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Controlling secondary flow in high-lift low-pressure turbine using boundary-layer slot suction

Chinese Journal of Aeronautics 2024年第3期37卷 21-33页

作者： Xiao qu Liunan LI Yingjie ZHANG Xingen LU Junqiang ZHU Yanfeng ZHANG School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing 100190China

The design of high-lift Low-Pressure Turbines(LPTs)causes the separation of the boundary layer on the suction side of the blade and leads to a strong secondary *** present study aims to minimize secondary losses through endwall slot suction and incoming wakes in a front-loaded high-lift LPT cascade with Zweifel of 1.58 under low Reynolds number of *** slotted schemes for the boundary layer of the endwall were designed(Plan A and Plan B),and the effects of suction mass flow on secondary flow were *** underlying physics of the endwall boundary layer of the suction and secondary flow under unsteady wakes was *** results show that slot suction at the endwall boundary layer can significantly suppress the secondary flow by removing low-momentum *** A and B significantly reduced the secondary kinetic energy by 44.2%and 36.9%,respectively,compared with the baseline cascade at the suction mass flow ratios of 1%.With an increase in the mass flow ratio of suction,the secondary flow was gradually reduced in both Plans A and *** is more beneficial to control the secondary flow to destroy the intersection of the pressure side and suction side of the horseshoe vortex before it develops into a passage *** unsteady wakes,the combined effects of incoming wakes and endwall boundary layer suction can further suppress the secondary flow at the suction mass flow ratios of 2%for Plan A,because the positive and negative vorticity inside upstream wakes accelerated the mixing of the main flow and secondary flow and thus increased the energy of secondary vortices.

关键词： Low-pressure turbine Secondary flow Flow control Boundary-layer suction Incoming wake

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An Effective Meshless Approach for Inverse Cauchy Problems in 2D and 3D Electroelastic Piezoelectric Structures

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2955-2972页

作者： Ziqiang Bai Wenzhen qu Guanghua Wu School of Automation Qingdao UniversityQingdao266071China School of Mathematics and Statistics Qingdao UniversityQingdao266071China Weifang University of Science and Technology Weifang262700China

In the past decade,notable progress has been achieved in the development of the generalized finite difference method(GFDM).The underlying principle of GFDM involves dividing the domain into multiple *** each sub-domain,explicit formulas for the necessary partial derivatives of the partial differential equations(PDEs)can be obtained through the application of Taylor series expansion and moving-least square approximation ***,the method generates a sparse coefficient matrix,exhibiting a banded structure,making it highly advantageous for large-scale engineering *** this study,we present the application of the GFDM to numerically solve inverse Cauchy problems in two-and three-dimensional piezoelectric *** our preliminary numerical experiments,we demonstrate that the proposed GFDMapproach shows great promise for accurately simulating coupled electroelastic equations in inverse problems,even with 3%errors added to the input data.

关键词： Generalized finite difference method meshless method inverse Cauchy problems piezoelectric problems electroelastic analysis

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Determining Sets and Determining Numbers of Finite Groups

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Algebra Colloquium 2024年第1期31卷 111-128页

作者： Dengyin Wang Chi Zhang Haipeng qu School of Mathematics China University of Mining and Technology XuzhouJiangsu 221116China School of Mathematics and Computer Science Shanxi Normal University LinfenShanxi 041000China

A subset D of a group G is a determining set of G if every automorphism of G is uniquely determined by its action on D,and the determining number of G,a(G),is the cardinality of a smallest determining set.A group G is called a DEG-group if α(G)equals(G),the generating number of *** main results are as *** groups with determining number 0 or 1 are classified;finite simple groups and finite nilpotent groups are proved to be DEG-groups;for a given finite group H,there is a DEG-group G such that H is isomorphic to a normal subgroup of G and there is an injective mapping from the set of all finite groups to the set of finite DEG-groups;for any integer k≥2,there exists a group G such that α(G)=2 and(G)≥k.

关键词： determining number automorphisms nilpotent groups

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Leveraging diverse cell-death patterns to predict the clinical outcome of immune checkpoint therapy in lung adenocarcinoma:Based on muti-omics analysis and vitro assay

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Oncology Research 2024年第2期32卷 393-407页

作者： HONGYUAN LIANG YANQIU LI YONGGANG qu LINGYUN ZHANG Department of Radiology Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Clinical Medicine China Medical UniversityShenyangChina Department of Medical Oncology The First Hospital of China Medical UniversityShenyangChina

