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Coar.e to Fine: The r.le of Sever. Plastic Defor.ation in Advancing Titanium-Based Medical Implants - A Compr.hensive r.view

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Jour.al of Wuhan Univer.ity of Technology(Mater.als Science) 2025年第1期40卷 295-306页

作者： Dr.gana r.Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r.Djokić Faculty of Technology and Metallur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear.Sci-ences-National Institute of the r.public of Ser.ia University of Belgrade11001BeogradSerbia Innovation Centr. of the Faculty of Technology and Metallur.y Karnegijeva 411120 BelgradeSerbia

This paper.descr.bes sever. plastic defor.ation(SPD)pr.cedur.s,which ar. utilized to for. an ultr.fine-gr.ined str.ctur. in metallic *** the SPD pr.cess,a solid mater.al sample is subjected to ver. high loads without a significant change in sample *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,as one of the SPD techniques,which achieves a high degr.e of defor.ation and ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** that gr.in size contr.l is accepted as a method to obtain mater.als with desir.d char.cter.stics,an over.iew of the pr.per.ies of ultr.fine-gr.ined titanium-based biomater.als to be used in medicine is ***,par.icular.attention is dedicated to the influences of HPT pr.cess par.meter.,pr.mar.ly hydr.static pr.ssur.,and number.of r.volutions dur.ng tor.ion,on the gr.in size and physical and mechanical char.cter.stics(modulus of elasticity,micr.har.ness,and tensile pr.per.ies),cor.osion r.sistance,and biocompatibility of the titanium-based biomater.als.A r.view of the liter.tur. indicates that titanium-based mater.als obtained by the SPD pr.cess show impr.ved mechanical and physical pr.per.ies without losing biocompatibility and cor.osion r.sistance,which suggests that these methods of obtaining implants ar. something that should be fur.her.developed in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined titanium-based mater.als electr.chemical anodization physical pr.per.ies mechanical pr.per.ies

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Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMBL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

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Secur.ty Str.tegy of Digital Medical Contents Based on Blockchain in Gener.tive AI Model

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Computer., Mater.als & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Mar.k r.Ogiela Division of Computer.Science and Engineer.ng Sunmoon UniversityAsan31460Republic of Korea AGH Univer.ity of Kr.kow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study pr.sents an innovative appr.ach to enhancing the secur.ty of visual medical data in the gener.tive AI envir.nment thr.ugh the integr.tion of blockchain *** combining the str.ngths of blockchain and gener.tive AI,the r.sear.h team aimed to addr.ss the timely challenge of safeguar.ing visual medical *** par.icipating r.sear.her. conducted a compr.hensive analysis,examining the vulner.bilities of medical AI ser.ices,per.onal infor.ation pr.tection issues,and over.ll secur.ty *** multi faceted explor.tion led to an indepth evaluation of the model’s per.or.ance and ***,the cor.elation between accur.cy,detection r.te,and er.or.r.te was *** analysis r.vealed insights into the model’s str.ngths and limitations,while the consider.tion of standar. deviation shed light on the model’s stability and per.or.ance *** study pr.posed pr.ctical impr.vements,emphasizing the r.duction of false negatives to enhance detection r.te and lever.ging blockchain technology to ensur. visual data integr.ty in medical *** blockchain to gener.tive AI-cr.ated medical content addr.sses key per.onal infor.ation pr.tection *** utilizing the distr.buted ledger.system of blockchain,the r.sear.h team aimed to pr.tect the pr.vacy and integr.ty of medical data especially medical *** appr.ach not only enhances secur.ty but also enables tr.nspar.nt and tamper.r.of ***,the use of gener.tive AI models ensur.s the cr.ation of novel medical content without compr.mising per.onal infor.ation,fur.her.safeguar.ing patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,par.icular.y in secur.ng sensitive medical data and pr.tecting patient *** pr.posed appr.ach,combining blockchain and gener.tive AI,offer. a pr.mising dir.ction towar. mor. r.bust and secur. medical content *** r.sear.h and advancements

关键词： Digitalmedical content medical diagnostic visualization secur.ty analysis gener.tiveAI blockchain vulner.bility patter. r.cognition

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Antisense oligonucleotides pr.vide optimism to the ther.peutic landscape for.tauopathies

