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Controlling segregation and hardenability of gear steel based on as-cast structure

Journal of Iron and Steel Research International 2025年第1期32卷 144-158页

作者： Hai-jie Wang Ze Zhang Peng Lan Gang Chen Pu Wang Chuan-hui Jiang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Weifang Iron and Steel Group Co. Ltd.Weifang 261000ShandongChina

Hardenability significantly impacts the distortion of gear during heat treatment,correlated to the uniformity of solute distribution in steel *** experimental analysis was conducted on the macrostructure,solute distribution,dendrite structure,and rod hardenability of 20CrMnTiH gear steel in continuously cast blooms and hot roller *** evaluation approach by the standards for the hardenability of gear steel rods and the corresponding blooms was analyzed,and the inheritance mechanism from solidification segregation to hardenability fluctuation of gear steel was *** results indicate that semi-macroscopic spot segregation located in the equiaxed zone exhibits larger size,higher solute enrichment,and worse solute homogeneity,leading to significant solute fluctuations in the blooms and hardenability fluctuation in the *** increasing the liquid steel superheat from 35 to 40℃,reducing the mold electromagnetic stirring from 300 to 100 A,and implementing the soft reduction(SR)of 7 mm at the solidification end,the equiaxed ratio of the strand decreased from 26.42%to 6.69%.Consequently,the solute fluctuation range and standard deviation decrease significantly in the transverse section,while the maximum segregation ratio,average fluctuation range,and average standard deviation of solutes C,Cr,and Mn in the spot segregation decrease at the same *** the meanwhile,the equiaxed ratio of the rod decreased from 24.89%to 4.09%,and the structure of the hardenability detection zone was transformed from equiaxed crystals to columnar ***,the solute fluctuation range and standard deviation in the transverse section decreased,while the homogeneity in spot segregation was also *** hardness difference of A and B surfaces at J9 and J15 positions was smaller than 2 HRC,meeting the qualification standard for hardenability.

关键词： Gear steel Continuous casting Solute distribution Dendritic structure Hardenability

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu hui Hong Wei quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu Xiao-Fen Yu Guo-Qiang Li Ming-Hao Qu Huan Wang Chuang Liu Yu-Ping Man Xiao-Han Jiang Mu-Zi Li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng Zhao Yun-Qiu Zhou Zheng-Wang Jiang Zuo-Zhou Li Shang Zheng Chang Dong Bai-Lin Wang Yan-Xiang Sun hui-Qin Zhang Jie-Wei Li quan-hui mo Ying Zhang Xin Lou Hai-Xu Peng Ya-Ting Yi He-Xin Wang Xiu-Jun Zhang Yi-Bo Wang Dan Wang Li Li Qiong Zhang Wen-Xia Wang Yongbo Liu Lei Gao Jin-Hu Wu Yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of Life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： quan Shi Yun-Hao Xu Ming-hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-moFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-moFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-moFs.2D RE-moFs (RE-DBP) and 3D RE-moFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-moFs were further synthesized to verify the universality of the *** crystalline RE-moFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-moFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) moFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D moF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-moFs,but also proposes a promising approach for the potential bulk production of RE-moFs at room temperature.

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Improved particle tracking velocimetry based on level set segmentation for measuring the velocity field of granular flow

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CHINESE PHYSICS B 2025年第2期34卷 262-272页

作者： Guo, Jing-Yi Chen, quan Li, Ran Sun, Ge Mu, Tong-Tong Yang, hui Univ Shanghai Sci & Technol Sch Opt Elect & Engn Shanghai 200093 Peoples R China Shanghai Univ Med & Hlth Sci Sch Med Instruments Shanghai 201318 Peoples R China

Using traditional particle tracking velocimetry based on optical flow for measuring areas with large velocity gradient changes may cause oversmoothing, resulting in significant measurement errors. To address this problem, the traditional particle tracking velocimetry method based on an optical flow was improved. The level set segmentation algorithm was used to obtain the boundary contour of the region with large velocity gradient changes, and the non-uniform flow field was divided into regions according to the boundary contour to obtain sub-regions with uniform velocity distribution. The particle tracking velocimetry method based on optical flow was used to measure the granular flow velocity in each sub-region, thus avoiding the problem of granular flow distribution. The simulation results show that the measurement accuracy of this method is approximately 10% higher than that of traditional methods. The method was applied to a velocity measurement experiment on dense granular flow in silos, and the velocity distribution of the granular flow was obtained, verifying the practicality of the method in granular flow fields.

关键词： granular flow particle tracking velocimetry optical flow method speed level set segmentation 42.30.-d 47.11.-j 47.57.Gc

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Influence of heat treatment on microstructure of a newβ-solidifyingγ-TiAl alloy

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Journal of Iron and Steel Research International 2025年第1期32卷 239-248页

作者： Li quan Xiao-bing Li Peng Xue Jun-jie Hao Kun Qian Bo Chen Jian-zhong Li Kui Liu School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Department of Materials Science and Technology Ji Hua LaboratoryFoshan528200GuangdongChina

The high strength and stability of the full-lamellar structure guarantee the industrial application of theβ-solidifyingγ-TiAl ***,it is a huge challenge to design an alloy with good hot-deformability as well as the full-lamellar *** low-cost Ti-42.5Al-2Mn-0.4mo-0.1B-0.1C(at.%)alloy was designed,which undergoes bothβandαsingle-phase region during the *** is found that the full-lamellar structure can be obtained by the solution heat treatment at 1230℃ for 20 min and then aging treatment at 800℃ for 3 ***,a new microstructure,namely,the pearlitic-like microstructure(PM)induced by theα_(2)/γ→βo+γcellular reaction was observed when the aging temperature is increased to above 800℃.The volume fraction of the PM is gradually increased from 0%to 25.5%,65%,and 94%according to elevated aging temperature from 800 to 900,1000,and 1050℃,*** mechanism of the reducedα_(2)/γlamellae and PM formation was discussed regarding the heterogeneous distribution ofβstabilizing elements and the interface energy stored inα_(2)/γlamellae.

