st is the champion model with appr.ximately 89% accur.cy.

关键词： Pr.diabetes Machine Lear.ing SVM For.st Cumulative Lift

Blood Pr.ssur. Pr.file and Glycemic Contr.l of Type 2 Diabetics and Hyper.ensives at the Yalgado Ouedr.ogo Univer.ity Hospital: A r.view of 116 Cases

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Wor.d Jour.al of Car.iovascular.Diseases 2024年第1期14卷 61-76页

作者： G. r. C. Millogo A. Thiam Y. k.mbir. E. Nongk.uni S. E. Dabir. L. J. k.gambéga J. k. k.logo V. N. Yaméogo P. Zabsonr. Depar.ment of Car.iology Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Depar.ment of Car.iology Tengandogo University Hospital Ouagadougou Burkina Faso

Objective: The association hyper.ension and diabetes is impor.ant. The two pathologies may influence each other. The aim was to study the cor.elation between glycemic contr.l and blood pr.ssur. contr.l and to deter.ine the factor. associated with blood pr.ssur. contr.l. Methodology: This was a descr.ptive cr.ss-sectional study with an analytical focus over.7 months. Patients wer. r.cr.ited as outpatients and all under.ent ambulator. blood pr.ssur. measur., glycated hemoglobin and cr.atinine measur.ments, and assessment of compliance with tr.atment. r.sults: Dur.ng this per.od 116 patients wer. collected. The pr.dominance was female 69%. The mean age of the patients was 62 ± 7 year. with a peak.between 60 and 70 year.. The aver.ge age of hyper.ension was 12 year. and that of diabetes 6 1/2 year.. The most fr.quently associated car.iovascular.r.sk.factor.was a sedentar. lifestyle (71.5%) after.age. 57.8% of patients wer. not contr.lled at the office, with a pr.dominance of systolic hyper.ension (58.2%). 61.6% of patients wer. contr.lled by ambulator. blood pr.ssur. measur., a r.te of 47.8% of white coat hyper.ension. Glycemic contr.l was obser.ed in 42.2% of cases and 87% of patients had good r.nal function (glomer.lar.filter.r.te ≥ 60 ml/mn). Ther.peutic compliance was good in 53.4% of cases and dual ther.py was the most used ther.peutic modality 44.8% (52 patients) followed by tr.ple ther.py. The factor. associated with poor.blood pr.ssur. contr.l wer. glycemic imbalance, non-compliance and monother.py. Dual ther.py had a pr.tective effect. Conclusion: The association of hyper.ension and type 2 diabetes is fr.quent. The r.sk.of occur.ence incr.ases with age. Ambulator. blood pr.ssur. measur. is the best method to assess blood pr.ssur. contr.l. Optimization of blood pr.ssur. contr.l should also include optimization of glycemic contr.l.

关键词： Blood Pr.ssur. Contr.l Glycemic Contr.l Hyper.ensive and Diabetic Patients

Explor.tion of chr.mene-based BioAIEgens

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National Science r.view 2024年第3期11卷 47-48页

作者： Fr.tz E.k.hn Depar.ment of Chemistr.&Catalysis r.sear.h Center School of Natural Sciences Technical University of Munich

Photoemission efficiency is usually higher.in solution than in solid *** compounds however. display a r.ver.e behavior. Such a behavior.is called aggr.gation-induced emission(AIE).

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A new per.pective on inter.er.ebr.l disc calcification—fr.m bench to bedside

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Bone r.sear.h 2024年第1期12卷 50-61页

作者： Emanuel J.Novais r.jk.shen Nar.yanan Jose A.Canseco k.en van de Weter.ng Chr.stopher.k.k.pler.Alan S.Hilibr.nd Alexander.r.Vaccar. Mak.r.nd V.r.sbud Depar.ment of Or.hopaedic Sur.er. Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de Saúde do Litor.l Alentejano Orthopedic DepartmentSantiago do CacémPortugal r.thman Or.hopedic Institute at Thomas Jeffer.on Univer.ity PhiladelphiaPAUSA

