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Phase Ib study of anti-EGFr.antibody(SCT200)in combination with anti-PD-1 antibody(SCT-I10A)for.patients with r.S/Br.F wild-type metastatic color.ctal cancer

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Cancer.Biology & Medicine 2024年第7期21卷 636-650页

作者： Ming bai Yao Lu Chunmei Shi Jianwei Yang Wei Li Xianli Yin Chenghui Huang Lin Shen Liangzhi Xie Yi ba Depar.ment of GI Medical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerTianjin 300060China Fujian Medical Univer.ity Union Hospital Fuzhou 350001China Fujian Pr.vincial Cancer.Hospital Fuzhou 350014China Cancer.Center The First Hospital of Jilin UniversityChangchun 130021China Depar.ment of Medical Oncology Gastr.enter.logy and Ur.logy Hunan Cancer HospitalAffiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Depar.ment of Oncology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Depar.ment of Gastr.intestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing)Peking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineer.ng r.sear.h Center.of Pr.tein and Antibody Sinocelltech Ltd.Bejing 100176China Depar.ment of Cancer.Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100010China

Objective:This study evaluated the safety and efficacy of an anti-epider.al gr.wth factor.r.ceptor.EGFr.antibody(SCT200)and an anti-pr.gr.mmed cell death 1(PD-1)antibody(SCT-I10A)as thir.-line or.subsequent ther.pies in patients with r.t sar.oma vir.l oncogene(r.S)/v-r.f mur.ne sar.oma vir.l oncogene homolog B(Br.F)wild-type(wt)metastatic color.ctal cancer.mCr.).Methods:We conducted a multicenter.open-label,phase Ib clinical *** with histologically confir.ed r.S/Br.F wt m Cr. with mor. than two lines of tr.atment wer. enr.lled and tr.ated with SCT-I10A and *** pr.mar. endpoints wer. the objective r.sponse r.te(Or.)and *** secondar. endpoints included disease contr.l r.te(DCr.,pr.gr.ssion-fr.e sur.ival(PFS),and over.ll sur.ival(OS).r.sults:Twenty-one patients wer. enr.lled in the study thr.ugh Januar. 28,*** Or. was 28.57%and the DCr.was 85.71%(18/21).The median PFS and OS wer. 4.14 and 12.84 months,*** tr.atment-r.lated adver.e events(Tr.Es)wer. ***,compar.d with the monother.py cohor. fr.m our.pr.vious phase I study evaluating SCT200 for.r.S/Br.F wt m Cr. in a thir.-line setting,no significant impr.vements in PFS and OS wer. obser.ed in the combination ***:SCT200 combined with SCT-I10A demonstr.ted pr.mising efficacy in pr.viously tr.ated r.S/Br.F wt m Cr. patients with an acceptable safety *** head-to-head studies with lar.er.sample sizes ar. needed to validate whether.the efficacy and safety of combined anti-EGFr.and anti-PD-1 ther.py ar. super.or.to anti-EGFr.monother.py in the thir.-line setting.(r.gistr.tion ***04229537).

关键词： Color.ctal cancer SCT-I10A SCT200 epider.al gr.wth factor.r.ceptor pr.gr.mmed cell death 1

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Ver.epor.in fluor.scence in antineoplastic-tr.ated pancr.atic cancer.cells found concentr.ted in mitochondr.a

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第3期16卷 968-978页

作者： Ying-Qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo r.n-Ze Wang Zhi-Chang ba Depar.ment of r.diology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Depar.ment of Digestive Inter.al Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

baCKGr.UND Tr.ditional tr.atments for.pancr.atic cancer.PC)ar. *** ther.py(PDT)is non-invasive,and pr.ven safe to kill cancer.cells,including ***,the mitochondr.al concentr.tion of the photosensitizer.such as ver.epor.in,is *** To investigate the distr.bution of fluor.scence of ver.epor.in in PC cells tr.ated with antitumor.dr.gs,*** Wor.able sur.ival r.tes of PC cells(AsPC-1,BxPC-3)wer. deter.ined with chemother.py[doxor.bicin(DOX)and gemcitabine(GEM)]and non-chemother.py[sir.limus(Sr.)and cetuximab(CTX)]dr.gs in vitr.,with or.without ver.epor.in,as measur.d via MTT,flow cytometr.,and laser.confocal *** cell pr.lifer.tion was associated with GEM that was mor. endur.ng compar.d with *** laser.micr.scopy allowed obser.ation of GEM-and ver.epor.in-tr.ated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTr.cker.Gr.en to differ.ntiate living and dead cells and subcellular.localization of ver.epor.in,*** Cell sur.ival significantly dr.pped upon exposur. to either.chemother.py dr.g,but not to Sr. or.*** cell lines r.sponded similar.y to *** intensity of fluor.scence was associated with the concentr.tion of *** exper.ments using GEM showed that sur.ival r.tes of the PC cells tr.ated with 10μmol/L ver.epor.in(but not less)wer. significantly lower.r.lative to nil *** and dead stained cells tr.ated with GEM wer. *** GEM tr.atment,ver.epor.in was obser.ed pr.mar.ly in the *** Ver.epor.in was obser.ed in living *** GEM-tr.ated human PC cells,ver.epor.in was par.icular.y pr.valent in the *** study suppor.s fur.her.study of PDT for.the tr.atment of PC after.neoadjuvant chemother.py.

