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应用微模型进行凝胶处理的机理研究

油田化学 1994年第3期11卷 220-225页

作者：张玉萍 dawe.,r. 新疆石油管理局油田工艺研究所

本文通过应用一种在玻璃上刻蚀的地层孔隙微模型进行凝胶封堵试验，观察油水通过凝胶封堵的孔隙介质和裂缝的方式以及残余油和孔隙介质润湿性对凝胶封堵能力的影响，对聚合物凝胶处理的机理进行研究。研究结果表明，凝胶的堵水能力大大... 详细信息

本文通过应用一种在玻璃上刻蚀的地层孔隙微模型进行凝胶封堵试验，观察油水通过凝胶封堵的孔隙介质和裂缝的方式以及残余油和孔隙介质润湿性对凝胶封堵能力的影响，对聚合物凝胶处理的机理进行研究。研究结果表明，凝胶的堵水能力大大高于堵油能力。原因在于油相穿过凝胶主要是从孔道中部指进，通过沿途带走一些凝胶碎片和凝胶内的部分水份而使凝胶收缩，油相流动通道增大，流动阻力降低。盐水穿过凝胶时则趋于进入凝胶结构内部使凝胶膨胀，使水相流动通道缩小，流动阻力增加。

关键词：凝胶处理堵水调剖剂水压驱动驱油

Flavonol Glycoside fr.m Psor.sper.um andr.saemifofium

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Chinese Jour.al of Chemistr. 2011年第1期29卷 85-88页

作者： Poumale, Poumale Her.e Mar.iat Kr.bs, Hans Chr.stoph Amadou, dawe Shiono, Yoshihito Guedem, Alphonsine Nkapwa1 Komguem, Justin Ngadjui, Bonaventur. Tchaleu r.ndr.anasolo, r.voar.sonI Depar.ment of Bior.sour.e Engineer.ng Faculty of Agriculture Yamagata University Tsuruoka Yamagata 997-8555 Japan Institut Fur.Lebensmitteltoxikologie and Chemische Analytik Chemische Analytik and Endokrinologie Stiftung Tierurztliche Hochschule Bischofsholer Damm 15/123 D-30173 Hannover Germany Depar.ment of Or.anic Chemistr. Faculty of Science University of Yaounde I P.O. Box 812 Yaounde Cameroon Depar.ment of Or.anic Chemistr. Faculty of Science University of Antananarivo Madagascar P.O. Box 906 Antananarivo 101 Madagascar

A new flavonol glycoside, 3＇-（4＇＂-（3＇＂＇,4＇＂＇-dihydr.xyphenoxy）-2＇＂-hydr.xyphenoxy）acanthophor.n B （la） to- gether.with 3＇-（2＇＂,4＂＇-dihydr.xyphenoxy）acanthophor.n B （1）, acanthophor.n B （2）, vismiaquinone （3）, r.eochr.sidin （3a）, lupeol acetate and fatty acid wer. isolated fr.m the chlor.for. extr.ct of the stem bar. of Psor.sper.um andr.saemifolium Baker.（Clusiaceae）. The str.ctur. of la was deter.ined on the basis of detailed spectr.scopic analysis and compar.son with the liter.tur.. Compounds la and 3a showed moder.te antimicr.bial activity.

关键词： Psor.sper.um andr.saemifolium natur.l pr.ducts flavonol glycoside clusiaceae hydr.lysis acanthophor.n B

Amyloid pr.cur.or.pr.tein cluster. at CNS nodes of r.nvier.and causes an APPThr.68 phosphor.lation-dependent incr.ase in Nav1.6 sodium channel cur.ents

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Amyloid precursor protein clusters at CNS nodes of Ranvier a...

Amyloid pr.cur.or.pr.tein cluster. at CNS nodes of r.nvier.and causes an APPThr.68 phosphor.lation-dependent incr.ase in Nav1.6 sodium channel cur.ents

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Melitta SCHACHNEr.Gavin S.dawe Depar.ment of Physiology Sino-German Neuroscience Institute of Dalian Medical UniversityDalian 116044China Zentr.m fur.Molekular. Neur.biologie University of HamburgHamburgGermany Depar.ment of Phar.acology Yong Loo Lin School of MedicineNational University of Singapore117597Singapore