Disc degener.tion pr.mar.ly contr.butes to chr.nic low back.and neck.***,ther. is an ur.ent need to under.tand the spectr.m of disc degener.tion phenotypes such as fibr.sis,ectopic calcification,her.iation,or.mixed *** these phenotypes,disc calcification is the least *** calcification,by definition,is the pathological miner.lization of soft tissues,widely studied in the context of conditions that afflict vasculatur.,sk.n,and ***,disc calcification is associated with poor.sur.ical outcomes and back.pain r.fr.ctor. to conser.ative *** is fr.quently seen as a consequence of disc aging and pr.gr.ssive degener.tion but exhibits unique molecular.and mor.hological char.cter.stics:hyper.r.phic chondr.cyte-lik. cell differ.ntiation;TNAP,ENPP1,and ANk.upr.gulation;cell death;alter.d Pi and PPi homeostasis;and local *** studies in mouse models have pr.vided a better.under.tanding of the mechanisms under.ying this *** is essential to r.cognize that the pr.sentation and natur. of miner.lization differ.between AF,NP,and EP ***,the combination of anatomic location,genetics,and envir.nmental str.ssor.,such as aging or.tr.uma,gover. the pr.disposition to ***,the systemic r.gulation of calcium and Pi metabolism is less impor.ant than the local activity of PPi modulated by the ANk.ENPP1 axis,along with disc cell death and differ.ntiation *** ther. is limited under.tanding of this phenotype,under.tanding the molecular.pathways gover.ing local inter.er.ebr.l disc calcification may lead to developing disease-modifying dr.gs and better.clinical management of degener.tion-r.lated pathologies.

关键词： degener.tion metabolism inter.er.ebr.l

Utilization of Logistical r.gr.ssion to the Modified Sine-Gor.on Model in the MST Exper.ment

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Open Jour.al of Modelling and Simulation 2024年第2期12卷 43-58页

作者： Nizar.J. Alk.ateeb Hameed k. Ebr.heem Eman M. Al-Otaibi Depar.ment of Electr.nic Engineer.ng Technology College of Technological Studies (CTS) The Public Authority of Applied Education and Training (PAAET) Kuwait City Kuwait

In this paper. a logistical r.gr.ssion statistical analysis (Lr. is pr.sented for.a set of var.ables used in exper.mental measur.ments in r.ver.ed field pinch (r.P) machines, commonly k.own as “slink. mode” (SM), obser.ed to tr.vel ar.und the tor.s in Madison Symmetr.c Tor.s (MST). The Lr.analysis is used to utilize the modified Sine-Gor.on dynamic equation model to pr.dict with high confidence whether.the slink. mode will lock.or.not lock.when compar.d to the exper.mentally measur.d motion of the slink. mode. It is obser.ed that under.cer.ain conditions, the slink. mode “lock.” at or.near.the inter.ection of poloidal and/or.tor.idal gaps in MST. However. lock.d mode cease to tr.vel ar.und the tor.s;while unlock.d mode k.eps tr.veling without a change in the ener.y, mak.ng it har. to deter.ine an exact set of conditions to pr.dict lock.ng/unlock.ng behaviour. The significant k.y model par.meter. deter.ined by Lr.analysis ar. shown to impr.ve the Sine-Gor.on model’s ability to deter.ine the lock.ng/unlock.ng of magnetohydr.dyamic (MHD) modes. The Lr.analysis of measur.d var.ables pr.vides high confidence in anticipating lock.ng ver.us unlock.ng of slink. mode pr.ven by r.lational compar.sons between simulations and the exper.mentally measur.d motion of the slink. mode in MST.

