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GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： qiwei jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

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The potent roles of salt-inducible kinases(SIKs)in metabolic homeostasis and tumorigenesis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1141-1155页

作者： Zicheng Sun qiwei jiang Jie Li Jianping Guo Institute of Precision Medicine the First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510275China Department of Breast and Thyroid Surgery the First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510275China

Salt-inducible kinases(SIKs)belong to AMP-activated protein kinase(AMPK)family,and functions mainly involve in regulating energy response-related physiological processes,such as gluconeogenesis and lipid ***,compared with another well-established energy-response kinase AMPK,SIK roles in human diseases,especially in diabetes and tumorigenesis,are rarely ***,the pilot roles of SIKs in tumorigenesis have begun to attract more attention due to the finding that the tumor suppressor role of LKB1 in non-small-cell lung cancers(NSCLCs)is unexpectedly mediated by the SIK but not AMPK ***,here we tend to comprehensively summarize the emerging upstream regulators,downstream substrates,mouse models,clinical relevance,and candidate inhibitors for SIKs,and shed light on SIKs as the potential therapeutic targets for cancer therapies.

关键词： tumorigenesis homeostasis kinases

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AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma

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Signal Transduction and Targeted Therapy 2021年第2期6卷 507-518页

作者： Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang qiwei jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouGuangdong 510632China Department of Musculoskeletal Oncology.the First Alilated Hospital of Sun Yat-sen University GuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong 510080China Department of Pathology the Seventh Aflited Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518017China

Osteosarcoma(OS)is the most common primary malignant bone tumor in children and *** activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely *** metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is *** this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma ***1 promotes the growth and metastasis of osteosarcoma both in vitro and in ***,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in ***,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 ***,the IDH1 protein level was positively correlated with AHA1 in *** IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of ***,high IDH1 level was also associated with poor prognosis of osteosarcoma *** study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients.

关键词： IDH1 osteosarcoma metastasis

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“双一流”建设高校研究生教育国际化探究

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现代大学教育 2019年第4期35卷 30-37页

作者：蒋琦玮中南大学土木工程学院

国际化是大学服务国家战略的使命要求。研究生教育国际化既是“双一流”建设的重要抓手,又是衡量大学办学水平的重要指标。中国研究生教育国际化仍有诸多亟待改进之处:学生结构的国际化呈现极为严重的“留学顺差”;“双一流”建设所必... 详细信息

国际化是大学服务国家战略的使命要求。研究生教育国际化既是“双一流”建设的重要抓手,又是衡量大学办学水平的重要指标。中国研究生教育国际化仍有诸多亟待改进之处:学生结构的国际化呈现极为严重的“留学顺差”;“双一流”建设所必需的师资队伍国际化仍有较大提升空间;研究生国际化教育运作模式的简单化无法满足“双一流”建设的多元化目标;国际化课程体系的设置距离“三强一高”的人才培养目标还任重道远。“双一流”建设高校欲借助研究生教育国际化来增强国际影响力、促进资源互通以及创造多元未来,需要做到:加速教育观念更新,推动国际理解教育;加紧一流学科创建,打造“留学中国”品牌;加大课程体系建设,面向精英人才培养;加强师资队伍培训,着力人力资本提升。

关键词：国际化研究生教育 “双一流”建设师资队伍留学顺差课程体系国际理解教育评价

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设施内不同遮阴处理对草莓生长和光合特性及产量品质的影响

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中国果树 2024年第5期 68-74页

作者：黄宁旺蒋琪玮王晶如李浩鹿高勇张培培薛俊龙宫明永赵林肖伟李玲山东农业大学园艺科学与工程学院山东果蔬优质高效生产协同创新中心泰安271018 沂源县农业技术服务中心山东省创新发展研究院

以雪沁香草莓为试验材料,分别设置遮阴度30%、50%和70%处理,探究设施内不同遮阴处理对草莓生长、光合特性及产量、品质的影响。结果表明,遮阴后植株间温度和叶面光合有效辐射(PAR)均显著降低,遮阴处理使净光合速率(Pn)、气孔导度(Gs)、... 详细信息

以雪沁香草莓为试验材料,分别设置遮阴度30%、50%和70%处理,探究设施内不同遮阴处理对草莓生长、光合特性及产量、品质的影响。结果表明,遮阴后植株间温度和叶面光合有效辐射(PAR)均显著降低,遮阴处理使净光合速率(Pn)、气孔导度(Gs)、蒸腾速率(Tr)、胞间CO_(2)浓度(Ci)的日变化曲线均由原来的“双峰”型变成了“单峰”型,且显著提高了叶绿素含量。30%遮阴处理下草莓植株的生长状态和果实产量均达到最佳,且对果实品质影响较小,而70%遮阴处理下各项指标均降至最差。综上,在设施内进行30%遮阴处理有助于设施草莓提质增产。

