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Jour.al of Cancer.Ther.py 2015年第1期6卷 40-44页

作者： Stanislaw r. Bur.ynski Gr.gor. S. Bur.ynski Sheldon Br.okman Bur.ynski Clinic Houston USA

Diffuse intr.nsic pontine glioma (DIPG) is the most common type of br.instem glioma and one of the most deadly br.in tumor.. DIPG in young adult patients is a r.r. disease for.which tr.atment options ar. limited. r.diation ther.py r.mains the standar.-of-car. for.newly-diagnosed DIPG, but no established ther.pies for.r.cur.ent disease ar. available. This paper.descr.bes the r.sults of tr.atment of a young adult patient diagnosed with DIPG that pr.gr.ssed after.r.diation ther.py. Ther.py included sodium phenylbutyr.te (PB) in combination with the tar.eted agents: pazopanib, ever.limus, er.otinib, and bevacizumab. The patient achieved a r.pid par.ial r.sponse, which per.isted over.a year.and five months. The patient opted to discontinue the ther.py and ther.after.elected chemother.py, which r.sulted in a subsequent r.pid pr.gr.ssion and death within one month. The tar.eted tr.atment was associated with minor.toxicity that included a Gr.de 2 skin r.sh and Gr.de 1 elevation of tr.nsaminases. In conclusion, a combination of PB and cur.ently available tar.eted dr.gs may offer.extended sur.ival in patients with r.cur.ent DIPG.

关键词： Antineoplastons Br.instem Glioma DIPG Phenylbutyr.te Tar.eted Agents Tr.atment of DIPG

Steady vor.ex for.e theor. and slender.wing flow diagnosis

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Acta Mechanica Sinica 2007年第6期23卷 609-619页

作者： Y.T.Yang r.K.Zhang Y.r.An J.Z.Wu State Key Labor.tor. for.Tur.ulence and Complex Systems College of EngineeringPeking UniversityBeijing 100871China

The concept vor.ex for.e in aer.dynamics is sys- tematically examined based on a new steady vor.ex-for.e theor. （Wu et al., Vor.icity and vor.ex dynamics, Spr.nger. 2006） which expr.sses the aer.dynamic for.e （and moment） by the volume and boundar. integr.ls of the Lamb vector. In this paper. the under.ying physics of this theor. is explor.d, including the gener.l r.le of the Lamb vector.in non- linear.aer.dynamics, its initial for.ation, and its r.levance to the total-pr.ssur. non-unifor.ity. As a typical example, the theor. is applied to the flow over.a slender.delta wing at a lar.e angle of attack. The highly localized flow str.ctur.s with high Lamb-vector.peaks ar. identified in ter.s of their.net contr.bution to var.ous constituents of the total aer.dy-namic for.e. This vor.ex-for.e diagnosis sheds new light on the flow contr.l and configur.tion optimization.

关键词： Vor.ex for.e - Delta-wing - Flow contr.l

Appr.ach for.Multiwor. Expr.ssion Identification in Natur.l Language Pr.cessing

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Computer.Technology and Application 2011年第8期2卷 663-666页

作者： Deepak Shar.a Pr.kash r. Devale Akhil K. Khar. Depar.ment of lnfor.ation Technology and Bhar.ti Vidyapeeth College of Engineer.ng ＆ r.sear.h Pune 411043 India

In this paper. the author. ar. pr.senting the appr.ach to extr.ct the multiwor. expr.ssion （MWEs） fr.m monolingual cor.or.. It both validates and gener.tes multiwor. candidates. The multiwor. expr.ssion pr.vides a list of candidates which ar. extr.cted and filter.d accor.ing to the number.of cr.ter.a and a set of standar. statistical association measur.s. The gener.tion of the multiwor. candidates is based on the sur.ace for.s, while the validation consists of ser.es of cr.ter.a for.r.moving noise using language independent association measur.s. For.gener.ting cor.us count, it pr.vides both a cor.us indexation facility. Also, this appr.ach allows easy integr.tion with a machine lear.ing tool for.thecr.ation and application of super.ised multiwor. extr.ction models if annotated data is available. The author. pr.sent the use of multiwor. in a standar. configur.tion, for.extr.cting MWEs fr.m a cor.us of gener.l pur.ose English.

关键词： Multiwor. candidates association measur.s sur.ace for.s monolingual cor.or..

