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Defining sustainable limits dur.ng and after.intensification in a mar.time agr.cultur.l ecosystem

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Ecosystem Health and Sustainability 2017年第8期3卷 15-31页

作者： Geoffr.y r.Squir. Ecological Sciences James Hutton InstituteDundeeUK

Intr.duction:Intensification of agr.cultur.l ecosystems in the 20th centur. pr.ceeded by a ser.es of innovations that initially ensur.d food secur.ty,but had negative consequences for.the in-field and wider.envir.nments.A case study in the nor.h Atlantic zone mar.time cr.pland of the UK identified thr.e phases:(1)r.or.anization between 1940 and 1960,(2)intensification leading to tr.pling of gr.in output(1960-1990),and(3)a leveling of output(1990-2015).Outcomes:Innovations that caused the changes together.with their.effect on life for.s,ecological pr.cesses and the evolving social,economic and biophysical conditions ar. *** to design futur. sustainable systems ar. hamper.d by the absence of a baseline befor. intensification,by inadequate knowledge of in-field pr.cesses,and by uncer.ainty over.safe r.nges"in which pr.cesses can oper.te without causing long-ter. system *** r.nges ar. examined for.thr.e attr.butes r.cor.ed over.all thr.e phases,namely gr.in output,fer.ilizer.input and the wild seedbank *** lower.limits for.gr.in and nitr.gen wer. quantified as those that ensur. gr.in *** upper.limits wer. identified as those that wer. economically acceptable to far.ing in the face of major.exter.al per.ur.ations r.lated to food policy and envir.nmental *** these upper.limits,fields can maintain a gener.list wild species seedbank that suppor.s a far.land food ***:Some pr.per.ies of the ecosystem ther.for. attained stability in phase ***,evidence of degr.ding soil,incr.asing pesticide use to maintain yield and collapse of specialist plant functions such as nitr.gen fixation and pollination,suggest the system is moving towar. a phase of decline.

关键词： Ecosystem ser.ices intensification r.silience safe limits biodiver.ity

Time-ser.es analysis with a hybr.d Box-Jenkins Ar.MA

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Jour.al of Har.in Institute of Technology(New Ser.es) 2004年第4期11卷 413-421页

作者： Dilli r.Ar.al 王要武 School of Management Harbin Institute of Technology Harbin 150001 China

Time-ser.es analysis is impor.ant to a wide r.nge of disciplines tr.nscending both the physical and social sciences for.pr.active policy decisions. Statistical models have sound theor.tical basis and have been successfully used in a number.of pr.blem domains in time ser.es for.casting. Due to power.and flexibility, Box-Jenkins Ar.MA model has gained enor.ous popular.ty in many ar.as and r.sear.h pr.ctice for.the last thr.e decades. Mor. r.cently, the neur.l networ.s have been shown to be a pr.mising alter.ative tool for.modeling and for.casting owing to their.ability to captur. the nonlinear.ty in the data. However. despite the popular.ty and the super.or.ty of Ar.MA and ANN models, the empir.cal for.casting per.or.ance has been r.ther.mixed so that no single method is best in ever. situation. In this study, a hybr.d Ar.MA and neur.l networ.s model to time ser.es for.casting is pr.posed. The basic idea behind the model combination is to use each model’s unique featur.s to captur. differ.nt patter.s in the data. With thr.e r.al data sets, empir.cal r.sults evidently show that the hybr.d model outper.or.s Ar.MA and ANN model noticeably in ter.s of for.casting accur.cy used in isolation.

关键词： time ser.es analysis Ar.MA Box-Jenkins methodology ar.ificial neur.l networ.s hybr.d model

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Association between her.ditar. hemochr.matosis and hepatocellular.carcinoma: a compr.hensive r.view

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作者： r.·贝克(r. Baker.