＜正＞Objective Amyloid pr.cur.or.pr.tein（APP）,commonly associated with Alzheimer.s disease（AD）,mar.s axonal *** its physiological distr.bution and function along myelinated axons r.main *** wor. was to investigate the physiological distr.bution of APP and its function in modulating the expr.ssion of Nav1.6 sodium channel. Under.tanding the physiological r.les of APP in axonal function may offer.new insights into the pr.cesses by which abnor.al pr.cessing of APP can contr.bute to the pathogenesis of *** Immunofluor.scences wer. per.or.ed to detect the location of APP along myelinated axons;Wester. blots wer. analyzed to investigate the expr.ssion of APP and sodium channel in the centr.l ner.ous system（CNS）;Co-immunopr.cipitations wer. done to explor. whether.APP and sodium channel for. a molecular.complex;Co-expr.ssed full length APP or.its intr.cellular.domain（AICD,Go pr.teinbinding domain,Fe65 binding domain,or.C31 domain） with Nav 1.6 sodium channels into Xenopus oocytes to study the function of APP in modulation of Nav 1.6 cur.ents using two-electr.de voltage clamp technique;Compar.d conduction velocity and cell sur.ace expr.ssion between WT and KO of APP and r.lated APPThr.68 phosphor.lation site mice to elucidate fur.her.the mechanism of APP on modulation of Nav 1.6 sodium *** Aaxonal APP for.s a complex with Nav 1.6 and aggr.gates only specifically at the nodes of r.nvier.of the centr.l ner.ous system（CNS）,but not the per.pher.l ner.ous system（PNS）.Notably,coexpr.ssion of APP or.its intr.cellular.domains containing a VTPEEr.motif with Nav 1.6 sodium channels in Xenopus oocytes r.sulted in an incr.ase in peak sodium cur.ents,which was enhanced by APPT668E mutation and blocked by APPT668A mutation and inhibitor. of CDK5 and *** cell sur.ace expr.ssion of Nav 1.6 sodium channels in the white matter.of spinal cor. is decr.ased in APP,p35 and JNK3 null ***, APP,p35 and JNK3 deficiency significantly r.duce s

关键词： APP sodium channels nodes of r.nvier phosphor.lation

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Amyloid precursor protein clusters at CNS nodes of Ranvier a...

大区互联电网稳控站分区联合(单站)调试的隔离

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Toshitaka Futagawa Sashi Kesavapany Melitta Schachner.Gavin S.dawe Depar.ment of Clinical r.sear.h Singapore General HospitalSingapore Depar.ment of Biochemistr. Yong Loo Lin School of MedicineNational University of SingaporeSingapore Depar.ment of Phar.acology and Depar.ment of Anatomy Yong Loo Lin School of MedicineNational University of SingaporeSingapore

＜正＞APP,commonly associated with Alzheimer.s disease,mar.s axonal *** physiological distr.bution and function along myelinated axons r.main *** r.por. that APP null and APP over.xpr.ssing tr.nsgenic（APPtg） mice show minor.hypo- and hyper.myelination,*** axoglial inter.ctions, APP aggr.gates at nodes of r.nvier.NOr.） in the ***,coexpr.ssion of APP or.its intr.cellular.domains containing a VTPEEr.motif with Navl.6 sodium channels in Xenopus oocytes r.sulted in an incr.ase in peak sodium cur.ents,which was enhanced by APPT668E mutation and blocked by APPT668A mutation and inhibitor. of CDK5 and *** cell sur.ace expr.ssion of Navl.6 sodium channels in the white matter.of spinal cor. is decr.ased in APP,p35 and JNK3 null ***,APP,p35 and JNK3 deficiency significantly r.duce spinal conduction ***,APP acts as a novel component at CNS NOr.,modulating Navl.6 sodium channels in an APPThr.68 phosphor.lation-dependent manner.

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电力自动化设备 2011年第4期31卷 147-150页

作者：葛大维姜浩徐光虎安顺供电局贵州安顺561000 贵州电力调度通信局贵州贵阳550002 中国南方电网电力调度通信中心广东广州510623

大区互联电网稳定控制系统调试的隔离措施是系统安全运行及调试成功的关键环节。阐述了大区互联电网稳定控制系统单站及联合调试的隔离措施及要求。本着稳控策略与逻辑一体化的原则,提出了不同调管权下稳控装置之间互有延伸的概念,使任... 详细信息

大区互联电网稳定控制系统调试的隔离措施是系统安全运行及调试成功的关键环节。阐述了大区互联电网稳定控制系统单站及联合调试的隔离措施及要求。本着稳控策略与逻辑一体化的原则,提出了不同调管权下稳控装置之间互有延伸的概念,使任何一个区域稳控系统开展单站或联合调试时,都能确保所有的稳控策略与逻辑保持在一个整体的状态下。系统互有延伸并保持完整的隔离措施在实际工程应用中能全面地对稳控系统进行试验,不存在测试的盲区,保证调试检验的完整性。

关键词：大区互联稳定控制系统联合调试隔离措施

大速比多项作业车辆采用一种牵引弧锥环轮式无级变速传动和牵引行星传动的变速箱

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传动技术 1998年第1期12卷 34-37,47页

作者： DanielJ.dawe Char.esB.Lohr

采用一牵引无级变速传动和一行星牵引定速比传动的一种新型变速箱已经设计、研制与试验。本文将以功率流概念和新部件结构两方面来描述这种变速箱的设计。把这种无级变速传动和行星传动综合成一体，可以据此由三个功率流实现总速比２０... 详细信息

采用一牵引无级变速传动和一行星牵引定速比传动的一种新型变速箱已经设计、研制与试验。本文将以功率流概念和新部件结构两方面来描述这种变速箱的设计。把这种无级变速传动和行星传动综合成一体，可以据此由三个功率流实现总速比２０∶１以上的大无级变速范围。不加其他设备可实现空档与倒档。该变速箱已装于０．５ｔ轻型货车做大速比车辆变速箱有关试验。

关键词：大速比多项作业牵引弧锥环轮式无级变速传动

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标准美国英语

标准美国英语

摄入贯叶连翘生粉(金丝桃素)会增强患者在大剂量UVA1治疗过程中的红斑反应吗?