关键词： β-γ-TiAl Alloy design Two-step heat treatment Full-lamellar structure Cellular reaction

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Systematic review and critical appraisal of predictive models for diabetic peripheral neuropathy:Existing challenges and proposed enhancements

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World Journal of Diabetes 2025年第4期16卷 270-283页

作者： Chao-Fan Sun Yu-Han Lin Guo-Xing Ling hui-Juan Gao Xing-Zhong Feng Chun-quan Sun Department of Endocrinology Tsinghua University Yuquan HospitalBeijing 100040China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Office of Drug Clinical Trial Institution Health Management Center(Preventive Treatment of Disease)Tsinghua University Yuquan HospitalBeijing 100040China

BACKGROUND The trend of risk prediction models for diabetic peripheral neuropathy(DPN)is increasing,but few studies focus on the quality of the model and its practical *** To conduct a comprehensive systematic review and rigorous evaluation of prediction models for *** A meticulous search was conducted in PubMed,EMBASE,Cochrane,CNKI,Wang Fang DATA,and VIP Database to identify studies published until October *** included and excluded criteria were applied by the researchers to screen the *** investigators independently extracted data and assessed the quality using a data extraction form and a bias risk assessment *** were resolved through consultation with a third *** from the included studies were extracted utilizing the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction modelling ***,the bias risk and applicability of the models were evaluated by the Prediction model Risk of Bias Assessment *** The systematic review included 14 studies with a total of 26 *** area under the receiver operating characteristic curve of the 26 models was *** studies had high risks of bias,mainly due to participants,outcomes,and *** most common predictors included glycated hemoglobin,age,duration of diabetes,lipid abnormalities,and fasting blood *** The predictor model presented good differentiation,calibration,but there were significant methodological flaws and high risk of *** studies should focus on improving the study design and study report,updating the model and verifying its adaptability and feasibility in clinical practice.

关键词： Diabetic peripheral neuropathy Predictive models Systematic review Risk factors Prognostic risk

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Positive effect of mo on mechanical properties of a Ni-42W-10Co-xmo medium heavy alloy

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China Foundry 2025年第1期22卷 108-116页

作者： Guo-xin Cao Jian-xin Dong Yong-sheng He He Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi'an Superalloy Technology Co. Ltd.Xi’an 710299China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina

In this study,a novel Ni-W-Co-mo medium heavy alloy(MHA)was designed to improve its mechanical strength via mo *** the Ni-42W-10Co-x mo alloy series,where x represents the weight percent of mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypo-eutectic structure as the mo content increases from 0 to 5wt.%.moreover,as the mo content increases from 0 to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-x mo alloys is mo-induced solid solution strengthening and precipitation strengthening.

关键词： medium-heavy alloys Ni-based alloy mechanical properties solid solution strengthening precipitation strengthening

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Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability

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Science China Life Sciences 2025年

作者： Wei Wang Meng-Ying Li Qing-hui Wen Yue Ma Zhi-Ming Zhang Muhammad Maqsood Ur Rehman Fei mo Hong-Yan Tao Bao-Luo Ma Joann K.Whalen You-Cai Xiong State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems College of Ecology Lanzhou University School of Ecology and Environmental Science Yunnan University College of Agronomy Northwest A&F University Ottawa Research and Development Centre Agriculture and Agri-Food Canada Department of Natural Resource Sciences McGill University

Increasing carbon（C） sequestration and stability in agricultural soils is a key strategy to mitigate climate change towards C neutrality. Crop diversification is an initiative to increase C sequestration in fields, but it is unclear how legume-based crop diversification impacts the functional components of soil organic carbon（SOC） in dryland, including the formation and transformation of particulate organic carbon（POC） and mineral-associated organic carbon（MAOC）. We investigated the decomposition of straw residues, the fate of photosynthesized C,as well as the formation of MAOC and POC fractions using an in situ13C labeling technique in the soybean-wheat intercropping, soybeanmaize intercropping and their respective monocropping systems, with and without cover crops. After 4-year treatments, the total SOC content in bulk soil remained unchanged, while MAOC content increased significantly by 5.6% with intercropping. moreover, the in situ13C labeling results confirmed that more photosynthesized C was transferred to MAOC, and less was retained in the POC fraction. Intercropping significantly increased total soil N and mineral N content by 15.3% and 13.4%, respectively, and decreased soil and microbial C/N ratio by11.3% and 17.4%, respectively. This outcome, therefore, relieved microbial N limitation and accelerated straw residue ***, the potential of MAOC formation was strengthened for better SOC persistence. Our study suggests that legume-based crop diversification can effectively enrich N and support POC transformation to MAOC, accordingly contributing to the persistent SOC pool and thus potentially achieving C neutrality under climate change in dryland agroecosystems.

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