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The Mitochondrion:A Potential Therapeutic Target for Alzheimer's Disease

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Neuroscience Bulletin 2018年第6期34卷 1127-1130页

作者： Mei-hong Lu Xiu-Yun Zhao Pei-Pei Yao De-En Xu quan-hong ma Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversitySuzhou 215123China Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Wuxi No.2People's Hospital Wuxi 214002China

Introduction The mitochondrion is a double-membrane organelle consisting of an outer membrane, intermembrane space, inner membrane, cristae, and matrix. It is the ‘‘energy plant’’ that provides most of the energy ... 详细信息

关键词： AD A Potential Therapeutic Target for Alzheimer’s Disease

Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases

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Neural Regeneration Research 2017年第9期12卷 1551-1558页

作者： Yan Zou Wei-feng Zhang Hai-ying Liu Xia Li Xing Zhang Xiao-fang ma Yang Sun Shi-yi Jiang quan-hong ma De-en Xu Department of Neurology The Second People's Hospital of Wuxi

The contactin-associated protein （Caspr） family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family- CNTNAP1 （Casprl）, CNTNAP2 （Caspr2）, CNTNAP3 （Caspr3）, CNTNAP4 （Caspr4） and CNTNAP5 （Caspr5）, Casprl-5 is not only involved in the formation of myelinated axons, but also participates in maintaining the stability of adjacent connections. Casprl participates in the formation, differentiation, and proliferation of neurons and astrocytes, and in motor control and cognitive function. We also analyzed the relationship between the Caspr family and neurodegenerative diseases, multiple sclerosis, and autoimmune encephalitis. However, the effects of Caspr on disease course and prognosis remain poorly understood. The effects of Caspr on disease diagnosis and treatment need further investigation.

关键词： nerve regeneration contactin-associated protein family myelinated axon structure function Alzheimer's disease multiple sclerosis autism spectrum disorders neurodegeneration neural regeneration

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朗飞结处神经突起生长抑制因子(英文)

神经疾病与精神卫生 2008年第1期8卷 5-16,F0003页

作者： Du-Yu Nie Qi-Dong Hu quan-hong ma Melitta Schachner Zhi-Cheng Xiao Institute of Molecular and Cell Biology Singapore Sino- Germany Center for Neuroscience Dalian Medical University Dalian China Zentrum fur Molekulare Neurobiologie University of Hamburg Hamburg Germany Department of Clinical Research Singapore General Hospital Singapore

朗飞结以及结侧区是有鞘轴突上的一些极化区域,越来越多的证据表明胶质细胞分泌的某些抑制中枢神经系统损伤后轴突再生过程中神经突起生长的分子如粘蛋白(tenascins)、硫酸软骨素蛋白聚糖(chondroitin sulphate pro-teoglycans)、髓鞘... 详细信息

朗飞结以及结侧区是有鞘轴突上的一些极化区域,越来越多的证据表明胶质细胞分泌的某些抑制中枢神经系统损伤后轴突再生过程中神经突起生长的分子如粘蛋白(tenascins)、硫酸软骨素蛋白聚糖(chondroitin sulphate pro-teoglycans)、髓鞘相关糖蛋白(myelin-associated glycopro-tein,maG)、轴突生长抑制因子(Nogo)以及少突胶质细胞髓鞘糖蛋白(OMGP)等非常特异性的富集于朗飞结区域。这些分子在体外组织培养过程中显示出强烈的神经突起生长抑制作用。在一些基因无义突变的动物模型,能够观察到朗飞结处轴突的生长,表明这些抑制分子能够生理性地保持轴突的完整性并且阻止轴突间随机和错误的联结,然而,大部分的基因无义突变动物模型显示不出明显的中枢神经系统再生改善。这些被称为抑制因子的分子是否是神经再生失败的真正元凶这些抑制因子体内体外实验结果的不一致以及它们特异的定位分布让我们有理由对它们在其他生理作用和功能方面进行重新评价。考虑到轴突-胶质细胞相互作用的双向特性,本综述认为这些抑制因子不仅通过神经元上的受体信号通路调节轴突的极化、离子通道的功能以及轴突的分枝,另一方面轴突产生的化学分子也能反馈性的通过朗飞结区域寡突胶质细胞上的胶质细胞受体信号通路影响寡突胶质细胞的发育。

关键词：朗飞结神经突起生长抑制分子中枢神经系统再生

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui hong Wei quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun hong Guo School of materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie quan Hao Liang Yong-hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Microstructure evolution and thermal physical properties of CuCr alloy after high pressure treatment

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Rare Metals 2014年第3期33卷 293-298页

作者： Yu-quan ma hong-ju Lin Dong-dong SongMechanical and Electrical Engineering College Hebei Normal University of Science and Technology

The thermal diffusion coefficient, thermal conductivity, and thermal expansion coefficient of CuCr alloy prepared by infiltration were measured by thermal constant tester and dilatometer before and after high pressure heat treatment, at the same time, the effect of high pressure treatment on the thermal physical properties of CuCr alloy was discussed by the analysis of its microstructure. The experimental results show that high pressure heat treatment can increase the thermal diffusion coefficient and thermal conductivity of CuCr alloy, but it changes slightly in the pressure range of 1-6 GPa. As for thermal expansion coefficient, when the temperature is higher than 130 °C, it is obviously higher than that of the alloy without high pressure treatment after 1 GPa pressure treatment, and the higher the temperature is, the larger their differences are.

关键词： CuCr alloy High pressure treatment Thermaldiffusion coefficient Thermal conductivity Thermalexpansion coefficient

Effects of Ta on the solidification behavior and microstructure of a rhenium-containing hot corrosion resistant single crystal

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International Journal of Minerals,Metallurgy and materials 2019年第7期26卷 901-907页

作者： Shi-hua ma hong-quan Hao Dong Wang Lang-hong Lou Jian Zhang Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China School of materials Science and Engineering University of Science and Technology of China Shenyang 110016 China National Natural Science Foundation of China Beijing 100085 China

The effects of Ta on the solidification microstructure of the Re-containing hot corrosion resistant Ni-base single crystal were investigated. Results showed that Ta addition significantly modified the solidification behavior and further influenced the as-cast microstructure. Ta addition changed the solidification characteristic temperatures and decreased the segregation of refractory elements (Re and W) as well as increased the solidification temperature range from 39.0 to 61.8℃ as Ta addition increased from 2wt% to 8wt%. The integration of these two factors increased the primary dendrite arm spacing and changed the morphology and size of γ′ precipitates. With increasing Ta addition from 2wt% to 8wt%, the size of γ′ precipitates in the dendrite core increased substantially from 0.24 to 0.40 μm, whereas the γ′ precipitates in the interdendritic region decreased slightly from 0.56 to 0.47 μm. This paper then discussed the mechanism of these “Ta effects”.

关键词： superalloys tantalum solidification behavior microstructure

Cooling the Earth:a polymer-based selective thermal emitter for all-day radiative cooling

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Science China Chemistry 2021年第3期64卷 339-340页

作者： quan-hong Yang Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityTianjin UniversityFuzhou 350207China

From fundamental thermodynamics considerations, cooling is more challenging than heating in reducing the energy consumption and relieving the greenhouse effect. While most of the currently used cooling methods require energy and resources to carry heat away, radiative cooling has attracted much attention since it can dissipate heat to outer atmosphere through a transparency window without any energy consumption [1,2].

关键词： Earth transparency thermodynamics