作者： E.A.·多南(E.A. Dor.an) C.W.·道厄(C.W. dawe)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 42-43页

作者： Beattie P.E. dawe r.S. Tr.ynor.N.J. 焦婷 Der.atology Depar.ment University ofDundee Ninewells Hospital and Medical School Dundee DD1 9SY United Kingdom

Backgr.und: St John s wor. (SJW) is widely used as a tr.atment for.depr.ssion. A phototoxic r.action, due to its content of hyper.cin, can occur.in animals and in cell cultur., and has been r.por.ed in humans. Hyper.cin displays absor.tion within the ultr.violet (UV) A1 spectr.m and ther. may ther.for. be a potential for.phototoxicity if taken dur.ng high-dose UVA1 ther.py. Objectives: To assess the phototoxicity r.sk of SJW ingestion. Methods: Eleven adult volunteer. of skin types I and II wer. exposed to a geometr.c dose ser.es of UVA1 ir.adiation fr.m a high-output sour.e (Der.alight Ultr. 1; Dr.H nle, Mar.insr.id, Ger.any; ir.adiance 70- 77 mW cm- 2) on the photopr.tected lower.back skin at eight 1.5-cm2 test ar.as. Ir.adiation was car.ied out at baseline and after.10 days of SJW extr.ct 1020 mg (equivalent to 3000 μ g of hyper.cin) daily. Four. 8, 24 and 48 h after.each exposur., the minimal er.thema dose (MED) and the pr.sence or.absence of pigmentation wer. r.cor.ed visually and er.thema was assessed objectively with an er.thema meter. r.sults: The median MED and D0.025, an objective measur. of MED, wer. lower.at all time-points after.SJW ingestion. The visual er.themal peak (lowest median MED), which was seen at 8 h postir.adiation, was lower.after.SJW (median 14 J cm- 2, r.nge 10- 56) than at baseline (median 20 J cm- 2, r.nge 14- 56) (P = 0.047). Similar.y, the median D0.025 at 8 h postir.adiation was lower.after.SJW(median 22.0 J cm- 2, r.nge 15.2- 53.9) than at baseline (median 33.7 J cm - 2, r.nge 22.9- 136.0) (P = 0.014). The MED and D0.025 wer. also significantly differ.nt at the 48-h and 4-h time-points, r.spectively. Significance was not r.ached at the 24-h time-point. Median intensity of postir.adiation er.thema incr.ased at all time-points after.ingestion of SJW. Despite these differ.nces, the maximum slope of the dose-r.sponse cur.e was not incr.ased after.SJW ingestion. Conclusions: These data suggest that SJW extr.ct has the potential to lower

关键词：治疗过程金丝桃素 UVA1 贯叶连翘大剂量红斑反应摄入光毒性反应患者培养的细胞

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UVA1红斑的量效与时程特征

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 25-26页

作者： Beattie P.E. dawe r.S. Fer.uson J. Ibbotson S.H. 潘敏 Photobiology Unit Ninewells Hospital and Medical School Ninewells AvenueDundee DD1 9SYUnited Kingdom

Objective: To deter.ine the time cour.e and dose-r.sponse char.cter.stics of UV-A1 er.thema in the Tayside r.gion of Scotland. Design: Adult volunteer. (skin types I and II [n=13]- and III and IV [n=11])wer. exposed to geometr.c dose ser.es of UV-A1 ir.adiation fr.m a high-output sour.e on photopr.tected lower.back and inner.for.ar. skin. Setting: Photobiology unit in a univer.ity hospital. MainOutcomeMeasur.s: The minimal er.thema dose (MED) was r.cor.ed visually and er.thema was assessed objectively by er.thema meter.at 4, 8, 24, and 48 hour. after.exposur.. r.sults: Peak er.thema (lowest visual MED) was seen at 8 hour. on the back and ar. in 11 subjects with skin types I and II and on the back at 8 hour. in 9 subjects and on the ar. at 4 hour. in 10 subjects with skin types III and IV. The lowest median (r.nge) MED was 20 J/cm2 (14- 56 J/cm2) on the back and 42 J/cm2 (20 to >80 J/cm2) on the ar. at 8 hour. for.subjects with skin types I and II and 28 J/cm2 (20- 112 J/cm2) at 8 hour. on the back and 56 J/cm2 (28- 80 J/cm2) at 4 hour. on the ar. for.subjects with skin types III and IV. The D0.025, an objective measur. that cor.esponds appr.ximately to the visual MED, demonstr.ted a br.ad peak fr.m 8 to 24 hour.. Conclusions: Our.local population is mor. er.themally sensitive to UV-A1 r.diation than r.por.s suggest. Daily dose r.gimens may r.sk cumulative er.thema. Lower.star.ing doses should be used in this population. The wide r.nge of MEDs highlights the need for.MED testing.

关键词：最小红斑剂量 UVA1 时程量效 Ⅳ型皮肤大学医院观察指标受试者照射苏格兰