An impr.ve d smoothe d par.icle hydr.dynamics appr.ach using new inver.e ker.el function

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Jour.al of Ocean Engineer.ng and Science 2022年第4期7卷 327-336页

作者： J.r.r.japr.yadhar.hini Depar.ment of Civil Engineer.ng Thiagarajar College of EngineeringMaduraiTNIndia

The main limitation of Smoothed Par.icle Hydr.dynamics(SPH)method that r.sists the method’s poten-tial is its lack of pr.viding stability and accur.cy to the numer.cal *** impr.ve the accur.cy of the standar. SPH technique,by for.ulating a new inver.e logar.thmic ker.el *** new ker.el function is der.ved based on the under.ying pr.per.ies of ker.el *** appr.ximation technique used her. is based on the Moving Least Squar.s based *** adequacy of the pr.posed ker.nel function is tested by simulation of 2D shock wave pr.pagation and 3D dam-br.ak fr.e sur.ace flow against a cuboidal *** method was validated against exper.mental data by Kleefsman et al.,[1].The numer.cal r.sults r.veal that our.new SPH appr.ach using inver.e logar.thmic ker.el function outper.for.s existing ones in par.icle r.stor.tion,zer. er.or.better.accur.cy and enhanced efficiency in ker.el *** new ker.el function showed some impr.vement over.existing ker.els by showing ver. less er.or.appr.ximation value of 0.035h *** r.sults showed some impr.vements over.standar. technique by being capable of handling pr.blems with lar.e defor.ations accur.tely and pr.cisely.

关键词： Inver.e logar.thmic function Moving least squar.s appr.ximation Shock wave pr.pagation 3D dam-br.ak flow Zer. er.or

The Application of the LDL Pr.nciple

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Wor.d Jour.al of Car.iovascular.Diseases 2016年第5期6卷 109-125页

作者： David S. Schade Br.ndan Cavanaugh Bar.y r.mo r. Philip Eaton Division of Endocr.nology DoIM School of Medicine University of New Mexico Albuquerque NM USA New Mexico Hear. Institute Albuquerque NM USA

The LDL Pr.nciple has r.cently been invoked to descr.be the obser.ation that lower.ng the LDL cholester.l (by whatever.means) r.sults in a lower.ng of ather.scler.tic car.iovascular.events. The scientific basis of the LDL Pr.nciple dates back to the discover. that the LDL r.ceptor.is the pr.me deter.inant of the cir.ulating LDL-c concentr.tion. Since that time, major.advances have been made at both the basic and clinical science level in our.under.tanding of the pathogenesis and r.ver.al of ather.scler.sis. The incor.or.tion of ather.genic lipopr.teins plus inflammator. mediator. into plaque for.ation per.its the tar.eted inter.ention into pr.venting plaque r.ptur.. In addition, genetic studies identifying individuals with unique phenotypes of either.abnor.ally high or.low LDL-c concentr.tions have pr.vided insight into possible ther.peutic modalities that have r.cently pr.vided the physician with the tools necessar. to apply the LDL Pr.nciple to achieve r.ver.al of ather.scler.sis. The epidemic of ather.scler.tic car.iovascular.disease has r.sulted in numer.us r.ndomized contr.lled inter.ention tr.als in an attempt to identify appr.aches to r.duce ASCD mor.idity and mor.ality. r.cently published data indicate that cir.ulating LDL-c levels of 50 mg/dl or.less ar. not only physiologic at bir.h but also effective in gr.atly r.ducing car.iovascular.disease. In addition, the r.cent availability of two PCSK9 inhibitor. pr.vides the pr.mar. car. physician with the possibility of achieving this low level of LDL-c even in statin intoler.nt patients. The widespr.ad availability of the cor.nar. ar.er. calcium scan plus the inclusion of tr.ditional car.iovascular.r.sk factor. in r.sk assessment has enabled the physician to r.adily identify asymptomatic individuals at high r.sk for.car.iovascular.events. Aggr.ssively applying the LDL Pr.nciple to these individuals has the potential of gr.atly r.ducing car.iovascular.mor.ality. This r.view will document the scientific basis for

关键词： LDL Pr.nciple Ather.scler.sis Myocar.ial Infar.tion Ather.scler.sis r.ver.al LDL Cholester.l

Anaplastic Lar.e Cell Lymphoma, ALK-Negative Pr.senting in the r.ctum: A Case r.por. and r.view of the Liter.tur.

