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Optics and Photonics Jour.al 2015年第1期5卷 15-27页

作者： Alexander.V. kir’yanov nikolai n. Il’ichev Elmir. S. Gulyamova Alexander.S. nasibov Peter.V. Shapkin Centr. de Investigaciones en Optica Loma del Bosque 115 Lomas del Campestre Leon Mexico M.V. Lomonosov Moscow State Univer.ity Physics Department Vorobyevy Gory 1 Moscow Russia A.M. Pr.khor.v Gener.l Physics Institute (r.ss. Acad. Sci.) Ul. Vavilova 38 Moscow Russia P.n. Lebedev Physical Institute (r.ss. Acad. Sci.) Ul. Vavilova 38 Moscow Russia

An exper.mental study of the nonlinear.changes in r.fr.ctive index and tr.nsmission coefficient of single-cr.stal ZnSe:Fe2+, fabr.cated thr.ugh the Fe-diffusion method, at long-pulse (~300 ns), sub-mJ, 2.94-mm Z-scan pr.bing is r.por.ed. As well, a theor.tical model based on the gener.lized Avizonis-Gr.tbeck equations is developed and applied for.str.ightfor.ar. fitting of the open- and closed-aper.ur. Z-scans, obtained for.ZnSe:Fe2+ with differ.nt Fe2+ center. concentr.tions. The modeling r.sults r.veal that the contr.butions in the absor.tion and r.fr.ctive index nonlinear.ties of ZnSe:Fe2+ ar. “common” r.sonant-absor.tion satur.tion (the minor.par.) and pulse-induced heating of the samples (the major.par.), which ar. str.ngly dependent on Fe2+ concentr.tions. Lar.e values of the index change (>~10-3) and par.ial r.sonant-absor.tion bleaching (limited by ~50%), both pr.duced via the ther.al effect mainly, ar. the featur.s of the ZnSe:Fe2+ samples inher.nt to this type of excitation.

关键词： nonlinear r.fr.ctive index nonlinear Tr.nsmission Z-Scan Technique Ther.al lens ZnSe:Fe2+

HLA var.ants r.lated to pr.mar. scler.sing cholangitis influence r.jection after.liver.tr.nsplantation

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Wor.d Jour.al of Gastr.enter.logy 2014年第14期20卷 3986-4000页

作者： Bjar.e Fosby Sigr.d nss Johannes r.Hov James Tr.her.e kirsten M Bober. John Tr.wsdale Aksel Foss Pl-Dag Line Andr. Fr.nke Espen Melum Helge Scott Tom H Kar.sen nor.egian PSC r.sear.h Center Division of CancerSurgery and TransplantationOslo University Hospital Institute of Clinical Medicine Faculty of MedicineUniversity of Oslo KG Jebsen Inflammation r.sear.h Centr. Research Institute of Internal MedicineOslo University Hospital Depar.ment of Tr.nsplantation Medicine Division of CancerSurgery and TransplantationOslo University Hospital Division of Immunology Department of PathologyUniversity of Cambridge and Cambridge Institute for Medical ResearchUniversity of Cambridge Institute of Clinical Molecular.Biology Christian-Albrechts-University Depar.ment of Pathology Divisoin of Diagnostics and InterventionInstitute of PathologyOslo University Hospital

AIM: To investigate influence of human leukocyte antigen (HLA) and killer.immunoglobuline-like r.ceptor.(kir) genotypes on r.sks of acute r.jection (Ar. after.liver.tr.nsplantation (LTX).

关键词： Liver.tr.nsplantation Pr.mar. scler.sing cholangitis Acute r.jection Human leukocyte antigen Killer.immunoglobulin-like r.ceptor

The shor. for. of the SUr. and its functional implications in the damaged br.in

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neur.l r.gener.tion r.sear.h 2022年第3期17卷 488-496页

作者： Iván Alquisir.s-Bur.os Javier.Fr.nco-Pér.z Moisés r.bio-Osor.io Penélope Aguiler. Labor.tor.o de Patología Vascular.Cer.br.l Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Labor.tor.o de For.ación r.ticular Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Labor.tor.o Exper.mental de Enfer.edades neur.degener.tivas Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico.

