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Evaluation of Thyr.id Hor.ones Levels in Libyan Patients with Chr.nic r.nal Failur. befor. and after.Maintenance Hemodialy

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Open Jour.al of Applied Sciences 2021年第1期11卷 11-20页

作者： r.ad M. Abughalia Milad A. Alr.ini Kar.ma r. Zar.g Edawib Higher.Institute for.Science & Medical Technologies Misallata Libya

Data fr.m r.cent studies r.vealed that kidney diseases might affect the thyr.id function in var.ous ways. A var.ety of alter.tions in thyr.id hor.one levels and metabolism have also been r.por.ed in patients with chr.nic r.nal failur. (Cr.) in some studied population. In addition, it was r.por.ed that ser.m levels of both T3 and T4 might alter.immediately after.a hemodialysis (HD) tr.atment than befor.. Ther.for., this study was aimed to investigate the level of tr.iodothyr.nine (T3) and thyr.xine (T4) in Cr. Libyan patients befor. and after.HD. This study was car.ied out on 46 Cr. patients (30 males and 16 females) with a mean age of 47.46 ± 15.75 year.. These patients wer. tr.ated at the hemodialysis unit of Educational Centr.l Zelitin Hospital, Zelitin, Libya. None of these patients appar.ntly have any thyr.id pr.blems and no histor. of dr.g intake that may affect thyr.id function. Blood samples wer. taken fr.m each patient to measur. ser.m levels of T3 and T4, befor. and after.HD. In addition, the effects of sever.l var.ables including age, gender. body mass index (BMI), pr.sence of both hyper.ension and, diabetes mellitus and dur.tion of kidney dialysis on ser.m levels of T3 and T4 befor. and after.HD wer. also studied. After.HD, ther. was a statistically significant incr.ase in the ser.m levels of T3, T4. The age, gender. BMI, dur.tion of kidney dialysis and the pr.sence of hyper.ension and diabetes mellitus did not have any significant effect on the ser.m level of T3 and T4 befor. and after.HD. However. the ser.m levels of T3 and T4 wer. still in the nor.al r.nge in these examined patients either.befor. or.after.HD. Fr.m these findings, it can be concluded that these Cr. patients may be in a euthyr.id state, because the ser.m levels of T3 and T4 wer. in the nor.al r.nge. In addition, HD was seemed to impr.ve the T3 and T4 thyr.id hor.one concentr.tions, suggesting that HD might activate the secr.tion of thyr.id gland and catabolism. The other.var.ables did no

关键词： Chr.nic r.nal Failur. (Cr.) Hemodialysis (HD) Tr.iodothyr.nine (T3) and Thyr.xine (T4)

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A Compar.son of Tur.ar.und-Times for.Two Popular.Specimen Types Used for.Newbor. Toxicology: Meconium and Umbilical Cor. Tissue

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Open Jour.al of Obstetr.cs and Gynecology 2024年第10期14卷 1541-1547页

作者： Joseph T. Jones Donna J. Coy Mar. r. Jones United States Dr.g Testing Labor.tor.es Des Plaines Illinois USA

Backgr.und: Pr.natal exposur. to illicit substances is r.sponsible for.sever.l long-ter. negative health consequences. It is cr.tical for.healthcar. pr.fessionals to know the extent and scope of pr.natal substance exposur. in their.cases. Sever.l studies exist with mixed r.sults compar.ng the effectiveness of umbilical cor. tissue (UCT) and meconium (MEC) as toxicology specimen types. The specific aim of this study is to compar. the use of UCT and MEC r.gar.ing the time inter.al between the bir.h of the neonate, r.ceipt of the specimen at the labor.tor., and the hospital’s r.ceipt of the final toxicology r.por.. Method: The study quer.ed de-identified r.sults of 5358 consecutive UCT and 706 MEC fr.m our.labor.tor.. r.sults: The mean time fr.m bir.h to r.ceipt of the specimen at the labor.tor. for.MEC and UCT was 4.5 days ± 2.9 days and 2.8 days ± 1.9 days, r.spectively. The mean time fr.m bir.h to final r.por. for.MEC was 6.9 days ± 3.8 days, 5.7 days ± 3.3 days, and 8.4 days ± 3.8 days for.all MEC specimens, negative MEC, and positive MEC, r.spectively. The mean time fr.m bir.h to final r.por. for.UCT was 4.3 days ± 2.4 days, 3.5 days ± 2.2 days, and 5.4 days ± 2.2 days for.all UCT, negative UCT and positive UCT, r.spectively. Discussion/Conclusion: r.ceipt of dr.g test r.sults of the neonate pr.or.to r.lease fr.m the hospital is cr.tical. This study shows that UCT offer. an advantage when r.sults ar. needed quickly to make infor.ed decisions about the health and well-being of newbor.s.

