检索结果-南通市图书馆

Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 180-188页

作者： Li-Kun Wang Lu-Wen Wang Xun Li Xiao-qun han Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospita of Wuhan University

BACKGROUND: The pathogenesis and progression of acute liver failure (ALF) are closely associated with intestinal endotoxemia because of the high permeability of the intestinal wall. Treatment with ethyl pyruvate (EP) has been shown to protect liver failure effectively. The current study aimed to explore the relationship between proinflammatory cytokines and intestinal permeability, and to investigate whether EP administration might prevent the release of multiple proinflammatory cytokines and decrease intestinal permeability and therefore, protect the liver from injury. METHODS: The ALF model was induced by D-galactosamine in rats. The rats were randomly divided into control (saline i.p.), model (D-galactosamine, 1.2 g/kg, i.p.), prevention [EP injection (40 mg/kg) 2 hours ahead of D-galactosamine] and treatment groups (EP injection 2 hours after D-galactosamine) Samples were obtained at 12 and 24 hours after ALF induction respectively. The histology of liver and intestinal tissue was accessed. Serum alanine aminotransferase, endotoxin, D(-) lactate, diamine oxidase (DAO), tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and high mobility group box-1 (HMGB1) were evaluated. The survival of rats was also recorded. RESULTS: The rats in model group showed severe damage to liver tissue and intestinal mucosa 12 and 24 hours after ALF induction. EP significantly improved liver or intestinal injury In addition, serum endotoxin, D(-)-lactate, DAO, TNF-α IFN-γ and HMGB1 levels were significantly increased in the model group compared with the control group. There was a positive correlation between intestinal permeability andproinflammatory cytokines. EP significantly reduced serum endotoxin, D(-)-lactate, DAO, TNF-α, IFN-γ and HMGB1 levels. The median survival time was significantly prolonged in both prevention and treatment groups (126 and 120 hours compared with 54 hours in the model group). CONCLUSIONS: EP has protective and therapeutic effects on intestinal mucos

关键词： acute liver failure ethyl pyruvate intestinal permeability cytokines

Predictors of pain response after endoscopic ultrasound-guided celiac plexus neurolysis for abdominal pain caused by pancreatic malignancy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第1期27卷 69-79页

作者： Chao-qun han Xue-Lian Tang Qin Zhang Chi Nie Jun Liu Zhen Ding Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Endoscopic ultrasound-guided celiac plexus neurolysis(EUS-CPN)has gained popularity as a minimally invasive approach and is currently widely used to treat pancreatic cancer-associated ***,response to treatment is *** To identify the efficacy of EUS-CPN and explore determinants of pain response in EUS-CPN for pancreatic cancer-associated *** A retrospective study of 58 patients with abdominal pain due to inoperable pancreatic cancer who underwent EUS-CPN were *** efficacy for palliation of pain was evaluated based on the visual analog scale pain score at 1 wk and 4 wk after *** and multivariable logistic regression analyses were performed to explore predictors of pain *** A good pain response was obtained in 74.1%and 67.2%of patients at 1 wk and 4 wk,*** located in the body/tail of the pancreas and patients receiving bilateral treatment were weakly associated with a good *** analysis revealed patients with invisible ganglia and metastatic disease were significant factors for a negative response to EUS-CPN at 1 wk and 4 wk,respectively,particularly for invasion of the celiac plexus(odds ratio(OR)=13.20,P=0.003 for 1 wk and OR=15.11,P=0.001 for 4 wk).No severe adverse events were *** EUS-CPN is a safe and effective form of treatment for intractable pancreatic cancer-associated *** ganglia,distant metastasis,and invasion of the celiac plexus were predictors of less effective response in EUS-CPN for pancreatic cancer-related *** these patients,efficacy warrants attention.

关键词： Endoscopic ultrasound Celiac plexus neurolysis Pancreatic cancer Pain Predictor

RFFsNet-SEI:a multidimensional balanced-RFFs deep neural network framework for specific emitter identification

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第3期35卷 558-574,F0002页

作者： FAN Rong SI Chengke han Yi WAN qun School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Electronic and Electrical Engineering Civil Aviation Flight University of ChinaGuanghan 618307China

