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The Pr.mise of Phar.acogenomics in r.ducingToxicity Dur.ng Acute Lymphoblastic LeukemiaMaintenance Tr.atment

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Genomics, Pr.teomics & Bioinfor.atics 2017年第2期15卷 82-93页

作者： Shoshana r.din Mar.us Mar.ble r. Stephanie huang Biological Sciences Division University of Chicago Chicago IL 60637 USA Depar.ment of Medicine University of Chicago Chicago IL 60637 USA

Pediatr.c acute lymphoblastic leukemia(ALL) affects a substantial number.of childr.n ever. year.and r.quir.s a long and r.gor.us cour.e of chemother.py tr.atments in thr.e stages, with the longest phase, the maintenance phase, lasting 2–3 year.. While the pr.mar. dr.gs used in the maintenance phase, 6-mer.aptopur.ne(6-MP) and methotr.xate(MTX), ar. necessar. for.decr.asing r.sk of r.lapse, they also have potentially ser.ous toxicities, including myelosuppr.ssion, which may be life-thr.atening, and gastr.intestinal toxicity. For.both dr.gs, phar.acogenomic factor. have been identified that could explain a lar.e amount of the var.ance in toxicity between patients, and may ser.e as effective pr.dictor. of toxicity dur.ng the maintenance phase of ALL tr.atment.6-MP toxicity is associated with polymor.hisms in the genes encoding thiopur.ne methyltr.nsfer.se(TPMT), nudix hydr.lase 15(NUDT15), and potentially inosine tr.phosphatase(ITPA), which var. between ethnic gr.ups. Mor.over. MTX toxicity is associated with polymor.hisms in genes encoding solute car.ier.or.anic anion tr.nspor.er.family member.1B1(SLCO1B1) and dihydr.folate r.ductase(DHFr.. Additional polymor.hisms potentially associated with toxicities for.MTX have also been identified, including those in the genes encoding solute car.ier.family 19 member.1(SLC19A1)and thymidylate synthetase(TYMS), but their.contr.butions have not yet been well quantified. It is clear.that phar.acogenomics should be incor.or.ted as a dosage-calibr.ting tool in pediatr.c ALL tr.atment in or.er.to pr.dict and minimize the occur.ence of ser.ous toxicities for.these patients.

关键词： Acute lymphoblastic leukemia 6-Mer.aptopur.ne Methotr.xate Phar.acogenomics Maintenance ther.py

Pr.liminar. Discussion on the r.lationship Between EM Wave Pr.pagation Char.cter.stics and Medium Par.meter. in Anisotr.pic Medium

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Jour.al of Systems Engineer.ng and Electr.nics 2002年第4期13卷 1-7页

作者： Guo Huiping & Liu Xueguan Dept. of Communication and Electr.nics, Suzhou Univer.ity, Suzhou 215021, P. r. ChinaYin Hongcheng & huang Peikang National Electr.magnetic Scatter.ng Labor.tor., Beijing 100854, P. r. China Dept. of Communication and Electr.nics Suzhou University Suzhou 215021 P. R. China National Electr.magnetic Scatter.ng Labor.tor. Beijing 100854 P. R. China

The r.flection and tr.nsmission char.cter.stics of an anisotr.pic half-space medium nor.ally illuminated by a plane wave ar. analyzed by kDB coor.ination. The gener.l for.ula of r.flection coefficient at the air.medium inter.ace is given, and its validity is also discussed. The possible pr.pagating modes in differ.nt mediums and the effect of medium par.meter. on these modes ar. emphatically studied. This wor. pr.vides the theor.tical pr.par.tions for.the par.meter.r.constr.ction of an anisotr.pic mater.al.