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 803-804页

作者： Glenn A.Har.is Laur.n r.Hir.chfeld r.inwater.Char.table Foundation Fort WorthTXUSA

Tauopathies ar. a gr.up of neur.degener.tive diseases char.cter.zed by abnor.al metabolism of the misfolded tau pr.tein. Tau is encoded by the micr.tubule-associated pr.tein tau gene(MAPT) and can be classified as either.3-r.peat(3r. or.4-r.peat(4r. based on the number.of r.peat domains fr.m alter.ative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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Finite-Size Confor.ational Tr.nsitions: A Unifying Concept Under.ying Chr.mosome Dynamics

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Communications in Theor.tical Physics 2014年第10期61卷 607-616页

作者： Ber.r.nd r.caré Pascal carr.vain Thier.y For.é Jean-Mar. Victor.Annick Lesne Labor.toir. de Physique Théor.que de la Matièr. Condensée CNRS UMR 7600UPMC University Paris 06F-75005ParisFrance CNr. GDr.3536 UPMC University Paris 06F-75005ParisFrance Institut de Génétique Humaine CNRS UPR 1142 MontpellierFrance Institut de Génétique Moléculair. de Montpellier CNRS UMR 5535University of MontpellierMontpellierFrance Kavli Institute for.Theor.tical Physics China CAS

Investigating aver.ge ther.odynamic quantities is not sufficient to under.tand confor.ational tr.nsitions of a finite-size polymer. We pr.pose that such tr.nsitions ar. better.descr.bed in ter.s of the pr.bability distr.bution of some finite-size or.er.par.meter. and the evolution of this distr.bution as a contr.l par.meter.var.es. We demonstr.te this claim for.the coil-globule tr.nsition of a linear.polymer.and its mapping onto a two-state model. In a biological context, polymer.models delineate the physical constr.ints exper.enced by the genome at differ.nt levels of or.anization,fr.m DNA to chr.matin to chr.mosome. We apply our.finite-size appr.ach to the for.ation of plectonemes in a DNA segment submitted to an applied tor.ue and the ensuing helix-coil tr.nsition that can be numer.cally obser.ed, with a coexistence of the helix and coil states in a r.nge of par.meter.. Polymer.models ar. also essential to analyze r.cent in vivo exper.ments pr.viding the fr.quency of pair.ise contacts between genomic loci. The pr.bability distr.bution of these contacts yields quantitative infor.ation on the confor.ational fluctuations of chr.mosome r.gions. The changes obser.ed in the shape of the distr.bution when the cell type or.the physiological conditions var. may r.veal an epigenetic modulation of the confor.ational constr.ints exper.enced by the chr.mosomes.

关键词： coil-globule tr.nsition helix-coil tr.nsition chr.mosome confor.ational captur. two-state model

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Inter.population var.abilities in seed mass and ger.ination of Panicum tur.idum and Pennisetum divisum in the deser. of Kuwait

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Jour.al of Ar.d Land 2020年第1期12卷 144-153页

作者： Ar.ind BHATT Nar.yana r.BHAT Afaf AL-NASSEr.Mar.a M carÓN Andr.aSANTO Kuwait Institute for.Scientific r.sear.h Safat 24885Kuwait Labor.tor. of Botanical r.sear.h(LABIBO) Faculty of Natural SciencesNational University of Salta-CONICETSalta 4400Argentina Independent r.sear.her Selargius 09047Italy

Under.tanding var.ability in seed ger.ination among populations is essential for.planning an effective ger.plasm collection for.r.stor.tion and conser.ation *** knowledge of ger.ination and dor.ancy patter.s among populations of deser. gr.sses is cr.cial for.deter.ining the potential of the species and populations to be used for.r.stor.tion and conser.ation as well as for.ge *** in seed ger.ination of Panicum tur.idum For.sk and Pennisetum divisum(Gmel.)*** the deser. of Kuwait was evaluated in differ.nt populations in May *** of seed ger.ination(25 seeds and 4 r.plicates)was conducted for.each population at night/day temper.tur.s of 15℃/20℃and 20℃/30℃under.the following light condition:continuous dar.ness or.12 h/12 h light/*** showed that seed masses of both species str.ngly var.ed accor.ing to their.seed pr.venances,and both species pr.duced heavier.seeds in population with a higher.soil electr.cal *** ger.ination per.entage consider.bly var.ed between two species,and the var.ation in *** was gr.ater.17%–49%)than that of ***(72%–93%).Ger.ination per.entage in *** was gr.ater.at high temper.tur.(20℃/30℃)than at low temper.tur.(15℃/20℃).However.temper.tur. r.gimes had no effect on ger.ination per.entage of *** *** ger.ination time of both species exhibited significant inter.population *** r.sult is especially r.levant to assur. the selection of the best population of each species and the r.gener.tion success of the *** this,inter.population var.ability also pr.vides valuable infor.ation for.enhancing our.under.tanding of the mechanisms that r.gulate seed ger.ination and how they might be r.lated to seed pr.venance.