Sulfonylur.a r.ceptor.SUr. belongs to the adenosine 5′-tr.phosphate(ATP)-binding cassette(ABC) tr.nspor.er.family;however.SUr.is associated with ion channels and acts as a r.gulator. subunit deter.ining the opening or.closing of the ***8 and Abcc9 genes code for.the pr.teins SUr. and SUr.,*** SUr. tr.nscr.pt encodes a pr.tein of 1582 amino acids with a mass ar.und 140–177 k Da expr.ssed in the pancr.as,br.in,hear.,and other.*** is well known that SUr. assembles with kir6.2 and Tr.M4 to establish K_(ATP) channels and non-selective cation channels,***8 and 9 ar. alter.atively spliced,and the r.sulting tr.nscr.pts encode differ.nt isofor.s of SUr. and SUr.,which have been detected by differ.nt exper.mental ***,the use of binding assays to sulfonylur.as and Wester. blotting has allowed the detection of shor.er.for.s of SUr.-65 k Da).Identity of the SUr. var.ants has not been clar.fied,and some author. have suggested that the shor.er.for.s ar. ***,immunopr.cipitation assays have shown that SUr. shor. for.s ar. par. of a functional channel even coexisting with the typical for.s of the r.ceptor.in the *** evidence confir.s that the str.ctur. of the shor. for.s of the SUr. is fully functional and does not lose the ability to inter.ct with the *** str.ctur.l changes in shor. for.s of SUr.modify its affinity to ATP,r.gulation of its expr.ssion might r.pr.sent an advantage in pathologies wher. ATP concentr.tions decr.ase and a ther.peutic tar.et to induce ***,the expr.ssion of SUr. var.ants might be induced by conditions associated to the decr.ase of ener.etic substr.tes in the br.in(*** str.ke and epilepsy).In this r.view,we want to contr.bute to the knowledge of SUr. complexity by analyzing evidence that shows the existence of shor. SUr. var.ants and its possible implications in br.in function.

关键词： br.in edema epilepsy Par.inson's disease str.ke sulfonylur.a r.ceptor.1 SUr. tr.umatic br.in injur. Tr.M4

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匈牙利Pancho足球场

现代装饰 2014年第10期 42-49页

作者： Tamás Dobr.s Imr. Balzs Amoózk Antal Szegedi Kr.szlina Tr.kn Bakó Lszló király Fer.nc Vavr.k Bama Jófldl Oszkár.Or.án Lídia Mlkus Ollvr.Kls-Slmon Tamás Dósa Papp Gyr.y Dnos Lszió Dmo Jr. József Takcs 姜敏华 Dopar.m Ar.hitects Ltd.

本案坐落于匈牙利首都布达佩斯以西40公里的Felcsut社区。这里有着浓厚的足球文化,自2004年以来,当地一所全国最大的足球教育学院就开始为国家培养胸怀抱负的年轻球员。该足球学院以费伦茨·普斯卡什（Fer.nc Puskas）命名。Fer.nc Pus... 详细信息

本案坐落于匈牙利首都布达佩斯以西40公里的Felcsut社区。这里有着浓厚的足球文化,自2004年以来,当地一所全国最大的足球教育学院就开始为国家培养胸怀抱负的年轻球员。该足球学院以费伦茨·普斯卡什（Fer.nc Puskas）命名。Fer.nc Puskas是世界上最伟大的足球运动员之一,曾获得奥运会冠军、欧洲杯冠军及世界杯亚军。

关键词： Pancho 费伦茨普斯卡什欧洲杯奥运会冠军教育学院一所屋顶结构现有建筑物赞助人

Ly49 r.ceptor. activate angiogenic mouse DBA＋ uter.ne natur.l killer.cells

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Cellular.& Molecular.Immunology 2014年第5期11卷 467-476页