关键词： Newbor. Toxicology Pr.natal Substance Exposur. Tur.ar.und Time

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Identification and Char.cter.zation of Simple Sequence r.peats (SSr. Mar.er. Associated with Downy Mildew r.sistance Locus “<i>r.V1</i>” in Gr.pes

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Advances in Bioscience and Biotechnology 2021年第11期12卷 371-387页

作者： Neetu Goyal Akshay Nag r.shni r. Samar.h Anur.dha Upadhyay Kashmir.Singh Depar.ment of Biotechnology Panjab University Chandigarh India National r.sear.h Centr. for.Gr.pes Pune India

The cultivation of gr.pes is sever.ly impacted by the emer.ence of downy mildew (DM) disease which negatively affects quality and yield possibly r.sulting in heavy losses. Due to cer.ain shor.comings in the usage of fungicides and the development of new cultivar. by plant br.eding, mar.er.assisted selection (MAS) will be an efficient alter.ative method to intr.duce desir.d genes into the cultivated var.eties in a shor. time per.od. The Simple sequence r.peats (SSr. mar.er. seem to be the most popular.genetic mar.er.of choice for.MAS. In the pr.sent study, we identified 14 new SSr.mar.er. in r.V1 locus that ar. associated with downy mildew r.sistance in gr.pes. The char.cter.zation of the identified mar.er. was car.ied out on the basis of var.ous par.meter. such as types of r.peat motifs, number.of r.peats, differ.nt classes and str.ctur. of micr.satellites. Additionally, SSr.genotyping in 56 differ.nt gr.pe accessions was done to deter.ine the susceptibility or.r.sistance of these accessions to DM.

关键词： Downy Mildew r.sistance Locus Simple Sequence r.peats Genotyping

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A Phase II Study of Antineoplastons A10 and AS2-1 in Childr.n with Low-Gr.de Astr.cytomas—Final r.por. (Pr.tocol BT-13)

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Jour.al of Cancer.Ther.py 2016年第12期7卷 837-850页

作者： Stanislaw r. Bur.ynski Tomasz J. Janicki Gr.gor. S. Bur.ynski Bur.ynski Clinic Houston TX USA

Nonr.sectable Low-Gr.de Astr.cytomas (LGA) can compr.mise function and thr.aten life. For.the major.ty of patients, the most appr.pr.ate str.tegy is initial chemother.py followed by r.diation Ther.py (r.). Since cur.tive tr.atment is not available for.most of these patients, it is r.asonable to conduct clinical studies to evaluate new agents. This Phase II study evaluates efficacy and safety of Antineoplastons A10 and AS2-1 (ANP) in LGA. Sixteen childr.n diagnosed with LGA wer. tr.ated. They included 12 males and 4 females, ages 1.6 - 17.4 year. (median 10.6). Efficacy was evaluated in 16 patients. The major.ty of patients wer. pr.viously tr.ated, but 1 patient had ster.otactic biopsy only. Out of the r.maining 15 patients, 6 patients r.ceived chemother.py, and 7 patients had sur.er., and 2 patients r.ceived r. and chemother.py after.sur.er.. The patients r.ceived tr.atment with ANP administer.d daily ever. 4 hour. (median dose of A10 was 7.71 g/kg/d and AS2-1 was 0.26 g/kg/d) until objective r.sponse or.stable disease was documented and for.8 months ther.after. The dur.tion of ANP IV r.nged fr.m 1.4 to 286 weeks with a median of 83 weeks. A complete r.sponse was documented in 25.0%, par.ial r.sponse in 12.5%, and stable disease in 37.5%. Over.ll sur.ival was 67.7% at 5 year., and 54.2% at 10 and 15 year.. Pr.gr.ssion-fr.e sur.ival was 48.1%, 34.4% and 34.4% at 5, 10, and 15 year. r.spectively. The tr.atment was associated with gr.de 3 or.gr.de 4 Adver.e Dr.g Exper.ences (ADE) in 6 patients. Ther. wer. two hyper.atr.mias of gr.de 4 (12%). Gr.de 3 ADE included ur.nar. fr.quency (6%), fatigue (6%) and hyper.atr.mia (6%). Ther. wer. no chr.nic toxicities, and ther. was a high quality of sur.ival. ANP shows efficacy with a ver. good toxicity pr.file in this cohor. of childr.n with low-gr.de astr.cytoma.