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作者： r.·艾伦(r. Allen)

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Hepatoma r.sear.h 2020年第3期6卷 1-14页

作者： Apar.a Jayachandr.n r.tu Shr.stha Kim r.Br.dle Dar.ell H.G.Cr.wfor. The Univer.ity of Queensland Faculty of MedicineBrisbaneQLD 4006Australia Gallipoli Medical r.sear.h Institute Greenslopes Private HospitalBrisbaneQLD 4120Australia

Hepatocellular.carcinoma(HCC)is a significant global health pr.blem with high mor.idity and *** incidence is incr.asing exponentially wor.dwide with a close over.ap between annual incidence and death *** though significant advances have been made in HCC tr.atment,fewer.than 20%of patients with HCC ar. suitable for.potentially cur.tive *** hemochr.matosis(HH)is an impor.ant genetic r.sk factor.for.*** is an autosomal r.cessive disor.er.of ir.n metabolism,char.cter.sed by elevated ir.n deposition in most or.ans including the liver.leading to pr.gr.ssive or.an *** is a complication of HH,near.y always occur.ing in patients with cir.hosis and contr.butes to incr.ased mor.ality *** the susceptibility of development of HCC in HH patients has gained much *** r.view summar.ses the cur.ent knowledge with r.gar. to the association of HH and HCC in or.er.to encour.ge fur.her.*** this r.view,we focus par.icular.y on HFE gene-r.lated ***,we highlight and discuss emer.ing clinical r.sear.h which addr.sses the pr.valence of HCC in HH patients and the coincidence of HH with other.r.sk factor. for.HCC *** also focus on the ther.peutic tools in the management of HCC associated with HH.

关键词： Hepatocellular.carcinoma her.ditar. hemochr.matosis HFE gene C282Y mutation H63D mutation liver.cir.hosis

Insight of magnesium alloys and composites for.or.hopedic implant applications-a r.view

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Jour.al of Magnesium and Alloys 2017年第3期5卷 286-312页

作者： r.r.dha D Sr.ekanth School of Mechanical and Building Sciences VIT UniversityChennaiIndia

Magnesium(Mg)and its alloys have been widely r.sear.hed for.or.hopedic applications *** alloys have stupendous advantages over.the commer.ially available stainless steel,Co-Cr.Ni alloy and titanium *** date,extensive mechanical,in-vitr. and in-vivo studies have been done to impr.ve the biomedical per.or.ance of Mg alloys thr.ugh alloying,pr.cessing conditions,sur.ace modification *** r.view compr.hensively descr.bes the str.tegies for.impr.ving the mechanical and degr.dation per.or.ance of Mg alloys thr.ugh pr.per.y tailor.ng the composition of alloying elements,r.infor.ements and pr.cessing *** also highlights the status and pr.gr.ss of r.sear.h in to(i)the selection of nutr.ent elements for.alloying,r.infor.ement and its effects(ii)type of Mg alloy system(binar.,ter.ar. and quater.ar.)and composites(iii)gr.in r.finement for.str.ngthening thr.ugh sever. plastic defor.ation *** it also emphasizes on the impor.ance of Mg composites with r.gar. to har. tissue applications.

关键词： Or.hopedic implants Magnesium Alloy system Composites Gr.in r.finement Pr.cessing,degr.dation,str.ngthening

Explor.ng the str.ctur.l and functional effect of pr. by significant nsSNP in the coding r.gion of r.1 gene causing r.tinoblastoma

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Science China(Life Sciences) 2010年第2期53卷 234-240页

作者： r.jasekar.n r.r.o Sethumadhavan Bioinfor.atics Division School of BiotechnologyChemical and Biomedical EngineeringVellore Institute of Technology

In this study,we identified the most deleter.ous nsSNP in r.1 gene thr.ugh str.ctur.l and functional pr.per.ies of its pr.tein (pr.) and investigated its binding affinity with *** of 956 SNPs,we investigated 12 nsSNPs in coding r.gion in which thr.e of them (SNPids r.3092895,r.3092903 and r.3092905) ar. commonly found to be damaged by I-Mutant 2.0,SIFT and PolyPhen *** this effor.,we modeled the mutant pr. pr.teins based on these deleter.ous *** a compar.son of total ener.y,stabilizing r.sidues and r.SD of these thr.e mutant pr.teins with native pr. pr.tein,we identified that the major.mutation is fr.m Glutamic acid to Glycine at the r.sidue position of 746 of ***,we compar.d the binding efficiency of both native and mutant pr. (E746G) with *** found that mutant pr. has less binding affinity with E2F-2 as compar.d to native *** is due to sixteen hydr.gen bonding and two salt br.dges that exist between native type and E2F-2,wher.as mutant type makes only thir.een hydr.gen bonds and one salt br.dge with *** on our.investigation,we pr.pose that the SNP with an id r.3092905 could be the most deleter.ous nsSNP in r.1 gene causing r.tinoblastoma.