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Open Jour.al of Pathology 2013年第1期3卷 37-40页

作者： Komal Galani Sur.akanth r. Gur.du Longwen Chen Katalin Kelemen Depar.ment of Gastr.enter.logy Mayo Clinic Phoenix USA Depar.ment of Labor.tor. Medicine and Pathology Mayo Clinic Phoenix USA Super.r.ligar. Labor.tor.es Nagpur India

ALK-negative anaplastic lar.e cell lymphoma (ALCL, ALK-) is a CD30+ T-cell neoplasm composed of lar.e lymphoid cells with abundant cytoplasm and pleomor.hic nuclei that lacks expr.ssion of ALK pr.tein. We descr.be a case of ALCL, ALK-with pr.mar. involvement of the r.ctum in a 37 year.old man, wher. the or.ginal diagnosis was established based on a colonoscopic biopsy. T-cell lymphomas ar. r.r. in the color.ctal ar.a and besides ALCL, their.differ.ntial diagnosis includes enter.pathic T-cell lymphoma, per.pher.l T-cell lymphoma, not other.ise specified, NK/T cell lymphoma, or.NK-cell enter.pathy. In addition, syncytial var.ant of classical Hodgkin lymphoma or.a pleomor.hic CD30-positive diffuse lar.e B-cell lymphoma should also be r.led out. We discuss pitfalls of the differ.ntial diagnosis and r.view the liter.tur. of anaplastic lar.e cell lymphoma in the gastr.intestinal tr.ct. Cor.ect diagnosis of ALCL in the colon is impor.ant to avoid a color.ctal sur.er. for.an assumed adenocar.inoma, and to open the possibility for.lymphoma-dir.cted chemother.py.

关键词： Anaplastic Lar.e Cell Lymphoma CD30+ Lymphoma Gastr.intestinal Lymphoma

Landfor.s Evolution of Wadi Qudaid Ar.a, West Centr.l Ar.bian Shield, Saudi Ar.bia: An Example of the r.le of the Geological Factor. in the Ur.an Extensions

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Open Jour.al of Geology 2020年第6期10卷 612-640页

作者： Ali A. Mesaed Mohammed A. M. Alghamdi Abdullah r. Sonbul Geo-Explor.tion Techniques Depar.ment Faculty of Earth Sciences King Abdulaziz University Jeddah KSA Geology Depar.ment Faculty of Sciences Cairo University Giza Egypt Engineer.ng and Envir.nmental Geology Depar.ment Faculty of Earth Sciences King Abdulaziz University Jeddah KSA

Wadi Qudaid is located in the west centr.l par. of Saudi Ar.bia. It about 135 km to the nor.heast of Jeddah city along Al Har.mein highway and it r.pr.sents the upstr.am of the ver. lar.e alluvial plain along the r.d ... 详细信息

Wadi Qudaid is located in the west centr.l par. of Saudi Ar.bia. It about 135 km to the northeast of Jeddah city along Al Haramein highway and it represents the upstream of the very large alluvial plain along the Red Sea coast. It runs in NE direction parallel to many wadis of the west central part of Saudi Arabia i.e. Wadi Fatima, wadi Sitarah. The wadi floor is filled by Quaternary deposits which represent good groundwater aquifer. Geologically, the present-day residual landforms of Wadi Qudaid are composed mainly of Precambrian Arabia shield rocks overlained by Tertiary sedimentary rocks and finally harrat (Tertiary volcanic). The Precambrian rocks are represented by 1) a lower layered basic and intermediate volcanic and the intercalated volcaniclastics. This unit is correlatable with Samran Group, 2) an upper layered acidic volcanic and the intercalated acidic volcaniclastics. The Arabian shield rocks are intensively folded and dragged along the major NE faults. They are directly overlain by Tertiary basic volcanic (harrat) and the related volcanoclastic red beds). The main geomorphologic elements of the study area include plateau, scarps, and the wadi floor. The plateau is represented by the black basaltic sheet that contains some semi-rounded depressions filled with Quaternary eolian sands. The scarps of the main wadi and its tributaries are nearly steep and contain many asphaltic roads with some isolated cone hills detached from the scarps. Geomorphological, Wadi Qudaidr.ana;font-size:12px;"> r.pr.sents the incomplete er.sion cycle that begins with

关键词： Wadi Qudaid Geomor.hology of Saudi Ar.bia Landfor.s Evolution Er.sion Cycle Ur.an Extensions

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全球预警 1991年世界形势评述

1992年

作者：（美）莱斯特·r.布朗等贡光禹等译

书名原文：State of the wor.d 1991：A wor.dwatch institute r.por. on pr.gr.ss towar. a sustainable socitey:本书是美国著名的世界观察研究所发表的向持续社会发展迈进的1991年度进展报告。重点阐述了今后30年建立在大力改善地球... 详细信息

ISBN: (纸本)7502315667

书名原文：State of the wor.d 1991：A wor.dwatch institute r.por. on pr.gr.ss towar. a sustainable socitey:本书是美国著名的世界观察研究所发表的向持续社会发展迈进的1991年度进展报告。重点阐述了今后30年建立在大力改善地球生态系统基础上的世界新秩序，大力开发可持续发展的能源系统，重新考虑城市交通，再造森林，恢复东欧和苏联环境等十大问题。

关键词：世界经济学科:研究人类生态学地点:世界

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苏联歌舞艺术

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