关键词： Antineoplastons A10 and AS2-1 Astr.cytoma Low-Gr.de Astr.cytoma Low-Gr.de Glioma Pediatr.c Br.in Tumor. Phase II Clinical Tr.al

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Analysis of Ozone Behaviour.in the City of Puebla-Mexico Using Non-Homogeneous Poisson Models with Multiple Change-Points

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Jour.al of Envir.nmental Pr.tection 2016年第12期7卷 1886-1903页

作者： Juan Antonio Cr.z-Juár.z Hor.ensia r.yes-Cer.antes Eliane r. r.dr.gues Facultad de Ciencias Fisico-Matemáticas Benemérita Universidad Autónoma de Puebla Puebla Mexico Instituto de Matemáticas Universidad Nacional Autónoma de México Mexico City Mexico

In this wor., some non-homogeneous Poisson models ar. consider.d to study the behaviour.of ozone in the city of Puebla, Mexico. Sever.l functions ar. used as the r.te function for.the non-homogeneous Poisson pr.cess. In addition to their.dependence on time, these r.te functions also depend on some par.meter. that need to be estimated. In or.er.to estimate them, a Bayesian appr.ach will be taken. The expr.ssions for.the distr.butions of the par.meter. involved in the models ar. ver. complex. Ther.for., Mar.ov chain Monte Car.o algor.thms ar. used to estimate them. The methodology is applied to the ozone data fr.m the city of Puebla, Mexico.

关键词： Non-Homogeneous Poisson Model Mar.ov Chain Monte Car.o Methods Bayesian Infer.nce Ozone Air.Pollution City of Puebla

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r.DESCr.PTION OF THE EAr.Y CAMBr.0} Tr.LOBITE Ar. Hr.COCEP HALUS CHAUVEAUI BEr.Er.N, 1899

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古生物学报 1988年第5期 557-560+671页

作者： P. D. Lane M. r. Blaker Depar.ment of Geology Univer.ity Keele Siaffs ST5 5BG U. K. Depar.ment of Geology Univer.ity Keele Siaffs ST5 5BG U. K.

The type ser.es of Ar.hr.cocephalus chauvea-ui Ber.er.n, 1899 is r.descr.bed and figur.d, anda lectotype selected. The genus is r.fer.ble to theOr.ctocephalidae. Ar.hr.cocephalus was descr.bed by Ber.er.n(1899, P. 514) fr.m a small number.of specimenson a slab of shale collected, and pr.sented to Ber.ger.n, by M. Chauveau. The pr.venance of theslab was said to be the mountain chain to the nor.th of Toung-yen-Fou, i. e. in Tongr.n Countywhich is located in nor.heaster. Guizhou. south-

关键词： r.DESCr.PTION OF THE EAr.Y CAMBr.0} Tr.LOBITE Ar. Hr.COCEP HALUS CHAUVEAUI BEr.Er.N 早寒武世下寒武世寒武纪 PI

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Influence of Family Status on the Dietar. Patter.s and Nutr.tional Levels of Childr.n

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Food and Nutr.tion Sciences 2012年第8期3卷 1055-1059页

作者： r. M. Kapila Thar.nga r.thnayaka Zhong-Jun Wang Depar.ment of Statistic Science Collage Wuhan University of Technology Wuhan P.R. China

A diver.ity of socio economic and cultur.l factor. contr.butes towar.s maintenance and changes in dietar. patter.s of people. Ther.for. People ar.und the wor.d have adapted differ.nt types of dietar. patter.s for.their.sur.ival. Aim of this study was to investigate the most r.levant factor. influencing human dietar. patter.s. Sample for.the study was selected by using the Str.tified sampling technique, which consists of 390 families r.siding ar.und the Abatenna estate, Bandar.wela municipal council, Sr. Lanka. Pr.ncipal component analysis techniques and cor.elation analysis wer. employed to identify the most r.levant factor. which affect human dietar. patter.s. r.sults of the study indicate that socio economic conditions, monthly income, number.of childr.n in a family, dietar. patter.s and weight-r.lated behavior. ar. highly co-r.lated with each other. These findings suggest that education and awar.ness pr.gr.ms on nutr.tion should tar.et low income gr.ups to enhance their.knowledge on dietar. patter.s.

关键词： Pr.ncipal Component Analysis Nutr.tional Level Dietar. Patter. Weight-r.lated Behavior.

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A Case of Sustained Objective r.sponse of r.cur.ent/Pr.gr.ssive Diffuse Intr.nsic Pontine Glioma with Phenylbutyr.te and Tar.eted Agents

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Jour.al of Cancer.Ther.py 2015年第1期6卷 40-44页

作者： Stanislaw r. Bur.ynski Gr.gor. S. Bur.ynski Sheldon Br.okman Bur.ynski Clinic Houston USA

Diffuse intr.nsic pontine glioma (DIPG) is the most common type of br.instem glioma and one of the most deadly br.in tumor.. DIPG in young adult patients is a r.r. disease for.which tr.atment options ar. limited. r.diation ther.py r.mains the standar.-of-car. for.newly-diagnosed DIPG, but no established ther.pies for.r.cur.ent disease ar. available. This paper.descr.bes the r.sults of tr.atment of a young adult patient diagnosed with DIPG that pr.gr.ssed after.r.diation ther.py. Ther.py included sodium phenylbutyr.te (PB) in combination with the tar.eted agents: pazopanib, ever.limus, er.otinib, and bevacizumab. The patient achieved a r.pid par.ial r.sponse, which per.isted over.a year.and five months. The patient opted to discontinue the ther.py and ther.after.elected chemother.py, which r.sulted in a subsequent r.pid pr.gr.ssion and death within one month. The tar.eted tr.atment was associated with minor.toxicity that included a Gr.de 2 skin r.sh and Gr.de 1 elevation of tr.nsaminases. In conclusion, a combination of PB and cur.ently available tar.eted dr.gs may offer.extended sur.ival in patients with r.cur.ent DIPG.

