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Comparative genomics of Helicobacter pylori

World Journal of Gastroenterology 2009年第32期15卷 3984-3991页

作者： quan-jiang dong qing wang ying-nin xin ni li shi-ying xuan Department of Gastroenterology Qingdao Municipal Hospital Qingdao 266071 Shandong Province China

Genomic sequences have been determined for a number of strains of Helicobacter pylori （H pylori） and related bacteria. With the development of microarray analysis and the wide use of subtractive hybridization techniques, comparative studies have been carried out with respect to the interstrain differences between H pylori and inter-species differences in the genome of related bacteria. It was found that the core genome of H pylori constitutes 1111 genes that are determinants of the species properties. A great pool of auxiliary genes are mainly from the categories of cag pathogenicity islands, outer membrane proteins, restriction-modification system and hypothetical proteins of unknown function. Persistence of H pylori in the human stomach leads to the diversification of the genome. Comparative genomics suggest that a host jump has occurs from humans to felines. Candidate genes specific for the development of the gastric diseases were identified. With the aid of proteomics, population genetics and other molecular methods, future comparative genomic studies would dramatically promote our understanding of the evolution, pathogenesis and microbiology of Hpylori.

关键词： Helicobacterpylori Genomics Pathogenesis Cancer

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Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition)

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World Journal of Pediatrics 2018年第5期14卷 437-447页

作者： xing-wang li xin ni Su-Yun Qian quan wang Rong-Meng jiang Wen-Bo Xu Yu-Cai Zhang Guang-Jun Yu Qiang Chen Yun-Xiao Shang Cheng-Song Zhao Hui Yu Ting Zhang Gang liu Hui-ling Deng Jie Gao Xian-Gui Ran Qiao-Zhi Yang Bian-li Xu Xue-Yong Huang xing-dong Wu Yi-Xiao Bao Yi-Ping Chen Zhi-Hai Chen qing-quan liu Guo-Ping Lu Chun-Feng liu Rong-Bing wang Guo-liang Zhang Fang Gu Hong-Mei Xu ying li Tao Yang Infectious Disease Diagnosis and Treatment Center Beijing Ditan Hospital Capital Medical UniversityBeijingChina Otorhinolaryngology Head andN eck Surgery Beijing Children’s HospitalCapital Medical UniversityBeijingChina Prediatric Intensive Care Unit Beijing Children’s Hospital of Capit al Medical UniversityBeijingChina National Institute For Viral Disease Control and Prevention Chinese Center for Disease Control and Pre ventionBeijingChina Children’s Hospital ofShanghai Jiaotong University ShanghaiChina Pneumology department Jiangxi Provincial Children’s HospitalNanchangChina Department of P ediatric Pneumology Shengjing Hospital of China Medical UniversityShenyangChina Department of Inf ectious Diseases Beijing Children’s HospitalCapital Medical UniversityBeijingChina Department of Inf ectious Diseases Children’s Hospital of Fudan UniversityShanghaiChina Digestive Department Children’s Hospital of Shanghai Jiaotong UniversityShanghaiChina Department of Inf ectious Diseases The Children’s Hospital of Xi'anXi’anChina Infection Control Offi ce Children’s Hospital ofShanghai Jiaotong UniversityShanghaiChina Department ofR espiratory Medicine People’s Hospital ofFuy ang CityFuyangChina Department of P ediatrics People’s Hospital of Liaoc heng CityLiaochengChina

Background Hand, foot, and mouth disease (HFMD) is a common infectious disease in childhood caused by an enterovirus (EV), and which is principally seen in children under 5 years of age. To promote diagnostic awareness and effective treat-ments, to further standardize and strengthen the clinical management and to reduce the mortality of HFMD, the guidelines for diagnosis and treatment have been developed. Methods National Health Commission of China assembled an expert committee for a revision of the guidelines. The com-mittee included 33 members who are specialized in diagnosis and treatment of HFMD. Results Early recognition of severe cases is utmost important in diagnosis and treatment of patients with HFMD. The key to diagnosis and treatment of severe cases lies in the timely and accurate recognition of stages 2 and 3 of HFMD, in order to stop progression to stage 4. Clinicians should particularly pay attention to those EV-A71 cases in children aged less than 3 years, and those with disease duration less than 3 days. The following indicators should alert the clinician of possible deterioration and impending critical disease: (1) persistent hyperthermia;(2) involvement of nervous system;(3) worsening respiratory rate and rhythm;(4) circulatory dysfunction;(5) elevated peripheral WBC count;(6) elevated blood glucose and (7) elevated blood lactic acid. For treatment, most mild cases can be treated as outpatients. Patients should be isolated to avoid cross-infection. Intense treatment modalities should be given for those severe cases. Conclusion The guidelines can provide systematic guidance on the diagnosis and management of HFMD.

