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COVID-19:Where is the treatment?

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World Journal of Clinical Oncology 2021年第5期12卷 309-322页

作者： Bonala Sabeerabi Sarojamma Vemula ramakrishna Vadde Ganji Purnachandra nagaraju Department of Biochemistry BiostandupsHyderabad 500039TelanganaIndia Department of Microbiology Government Medical CollegeAnantapur 515001Andhra PradeshIndia Department of Biotechnology&Bioinformatics Yogi Vemana UniversityKadapa 516003Andhra PradeshIndia Department of Hematology and Medical Oncology Emory UniversityAtlantaGA 30322United States

Even though the severe acute respiratory syndrome coronavirus 2(SArS-CoV-2)is related to SArS-CoV and Middle East respiratory syndrome coronavirus(MErS-CoV),identifying effective and safe therapeutic strategies remains *** search of finding effective treatments to eradicate the virus and improve disease symptoms,scientists are exploring possible therapies such as anti-viral,anti-malaria,immune therapy,and hormone ***,the efficacy of these treatments was not validated on either SArS-CoV or *** this study,we have reviewed synthetic evidence achieved through systematic and meta-analysis of therapeutics specific for SArS-CoV-2 and observed that the use of the above-mentioned therapies had no clinical benefits in coronavirus disease 2019 patients and,conversely,displayed side effects.

关键词： COVID-19 Meta-analysis Therapeutics Anti-viral drugs Immune therapy Corticosteroids

Inter-row tillage for improved soil and water conservation and crop yields on crusted Alfisols

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Agricultural Sciences 2013年第8期4卷 36-45页

作者： Prabhakar Pathak Suhas P. Wani raghavendra Sudi nagaraju Budama resilient Dryland Systems International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Hyderabad India

In the semi-arid tropics (SAT),33% areas are occupied by Alfisols and related soils. In SAT these soils have low structural stability and thereby tend to form seal and crusts at the surface. Due to this a large proportion of the rain that falls on Alfisols during the early part of the rainy season,is normally lost as runoff thus causing high soil loss as well as moisture stress to crops. Two tillage studies were conducted first at plot scale (320 m2) during 1991-95 and second at small watershed scale (1.45 ha) during 2007-10,at ICrISAT research station,Hyderabad,India. These studies were conducted to find out whether the problem of excessive runoff and soil loss during the early part of the rainy season can be controlled by various inter-row tillage systems in addition to normal intercultivation by breaking the crust or seal and thereby improving infiltration and soil moisture and reducing runoff and soil loss. The observations on rainfall,runoff,soil moisture,soil loss,soil surface roughness and crop yields were collected from both the studies. results from these studies have shown that inter-row tillage in addition to normal intercultivation is found effective in controlling early season runoff and soil loss and increasing crop yields. The additional tillage systems are found most effective during low and medium rainfall years and not so much during high rainfall years. The additional tillage with shoe cultivators,which creates rough soil surface (11 mm depression storage),is found most effective in increasing crop yields and reducing runoff and soil loss. The additional tillage with blade harrow which generates smooth soil surface is relatively less effective. In most rainfall conditions,the normal intercultivation with one additional tillage is found adequate for controlling early season runoff and improving soil moisture and crop yields.

关键词： runoff Soil Loss Crusting Sealing Semi-Arid Tropics Alfisols Soil Surface roughness

Synthesis and characterization of ZnS-based quantum dots to trace low concentration of ammonia

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Journal of Semiconductors 2021年第12期42卷 72-79页

作者： Uma Devi Godavarti P.nagaraju Vijayakumar Yelsani Yamuna Pushukuri P.S.reddy Madhavaprasad Dasari Nanosensor research Laboratory Department of PhysicsCMR Technical CampusMedchalHyderabadTelangana 501401India Department of Physics Anurag UniversityHyderabadTelangana 500088India Department of Physics Mallareddy Engineering College(Autonomous)DulapallyHyderabad 500100India Department of Applied Sciences NIT GoaGoa 403401India Department of Physics Gitam UniversityVisakhapatnam(A.P.)530045India

In the present work,a solution-based co-precipitation method has been adopted to synthesize pure and cobalt-doped ZnS quantum dots and characterized by XrD,SEM,TEM with EDX,FTIr and gas sensing *** analysis has shown a single phase of ZnS quantum dots having a zinc blend *** and XrD line broadening indicated that the average crystallite size in the sample is in the range of 2 to 5 *** micrographs show spherical-shaped quantum *** studies show that cobalt has been successfully doped into the ZnS cubic *** spectra have analyzed the elemental presence in the samples and it is evident that the spectra confirmed the presence of cobalt(Co),zinc(Zn),oxygen(O),and sulphur(S)elements only and no other impurities are *** ZnS-based quantum dot sensors reveal high sensitivity towards 50 ppm of ammonia vapors at an operating temperature of 70℃.Hence,ZnS-based quantum dots can be a promising and quick traceable sensor towards ammonia sensing applications with good response and recovery time.

