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The Qualitative Assesment of Emerging risks to Workers Exposed to HAV

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材料科学与工程（中英文A版） 2014年第9期4卷 315-320页

作者： Mihaela picu Engineering Faculty Galati University Galati Romania

congenital central Hypoventilation Syndrome in a chinese infant and Literature review

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Congenital Central Hypoventilation Syndrome in a Chinese inf...

continuous renal replacement Therapy in Acute Kidney Injury Due to Melamine-related Urolithiasis

中华医学会第十七次全国儿科学术大会

作者： Hong ren picu Shanghai childrens Medical center

Objective congenital central Hypoventilation Syndrome(ccHS) is a rare autosomal dominant disorder characterized by failure in the autonomic control of breathing.A mutation in the PHOX2B gene has recently been identified in more than 90%of cases,playing a major role in ccHS. Method clinical data:Gather the clinical data of this patient include of recording the vital sign of patient,testing BG,biochemical detection,EcG,echocardiography,EEG,cT of chest,MrI of brain,electromyo- graphy,tandem mass spectrometry et *** sequencing:The PHOX2B gene mutation were analyzed in patient and his parents known to have *** genomic DNA of them was isolated from whole *** three exons of the PHOX2B gene were analyzed by *** mutation ruled out polymorphism using rFLP in 100 unrelated normal control *** testing was used to confirm familial relationships. result According to the clinical data,this patient typically present hypoventilation during sleeping, without any associated primary cardiac, pulmonary,neuromuscular or brainstem lesions,without any metabolic *** sequencing of the PHOX2B gene shows expanded alleles containing polyalanine 25 repeats in the patient. conclusion According to the clinical and gene diagnosis,this patient present *** ccHS is a rare disease,we can do DNA sequencing of the PHOX2B gene when we notice the patient with *** gene sequencing is very useful during the clinical work.

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Continuous Renal Replacement Therapy in Acute Kidney Injury ...

基于医护一体化有效沟通的移动视频探视在picu中的应用

第六届江浙沪儿科学术会议暨儿科学基础与临床研究进展学术班

作者： Zi-Hao Yang chen-Mei Zhang Tao Liu Xiao-Fang Lou Zhen-Jie chen Sheng Ye Department of picu The children’s Hospital of Zhejiang University School of Medicine

Melamine,a synthetic nitrogenous product found in many industrial goods,was been added to many different powder infant formulas in china in late 2008 to increase their measured protein *** of the infants fed with such milk were asymptomatic or with mild symptoms.A few however suffered from acute obstructive kidney injury secondary to melamine containing renal stones(8 out of 1 5577 children screened at our hospital for urolithiasis).This study was aimed to retrospectively review the management of acute kidney injury using continuous renal replacement therapy(crrT)in the 8 infants.

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海南医学 2016年第22期27卷 3777-3779页

作者：王文杰王梦荷詹艳杨玉梅十堰市太和医院护理部湖北十堰442000 十堰市太和医院picu 湖北十堰442000

目的探讨在儿童重症监护病房(picu)利用移动视频探视系统结合医护一体化的有效沟通实施的方法和效果。方法选择2014年8月至2015年1月在picu住院的120名患儿家属为对照组,2015年2月至2015年7月在picu住院的131名患儿家属为观察组。对照... 详细信息

目的探讨在儿童重症监护病房(picu)利用移动视频探视系统结合医护一体化的有效沟通实施的方法和效果。方法选择2014年8月至2015年1月在picu住院的120名患儿家属为对照组,2015年2月至2015年7月在picu住院的131名患儿家属为观察组。对照组采用单一的视频探视方法,观察组在视频探视的基础上,评估患儿家属的需求,组成医护协同小组,完善"沟通—探视—沟通"工作制度,制定探视指引,确认探视流程,实施医护一体化的有效沟通,反馈探视沟通效果。采用焦虑自评量表和EMPATIc-30picu患儿家属满意度测评量表对两组患儿家属进行问卷调查。结果对照组均发放120份问卷,收回115份,有效回收率为95.8%;观察组均发放131份问卷,收回128份,有效回收率为97.7%。观察组患儿家属焦虑程度为(49.4±5.9)分,明显低于对照组的(57.3±6.8)分,差异有统计学意义(Ppicu进行移动视频探视,结合医护一体化有效的沟通,动态了解患儿家属的心理需求,提供心理支持,缓解了家属的焦虑情绪,体现人文关怀,提高患儿家属的满意度,改善就医感受,有利于构建和谐的护患关系。