关键词： Antineoplastons Br.instem Glioma DIPG Phenylbutyr.te Tar.eted Agents Tr.atment of DIPG

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Legacy Effects of Explosive Contamination on Vegetative Communities

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Open Jour.al of Ecology 2016年第8期6卷 496-508页

作者： Stephen M. Via Julie C. Zinner. Donald r. Young Depar.ment of Biology Virginia Commonwealth University Richmond VA USA

Natur.l selection pr.cesses ar. constantly influencing vegetation community composition. In the pr.sence of anthr.pogenic contaminants additional for.es act as filter. contr.lling per.istence of natur.lly occur.ing species. Classical species diver.ity and r.chness metr.cs can miss subtle changes under.distur.ance r.gimes while species composition and functional char.cter.stics may be able to detect them. Our.study was designed to investigate legacy impacts of explosives contaminated soils in an exper.mental minefield on vegetative communities using ecological metr.cs. As hypothesized, species diver.ity and r.chness showed no change in the pr.sence of explosive compounds while species composition pr.vided clear.separ.tion of gr.ups and functional tr.it dominance was also obser.ed to change. Over.ll, pr.sence of anthr.pogenic contaminates have led to community composition and functional shifts for.vegetation after.initial contamination. The r.sponses in species composition and functional diver.ity/r.chness wer. a r.sult of new toler.nt species filling open niches in contaminated plots. Mor. wor. is needed to confir. this in var.ed systems and in the pr.sence of diver.e contaminants.

关键词： r.X TNT Composition B Functional Tr.its Community

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Benefits and Limitations of Volumetr.c Modulated Ar. Ther.py in Tr.ating Bilater.l Br.ast Cancer.with r.gional Lymph Nodes

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Advances in Br.ast Cancer.r.sear.h 2020年第4期9卷 119-126页

作者： r. P. Sr.vastava K. Vandeputte C. De Wagter r.diother.py Association Meuse Picar.ie Centre Hospitalier Mouscron Avenue de Fécamp 49 B-7700 Mouscron Belgium Depar.ment of r.diation Oncology Ghent University Hospital Corneel Heymanslaan 10 9000 Gent Belgium

Pur.ose: The study was per.or.ed compar.ng dosimetr.c char.cter.stics of volumetr.c modulated ar. ther.py (VMAT) and field-in-field (FiF) techniques on a patient with synchr.nous bilater.l br.ast car.inoma. Methods: T... 详细信息

r.ng>Pur.ose:r.ng> The study was performed comparing dosimetric characteristics of volumetric modulated arc therapy (VMAT) and field-in-field (FiF) techniques on a patient with synchronous bilateral breast carcinoma. Methods: The patients with bilateral breast cancer treatment were included in this study. A total dose of 40.05 Gy in 15 fractions was prescribed to the Planning Target Volume (PTV) of the whole bilateral breast cancer with the supraclavicular and infraclavicular nodes, with a complementary boost of 10 Gy in 4 fractions to the surgical bed (PTVboost). For both radiotherapy techniques, several VxGy parameters were analyzed for the PTVs, together with the Conformity index (CI), the Homogeneity index (HI) and the critical organs at risk (OARs), lungs and heart. Results: The patient was treated by the VMAT technique and the daily treatment time was less than 20 minutes with daily CBCT imaging. In the VMAT plan, the PTV 95% dose covered 38.89 ± 0.81 Gy, compared to 37.26 ± 1.02 Gy in the FiF technique. The VMAT plan improved the dose homogeneity index and lower dose in lung towards high dose region. Conclusion:r.ana;"> The study demonstr.tes the viability of the VMAT technique in the tr.atment of bilater.l br.ast cancer. The intr.duced single isocentr.c VMAT technique is fast to deliver.and it incr.ases the dose homogeneity of the tar.et volume with some limitations. The tr.atment was well toler.ted, without inter.uption of the tr.atment cour.

关键词： Bilater.l Br.ast Cancer.(BCC) Volumetr.c Modulated Ar. Ther.py (VMAT) Field in Field (FiF) Planning Tar.et Volume (PTV) Or.an’s Volume That r.ceives x Gy of Dose (VxGy)

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