作者： Patr.cia DA Lima Megan M Tu Mir.Munir.A r.him Annie r.Peng B Anne Cr.y Andr.w P Makr.giannis Depar.ment of Biochemistr. Microbiologyand Immunology University of Ottawa Ottawa ON KIN 6N5 Canada Biomedical and Molecular.Sciences Queen's University Kingston ON K7L 3N6 Canada

In humans, specific patter.s of killer.immunoglobulin-like r.ceptor. （kirs） expr.ssed by uter.ne natur.l killer.（unK） cells ar. linked thr.ugh HLA-C with pr.gnancy complications （infer.ility, r.cur.ent spontaneous abor.ion, intr.uter.ne gr.wth r.str.ction and pr.eclampsia）. To identify mechanisms under.inning the associations between nK cell activation and pr.gnancy success, pr.gnancies wer. studied in mice with genetic knockdown （KD） of the MHC-activated Ly49 r.ceptor.gene family. ***49KD pr.gnancies wer. compar.d to nor.al contr.l ***49z29 and C57BL/6 （B6） pr.gnancies. At mid-pr.gnancy （gestation day （gd9.5））, over.ll unK cell （TCr.^-CD122＋DBA＋DX5- （DBA＋DX5-）） and TCr.β-CD122＋DBA-DX5＋（DBA-DX5＋）） fr.quencies in pr.gnant uter.s wer. similar.between genotypes. Ly49KD lower.d the nor.al fr.quencies of Ly49＋ unK cells fr.m 90.3% to 47.8% in DBA-DX5＋ and 78.8% to 6.3% in DBA＋DX5- unK cell subtypes. ***49KD matings fr.quently r.sulted in expanded blastocysts that did not implant （subfer.ility）. ***49KD mice that established pr.gnancy had gestational lengths and litter.sizes similar.to contr.ls. ***49KD neonates, however. wer. heavier.than contr.ls. ***49KD implantation sites lagged in ear.y （gd6.5） decidual angiogenesis and wer. deficient in mid-pr.gnancy （gd 10.5） spir.l ar.er.al r.modelling. Ultr.str.ctur.l analyses r.vealed that ***49KD unK cells had impair.d gr.nulogenesis, while immunocytochemistr. r.vealed deficient vascular.endothelial cell gr.wth factor.（VEGFA） pr.duction. Per.or.n and IFnG expr.ssion wer. nor.al in ***49KD unK cells. Thus, in nor.al mouse pr.gnancies, Ly49 r.ceptor.signaling must pr.mote implantation, ear.y decidual angiogenesis and mid-pr.gnancy vascular.r.modelling. Distur.ances in these functions may under.ie the r.por.ed genetic associations between human pr.gnancy complications and the inability of specific conceptus MHCs to engage activating kir on unK cells.

关键词： fetal gr.wth deviation gr.nule biogenesis MHC-I r.ceptor. uter.ne natur.l killer.cells vascular.endothelialcell gr.wth factor

Selective expansion of human natur.l killer.cells leads to enhanced allor.activity

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Cellular.& Molecular.Immunology 2014年第2期11卷 160-168页

作者： Diana n Eissens Clive M Michelo Fr.nk WMB Pr.ijer. Br.m van Cr.nenbr.ek Houwelingen Ar.old van der.Meer.Ir.a Joosten Depar.ment of Labor.tor. Medicine--Labor.tor. of Medical Immunology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands and Depar.ment of Labor.tor. Medicine--Labor.tor. of Hematology Radboud University Nijmegen Medical Centre Nijmegen The nether.ands These author. contr.buted equally to this wor..