Existing specific emitter identification(SEI)methods based on hand-crafted features have drawbacks of losing feature information and involving multiple processing stages,which reduce the identification accuracy of emitters and complicate the procedures of *** this paper,we propose a deep SEI approach via multidimensional feature extraction for radio frequency fingerprints(RFFs),namely,***,we extract multidimensional physical RFFs from the received signal by virtue of variational mode decomposition(VMD)and Hilbert transform(HT).The physical RFFs and I-Q data are formed into the balanced-RFFs,which are then used to train *** introducing model-aided RFFs into neural network,the hybrid-driven scheme including physical features and I-Q data is *** improves physical interpretability of ***,since RFFsNet-SEI identifies individual of emitters from received raw data in end-to-end,it accelerates SEI implementation and simplifies procedures of ***,as the temporal features and spectral features of the received signal are both extracted by RFFsNet-SEI,identification accuracy is ***,we compare RFFsNet-SEI with the counterparts in terms of identification accuracy,computational complexity,and prediction *** results illustrate that the proposed method outperforms the counterparts on the basis of simulation dataset and real dataset collected in the anechoic chamber.

关键词： specific emitter identification(SEI) deep learning(DL) radio frequency fingerprint(RFF) multidimensional feature extraction(MFE) variational mode decomposition(VMD)

Sodium butyrate protects against toxin-induced acute liver failure in rats

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2014年第3期13卷 309-315页

作者： Fan Yang Li-Kun Wang Xun Li Lu-Wen Wang Xiao-qun han Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan University Department of Infectious Diseases Linyi People's Hospital

BACKGROUND: Acute liver failure(ALF) is a serious clinical syndrome with high mortality. Sodium butyrate has been shown to alleviate organ injury in a wide variety of preclinical models of critical diseases. The aim of this study was to investigate the protective effect of sodium butyrate on ALF in ***: All rats were randomly divided into control,model and sodium butyrate treatment groups. Except the control group, the rats were induced ALF animal model by subcutaneous injection of human serum albumin+D- galactosamine+lipopolysaccharide. After induction of ALF,the rats in the treatment group received sodium butyrate(500mg/kg) at 12-hour or 24-hour time point. Fourty-eight hours after ALF induction, the animals were sacrificed and samples were harvested. Serum endotoxin, high mobility group box-1(HMGB1), liver function parameters, tumor necrosis factoralpha(TNF-α) and interferon-gamma(IFN-γ) were *** expression of HMGB1 and nuclear factor-kappa B(NF-κB)p65 protein in liver tissue was detected by Western blotting. The histological changes of liver and intestine were examined. The survival duration was also ***: Serum endotoxin, alanine aminotransferase, HMGB1,TNF-α and IFN-γ were significantly increased and the liver histology showed more severe histopathological injury in the model group compared with the control group(Phanges in the liver and intestine, reduced serum endotoxin and inflammatory cytokines, suppressed HMGB1 and NF-кB p65 proteins in liver tissue, and prolonged the survival duration regardless of treatment at 12 hours or 24 hours after induction of ALF(Phanisms may be due to direct hepatoprotection and decreased intestinal permeability.

关键词： acute liver failure high mobility group box-1 nuclear factor-kappa B p65 animal model sodium butyrate

Polarization-sensitive and active controllable electromagnetically induced transparency in U-shaped terahertz metamaterials

在线全文

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2021年第2期14卷 221-228页

作者： Kun REN Ying ZhanG Xiaobin REN Yumeng HE qun han College of Precision Instrument and Opto-electronics Engineering Tianjin UniversityKey Laboratory of Opto-electronics Information TechnologyMinistry of EducationTianjin 300072China School of Science Tianjin University of Science and TechnologyTianjin 300222China

Electromagnetically induced transparency(EIT)phenomenon is observed in simple metamaterial which consists of concentric double U-shaped resonators(USRs).The numerical and theoretical analysis reveals that EIT arises from the bright-bright mode *** transmission spectra at different polarization angle of incident light shows that EIT transparency window is polarization *** interestingly,Fano resonance appears in the transmission spectrum at certain polarization *** sharp and asymmetric Fano lineshape is high valuable for *** performance of sensor is investigated and the sensitivity is high up to 327 GHz/***,active control of EIT window is realized by incorporating photosensitive *** proposed USR structure is simple and compact,which may find significant applications in tunable integrated devices such as biosensor,filters,and THz modulators.