关键词： Photodynamic ther.py Pancr.atic cancer Ver.epor.in Mitochondr.a Chemother.py Gemcitabine

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The r.le of r.newable Pr.tocatechol Acid in Epoxy Coating Modification: Significantly Impr.ved Antibacter.al and Adhesive Pr.per.ies

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Chinese Jour.al of Polymer.Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue Dai Li-Yue Zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang Wu Xin-Wu ba Xiao-Qing Liu School of Chemistr. and Mater.als Science Hebei UniversityBaoding 071000China Ningbo Institute of Mater.als Technology and Engineer.ng Chinese Academy of SciencesNingbo 315201China Key Labor.tor. of Mar.ne Mater.als and r.lated Technologies Chinese Academy of SciencesNingbo 315201China

It is of gr.at significance to design epoxy coatings with super.or.antibacter.al pr.per.ies and high adhesive pr.per.ies, as well as excellent pr.cessing, super.or.dur.bility, and high tr.nspar.ncy. However. it is still a challenge because of the common complex design and synthesis. Her.in, the bio-based monomer.pr.tocatechuic acid(PCA) was used as r.w mater.al, the catechol str.ctur. with high bonding and antibacter.al pr.per.ies was intr.duced into the flexible alkane segment of ethylene glycol diglycidyl ether.EGDE) thr.ugh an efficient, and gr.en method, and it was cur.d with isophor.ne diamine(IPDA) to pr.par. cor.esponding ther.osets. The cur.d r.sins exhibited excellent allar.und qualities, par.icular.y in bonding and antibacter.al. When 30% PCA was added to pur. epoxy r.sin, the adhesion between substr.te and coating incr.ased fr.m 4.40 MPa to 13.60 MPa and the antibacter.al r.te of coating against E. coli and S. aur.us could appr.ach 100%. All of this is due to the fact that the catechol str.ctur. pr.sent in PCA has the ability to inter.ct with var.ous substr.tes and alter.the per.eability of bacter.al cell membr.nes. The ar.hitectur. of this method offer. a fr.sh appr.ach to dealing with the issues of challenging r.w mater.al selection and complex synthesis techniques.

关键词： Epoxy coatings Ther.osets Catechol str.ctur. Antibacter.al High adhesion

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cir.r.A3669 pr.motes goat endometr.al epithelial cells pr.lifer.tion via mir.26a/r.N2 to activate PI3K/AKT-mTOr.and MAPK pathways

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Jour.al of Integr.tive Agr.cultur. 2024年第3期23卷 960-974页

作者： Xiaor.i Liu Jiuzeng Cui Mengyao Wei Xiaofei Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui ba Langda Suo Yuxuan Song Lei Zhang Division of Labor.tor. Safety and Ser.ices Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of r.ceptive endometr.um(r.) fr.m pr.-r.ceptive endometr.um(PE) for.successful embr.o implantation is a complex dynamic pr.cess in which the mor.hology and physiological states of the endometr.al epithelium under.o a ser.es of significant changes, including cell pr.lifer.tion and apoptosis. However. the molecular.mechanisms ar. not yet fully under.tood. In this study, a higher.cir.r.A3669 level was obser.ed in PE than in r. of goats. Functional assays r.vealed that this over.xpr.ssion pr.moted the pr.lifer.tion of goat endometr.al epithelial cells(GEECs) by activating the expr.ssion of genes r.lated to the PI3K/AKT-mTOr.and MAPK pathways,ther.by inhibiting apoptosis in vitr.. Fur.her.or., cir.r.A3669 functioned as a competing endogenous r.A(cer.A) to upr.gulate r.ticulocalbin-2(r.N2) expr.ssion at the post-tr.nscr.ptional level by inter.cting with and downr.gulating mir.26a in GEECs. In addition, r.N2, which is highly expr.ssed in the PE of goats, was found to be r.gulated by β-estr.diol(E2) and pr.gester.ne(P4). Our.r.sults demonstr.ted that r.N2 also affected the key pr.teins PI3K, AKT, mTOr. JNK, and P38 in the PI3K/AKT-mTOr.and MAPK pathways, ther.by facilitating GEECs pr.lifer.tion and suppr.ssing their.apoptosis in vitr.. Collectively, we constr.cted a new cir.r.A3669-mir.26ar.N2 r.gulator. networ. in GEECs, which fur.her.pr.vides str.ng evidence that cir.r.A could potentially play a cr.cial r.gulator. r.le in the development of r. in goats.