关键词： r.tinoblastoma non synonymous SNP r.1 gene pr. E2F-2

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Tunable Fiber.Gr.tings and Their.Applications

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光学学报 2003年第S1期23卷 223-224页

作者： Z. Fang L. Zhao L. Li K. Gao Y. Zhou J. Geng r. Qu G. Chen Shanghai Institute of Optics and Fine Mechanics The Chinese Academy of SciencesP.R. ChinaShanghai Institute of Optics and Fine MechanicsThe Chinese Academy of SciencesP.R. ChinaShanghai Institute of Optics and Fine MechanicsThe Chinese Academy of SciencesP.R. ChinaShanghai Institute of Optics and Fine MechanicsThe Chinese Academy of SciencesP.R. ChinaShanghai Institute of Optics and Fine MechanicsThe Chinese Academy of SciencesP.R. ChinaShanghai Institute of Optics and Fine MechanicsThe Chinese Academy of SciencesP.R. ChinaShanghai Institute of Optics and Fine MechanicsThe Chinese Academy of SciencesP.R. ChinaShanghai Institute of Optics and Fine MechanicsThe Chinese Academy of SciencesP.R. China

Some pr.ctical r.sear.h topics on tunable fiber.gr.tings in author.s gr.up ar. pr.sented, including tuning speed, tuning r.nge, tuning char.cter.stics of gr.tings in HB fiber. and the tunability of the line-width. The... 详细信息

关键词： been of in as FBG wer. Tunable Fiber.Gr.tings and Their.Applications than have EDFA for that

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Immune checkpoint blockade ther.pies for.HCC: cur.ent status and futur. implications

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Hepatoma r.sear.h 2019年第9期5卷 1-17页

作者： r.tu Shr.stha Kim r.Br.dle Dar.ell H.G.Cr.wfor. Apar.a Jayachandr.n The Univer.ity of Queensland Faculty of MedicineBrisbaneQueensland 4120Australia Gallipoli Medical r.sear.h Institute Greenslopes Private HospitalBrisbaneQueensland 4120Australia

Hepatocellular.carcinoma(HCC)is the most lethal and common type of liver.cancer.with limited tr.atment options at the advanced *** use of immune checkpoint inhibitor.ICI)based immunother.py is exponentially incr.asing in the tr.atment of patients with advanced solid *** expr.ssion of immune checkpoints on tumor.cells leading to lower.activity of T-cells is one of the major.mechanisms of immune *** blockade immunother.pies with antibodies against PD-1,PD-L1 or.CTLA-4 ar. being investigated in clinical tr.als in HCC *** have impr.ved sur.ival in patients with inoper.ble advanced stage HCC wher. other.cur.tive tr.atments ar. not ***,the r.sponse r.tes r.main low with only a small subset of patients r.sponding to this *** is an unmet need to identify pr.dictive mar.er. to select those HCC patients who would benefit fr.m ICI ***,epithelial-to-mesenchymal tr.nsition(EMT),a major.pr.cess dr.ving HCC invasion and metastasis by r.gulating the phenotypic cellular.switching fr.m epithelial to mesenchymal state,has been implicated as a r.sistance mechanism associated with ICI *** r.le of EMT as a r.gulator.of immune checkpoint molecule in HCC is just ***,the consequence of EMT as a r.sistance mechanism in HCC patients under.oing ICI tr.atments r.mains *** this r.view,we summar.ze the r.cent clinical studies with ICIs in HCC and highlight the tr.als under.ay featur.ng novel monother.pies and combinator.al appr.aches based on immune and non-immune *** will discuss the ongoing effor.s to discover.new immune checkpoint molecules in HCC as potential dr.g *** also highlight the r.le of EMT in facilitating ther.py r.sistance in HCC tr.ated with ICIs and discuss potential str.tegies to cir.umvent r.sistance in ICI tr.ated HCC patients.

关键词： Hepatocellular.carcinoma immunother.py immune checkpoint inhibitor. epithelial-to-mesenchymal tr.nsition pr.gr.mmed cell death pr.tein-1 pr.gr.mmed death-ligand 1 r.sistance