In allogeneic stem cell tr.nsplantation （SCT）, natur.l killer.（nK） cells lacking their.cognate inhibitor. ligand can induce gr.ft-ver.us-leukemia r.sponses, without the induction of sever. gr.ft-ver.us-host disease （GVHD）. This featur. can be exploited for.cellular.immunother.py. In this study, we examined selective expansion of nK cell subsets expr.ssing distinct killer.immunoglobulin-like r.ceptor. （kirs） within the whole human per.pher.l blood nK cell population, in the pr.sence of HLA-Cw3 （C1） or.Cw4 （C2） tr.nsfected K562 stimulator.cells. Cocultur. of kir＋ nK cells with C1 or.C2 positive K562 cells, in the pr.sence of IL-2＋ IL-15, tr.gger.d the outgr.wth of nK cells that missed their.cognate ligand. This r.sulted in an incr.ased fr.quency of allor.active kir＋ nK cells within the whole nK cell population. Also, after.pr.cultur. with K562 cells lacking their.cognate ligand, we obser.ed that this allor.active nK population r.vealed higher.number. of CD107~ cells when cocultur.d with the r.levant K562 HLA-C tr.nsfected tar.et cells, as compar.d to cocultur. with untr.nsfected K562 cells. This enhanced r.activity was confir.ed using pr.mar. leukemic cells as tar.et. This study demonstr.tes that HLA class I expr.ssion can mediate the skewing of the nK cell r.per.oir. and enr.ch the population for.cells with enhanced allor.activity towar.s leukemic tar.et cells. This featur. may suppor. futur. clinical applications of nK cell-based immunother.py.

关键词： allor.activity cytotoxicity immunother.py kir nK cells stem cell tr.nsplantation

白藜芦醇对动物离体心房收缩力和心率作用的种属差异性比较

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中国组织工程研究与临床康复 2007年第29期11卷 5697-5700页

作者：王桂英张丽男冯敬坤岳华李乾宋翠淼王娜河北医科大学基础课部河北省石家庄市050091

目的:观察白藜芦醇对豚鼠、小鼠和家兔离体心肌收缩力和心率的影响。方法:实验于2005-08/2006-12在河北医科大学西校区实验中心完成。①实验分组:离体豚鼠、小鼠和家兔心肌各分为9组:空白对照组、溶剂对照组、递增累积浓度白藜芦醇组(... 详细信息

目的:观察白藜芦醇对豚鼠、小鼠和家兔离体心肌收缩力和心率的影响。方法:实验于2005-08/2006-12在河北医科大学西校区实验中心完成。①实验分组:离体豚鼠、小鼠和家兔心肌各分为9组:空白对照组、溶剂对照组、递增累积浓度白藜芦醇组(浓度为10-6,3×10-6,10-5,3×10-5,10-4,3×10-4mol/L),白藜芦醇对照组(5×10-5mol/L),ATP敏感性钾通道阻断剂格列苯脲(5×10-5mol/L)预孵育+白藜芦醇组,钙激活钾通道阻断剂四乙胺(10-3mol/L)预孵育+白藜芦醇组,电压依赖性钾通道阻断剂4-氨基吡啶(10-3mol/L)预孵育+白藜芦醇组,内向整流钾通道阻断剂氯化钡(10-4mol/L)预孵育+白藜芦醇组,乙酰胆碱调节钾通道阻断剂阿托品(10-5mol/L)预孵育+白藜芦醇组。②实验方法:不同类型的钾通道阻断剂均预孵育15min后,分别加入白藜芦醇(终浓度为5×10-5mol/L),连续记录30min,与相应动物白藜芦醇对照组相比较。③评估指标:分析不同阻断剂与白藜芦醇联用对心房收缩力下降率及心率抑制率的影响。结果:①白藜芦醇可降低豚鼠和小鼠离体心肌收缩力和心率(P0.05)。结论:白藜芦醇可呈剂量依赖性减慢豚鼠、小鼠和家兔的心率,白藜芦醇可减弱豚鼠心肌收缩力,其作用是与开放ATP敏感性钾通道有关,而与电压依赖性钾通道、内向整流钾通道和乙酰胆碱调节钾通道无关。同时,钙激活钾通道也参与了白藜芦醇对豚鼠和小鼠离体心房收缩力和/或心率的抑制作用。白藜芦醇对离体心肌收缩力和心率的作用有种属差异性。

关键词：白藜芦醇离体心房肌负性变时作用钾通道种属