关键词： ZnS co-precipitation cobalt doped ZnS XrD quantum dots gas sensor ammonia response

The Stratigraphic, Palaeobiogeographic and Phylogenetic Significance of <i>Aquilapollenites</i>

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Open Journal of Geology 2019年第10期9卷 597-600页

作者： Shreya Mishra Shiva Prakash Kadukothanahalli nagaraju Mahi Bansal Vandana Prasad Terminal Cretaceous-Cenozoic Ecosystem Laboratory Birbal Sahni Institute of Palaeosciences Lucknow India Centre for Structural and Functional Genomics Biology Department Concordia University Montreal Canada The Nature Conservancy Centre India New Delhi Delhi India

Angiosperm evolved and diversified during Cretaceous. During this course of evolution and radiation, various pollen of uncertain origin had evolved. Aquilapollenites represents the early stock of angiosperms attaining its acme with respect to diversity and dominance during Campanian and Maastrichtian age. It was globally present (except Antarctica) however more dominant in northern hemisphere (Canada, North America, Sakhlain Oblast and China). In India, the Aquilapollenites sp. is present in Maastrichtian aged deposits. The pollen affinity has been associated with Loranthaceae and Santalaceae plant families. Here, a comparative description of all the Aquilapollenites sp. comprising a wide range of morphological diversity has been discussed. The wider morphological diversity and ecological adaptability of Aquilapollenites sp. infer that it is globally significant and warrants a more detailed study.

关键词： Triprojectate Pollens Late Cretaceous Maastrichtian Paleocene

Oral Administration of Nicotinamide Mononucleotide with Bioenhancer BioPerine® Increases the Serum Concentration of Nicotinamide Adenine Dinucleotide in Healthy Human Volunteers: A Pilot, Open-Label, Cross-Over Study

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Advances in Bioscience and Biotechnology 2024年第10期15卷 573-589页

作者： Anju Majeed Shaheen Majeed Thontadarya Shivakumar Satish Gudimallam Kadlajji Parameshwarappa Avinash Vasantha nagaraju Lakshmi Mundkur Department of Pharmacology Sami-Sabinsa Group Limited Bangalore India Department of Pharmacology Sabinsa Corporation East Windsor USA General Medicine TR Super Speciality Hospital Bengaluru India Clinical research Sami-Sabinsa Group Limited Bangalore India Biological research & Development Sami-Sabinsa Group Limited Bangalore India

Background: Bioenhancers augment the bioavailability of co-administered molecules without showing any significant effect on their own. Piperine, an alkaloid from Piper nigrum, is an established natural bioenhancer. Nicotinamide mononucleotide (NMN), an antiaging supplement, is the precursor of coenzyme nicotinamide adenine dinucleotide (NAD) that plays an important role in intracellular redox reactions. Objective: The study compared the serum concentrations of NAD in normal healthy participants, supplemented with NMN 500 mg and NMN 500 mg + 5 mg BioPerine® (95% piperine). Methods: In a randomized, open-label, crossover study, NMN (500 mg) was compared to NMN + BioPerine® (500 mg + 5 mg) in 6 healthy adults, aged 18 - 45 years. The participants received a single oral dose of NMN or NMN + BioPerine® capsules with 240 mL water, and blood samples were collected over 8hr. After a 4-day washout period, the same procedures were repeated as per the crossover design. Total NAD (NADtotal), including oxidized NAD (the oxidized) and its reduced form NADH, was measured in human serum samples. results: The maximum concentration (Cmax) of NAD in serum was higher with NMN + BioPerine® (282 pmol/mL) compared to NMN (246 pmol/mL) alone. In the presence of BioPerine®, the NAD concentrations reached 257 pmol/mL during the first 2 hr, whereas a comparable serum concentration (246 pmol/mL) was attained only after 6 hr in NMN alone. The AUC0-8hr was 1738 pmol/mL/hr in NMN compared to 2004 pmol/mL/hr in NMN+ BioPerine®. The time to reach peak concentration (t1/2) was similar (6hr) in both groups. No clinically relevant adverse events (AE) were observed, and safety parameters remained within normal ranges in all the participants with both formulations. Conclusion: These results reveal that BioPerine® can effectively increase the NAD concentrations in the serum following NMN supplementation in healthy volunteers. The present study was registered prospectively with the Clinical Trials registr