关键词：儿童重症监护病房医护一体化沟通探视应用

Perspectives on non-emergent neonatal intensive care unit to pediatric intensive care unit care transfers in the United States

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World Journal of critical care Medicine 2024年第4期13卷 73-80页

作者： Phillip D cohen renee D Boss David c Stockwell Meghan Bernier Joseph M collaco Sapna r Kudchadkar Department of Anesthesiology and critical care Medicine Johns Hopkins School of MedicineBaltimoreMD 21287United States Department of Pediatrics Johns Hopkins School of MedicineBaltimoreMD 21287United States

BAcKGrOUND There is a substantial population of long-stay patients who non-emergently transfer directly from the neonatal intensive care unit(NIcU)to the pediatric intensive care unit(picu)without an interim discharge *** infants are often medically complex and have higher mortality relative to NIcU or picuonly *** an absence of data surrounding practice patterns for nonemergent NIcU to picu transfers,we hypothesized that we would encounter a broad spectrum of current practices and a high proportion of dissatisfaction with current *** To characterize non-emergent NIcU to picu transfer practices across the United States and query picu providers’evaluations of their *** A cross-sectional survey was drafted,piloted,and sent to one physician representative from each of 115 picus across the United States based on membership in the PArK-picu research consortium and membership in the children’s Hospital *** survey was administered via internet(rEDcap).Analysis was performed using STATA,primarily consisting of descriptive statistics,though logistic regressions were run examining the relationship between specific transfer steps,hospital characteristics,and effectiveness of *** One picu attending from each of 81 institutions in the United States completed the survey(overall 70%response rate).Over half(52%)indicated their hospital transfers patients without using set clinical criteria,and only 33%indicated that their hospital has a standardized protocol to facilitate non-emergent *** than half of respondents reported that their institution’s nonemergent NIcU to picu transfer practices were effective for clinicians(47%)or patient families(38%).respondents evaluated their centers’transfers as less effective when they lacked any transfer criteria(P=0.027)or set transfer protocols(P=0.007).respondents overwhelmingly agreed that having set clinical criteria and standardized protocols for non-emergen

关键词： Transfer chronic critical illness Intensive care units Pediatric intensive care Neonatal intensive care care transition

SArS-coV-2 variants are associated with different clinical courses in children with MIS-c

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane c.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease research center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background recent infection with SArS‑coV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-c).SArS‑coV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-c at rady children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-c waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to c,20G,21c(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22c).MIS-c presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(picu)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SArS-coV-2 triggered MIS-c with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： complications cOVID-19 MIS-c SArS-coV-2 variants

characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review

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World Journal of critical care Medicine 2017年第2期6卷 124-134页

作者： Elizabeth A Herrup Beth Wieczorek Sapna r Kudchadkar Departments of Anesthesia and critical care Medicine Johns Hopkins Hospital Departments of Anesthesia and critical care Medicine and Pediatrics Johns Hopkins Hospital

