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X-ray microscopic investigation of molecular orientation in a hole carrier thin film for organic solar cells

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Nano Research 2018年第5期11卷 2771-2782页

作者： quentin Arnoux Benjamin Watts Sufal Swaraj Francois Rochet Ludovic Tortech Laboratoire de Chimie Physique Matiere et Rayonnement (LCPMR) UMR 7614 Sorbonne Universites UPMC Univ Paris 06 Paris F-75005 France Institut Parisien de Chimie Moleculaire (IPCM) UMR 8232 Sorbonne Universites UPMC Univ Paris 06 Paris F-75005 France Laboratoire d'Innovation en Chimie des Surfaces et Nanosciences (LICSEN) NIMBE UMR 3685 CEA Saday Gif-sur-Yvette F-91191 France Paul Scherrer Institute Villigen Psi 5232 Switzerland Synchrotron SOLEIL L'Orme des Merisiers Saint-Aubin BP 48 Gif-sur-Yvette F-91192 France

As dipyranylidenes are excellent hole carriers, applications in organic solar cells or organic light emitting diode are envisaged. In the present study, we investigate the morphology of 2,2＇,6,6＇-tetraphenyl-4,4＇-dipyranylidene （DIPO-Ph4） deposited under vacuum on a silicon nitride （Si3N4） substrate, a paradigmatic system for the study of molecular crystal/inorganic substrate interfaces. Samples with various coating ratios and different thermal treatments were prepared. The films were characterized by atomic force microscopy and scanning transmission X-ray microscopy to gain insight into material growth. The results show a change in orientation at a molecular level depending upon the evaporation conditions. We are now able to tailor an organic layer with a specific molecular orientation and a specific electronic behavior.

关键词： organic solar cells scanning transmission X-ray microscopy molecular orientation inorganic/organic interface

Population structure of the blacklegged tick Ixodes scapularis revealed by SSCP data using the mitochondrial Cyt b and the nuclear ITS1 markers

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动物学报 2004年第2期50卷 176-186页

作者： Tonya R. MIXSON quentin q. fang D. Kelly McLAIN James H. OLIVER Jr Georgia Southern University Department of Biology and Institute of Arthropodology and Parasitology PO Box 8042 Statesboro GA 30460-8042 USA

The population genetic structure of the blacklegged tick Ixodes scapularis was analyzed using 853 individual ticks collected from 12 sites along the eastern seaboard of the United States. PCR-based DNA single strand conformation polymorphism(SSCP) was used for analysis of one haploid locus, the mitochondrial cytochrome b(Cyt b), and one diploid locus, the internal transcribed spacer 1(ITS1) of nuclear ribosomal RNA. Seven haplotypes in the Cyt b locus and 13 genotypes in the ITS1 locus were identified. Population differentiation and isolation by distance were found. Distribution of haplotype and genotype frequencies across geographic regions suggests that two distinct populations exist along the Eastern Coast of the US. However, genetic variation among individuals within regions was large. This degree of variation suggests frequent gene flow between regions. Moreover, overall genetic diversity among individuals was much higher in ticks from the southern population.

关键词： Blacklegged tick Population genetics Genetic variation Gene flow SSCP

Embedding laser-generated CdTe nanocrystals into ultrathin ZnIn_(2)S_(4) nanosheets with sulfur vacancies for boosted photocatalytic H_(2) evolution

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Journal of Materials Science & Technology 2023年第35期166卷 113-122页

作者： Z.G.Tai G.T.Sun X.H.Zhang X.B.Yang T.Wang Z.Y.fang q.Ye L.C.Jia H.q.Wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China School of Materials Science and Engineering Shaanxi Normal UniversityXi’an 710119China

To suppress the inner charge recombination and inject vast electrons,CdTe nanocrystals are embedded into ultrathin ZnIn_(2)S_(4) nanosheets to construct ZnIn_(2)S_(4)/CdTe heterostructures,where the nanocrystals are generated by a laser irradiation *** optimal ZnIn_(2)S_(4)/CdTe heterojunction exhibits an excellent catalytic activity of 24.3 mmol/h/g,which is relatively high among the ZnIn_(2)S_(4)-based photocatalysts with-out noble *** enhancement is ascribed to a win-win mechanism of nanoscale heterojunctions and sulfur *** strong electron coupling effect,which is verified by density functional the-ory(DFT)calculations,impels the photo-generated electrons transfer from CdTe to ZnIn_(2)S_(4),boosting the charge ***,the sulfur vacancies existing in ZnIn_(2)S_(4) can capture photoelectrons and act as active sites,facilitating the H_(2) generation *** addition,the ZnIn_(2)S_(4) base and the ZnIn_(2)S_(4)/CdTe heterojunction also possess an evident photothermal effect and renewable cycle phenomena,enhancing the photocatalytic *** research provides new insights into the regulation of charge transfer through embedding nanocrystals.