关键词： Bioavailability BioPerine® Nicotinamide Mononucleotide Nicotinamide Adenine Dinucleotide Bioenhancer

A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study

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Oncology research 2023年第2期31卷 207-220页

作者： GUSTAVO MArTÍN VILLOLDO MArÍA TErESA POMBO MArIANA ArIS JOAQUÍN CHEMI PABLO MANDÓ SUPrIYA nagaraju JUAN CAMEAN ADrIÁN BUrIONI DEBOrAH EGEA MOrA AMAT JOSÉLEÓN MELLADO JOSÉMOrDOH ALBErTO VILLArONGA MArÍA MArCELA BArrIO Urology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Immunohistochemistry Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Centro de Investigaciones Oncológicas Fundación Cáncer FUCACiudad Autónoma de Buenos Aires1426Argentina Urology Department MD Anderson Cancer CenterHoustonTX77030USA Pathology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina

Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive *** induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor *** searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment ***-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by *** polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EPX+*** addition,PD-1/PD-L1 staining was *** results correlated with BCG *** most non-responders,Th1/Th2 markers were compared in pre-and post-BCG *** was 65.6%in the study *** responders had a higher G/T ratio and a greater number of degranulated EPX+*** combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower ***-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of ***-L1/PD-1 expression was not associated with the response to *** results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity.

关键词： Non-muscle invasive bladder cancer BCG predictive biomarkers Lymphocyte polarization

粉末冶金Al-5.6Zn-2Mg合金在热压缩过程中加工硬化特性及本构模型的比较（英文）

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Journal of Central South University 2024年第2期 346-368页

作者： KATIKA Harikrishna DAMODA r.K. DAVIDSON M.J. SEETHArAM r. KASAGANI Veera Venkata nagaraju Department of Mechanical Engineering National Institute of Technology Department of Mechanical Engineering The Indian Institute of Information Technology Design and Manufacturing

在300～5000℃、应变速率为0.1～0.0001 s-1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σc(εc)以及关键特征σc(εc)、σp(εp)和σss与Z系数之间的相关性。使用了四个本... 详细信息

在300～5000℃、应变速率为0.1～0.0001 s-1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σc(εc)以及关键特征σc(εc)、σp(εp)和σss与Z系数之间的相关性。使用了四个本构模型,Arrhenius模型、改进的Johnson-Cook模型(MJC)、改进的Zerilli-Armstrong模型(MZA)和开发的人工神经网络(ANN)。结果表明,ANN型模型和Arrhenius模型的相对误差的绝对平均值最低,分别为0.486%和3.36%,MZA型模型和MJC型模型的相对误差的绝对平均值较高,分别为8.84%和3.93%。由于Arrhenius模型能够处理各种因素之间的非线性关系,因此它被认为是最合适的预测模型,但在材料性质未知或实验数据有限的情况下,MJC模型可能是一种更简单的替代方法。MZA模型不适合估计热压缩时的流变应力。此外,训练最好的神经网络模型的预测性能最好,相对误差的绝对平均值为0.486%,r值为0.99。

关键词：加工硬化速率曲线本构建模热压缩 EBSD分析流变曲线

终末期心力衰竭患者的肌成纤维细胞表型和纤维化的可逆性

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中华高血压杂志(中英文) 2019年第10期 999-999页

作者： nagaraju CK robinson EL Abdesselem M Trenson S Dries E Gilbert G Janssens S Van Cleemput J rega F Meyns B roderick HL Driesen rB Sipido Kr 林立超余惠珍朱鹏立

心肌间质纤维化通过激活成纤维细胞分化为肌成纤维细胞(myofibroblasts, MyoFb)导致舒张及收缩功能不全,为心力衰竭的重要病理基础。近期临床证据表明,在终末期心力衰竭患者中,心肌间质纤维化是不可逆转的病理过程。本文研究目的为探讨... 详细信息

心肌间质纤维化通过激活成纤维细胞分化为肌成纤维细胞(myofibroblasts, MyoFb)导致舒张及收缩功能不全,为心力衰竭的重要病理基础。近期临床证据表明,在终末期心力衰竭患者中,心肌间质纤维化是不可逆转的病理过程。本文研究目的为探讨终末期心力衰竭患者的心肌组织中MyoFb的分化程度和细胞表型逆转的潜在性。方法:两种来源获取成纤维细胞:①从因缺血性或扩张性心肌病需心脏移植患者的左心室分离;②从捐献者的心脏中分离。成纤维细胞经体

关键词：终末期心力衰竭肌成纤维细胞纤维化可逆性