关键词： cir.r.A3669 r.N2 mir.26a goat endometr.al epithelial cells(GEECs) pr.lifer.tion

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Discover.ng genetic biomar.er. for.tar.eted cancer.ther.peutics with eXplainable Ar.ificial Intelligence

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Cancer.Communications 2024年第5期44卷 584-588页

作者： Debaditya Chakr.bor.y Elizabeth Gutier.ez-Chakr.bor.y Cr.stian r.dr.guez-Aguayo Hakan başağaoğlu Gabr.el Lopez-Ber.stein Paola Amer. School of Civil and Envir.nmental Engineer.ng and Constr.ction Management The University of Texas at San AntonioSan AntonioTexasUSA Depar.ment of Cell Systems and Anatomy University of Texas Health Science CenterSan AntonioTexasUSA Depar.ment of Exper.mental Ther.peutics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Edwar.s Aquifer.Author.ty San AntonioTexasUSA

High-Gr.de Ser.us Ovar.an Cancer.HGSC)is the most pr.valent and lethal for. of gynecologic malignancies[1],accounting for.70%-80%of ovar.an cancer.*** decades of r.sear.h,the over.ll sur.ival r.te for.HGSC has r.mained lar.ely unchanged[2],and patients with advanced stages of the disease have only a 41%chance of sur.iving beyond five year.[3].

关键词： cancer Cancer tar.eted

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Investigation of Fr.ctur. Str.ngth of Cur.ent Post Mater.als (Peek, Fiber. Cast Metal) in Differ.nt Fer.ule Conditions

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Open Jour.al of Stomatology 2024年第3期14卷 153-172页

作者： başak Topdaği Funda bayindir Depar.ment of Pr.sthetic Dentistr. Atatürk University Erzurum Türkiye

Aim: The fr.ctur. r.sistance of the post mater.als used nowadays significantly impacts the fr.ctur. type of the post mater.al. The cur.ent study aimed to examine the impact of the fr.ctur. r.sistance of PEEK posts, whose use as a post mater.al has not yet become widespr.ad, on the fr.ctur. patter. that will occur. Mater.als and Methods: Sixty-six extr.cted upper.centr.l incisor.human teeth wer. used in the study. Six gr.ups of posts wer. pr.duced fr.m metal, fiber. and PEEK mater.als (n = 11). After.ar., the fr.ctur. r.sistance test was applied to the samples. Samples wer. classified accor.ing to fr.ctur. type as r.pair.ble or.ir.epar.ble. The ANOVA and test wer. used in statistical analysis. Post-hoc tests wer. car.ied out using Tukey’s and Tamhane’s T2 tests. On the other.hand, Pear.on’s chi-squar. test and the Fisher.Fr.eman-Halton test wer. conducted for.compar.sons between categor.cal var.ables. The statistical significance level was accepted as p r.sults: Accor.ing to the fr.ctur. r.sistance test r.sults, the gr.ups wher. metal per.onal posts wer. used displayed higher.fr.ctur. r.sistance in compar.son with all other.gr.ups. Accor.ing to the r.sults of the optical micr.scope examination, the incidence of r.pair.ble fr.ctur.s was significantly higher.in the PEEK post gr.up with fer.ule pr.par.tion (p 0.05). Conclusion: In the absence of the fer.ule effect, fr.ctur.s ar. catastr.phic, r.gar.less of the mater.al used. The use of PEEK as a post mater.al contr.butes to keeping fr.ctur.s at a r.pair.ble level.

关键词： Component For.atting Style Styling Inser.

