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Nucleon tr.nsition for. factor. at JLab:status and outlook

Chinese Physics C 2009年第12期33卷 1216-1221页

作者： r. w. gothe Univer.ity of South Car.lina Columbia SC 29208 USA

The measur.ments of exclusive single-meson and double-pion electr.-pr.duction cr.ss sections off the pr.ton to study nucleon r.sonances w.ll be extended to higher.momentum tr.nsfer. w.th the CLAS12 detector.and the ener.y upgr.ded CEBAF beam. Based on new.theor.tical developments to extr.ct and inter.r.t the electr.magnetic tr.nsition for. factor. and on the exper.ence gained fr.m the most r.cent r.sults, the new.y for.ed collabor.tion of exper.mentalists and theor.sts shall enable us to pr.vide unpr.cedented high- pr.cision data, high-quality analyses, and state-of-the-ar. model and QCD based calculations in a Q2 domain up to 10 GeV2. For.the fir.t time nucleon r.sonance str.ctur.s w.ll be studied at still unexplor.d distance scales, w.er. the dr.ssed quar. contr.butions ar. the dominating degr.es of fr.edom and their.str.ng inter.ction is r.sponsible for.the gr.und and excited nucleon state for.ation. These studies also open up a pr.mising oppor.unity to under.tand the or.gin of mor. than 98% of the nucleon mass that is cr.ated by str.ng fields pr.dominantly at these distance scales by dr.ssing the cur.ent quar.s.

关键词： bar.on str.ctur. str.ng degr.es of fr.edom

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Photosw.tchable molecular.dipole antennas w.th tailor.d coher.nt coupling in glassy composite

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Light(Science & Applications) 2015年第1期4卷 259-266页

作者： Mady Elbahr. Ahnaf Usman Zillohu Bastian gothe Mehdi Keshavar. Hedayati r.mzy Abdelaziz Hala Jar.llah El-Khozondar.Muhammad Baw.’aneh Moheb Abdelaziz Andr.i Lavr.nenko Ser.ei Zhukovsky Shahin Homaeigohar Nanochemistr. and Nanoengineer.ng Faculty of EngineeringInstitute for Materials ScienceUniversity of KielKaiserstrasse 224143 KielGermany Nanochemistr. and Nanoengineer.ng Institute of Polymer ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Strasse 121502 GeesthachtGermany r.fr.ctor.es Ceramics and Building Materials DepartmentNational Research CentreDokkiCairoEgypt Electr.cal Engineer.ng Depar.ment Islamic University of GazaGazaPO Box 108Palestine The Hashemite Univer.ity Department of PhysicsZarqaJordan&Khalifa University of ScienceTechnology&Research(KUSTAR)PO Box 573SharjahUAE DTU Fotonik Technical University of DenmarkOersteds pl.343Kongens LyngbyDK-2800Denmark

Her.,w. intr.duce the fir.t exper.mental pr.of of coher.nt oscillation and coupling of photosw.tchable molecules embedded r.ndomly in a polymer.c matr.x and acting cooper.tively upon illumination w.th UV *** par.icular.w. demonstr.te the specular.r.flection and Br.w.ter.phenomenon alter.tion of photochr.mic molecular.dipole *** successfully demonstr.te the concept of Br.w.ter.w.velength,w.ich is based on the dipolar.inter.ction betw.en r.diating dipoles and the sur.ounding matr.x possessing a net dipole moment,as a key tool for.highly localized sensing of matr.x *** also intr.duce the concept of‘tailor.d molecular.photonic coupling’w.ile highlighting the r.le of inter.er.nces for.the design of optically active media by adjusting the photonic r.sponse of the medium w.th the r.al and imaginar. r.fr.ctive index of photosw.tchable molecules in the‘ON’*** r.sults enhance our.fundamental under.tanding of coher.nt dipole r.diation and open a new.vein of r.sear.h based on glassy disor.er.d dipolar.composites that act as macr.scopic antenna w.th cooper.tive action;fur.her.or.,these r.sults have impor.ant implications for.new.design r.les of tailor.d photonics.

关键词： Br.w.ter.angle coher.nt coupling collective oscillation photosw.tchable molecular.photonics specular.r.flection

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Disr.ption of NAD^+ binding site in glycer.ldehyde 3-phosphate dehydr.genase affects its intr.nuclear.inter.ctions

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w.r.d Jour.al of Biological Chemistr. 2015年第4期6卷 366-378页

作者： Manali Phadke Natalia Kr.netskaia Anur.g Mishr. Car.os Bar.er. Salim Mer.li Scott A gothe Evgeny Kr.netskiy Temple Univer.ity School of Phar.acy Jayne Haines Center.for.Phar.acogenomics and Dr.g Safety Temple University