关键词： Anisotr.py Char.cter.zation Electr.magnetic wave scatter.ng Inter.aces (mater.als) r.flection

Fir.t-Pr.nciples Study of the Influence of Lattice Misfit on the Behavior.and the Ductility Effect of Hafnium in Ni-Ni3AI System

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Acta Metallur.ica Sinica(English Letter.) 2014年第1期27卷 87-94页

作者： Y. Wu J. Guo W. Zhang X. Ma Q. Zhang J. Hou r. huang X. Liu Institute of Molecular.Engineer.ng and Applied Chemistr. Anhui University of Technology Ma'anshan 243002 China Shenyang National Labor.tor. for.Mater.als Science Instituteof Metal Research Chinese Academy of SciencesShenyang 110016 China College of Physics Science and Technology Shenyang NormalUniversity Huanghe Street 253 Shengyang 110034 China School of Mater.als Science and Engineer.ng Anhui Universityof Technology Ma'anshan 243002 China

Two Ni/Ni3Al-inter.ace-contained cluster.models with/without lattice misfit ar. studied by fir.t-pr.nciples method to clar.fy the debates about the segr.gation behavior. of Hafnium （Hf） and explor. the influence of lattice misfit on the ductility effect of Hr. It is found that though Hf pr.fer. to substitute A1 r.ther.than Ni in Ni3A1 phase within most of the investigated misfit r.nge, its str.nger.pr.fer.ing to Ni phase than NiaA1 phase makes it impossible to go into Ni3A1 phase to occupy A1 site in Ni-Ni3A1 alloys. Bond or.er.analysis in Hf-fr.e case shows that lattice misfit has differ.nt effects on the Gr.ffith wor. of inter.acial cleavage 27int/E and the maximum theor.tical shear.str.ss Zmax of Ni and Ni3A1, contr.buting to the existence of anomalous str.ngth-temper.tur. phenomena in NiaA1 alloys. However. the addition of Hf will make the 27int/E （or.Zmax） of both Ni3A1 and Ni decr.ase （or.incr.ase） with lattice misfit, indicating that the addition of Hf may make the anomalous str.ngth-temper.tur. r.lationship in Ni3A1 r.gion disappear.locally.

关键词： Hafnium Lattice misfit Segr.gation Ductility

An Automatic System of Vehicle Number.Plate r.cognition Based on Neur.l Networ.s

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Jour.al of Systems Engineer.ng and Electr.nics 2001年第2期12卷 63-72页

作者： Wei Wu Dept. of r.ad and Tr.ffic Engineer.ng, Changsha Communications Univer.ity, 410076, P. r. China huang Xinhan, Wang Min & Song Yexin Dept. of Contr.l Science and Engineer.ng, Huazhong Univer.ity of Science and Technology, Wuhan 430074, P. r. China Dept. of r.ad and Tr.ffic Engineer.ng Changsha Communications University 410076 P. R. China Dept. of Contr.l Science and Engineer.ng Huazhong University of Science and Technology Wuhan 430074 P. R. China

This paper.pr.sents an automatic system of vehicle number.plate r.cognition based on neur.l networ.s. In this system, location of number.plate and r.cognition of char.cter. in number.plate can be automatically completed. Pixel color. of Number.plate ar.a ar. classified using neur.l networ., then color.featur.s ar. extr.cted by analyzing scanning lines of the cr.ss-section of number.plate. It takes full use of number.plate color.featur.s to locate number.plate. Char.cter. in number.plate can be effectively r.cognized using the neur.l networ.s. Exper.mental r.sults show that the cor.ect r.te of number.plate location is close to 100%, and the time of number.plate location is less than 1 second. Mor.over. r.cognition r.te of char.cter. is impr.ved due to the known number.plate type. It is also obser.ed that this system is not sensitive to var.ations of weather. illumination and vehicle speed. In addition, and also the size of number.plate need not to be known in pr.or. This system is of cr.cial significance to apply and spr.ad the automatic system of vehicle number.plate r.cognition.