Advanced LUAD shows limited response to treatment including immune *** the development of sequencing omics,it is urgent to combine high-throughput multi-omics data to identify new immune checkpoint therapeutic response *** GSE72094(n=386)and GSE31210(n=226)gene expression profile data in the GEO database,we identified genes associated with lung adenocarcinoma(LUAD)death using tools such as“edgeR”and“maftools”and visualized the characteristics of these genes using the“circlize”R *** constructed a prognostic model based on death-related genes and optimized the model using LASSO-Cox regression *** calculating the cell death index(CDI)of each individual,we divided LUAD patients into high and low CDI groups and examined the relationship between CDI and overall survival time by principal component analysis(PCA)and Kaplan-Meier *** also used the“ConsensusClusterPlus”tool for unsupervised clustering of LUAD subtypes based on model *** addition,we collected data on the expression of immunomodulatory genes and model genes for each cohort and performed tumor microenvironment *** also used the TIDE algorithm to predict immunotherapy responses in the CDI ***,we studied the effect of PRKCD on the proliferation and migration of LUAD cells through cell culture *** study utilized the TCGA-LUAD cohort(n=493)and identified 2,901 genes that are differentially expressed in patients with *** KEGG and GO enrichment analysis,these genes were found to be involved in a wide range of biological *** study also used univariate Cox regression models and LASSO regression analyses to identify 17 candidate genes that were best associated with mortality prognostic risk *** comparing the overall survival(OS)outcomes of patients with different CDI values,it was found that increased CDI levels were significantly associated with lower OS *** addition,the study used unsupervised cluster analysis to d

关键词： Lung adenocarcinoma Programmed cell death Iron-death Drug sensitivity Cancer therapy

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Numerical Study on the Aerodynamic and Fluid−Structure Interaction of An NREL-5MW Wind Turbine

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China Ocean Engineering 2024年第3期38卷 363-378页

作者： ZHAO Mi YU Wan-li WANG Pi-guang qu Yang DU Xiu-li Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China

A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic *** this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.

关键词： computational fluid dynamics methods(CFD) tower shadow effect aerodynamic performance fluidstructure interaction space flow field

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Doubled haploid technology and synthetic apomixis:Recent advances and applications in future crop breeding

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Molecular Plant 2024年第7期17卷 1005-1018页

作者： Yanzhi qu Alisdair R.Fernie Jie Liu Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Department of Molecular Physiology Max-Planck-Institute of Molecular Plant Physiology14476 Potsdam-GolmGermany Center of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria azhouwan National Laboratory Sanya 572024China

Doubled haploid(DH)technology and synthetic apomixis approaches can considerably shorten breeding cycles and enhance breeding *** with traditional breeding methods,DH technology offers the advantage of rapidly generating inbred lines,while synthetic apomixis can effectively fix hybrid *** this review,we focus on(i)recent advances in identifying and characterizing genes responsible for haploid induction(Hl),(ii)the molecular mechanisms of Hl,(ili)spontaneous haploid genome doubling,and(iv)crop synthetic *** also discuss the challenges and potential solutions for future crop breeding programs utilizing DH technology and synthetic ***,we provide our perspectives about how to integrate DH and synthetic apomixis for precision breeding and de novo domestication.

关键词： maize doubled haploid technology haploid induction synthetic apomixis precision breeding

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Network Configuration Entity Extraction Method Based on Transformer with Multi-Head Attention Mechanism

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Computers, Materials & Continua 2024年第1期78卷 735-757页

作者： Yang Yang Zhenying qu Zefan Yan Zhipeng Gao Ti Wang State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Product Development Department China Unicom Smart City Research InstituteBeijing100044China

Nowadays,ensuring thequality of networkserviceshas become increasingly *** are turning toknowledge graph technology,with a significant emphasis on entity extraction in the identification of device *** research paper presents a novel entity extraction method that leverages a combination of active learning and attention ***,an improved active learning approach is employed to select the most valuable unlabeled samples,which are subsequently submitted for expert *** approach successfully addresses the problems of isolated points and sample redundancy within the network configuration sample *** the labeled samples are utilized to train the model for network configuration entity ***,the multi-head self-attention of the transformer model is enhanced by introducing the Adaptive Weighting method based on the Laplace mixture *** enhancement enables the transformer model to dynamically adapt its focus to words in various positions,displaying exceptional adaptability to abnormal data and further elevating the accuracy of the proposed *** comparisons with Random Sampling(RANDOM),Maximum Normalized Log-Probability(MNLP),Least Confidence(LC),Token Entrop(TE),and Entropy query by Bagging(EQB),the proposed method,Entropy query by Bagging and Maximum Influence Active Learning(EQBMIAL),achieves comparable performance with only 40% of the samples on both datasets,while other algorithms require 50% of the ***,the entity extraction algorithm with the Adaptive Weighted Multi-head Attention mechanism(AW-MHA)is compared with BILSTM-CRF,Mutil_Attention-Bilstm-Crf,Deep_Neural_Model_NER and BERT_Transformer,achieving precision rates of 75.98% and 98.32% on the two datasets,*** tests demonstrate the statistical significance and effectiveness of the proposed algorithms in this paper.