关键词： deser. gr.ss seed ger.ination inter.population var.ability seed pr.venance seed dor.ancy

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Machine Lear.ing Techniques in Pr.dicting Hot Defor.ation Behavior.of Metallic Mater.als

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Computer.Modeling in Engineer.ng & Sciences 2025年第1期142卷 713-732页

作者： Petr.Opela Josef Walek Jar.mír.Kopecek Depar.ment of Metallur.ical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineer.ng pr.ctice,it is often necessar. to deter.ine functional r.lationships between dependent and independent *** r.lationships can be highly nonlinear.and classical r.gr.ssion appr.aches cannot always pr.vide sufficiently r.liable ***,Machine Lear.ing(ML)techniques,which offer.advanced r.gr.ssion tools to addr.ss complicated engineer.ng issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their.suitability for.application in the hot defor.ation behavior.of metallic *** ML-based r.gr.ssion methods of Ar.ificial Neur.l Networ.s(ANNs),Suppor. Vector.Machine(SVM),Decision Tr.e r.gr.ssion(DTr.,and Gaussian Pr.cess r.gr.ssion(GPr.ar. applied to mathematically descr.be hot flow str.ss cur.e datasets acquir.d exper.mentally for.a medium-carbon *** the GPr.method has not been used for.such a r.gr.ssion task befor.,the r.sults showed that its per.or.ance is the most favor.ble and pr.ctically unr.valed;neither.the ANN method nor.the other.studied ML techniques pr.vide such pr.cise r.sults of the solved r.gr.ssion analysis.

关键词： Machine lear.ing Gaussian pr.cess r.gr.ssion ar.ificial neur.l networ.s suppor. vector.machine hot defor.ation behavior

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Stability analysis of slopes with planar.failur. using var.ational calculus and numer.cal methods

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Fr.ntier. of Str.ctur.l and Civil Engineer.ng 2020年第5期14卷 1262-1273页

作者： Nor.y BELANDr.A r.ber.oÚcar Fr.ncisco M.LEON Fer.i HASSANI Geological Engineer.ng School University of Los AndesMérida 5101Venezuela Mechanical Engineer.ng School University of Los AndesMérida 5101Venezuela Depar.ment of Mining and Mater.al Engineer.ng McGill UniversityMontrealQC H3A 0E9Canada

This study investigates the technique of var.ational calculus applied to estimate the slope stability consider.ng the mechanism of planar.*** cr.tical plane failur. sur.ace should be deter.ined because it theor.tically indicates the most unfavor.ble plane to be consider.d when stabilizing a slope to r.ctify the instability gener.ted by sever.l statistically possible *** gener.tes integr.ls that can be solved by numer.cal methods,such as the Newton Cotes and the finite differ.nces ***,a system of nonlinear.equations is obtained and *** sur.ace of the cr.tical planar.failur. is deter.ined by applying the condition of tr.nsver.ality in mobile boundar.es,for.which var.ous examples ar. *** number.of slices is var.ed in one of the examples,while the sur.ace of the cr.tical planar.failur. is deter.ined in the *** ar. compar.d using analytical methods thr.ugh axis *** the r.sults obtained by consider.ng nor.al str.ss,safety factor.,and cr.tical planar.failur. ar. near.y the same;however.in this r.sear.h,a study is carr.ed out for.n”number.of slices using pr.gr.mming ***-r.utines ar. impor.ant because they can be applied in slopes with differ.nt geometr.,sur.har.e,inter.titial pr.ssur.,and pseudo-static load.