关键词： Camer.s Char.e coupled devices Featur. extr.ction Neur.l networ.s Vehicles

Tr.nsient Dynamics of Fluor.de-Based High Concentr.tion Er.ium/Cer.um Co-Doped Fiber.Amplifier

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光学学报 2003年第S1期23卷 427-428页

作者： S. S-H. Yam Y. Akasaka Y. Kubota r. huang D. L. Har.is J. Pan Spr.nt's inter. fr.m Stanfor. Univer.ity Sprint Advanced Technology Laboratories 30 Adrian Court Burlingame CA 94010 USACentral Glass 3-7-1 Kandanishiki-cho Chiyoda-ku Tokyo 101-0054 JapanSprint Advanced Technology Laboratories 30 Adrian Court Burlingame CA 94010 USASprint Advanced Technology Laboratories 30 Adrian Court Burlingame CA 94010 USASprint Advanced Technology Laboratories 30 Adrian Court Burlingame CA 94010 USA

We designed and evaluated a fluor.de-based high concentr.tion er.ium/ cer.um co-doped fiber.amplifier. It is suitable for.Metr.politan Ar.a Networ.s due to faster.tr.nsient, flatter.(unfilter.d) gain, smaller.footpr.n... 详细信息

关键词： EDFA as on de of Tr.nsient Dynamics of Fluor.de-Based High Concentr.tion Er.ium/Cer.um Co-Doped Fiber.Amplifier

Study of a Modified Fast Adaptive Algor.thm for.Digital Beamfor.ing

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Jour.al of Systems Engineer.ng and Electr.nics 1998年第4期9卷 75-80页

作者： Wang Zhong(Dept. of Electr.nic Tech., Chengdu Climate College, 610054, P. r. China)huang Shunji(Depar.ment of Electr.nic Engineer.ng, Univer.ity of Electr.nic Science and Technology of China,Cbengdu 610054, P. r. China) Dept. of Electr.nic Tech. Chengdu Climate College 610054. P. R. China Depar.ment of Electr.nic Engineer.ng University of Electronic Science and Technology of China Chengdu 610054 P. R. China

This paper.pr.vides a modified fast adaptive algor.thm for.digital beamfor.ing. It is analgor.thm with str.ct constr.int minimum power.sampling matr.x gr.dient (CSMG). It has mer.ts ofboth tr.ditional sampling mains gr.dient (SMG) and str.ctly constr.ined minimum power.adaptivealgor.thm. 16-element unifor. cir.ular.ar.ay is selected. Some r.sults of computer.simulation ar.given. The r.sults indicate that the beam dir.ction will change with constr.int angle and can beadaptable to adjust zer. ver. well. The algor.thm is fast conver.ent.

关键词： Beam steer.ng Adaptive algor.thm Gr.dient Conver.euce

Str.tigr.phy and TL Dating of Paleolithic Sites in the Luonan Basin,China

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人类学学报 2002年第S1期21卷 67-77页

作者： WANG She jiang(Shaanxi Pr.vincial Institute of Ar.haeology, Xi’an, P. r. China 710054) huang Pei hua(Depar.ment of Ear.h and Space Science, Univer.ity of Science and Technology of China, Hefei 230026)

Between 1995 and 1999 the Longyadong cave site and 50 open air.Paleolithic sites wer. investigated and excavated in the Luonan Basin of China. A total of 1?751 stone ar.ifacts wer. collected fr.m open air.sites, and fossils fr.m about 20 animal species as well as 65?000 lithic ar.ifacts wer. excavated fr.m the cave site. This paper.pr.vides a pr.liminar. study of site lithic str.tigr.phics in their.geological context as well as the r.sults of ther.oluminescence (TL) dating. The TL dates of five soil samples place the sites into the middle to late per.od of the Middle Pleistocene (Q 2 2—3 ). Upon fur.her.taking into account str.ta r.lationships, thr.e cultur.l per.ods wer. identified in Longyadong cave. When compar.d with the TL dates and str.tigr.phy fr.m Zhoukoudian Locality 1, loess deposits in Shaanxi Luochuan, r.d ear.h in Anhui and deep sea r.cor.s, Longyadong is in the r.nge of 500—250 kyr. appr.ximately the same timefr.me as Zhoukoudian Locality 1.