AIM:To char.cter.ze phosphor.lation of human glycer.ldehyde 3-phosphate dehydr.genase(GAPDH),and mobility of GAPDH in cancer.cells tr.ated w.th chemother.peutic agents. METHODS:w. used pr.teomics analysis to detect and char.cter.ze phosphor.lation sites w.thin human GAPDH. Site-specific mutagenesis and alanine scanning w.s then per.or.ed to evaluate functional significance of phosphor.lation sites in the GAPDH polypeptide chain. Enzymatic pr.per.ies of mutated GAPDH var.ants w.r. assessed using kinetic studies. Intr.nuclear.dynamics par.meter.(diffusion coefficient and the immobile fr.ction) w.r. estimated using fluor.scence r.cover. after.photobleaching(Fr.P) exper.ments and confocal micr.scopy. Molecular.modeling exper.ments w.r. per.or.ed to estimate the effects of mutations on NAD+ cofactor.***:Using MALDI-TOF analysis,w. identified novel phosphor.lation sites w.thin the NAD+ binding center.of GAPDH at Y94,S98,and T99. Using polyclonal antibody specific to phospho-T99-containing peptide w.thin GAPDH,w. demonstr.ted accumulation of phospho-T99-GAPDH inthe nuclear.fr.ctions of A549,HCT116,and Sw.8 cancer.cel s after.cytotoxic str.ss. w. per.or.ed site-mutagenesis,and estimated enzymatic pr.per.ies,intr.nuclear.distr.bution,and intr.nuclear.mobility of GAPDH mutated var.ants. Site-mutagenesis at positions S98 and T99 in the NAD+ binding center.r.duced enzymatic activity of GAPDH due to decr.ased affinity to NAD+(Km = 741 ± 257 μmol/L in T99 I vs 57 ± 11.1 μmol/L in w.ld type GAPDH. Molecular.modeling exper.ments r.vealed the effect of mutations on NAD+ binding w.th GAPDH. Fr.P(fluor.scence r.cover. after.photo bleaching) analysis show.d that mutations in NAD+ binding center.of GAPDH abr.gated its intr.nuclear.inter.ctions. CONCLUSION:Our.r.sults suggest an impor.ant functional r.le of phosphor.lated amino acids in the NAD+ binding center.in GAPDH inter.ctions w.th its intr.nuclear.par.ner..

关键词： NAD+ Binding site Fluor.scence r.cover. after phot

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Genetic Var.ation for.Anaer.bic Ger.ination and Emer.ence fr.m Deeper.Soil Depth in Or.za nivar. Accessions

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r.ce science 2022年第4期29卷 304-308页

作者： r.vanayya Mgothe Dhar.inder.BHATIA Akashdeep KAMBOJ Nitika SANDHU Buta Singh DHILLON Depar.ment of Plant Br.eding and Genetics Punjab Agricultural UniversityLudhiana 141004India School of Agr.cultur.l Biotechnology Punjab Agricultural UniversityLudhiana 141004India

Anaer.bic ger.ination and emer.ence fr.m deeper.soil depth ar. tw. impor.ant tr.its for.br.eding r.ce suitable for.dir.ct seeded *** or.er.to evaluate genetic var.ation for.these tr.its,a total of 300 Or.za nivar. accessions w.r. evaluated along w.th checks,of w.ich,159 accessions ger.inated under.anaer.bic conditions indicating pr.sence of immense var.ability in *** 159 accessions,69 ger.inated in submer.ed conditions and 90 ger.inated after.r.moving w.ter.w.th availability of aer.bic conditions,indicating tw. differ.nt mechanisms oper.ting in ***,out of 300 *** accessions,218 ger.inated fr.m 6 cm and 95 ger.inated fr.m 8 cm soil *** accessions that ger.inated fr.m deeper.soil depth had longer.mesocotyl and coleoptile lengths.

关键词： soil br.eding r.moving

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内生型发展导向下德国乡村地区存量空间的潜力激活——以巴登—符滕堡州MELAP项目为例

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国际城市规划 2020年第5期35卷 35-44页

作者：克斯廷·戈特蒋薇丁宇新德国卡尔斯鲁厄工业大学(KIT) 德国巴登-符腾堡州经济、就业与住房建设部城市设计与法规科上海同济城市规划设计研究院有限公司

相比以德国东部为代表的人口收缩地区,位于德国西南部巴登—符腾堡州的小城镇和乡村地区的经济分布虽整体上较为合理,但现阶段仍面临着人口老龄化、乡村经济结构重构、村镇中心空心化、传统基础设施利用率不高以及生活品质降低等新的发... 详细信息

相比以德国东部为代表的人口收缩地区,位于德国西南部巴登—符腾堡州的小城镇和乡村地区的经济分布虽整体上较为合理,但现阶段仍面临着人口老龄化、乡村经济结构重构、村镇中心空心化、传统基础设施利用率不高以及生活品质降低等新的发展趋势和挑战,而这促使现有的政策条文相应发生改变,并催生出了新的战略措施。为了应对乡村发展的新问题,巴登—符滕堡州乡村地区和消费者保护部近年推出了"通过激活内部空间潜力减少土地开发的示范项目"(MELAP),旨在通过盘活村镇中心存量空间来吸引本地居民回归,提升村镇生活品质并激发村镇可持续发展的动力。本文通过探究MELAP的由来、目标和实施,并以米歇尔巴赫村为例进行成效分析,阐述内生型发展对激活小城镇和乡村地区存量空间潜力可能产生的作用,以期为中国乡村地区存量空间发展开拓思路,提出建议。

关键词：内生型发展乡村地区巴登—符滕堡州 MELAP 米歇尔巴赫村

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