关键词： Photocatalysis Hydrogen evolution Laser irradiation Heterostructure Sulfur vacancies

Clarifying predictions for COVID-19 from testing data: The example of New York State

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Infectious Disease Modelling 2021年第1期6卷 273-283页

作者： quentin Griette Pierre Magal Univ.Bordeaux IMBUMR 5251F-33400TalenceFrance CNRS IMBUMR 5251F-33400TalenceFrance

With the spread of COVID-19 across the world,a large amount of data on reported cases has become *** are studying here a potential bias induced by the daily number of tests which may be insufficient or vary over ***,tests are hard to produce at the early stage of the epidemic and can therefore be a limiting factor in the detection of *** a limitation may have a strong impact on the reported cases ***,some cases may be missing from the official count because the number of tests was not sufficient on a given *** this work,we propose a new differential equation epidemic model which uses the daily number of tests as an *** obtain a good agreement between the model simulations and the reported cases data coming from the state of New *** also explore the relationship between the dynamic of the number of tests and the dynamics of the *** obtain a good match between the data and the outcome of the ***,by multiplying the number of tests by 2,5,10,and 100 we explore the consequences for the number of reported cases.

关键词： Corona virus Testing data Reported and unreported cases Isolation quarantine Public closings Epidemic mathematical model

The importance of a potential phosphorylation site in enamelin on enamel formation

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International Journal of Oral Science 2017年第4期9卷 210-215页

作者： Wen-Juan Yan Pan Ma Ye Tian Jing-Ya Wang Chun-Lin qin Jian q Feng Xiao-fang Wang Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis Texas A&M University College of DentistryDallasUSA Department of Endodontics Nanfang HospitalSouthern Medical UniversityGuangzhouChina

Enamelin （ENAM） has three putative phosphoserines （pSers） phosphorylated by a Golgi-associated secretory pathway kinase （FAM20C） based on their distinctive Ser-x-Glu （S-x-E） motifs. Fam2OC-knockout mice show severe enamel defects similar to those in the Enam-knockout mice, implying an important role of the pSers in ENAM. To determine the role of pSer5s in ENAM, we characterized ENAMRgsc514 mice, in which Sers5 cannot be phosphorylated by FAM20C due to an E57〉Gs7 mutation in the S-x-E motif, The enamel microstructure of 4-week-old mice was examined by scanning electron microscopy. The teeth of 6-day-old mice were characterized by histology and immunohistochemistry. The protein lysates of the first lower molars of 4-day-old mice were analyzed by Western immunoblotting using antibodies against ENAM, ameloblastin and amelogenin. ENAMRgsc514 heterozygotes showed a disorganized enamel microstructure, while the homozygotes had no enamel on the dentin surface. The N-terminal fragments of ENAM in the heterozygotes were detained in the ameloblasts and localized in the mineralization front of enamel matrix, while those in the WT mice were secreted out of ameloblasts and distributed evenly in the outer 1/2 of enamel matrix. Surprisingly, the 15 kDa C-terminal fragments of ameloblastin were not detected in the molar lysates of the homozygotes. These results suggest that the phosphorylation of SerSS may be an essential posttranslational modification of ENAM and is required for the interaction with other enamel matrix molecules such as ameloblastin in mediating the structural organization of enamel matrix and protein-mineral interactions during enamel formation.

关键词： ameloblastin enamel enamelin FAM20C phosphorylation phosphoserine

Synthesis and Characterization of a New Organic Up-conversion Laser Dye HMASPS

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Chinese Chemical Letters 2000年第5期11卷 395-398页

作者： Ren, Y fang, q Yan, YX Wang, XM Liu, Z Zhou, GY Wang, C Zhao, X Jiang, MH Shandong Univ State Key Lab Crystal Mat Jinan 250100 Peoples R China

A new organic dye, trans-4-[4'-(N-hydroxyethyl-N-methylamino)styryl]-N-methylpyridinium p-toluene sulfonate (HMASPS) has been synthesized and its structure has been determined. Pumped with a 1064 nm, 50 ps laser pulses, 0.05 mol/L HMASPS/DMF solution showed the two-photon pumped (TPP) output/input efficiency of 8.4% which is higher than that of trans-4-[p-(N-hydroxyethyl-N-methylamino) styryl]-N-methylpyridinium iodide (ASPI)(1) at the same pump level.