AIM To synthesize the available evidence focusing on morbidities in pediatric survivors of critical illness that fall within the defined construct of postintensive care syndrome(PIcS) in adults, including physical, neurocognitive and psychological *** A comprehensive search was conducted in MEDLINE, EMBASE, the cochrane Library, Psyc INFO, and cINAHL using controlled vocabulary and key word terms to identify studies reporting characteristics of PIcS in pediatric intensive care unit(picu) patients. Two reviewers independently screened all titles and abstracts and performed data extraction. From the 3176 articles identified in the search, 252 abstracts were identified for full text review and nineteen were identified for inclusion in the review. All studies reporting characteristics of PIcS in picu patients were included in the final synthesis. rESULTS Nineteen studies meeting inclusion criteria published between 1995 and 2016 were identified and categorized into studies reporting morbidities in each of three categories-physical, neurocognitive and psychological. The majority of included articles reported prospective cohort studies, and there was significant variability in the outcome measures utilized. A synthesis of the studies indicate that morbidities encompassing PIcS are well-described in children who have survived critical illness, often resolving over time. risk factors for development of these morbidities include younger age, lower socioeconomic status, increased number of invasive procedures or interventions, type of illness, and increased benzodiazepine andnarcotic *** PIcS-related morbidities impact a significant proportion of children discharged from picus. In order to further define PIcS in children, more research is needed using standardized tools to better understand the scope and natural history of morbidities after hospital discharge. Improving our understanding of physical, neurocognitive, and psychological morb

关键词： Pediatric intensive care Pediatric intensive care unit critical illness Postintensive care syndrome Post-traumatic stress Trauma Patient outcomes

Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais r.Briant Etienne Javouhey Sophie Breinig Julia Dina Marion caseris Francois Angoulvant Stephane Leteurtre Morgan recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-cite ParisFrance Biostatistics and clinical research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive care Hospices Civils de LyonLyonFrance Neonatal andPediatric Intensivecare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance cHU Sainte Justine research center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SArS-coV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SArS-coV-2 on the mortality rate associated with SArS-coV-2-related illnesses in the pediatric intensive care unit(picu).Secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive SArS-coV-2 polymerase chain reactions(Pcrs)[acute corona virus disease 2019(cOVID-19)or incidental SArS-coV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French picu registry(picure)between September 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their picu *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SArS-coV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SArS-coV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to SArS-coV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SArS-coV-2 mortality in the French pediatric population was *** though the imputability of SArS-cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit SArS-coV-2

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儿童体外膜肺氧合支持治疗的护理专家共识

中华急危重症护理杂志 2023年第3期4卷 232-238页

作者：浙江大学医学院附属儿童医院护理部首都医科大学附属儿童医院儿科重症监护病房上海复旦大学附属儿科医院护理部上海交通大学附属上海儿童医学中心儿科重症监护病房重庆医科大学附属儿童医院儿科重症监护病房国家医学中心儿科护理联盟诸纪华曲斌胡静张悦玥刘鹏丁亚萍不详浙江大学医学院附属儿童医院护理部杭州市310052 首都医科大学附属儿童医院儿科重症监护病房上海复旦大学附属儿科医院护理部上海交通大学附属上海儿童医学中心儿科重症监护病房重庆医科大学附属儿童医院儿科重症监护病房

目的形成儿童体外膜肺氧合支持治疗的护理专家共识(以下简称《共识》),规范体外膜肺氧合支持治疗期间的患儿护理。方法在系统检索国内外文献的基础上,结合利益相关人群访谈结果,列出具体问题并设计专家函询表,邀请北京市、上海市、重庆... 详细信息

目的形成儿童体外膜肺氧合支持治疗的护理专家共识(以下简称《共识》),规范体外膜肺氧合支持治疗期间的患儿护理。方法在系统检索国内外文献的基础上,结合利益相关人群访谈结果,列出具体问题并设计专家函询表,邀请北京市、上海市、重庆市和浙江省15名相关领域专家,进行2轮德尔菲专家函询和1轮专家论证会议,对各个条目进行调整、修改和完善。结果《共识》包括EcMO建立前准备工作、EcMO支持模式选择、参数设定及系统监测、循环管理、呼吸管理、药物管理、营养管理、并发症管理、转运管理与出院随访管理10个方面。结论该《共识》具有科学性和实用性,为儿童体外膜肺支持治疗的护理实践提供指导依据。

关键词：儿童体外膜肺氧合临床实践危重病护理专家共识