关键词： electromagnetically induced transparency(EIT) metamaterial polarization-sensitive active optical devices sensor

CPT-11 Chemotherapy Rescued A Patient with Atypical Sclerosing Epithelioid Fibrosarcoma from Emergent Condition

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2012年第3期24卷 253-256页

作者： Chun-hua Pan Xi-qun han Jian-sheng Li Department of Medical Oncology Affiliated Tumor Hospital of Guangzhou Medical CollegeGuangzhou 510095China Department of Pathology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 520515China Department of Image Affiliated Tumor Hospital of Guangzhou Medical CollegeGuangzhou 510095China

Sclerosing epithelioid fibrosarcoma （SEF） is a rare and poorly defined variant of fibrosarcoma, but generally insensitive to chemotherapy and progresses with poor prognosis. We report the marvelous effect of irinotecan hydrochloride （CPT-11） chemotherapy in rescuing a patient with atypical SEF from emergent condition, who underwent recurrences after several treatment methods. Small dose of CPT-11 was administered to the patient, with which, the size of superficial mass （cervical lymph node） gradually decreased observed by the naked eyes in 5 days. X-ray and CT image proved a marked reduction in the size of the tumor. CPT-11 is valuable for the treatment of this aggressive sarcoma. In condition of emergency caused by sarcoma oppression, administering a tolerable small dose of topoisomerase I-inhibiting drug could be a beneficial choice.

关键词： Sclerosing epithelioid fibrosarcoma CPT- Chemotherapy

Fiber loop ring-down cavity integrated U-bent single-mode-fiber for magnetic field sensing

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2016年第6期4卷 322-326页

作者： Yaofei Chen Tiegen Liu qun han Wenchuan Yan Lin Yu College of Precision Instrument and Opto-Electronics Engineering Tianjin University Department of Mechanical Engineering Columbia University Key Laboratory of Opto-electronics Information Technology (Tianjin University) Ministry of Education

A novel magnetic field sensing system based on the fiber loop ring-down technique is proposed in this paper. In the fiber loop, a U-bent single-mode-fiber structure coated with magnetic fluid(MF) serves as the sensing head, and an erbium-doped fiber amplifier(EDFA) is introduced to compensate for the intrinsic loss of the cavity. The ring-down time of the system varies with the change of applied magnetic field due to the tunable absorption coefficient and refractive index of the MF. Therefore, measurement of the magnetic field can be realized by monitoring the ringdown time. The experimental results show that the performance of the system is extremely dependent on the interrogation wavelength, because both the gain of the EDFA and the loss of the sensing head are wavelength *** found that at the optimal wavelength, the ratio of the gain to loss attained its maximum. The sensing system was experimentally demonstrated and a sensitivity of-0.5951 μs∕Oe was achieved.

关键词： mode down ring EDFA Fiber loop ring-down cavity integrated U-bent single-mode-fiber for magnetic field sensing

Principal resonance response of a stochastic elastic impact oscillator under nonlinear delayed state feedback

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2015年第4期24卷 90-99页

作者：黄冬梅徐伟谢文贤韩群 Department of Applied Mathematics Northwestern Polytechnical University Department of Civil and Environmental Engineering Rice University

In this paper, the principal resonance response of a stochastically driven elastic impact （El） system with time-delayed cubic velocity feedback is investigated. Firstly, based on the method of multiple scales, the steady-state response and its dynamic stability are analyzed in deterministic and stochastic cases, respectively. It is shown that for the case of the multi- valued response with the frequency island phenomenon, only the smallest amplitude of the steady-state response is stable under a certain time delay, which is different from the case of the traditional frequency response. Then, a design criterion is proposed to suppress the jump phenomenon, which is induced by the saddle-node bifurcation. The effects of the feedback parameters on the steady-state responses, as well as the size, shape, and location of stability regions are studied. Results show that the system responses and the stability boundaries are highly dependent on these parameters. Furthermore, with the purpose of suppressing the amplitude peak and governing the resonance stability, appropriate feedback gain and time delay are derived.

关键词： elastic impact system time delay frequency island jump avoidance

Research on the Personalized Recommendation of Clothing Based on Rough Set Theory

在线全文

学校读者我要写书评

暂无评论

International English Education Research 2015年第5期 6-10页

作者： Lin qun Yan Ruixia han Qiuying School of Management Shanghai University of Engineering Science Shanghai 201620 China

With time going on, the fact that pace of life becomes faster make more and more customers pay more attention to of clothing. In order to survive and develop better and to attract more customers, enterprisesmust have the ability to provide the personalized recommendations and the implementation of differentiated business strategy. This text aims to make enterprises understand the customers＇ personalized requirement by using the data processed though questionnaire and rough set theory. And enterprises can provide production and marketing auxiliary decision-making effectively. The feasibility and practicality of rough set theory is verified through the personalized recommendationseases.

关键词： rough set clothing personalized recommendation