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Common-path illumination in ESPI:enhancing sensitivity for.measur.ng specular.defor.ation

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Chinese Optics Letter. 2024年第8期22卷 47-51页

作者： Peizheng Yan Xiangwei Liu Xinda Zhou r.ngsheng ba Hanxuan Zhou Yonghong Wang Jie Li School of Instr.ment Science and Optoelectr.nics Engineer.ng Hefei University of TechnologyHefei 230009China Anhui Pr.vince Key Labor.tor. of Measur.ng Theor. and Pr.cision Instr.ment Hefei University of TechnologyHefei 230009China Laser.Fusion r.sear.h Center China Academy of Engineering PhysicsMianyang 621900China

In this study,an innovative technique is intr.duced to significantly enhance the sensitivity of electr.nic speckle patter. inter.er.metr.(ESPI)for.the dynamic assessment of specular.mir.or.ike)object *** utilizing a common-path illumination str.tegy,wher.in illumination and obser.ation beams ar. pr.cisely aligned,this method effectively doubles the optical path differ.nce,leading to a twofold incr.ase in measur.ment *** addition,this method mitigates the effects of speckle noise on the measur.ment of minor.defor.ations,expanding the applications of *** and exper.mental evaluations cor.obor.te the efficacy of this appr.ach.

关键词： ESPI common-path illumination measur.ment sensitivity specular.defor.ation

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Influence of donor.age on liver.tr.nsplantation outcomes: A multivar.ate analysis and compar.tive study

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Wor.d Jour.al of Gastr.intestinal Sur.er. 2024年第2期16卷 331-344页

作者： Mir.n Bezjak Ivan Str.sec Br.nislav Kocman Stipislav Jadr.jević Tajana Filipec Kanizaj Mir. Antonijević Bojana Dalbelo bašić Danko Mikulić Depar.ment of Sur.er. University Hospital MerkurZagreb 10000Croatia Depar.ment of Electr.nics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Depar.ment of Gastr.enter.logy University Hospital MerkurZagreb 10000Croatia Development of Softwar. Nanobit Ltd.Zagreb 10000Croatia

baCKGr.UND The gr.wing dispar.ty between the r.sing demand for.liver.tr.nsplantation(LT)and the limited availability of donor.or.ans has pr.mpted a gr.ater.r.liance on older.liver.***,utilizing liver. fr.m elder.y donor. has been associated with outcomes infer.or.to those achieved with gr.fts fr.m younger.*** accounting for.additional r.sk factor.,we hypothesize that the utili-zation of older.liver.gr.fts has a r.latively minor.impact on both patient sur.ival and gr.ft *** To evaluate the impact of donor.age on LT outcomes using multivar.ate analysis and compar.ng young and elder.y donor.*** In the per.od fr.m Apr.l 2013 to December.2018,656 adult liver.tr.nsplants wer. per.or.ed at the Univer.ity Hospital *** multivar.ate Cox pr.por.tional hazar.s models wer. developed to independently assess the significance of donor.*** age was tr.ated as a continuous *** appr.ach involved univar.ate and multivar.ate analysis,including var.able selection and assessment of inter.ctions and ***,to exemplify the similar.ty of using young and old donor.liver.gr.fts,the gr.up of 87 r.cipients of elder.y donor.liver.gr.fts(≥75 year.)was compar.d to a gr.up of 124 r.cipients of young liver.gr.fts(≤45 year.)fr.m the *** r.tes of the two gr.ups wer. estimated using the Kaplan-Meier.method and the log-r.nk test was used to test the differ.nces between *** Using multivar.ate Cox analysis,we found no statistical significance in the r.le of donor.age within the constr.cted *** when r.tained dur.ng the entir. model development,the donor.age's impact on sur.ival r.mained insignificant and tr.nsfor.ations and inter.ctions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor.age does not impact patient sur.ival in our.***,ther. was no statistical evidence that the five developed models did not adhe

关键词： Liver.tr.nsplantation Elder.y donor. Sur.ival analysis Postoper.tive complications Cox pr.por.ional hazar. models

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舞蹈高等教育面向未来发展的八个引擎

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北京舞蹈学院学报 2024年第1期 1-7页

作者：巴图北京舞蹈学院北京100081

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育... 详细信息

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育的数字化赋能、舞蹈课堂中的革命风暴。

关键词：舞蹈高等教育未来发展引擎

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新文科建设背景下中国教育人类学学科建设研究

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西北民族研究 2024年第1期 75-88页

作者：巴战龙北京师范大学社会学院北京100875

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会... 详细信息

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会组织为核心的学科创新生态系统。为实现“世界水平、中国特色”的学科建设目标和任务,中国教育人类学界需要齐心协力,从开发和健全学会组织功能、激励和加强高等学校教学、构建和密织学术合作网络、加强和提升学术创新能力、普及和传播学科视角方法等五个方面着手构建学科创新生态系统。通过不懈努力将教育人类学打造成文科教育中国范式的典型案例和示范学科,真正开创出国际学界公认和国内学界自豪的“教育人类学的中国时代”。

关键词：创新生态系统新文科建设学科建设教育人类学

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