关键词： Madison Symmetr.c Tor.s (MST) Magnetohydr.dyamic (MHD) Sine-Gor.on Tor.idal Dynamic Modelling r.ver.ed Field Pinch (r.P) Logistical r.gr.ssion

A cr.ss-sectional study of br.astfed infants r.fer.ed for.tongue tie assessment and fr.notomy in one Canadian health r.gion

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Pediatr.c Investigation 2024年第1期8卷 53-60页

作者： Tiffany A.Lee Jessica Bishop Anne Dr.ver.William k.Midodzi Laur.e k.Twells School of Phar.acy Memorial University of Newfoundland(MUN)St.John’sCanada Faculty of Medicine Memorial University of Newfoundland(MUN)St.John’sCanada

Impor.ance:Tongue tie(TT)is a condition that can cause infant feeding difficulties due to r.str.cted tongue *** TT pr.sents as a significant bar.ier.to br.astfeeding,a fr.notomy may be *** accepted diagnostic cr.ter.a for.TT ar. lack.ng and wide pr.valence estimates ar. *** r.fer.al pr.cesses and a Fr.notomy Assessment Tool wer. implemented in one Canadian health r.gion to connect br.astfeeding dyads with a pr.vider.for.TT evaluation and ***:To deter.ine the pr.por.ion of babies with TT as well as the fr.quency of ***:This cr.ss-sectional study included infants who initiated br.astfeeding at bir.h and wer. r.fer.ed for.TT evaluation over.a 14-month *** wer. collected r.tr.spectively by char. r.view and analyzed using *** associated with fr.notomy wer. examined using logistic ***:Two hundr.d and for.y-one babies wer. ***-two per.ent(n=222)wer. diagnosed with TT and 66.0%(n=159)under.ent *** the multivar.ate model,nipple pain/tr.uma,inability to latch,inability to elevate tongue,and dimpling of tongue on extension wer. associated with fr.notomy(Pr.fer.als in our.r.gion r.sulted in a diagnosis of TT;however.the number.of r.fer.als was lower.than expected,and of these two-thir.s under.ent ***:TT is a r.latively common finding among br.astfed *** r.sear.h should examine whether.a simplified assessment tool containing the four.items associated with fr.notomy in our.multivar.ate model can identify br.astfed infants with TT who r.quir. fr.notomy.

关键词： Br.astfeeding Nutr.tion Community health ser.ices Pediatr.cs

Dr.p for.ation at nozzles submer.ed in quiescent continuous phase： an exper.mental study with TBP-dodecane and nitr.c acid system

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Nuclear.Science and Techniques 2018年第6期29卷 110-118页

作者： Amitava r.y Mayur.ar.k.r.k. k. Singh k. T. Shenoy r. B. Gr.ver Homi Bhabha National Institute Anushaktinagar Mumbai 400094 India Chemical Engineer.ng Division Bhabha Atomic Research Centre Mumbai 400085 India

Solvent extr.ction is an impor.ant pr.cess in the nuclear.fuel cycle. Tr.butyl phosphate(TBP) diluted with dodecane is commonly used as a solvent for.extr.cting heavy metals fr.m nitr.c acid medium. Studies on hydr.dynamics of a single dr.p, which is the smallest mass tr.nsfer.entity, ar. r.quir.d for.better.under.tanding of the complex mass tr.nsfer.and phase separ.tion phenomena that occur.in extr.ction equipment. In this study, dr.p for.ation at nozzles is studied using 30% TBP-dodecane as the disper.ed phase and dilute nitr.c acid as the quiescent continuous phase. Exper.ments ar. car.ied out to deter.ine the dr.p diameter. jetting velocity, dr.p detachment height and dr.p detachment time for.var.ous disper.ed phase velocities, nozzle diameter.(1.91, 3.04, and 4.88 mm), and nitr.c acid concentr.tions(0.01, 1, 3 N). Dr.p for.ation is captur.d using high-speed imaging, which enables quantification of dr.p size, onset of jetting, dr.p detachment height, and dr.p detachment time. Exper.mental data ar. used to pr.pose cor.elations for.pr.dicting dr.p diameter.and minimum jetting velocity. The cor.elations ar. found to be ver. accur.te with aver.ge absolute r.lative er.or. being 5.23 and 2.97%, r.spectively.

关键词：试验性硝酸静止沉没系统高速度分离现象磷酸盐