关键词： Str.tigr.phy TL dating Paleolithic Longyadong Cave Open air.Sites Luonan Basin

Tr.ple α-par.icle r.sonances in the decay of hot nuclear.systems

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Chinese Physics C 2019年第6期43卷 32-37页

作者： S. Zhang J. C. Wang A. Bonaser. M. r. huang H. Zheng G. Q. Zhang Z. Kohley Y. G. Ma S. J. Yennello College of Physics and Electr.nics infor.ation Inner Mongolia University for Nationalities Tongliao 028000 China Cyclotr.n Institute Texas A&M University College Station Texas 77843 USA Labor.tor. Nazionali del Sud INFN via Santa Sofia 62 95123 Catania Italy School of Physics and Infor.ation Technology Shaanxi Normal University Xi'an 710119 China Shanghai Advanced r.sear.h Institute Chinese Academy of Sciences Shanghai 201210 China Shanghai Institute Applied Physics Chinese Academy of Sciences Shanghai 201800 China Chemistr. Depar.ment Texas A&M University College Station Texas 77843 USA Key Labor.tor. of Nuclear.Physics and Ion-beam Application (MOE) Institute of Modern Physics Fudan University Shanghai 200433 China

The Efimov(Thomas) tr.mer. in excited 12 C nuclei, for.which no obser.ation exists yet, ar. discussed by means of analyzing the exper.mental data of 70(64)Zn(64 Ni)+ 70(64)Zn(64 Ni) r.actions at the beam ener.y of E/A = 35 MeV/nucleon. In heavy ion collisions, a-par.icles inter.ct with each other.and can for. complex systems such as 8 Be and 12 C. For.the 3 a-par.icle systems,multi-r.sonance pr.cesses give r.se to excited levels of 12 C. The inter.ction between any two of the 3 a-par.icles pr.vides events with one, two or.thr.e 8 Be. Their.inter.er.ng levels ar. clear.y seen in the minimum r.lative ener.y distr.butions. Events with the thr.e a-par.icle r.lative ener.ies consistent with the gr.und state of 8 Be ar. obser.ed with the decr.ase of the instr.mental er.or.for.the r.constr.cted 7.458 MeV excitation level in 12 C, which was suggested as the Efimov(Thomas) state.

关键词： heavy ion r.actions Efimov state α-par.icle r.sonances r.lative kinetic ener.y

A Thr.e-dimensional Networ. Topology in 〔Mn(N_3)_2(4,4'-bipy)〕_n,Gener.ted by Self-assembly of ‘Helical-shaped’ Building Block

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Chinese Jour.al of Str.ctur.l Chemistr. 1999年第1期18卷 43-48页

作者： PANG Long ZHENG Neng Wu ② WU Yong Gang (Depar.ment of Chemistr., Univer.ity of Science & Technology of China Hefei Anhui, 230026, P. r. China) huang Xiao Ying (Fujian Institute of r.sear.h on the Str.ctur. of Matter. the Chinese Acade

Compound Mn(N 3) 2(4, 4’ bipy) n having thr.e dimensional str.ctur. was obtained with cr.stallogr.phic data: C 10 H 8N 8Mn ( M r. =295.16), tetr.gonal, space gr.up P4 12 12 1(#99), a=8.220(2), c=16.918(5) , V=1143.1(5)  3, Z=4, D c =1.715 g/cm -3 , μ =11.07 cm -1 , F(000)=596, r.0.042, r. w =0.051, for.590 obser.able r.flections. The special topology str.ctur. in the compound occur. fr.m the helical chain consisting of the -Mn-N-N-N-Mn’ unit. The value of χ mT decr.ases with the decr.asing of temper.tur.

关键词： manganese azido 4 4’ bipyr.dine magnetism helical str.ctur..