关键词： Diagnosis Guidelines HFMD Treatment

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong shi Xiang-Qun Cui Yao-quan Chu Guo-Ping li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-xin Chen li Chen Xue-Lei Chen Xiao-Yan Chen ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao dong Bing Du dong-Wei Fan Lei Feng Jian-ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu ning-Sheng Hu Zhong-Wen Hu Zhi-ying Huo Lei Jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-Wei li Hai-ning li Jian li Qi li Shuang li Sha-Sha li xin-Nan li Yan li Yin-Bi li Ye-Ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun ni Zhao-Xiang Qi Yong-Jun Qi shi-Yin Shen Huo-Ming shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-ning wang Jian-ling wang Jian-Ping wang Jun-Xian wang Lei wang Meng-xin wang Shou-Guan wang Shu-qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng xing ling-Zhe Xu xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014–2015

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Infectious Diseases of Poverty 2016年第1期5卷 670-679页

作者： Zhong-Jie li Wen-Xiao Tu Xiao-Chun wang Guo-qing shi Zun-dong Yin Hai-Jun Su Tao Shen Da-Peng Zhang Jian-dong li Shan Lv Chun-li Cao Rui-Qian Xie Hong-Zhou Lu Rong-Meng jiang Zheng Cao Zhi-Jie An Lei-Lei li Jie Xu Yan-Wen Xiong Wei Zang Wei Zhang Hong-Wei Zhang Wen-Sen Chen Hua ling Wen Xu Jian Cai Huan-Jin Luo Xue-Sheng xing Can-Jun Zheng Qiang Wei xin-Xu li Mei li Hai jiang li-quan Deng Ming-quan Chen Xiang Huo Feng Xu Xue-Hui Lai Xi-Chen Bai Long-Jie Ye Jian-Yi Yao Wen-Wu Yin Jiao-Jin Sun lin Xiao Fu-Qiang liu Xiao-Qiang liu Hong-Wei Fan Zeng-Qiang Kou Ji-Kun Zhou Hao Zhang Da-xin ni Thomas TSamba Qun li Hong-Jie Yu Yu wang Xiao-Feng liang Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijingChina Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Bureau of Disease Prevention and Control National Health and Family Planning Commission of the People’s Republic of ChinaBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionShanghaiChina Chinese Center for Health Education BeijingChina Department of Infectious Diseases Shanghai Public Health Clinical CenterShanghaiChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Health News BeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Training Chinese Center for Health EducationBeijingChina Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijingChina Infection Management The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Chongqing Municipal Center for Disease Control and Prevention ChongqingChina Yunnan Provincial Center for Disease Control and Prevention KunmingChina Division of Infectious Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhouChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouChina Division of Acute Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and PreventionW

Background:The Ebola virus disease spread rapidly in West Africa in 2014,leading to the loss of thousands of *** engagement was one of the key strategies to interrupt Ebola transmission,and practical community level measures needed to be explored in the field and tailored to the specific context of ***:First,community-level education on Ebola virus disease(EVD)prevention was launched for the community’s social mobilizers in six districts in Sierra Leone beginning in November ***,from January to May of 2015,in three pilot communities,local trained community members were organized to engage in implementation of EVD prevention and transmission interruption measures,by involving them in alert case report,contact tracing,and social *** epidemiological indicators of transmission interruption in three study communities were ***:A total of 6016 community social mobilizers from 185 wards were trained by holding 279 workshops in the six districts,and EVD message reached an estimated 631680 *** three pilot communities,72 EVD alert cases were reported,with 70.8%of them detected by trained local community members,and 14 EVD cases were finally *** tracing detected 64.3%of EVD *** median duration of community infectivity for the cases was 1 *** secondary attack rate was 4.2%,and no third generation of infection was *** health worker was infected,and no unsafe burial and noncompliance to EVD control measures were *** community-based measures were modeled to reduce 77 EVD cases,and the EVD-free goal was achieved four months earlier in study communities than whole country of Sierra ***: The community-based strategy of social mobilization and community engagement was effective in casedetection and reducing the extent of Ebola transmission in a country with weak health system. The successfullypractical experience to reduce the risk of Ebola transmission in the

关键词： Ebola virus disease Community engagement Health education Outbreak control

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甲型H1N1患者循环血白细胞VCS参数分析

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军医进修学院学报 2010年第10期31卷 995-996页

作者：李安全周珊李庆勇高德禄蒋知新王飞清祝丙华龙炫辉解放军305医院检验科北京100017 绍兴文理学院浙江绍兴312000

目的探讨VCS(Volume Conductivity Scatter)参数在甲型H1N1患者白细胞中的变化及其辅助诊断价值。方法用Beckman Coulter LH750型全自动血液分析仪,分别测定基因扩增法确诊甲型H1N1患者(实验组)和健康人群(对照组)白细胞VCS的参数。结... 详细信息

目的探讨VCS(Volume Conductivity Scatter)参数在甲型H1N1患者白细胞中的变化及其辅助诊断价值。方法用Beckman Coulter LH750型全自动血液分析仪,分别测定基因扩增法确诊甲型H1N1患者(实验组)和健康人群(对照组)白细胞VCS的参数。结果甲型H1N1患者VCS参数MMV(171.615±9.156)明显高于对照组(157.157±10.026)(P<0.001);MLS(62.003±6.916)比对照组(54.263±3.817)明显增加(P<0.001);MNS(114.946±1.603)较正常对照组(154.263±3.817)明显减低(P<0.001)。结论甲型H1N1患者白细胞VCS参数改变不同于健康人群,对早期诊断有一定参考价值。

关键词：流感人流感病毒A型 H1N1亚型

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