关键词： C24H28N2O4S.H2O TPP up-conversion laser dye

CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer

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Cancer Communications 2021年第2期41卷 121-139页

作者： Ailin Chen Shijun Wen fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang quentin Liu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China Institute of Cancer Stem Cell Dalian Medical UniversityDalianLiaoning 116044P.R.China Department of Surgery and Cancer Imperial College LondonW120NNLondonUK

Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse *** selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor responses as a single agent in various cancer types but its phase III clinical trial was reported as a failure since MLN8237 did not show an apparent effect in prolonging the survival of ***,identification of potential targets that could enhance the activity of MLN8237 would provide a rationale for drug combination to achieve better therapeutic ***:Here,we conducted a systematic synthetic lethality CRISPR/Cas9 screening of 507 kinases using MLN8237 in breast cancer cells and identified a number of targetable kinases that displayed synthetic lethality interactions with ***,we performed competitive growth assays,colony formation assays,cell viability assays,apoptosis assays,and xenograft murine model to evaluate the synergistic therapeutic effects of Haspin(GSG2)depletion or inhibition with *** mechanistic studies,immunofluorescence was used to detect the state of microtubules and the localization of Aurora-B and mitotic centromere-associated kinesin(MCAK).Results:Among the hits,we observed that Haspin depletion or inhibition marginally inhibited breast cancer cell growth but could substantially enhance the killing effects of *** studies showed that co-treatment with Aurora-A and Haspin inhibitors abolished the recruitment of Aurora-B and mitotic centromere-associated kinesin(MCAK)to centromeres which were associated with excessive microtubule depolymerization,kinetochore-microtubule(KT-MT)attachment failure,and severe mitotic *** further showed that the combination of MLN8237 and the Haspin inhibitor CHR-6494 synergistically reduced breast cancer cell viability and significantly inhibited both in vitro and in vivo tumor ***:These findings establish Haspin as a synthetic lethal targe

关键词： alisertib Aurora-A breast cancer CHR-6494 CRISPR/Cas9 screening haspin kinetochoremicrotubule mitotic centromere-associated kinesin synthetic lethal xenograft

Hybrid TiO_(2)/Ag NPs/g-C_(3)N_(4) nanocomposite coatings on TC4 titanium alloy for enhanced synergistic antibacterial effect under full spectrum light

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Journal of Materials Science & Technology 2022年第23期118卷 35-43页

作者： Xi.Rao L.Du J.J.Zhao X.D.Tan Y.X.fang L.q.Xu Y.P.Zhang School of Materials and Energy Southwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing Southwest UniversityChongqing 400715China

The hybrid TiO_(2)/AgNPs/g-C_(3) N_(4) nanocomposite coatings were constructed on TC4 alloy by a hydrothermal and calcining ***_(2)/AgNPs/g-C_(3) N_(4) nanocomposite coatings demonstrated excellent biocompatibility and osteogenesis compared to those of titanium *** existence of trace AgNPs on the surface and interface of the heterojunction could further enhance the transfer and separation of photogenerated electron/hole pairs,which greatly improved the antibacterial performance under full spectrum *** at the valence band of TiO_(2) and g-C_(3) N_(4) reacted with adsorbed H_(2) O to generate·OH,killing bacteria through photocatalytic redox reaction under light irradiation,while released AgNPs exhibited bacteriostatic efficacy with or without *** study provides a pathway of coating modification for further improving the antibacterial properties of heterojunction coatings and maintaining the biocompatibility of matrix materials.

关键词： TiO_(2)/AgNPs/g-C_(3)N_(4)nanocomposite g-C_(3)N_(4) Photocatalysis Photocatalytic inactivation of bacteria Disinfection mechanism

IN SITU OBSERVATION OF GROWTH BEHAVIOR AND MORPHOLOGY OF DELTA-FERRITE AS FUNCTION OF SOLIDIFICATION RATE IN AN AISI304 STAINLESS STEEL

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Acta Metallurgica Sinica(English Letters) 2006年第6期19卷 441-448页

作者： G.F.Liang C.q.Wan J.C.Wu G.M.Zhu Y.Yu Y.fang Advanced Technology Institute Technology Center of BaosteelShanghai 201900China Department of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200030China

It was presented the in situ observation of growth behavior and morphology of delta-ferrite as a function of solidification rate in an AISI304 stainless steel. The specimens have been solidified and observed using confocal scanning laser microscopy (CSLM). The δ-phase always appears like cells on the sample surface when critical supercooling occurs, during which the L→δ transformation starts. The solid-liquid (S-L) interface is found to be finger shaped and has no faceted shape. γ phase appears among δ grains due to partitioning of Ni into the melt during solidification, when solidification rate is higher. The mergence of observed δ cells is possible for the steel sample cooled at 7.5℃/min. The formation of dendrites can be observed on the free surface of the steel sample cooled at 150℃/min. The size of solidified delta grains decreases from 120 to 20-80μm, and the volume fraction of solidified austenite increases with increase in solidification rate from 7.5 to 150℃/min. The relation between the tip radius of δ cell and its growth rate is deduced, and the results agree with the experimental values.

关键词： stainless steel confocal scanning laser microscopy δ-ferrite in situ observation solidification