关键词： Entity extraction network configuration knowledge graph active learning transformer

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Privacy-Preserving Federated Deep Learning Diagnostic Method for Multi-Stage Diseases

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3085-3099页

作者： Jinbo Yang Hai Huang Lailai Yin Jiaxing qu Wanjuan Xie School of Computer Science and Technology Harbin University of Science and TechnologyHarbin150080China Shanghai Futures Information Technology Co. Ltd.Shanghai201201China Heilongjiang Province Cyberspace Research Center Harbin150001China Information Network Engineering and Research Center South China University of TechnologyGuangzhou510641China

Diagnosing multi-stage diseases typically requires doctors to consider multiple data sources,including clinical symptoms,physical signs,biochemical test results,imaging findings,pathological examination data,and even genetic *** applying machine learning modeling to predict and diagnose multi-stage diseases,several challenges need to be ***,the model needs to handle multimodal data,as the data used by doctors for diagnosis includes image data,natural language data,and structured ***,privacy of patients’data needs to be protected,as these data contain the most sensitive and private ***,considering the practicality of the model,the computational requirements should not be too *** address these challenges,this paper proposes a privacy-preserving federated deep learning diagnostic method for multi-stage *** method improves the forward and backward propagation processes of deep neural network modeling algorithms and introduces a homomorphic encryption step to design a federated modeling algorithm without the need for an *** also utilizes dedicated integrated circuits to implement the hardware Paillier algorithm,providing accelerated support for homomorphic encryption in ***,this paper designs and conducts experiments to evaluate the proposed *** experimental results show that in privacy-preserving federated deep learning diagnostic modeling,the method in this paper achieves the same modeling performance as ordinary modeling without privacy protection,and has higher modeling speed compared to similar algorithms.

关键词： Vertical federation homomorphic encryption deep neural network intelligent diagnosis machine learning and big data

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A gold-based multiplex immunochromatographic sensor for detecting paclitaxel

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Nano Research 2024年第7期17卷 6420-6429页

作者： Xiaoqian Jiang Aihua qu Xinxin Xu Hua Kuang Liqiang Liu Chuanlai Xu State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

Paclitaxel(PTX),methotrexate(MTX),and 5-fluorouracil(5-FU)are commonly-used small molecule anti-tumor drugs for breast ***,drug resistance occurs with long-term treatment or excessive use,and the high concentrations of PTX,MTX,and 5-FU in patients may lead to side effects with dose-limiting toxicities,such as myelosuppression,hepatotoxicity,and peripheral ***,concentration monitoring of PTX,MTX,and 5-FU in clinical treatment is very *** prepared highly sensitive and specific monoclonal antibodies using several haptens,and established a multiple paper-based sensor utilizing optical signals of gold nanoparticles,which simultaneously detected PTX,MTX,and 5-FU in human plasma or urine with 10 min.A portable scanner for quantitative detection in plasma and urine samples was used,and the calculated limit of detection(cLOD)values were 0.002 and 0.142μg/mL for PTX,0.187 and 0.976 ng/mL for MTX,and 0.057 and 0.128μg/mL for 5-FU,*** the recovery test,the recovery rates and the coefficient of variation were 85.84%–108.81%and 1.23%–8.80%,respectively,indicating the reliability and accuracy of the multiple gold immunochromatographic strip(GIS).In addition,for the determination of collected clinical plasma samples,the correlation between the test data of the multiple GIS and liquid chromatography–tandem mass spectrometry(LC–MS/MS)was ***,the developed multiple GIS could be applied to the rapid detection of PTX,MTX,and 5-FU in different clinical samples.

关键词： paclitaxel methotrexate 5-fluorouracil immunochromatographic assay plasma urine

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Analytical Solution and Simplified Formula for Added Mass of Horizontal and Vertical Motions of Truncated Cylinders Under Earthquake Action

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China Ocean Engineering 2024年第1期38卷 54-67页

作者： WANG Pi-guang LYU Si-yu qu Yang ZHAO Mi DU Xiu-li State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of Tech-nologyBeijing 100124China

This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water *** governing equation of the hydrodynamic pressure acting on the cylinder is derived based on the radiation theory with the inviscid and incompressible *** governing equation is solved by using the method of separating variables and analytical solutions are obtained by assigning reasonable boundary *** analytical result is validated by a numerical model using the exact artificial boundary simulation of the infinite *** main variation and distribution characteristics of the hydrodynamic pressure acting on the side and bottom of the cylinder are analyzed for different combinations of wide-height and immersion *** added mass coefficient of the cylinder is calculated by integrating the hydrodynamic pressure and simplified formulas are proposed for engineering *** calculation results show that the simplified formulas are in good agreement with the analytical solutions.

关键词： earthquake hydrodynamic pressure truncated cylinder added mass simplified formula

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