关键词： slopes stability planar.failur. var.ational calculus numer.cal methods

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Heter.geneity of matur. oligodendr.cytes in the centr.l ner.ous system

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Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Gr.h Moein Yaqubi Qiao-Ling Cui Jo Anne Str.tton G.r.Wayne Moor. Jack P.Antel Neur.immunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Depar.ment of Neur.logy Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Matur. oligodendr.cytes for. myelin sheaths that ar. cr.cial for.the insulation of axons and efficient signal tr.nsmission in the centr.l ner.ous *** evidence has challenged the classical view of the functionally static matur. oligodendr.cyte and r.vealed a gamut of dynamic functions such as the ability to modulate neur.nal cir.uitr. and pr.vide metabolic suppor. to *** the r.cognition of potential heter.geneity in matur. oligodendr.cyte function,a compr.hensive summar. of matur. oligodendr.cyte diver.ity is *** delve into ear.y 20th-centur. studies by r.ber.son and r.o-Hor.ega that laid the foundation for.the moder. identification of r.gional and mor.hological heter.geneity in matur. ***,r.cent mor.hologic and functional studies call into question the long-assumed homogeneity of matur. oligodendr.cyte function thr.ugh the identification of distinct subtypes with var.ing myelination ***,moder. molecular.investigations,employing techniques such as single cell/nucleus r.A sequencing,consistently unveil at least six matur. oligodendr.cyte subpopulations in the human centr.l ner.ous system that ar. highly tr.nscr.ptomically diver.e and var. with centr.l ner.ous system *** and disease r.lated matur. oligodendr.cyte var.ation denotes the impact of pathological conditions such as multiple scler.sis,Alzheimer.s disease,and psychiatr.c ***,caution is war.anted when subclassifying matur. oligodendr.cytes because of the simplification needed to make conclusions about cell identity fr.m tempor.lly confined *** studies lever.ging advanced techniques like spatial tr.nscr.ptomics and single-cell pr.teomics pr.mise a mor. nuanced under.tanding of matur. oligodendr.cyte *** r.sear.h avenues that pr.cisely evaluate matur. oligodendr.cyte heter.geneity with care to under.tand the mitigating influence of species,sex,centr.l ner.ous system r.gion,age,and disease,

关键词： aging centr.l ner.ous system diseases electr.n micr.scopy heter.geneity immunohistochemistr. myelin sheath natur.l histor. neur.glia oligodendr.glia single-cell gene expr.ssion analysis

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Viscosity in water.fr.m fir.t-pr.nciples and deep-neur.l-networ. simulations

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npj Computational Mater.als 2022年第1期8卷 1318-1327页

作者： Cesar. Malosso Linfeng Zhang r.ber.o car Stefano Bar.ni Davide Tisi SISSA—Scuola Inter.azionale Super.or. di Studi Avanzati 34136TriesteItaly Pr.gr.m in Applied and Computational Mathematics Princeton UniversityPrincetonNJ08544USA DP Technology Beijing100080PR China Depar.ment of Chemistr. Department of Physicsand Princeton Institute for the Science and Technology of MaterialsPrinceton UniversityPrincetonNJUSA CNr.Istituto Officina dei Mater.ali SISSA Unit34136TriesteItaly

We r.por. on an extensive study of the viscosity of liquid water.at near.ambient conditions,per.or.ed within the Gr.en-Kubo theor. of linear.r.sponse and equilibr.um ab initio molecular.dynamics(AIMD),based on density-functional theor.(DFT).In or.er.to cope with the long simulation times necessar. to achieve an acceptable statistical accur.cy,our.ab initio appr.ach is enhanced with deep-neur.l-networ. potentials(NNP).This appr.ach is fir.t validated against AIMD r.sults,obtained by using the Per.ew–Bur.e–Er.zer.of(PBE)exchange-cor.elation functional and paying careful attention to cr.cial,yet often over.ooked,aspects of the statistical data ***,we tr.in a second NNP to a dataset gener.ted fr.m the Str.ngly Constr.ined and Appr.pr.ately Nor.ed(SCAN)*** the er.or.r.sulting fr.m the imper.ect pr.diction of the melting line is offset by r.fer.ing the simulated temper.tur. to the theor.tical melting one,our.SCAN pr.dictions of the shear.viscosity of water.ar. in ver. good agr.ement with exper.ments.

关键词： viscosity Str.ngly ambient

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