关键词：草莓设施内遮阴生长特性光合特性产量品质温度光照

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Slc43a2^(+)T cell metastasis from spleen to brain in RGNNV infected teleost

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Science China(Life Sciences) 2024年第4期67卷 733-744页

作者： Qing Wang Yali Liu Minlin Zhang Min Yang Jiantao Liang Xiaoling Zuo Shaowen Wang Xianze Jia Huihong Zhao Han jiang Qiang Lin qiwei Qin College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Nansha-South China Agricultural University Fishery Research Institute Guangzhou 511457China Joint University Laboratory of Guangdong Province Hong Kong and Marco Region on Marine Bioresource Conservation and ExploitationGuangzhou 510642China University of Chinese Academy of Sciences Beijing 100101China

The origin of T cells in the teleost's brain is *** viewing the central nervous system(CNS)as immune privileged has been widely accepted,previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral ***,we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper(Epinephelus coioices)through single-cell RNA-sequencing *** viral CNS infection with red-spotted grouper nervous necrosis virus(RGNNV),the number of slc43a2^(+)T cells synchronously increased in the spleen and *** the infection tests in asplenic zebrafish(tlx1^▲zebrafish model),no increase in the number of slc43a2^(+)T cells was observed in the ***-cell transcriptomic analysis indicated that slc43a2^(+)T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune *** study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish.

关键词： central nervous system slc43a2^(+)T cell RGNNV T cell migration teleost

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Synergistic Anticancer Effects of Triptolide and Celastrol,Two Main Compounds from Thunder God Vine

Synergistic Anticancer Effects of Triptolide and Celastrol,T...

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第十四届全国中药和天然药物学术研讨会

作者： Kejun Cheng qiwei jiang Xu Zhang Zhi Shi Xing Wei Lishui Institute of Agriculture Sciences Fudan University National First-Class Key Discipline for Traditional Chinese Medicine of Nanjing University of Chinese Medicine Jinan University

Objective Triptolide and celastrol are two most widely studied and promising compounds isolated from Thunder God Vine（Trypterigium wilfordii Hook.f.） with promising anticancer ***,their clinical application was limited by *** aim to investigate the synergistic anti-proliferative effects of triptolide with celastrol in cancer and the molecular *** The effects of triptolide and celastrol in cancer cells and the molecular mechanism were assessed by using MTT assay in vitro,xenografts mouse model in vivo,flow cytometry,fluorescence microscope and Western blot *** The combination of triptolide with celastrol induced strong cell growth inhibition,cell cycle arrest at G2/M phase and apoptosis with the increasing intracellular ROS accumulation in cancer *** with ROS scavenger N-acetyl-L-cysteine totally blocked the apoptosis induced by triptolide with *** with celastrol alone decreased many Hsp90 client proteins including Akt,Cdks,EGFR and Raf1,but lead to stress-induced increase of Hsp70 and *** triptolide to celastrol treatment abrogated this phenomenon and induced more *** xenografts mouse model,the lower-dose combination of triptolide with celastrol significantly inhibited the growth of tumors without obvious *** Triptolide in combination with celastrol showed outstanding synergistic anticancer effects,suggesting that this beneficial combination may offer a promising treatment option for cancer patients.

关键词： Triptolide Celastrol Combination therapy Cancer

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上皮样肉瘤一例

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中华皮肤科杂志 1990年第1期23卷 54-56页

作者：唐曙王仁绪上海第二医科大学附属新华医院

上皮样肉瘤系一少见的恶性软组织肿瘤,常伴皮肤损害.

关键词：上皮样肉瘤软组织肿瘤

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手性1,2-二苯基乙二醇衍生物的合成及催化性能研究

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化学通报 2010年第7期73卷 665-668页

作者：姜艳蒋奇伟孟启席海涛孙小强江苏工业学院精细化工重点实验室常州213164

合成了3种含吡啶环的手性1,2-二苯基乙二醇衍生物,并通过1HNMR、13CNMR、LCMS和IR的结构表征。将3种衍生物用于催化苯甲醛与二乙基锌的不对称加成反应的结果表明,其中的(1R,2R)-2-(2-吡啶甲氧基)-1,2-二苯基乙醇具有较好的催化活性,获得... 详细信息

合成了3种含吡啶环的手性1,2-二苯基乙二醇衍生物,并通过1HNMR、13CNMR、LCMS和IR的结构表征。将3种衍生物用于催化苯甲醛与二乙基锌的不对称加成反应的结果表明,其中的(1R,2R)-2-(2-吡啶甲氧基)-1,2-二苯基乙醇具有较好的催化活性,获得了78%的收率和56%e.e.。

关键词：手性1,2-二苯基乙二醇衍生物催化活性

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考虑跨站停车的地铁客流协同控制模型

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铁道科学与工程学报 2021年第11期18卷 2857-2864页

作者：蒋琦玮苏建凯陈维亚中南大学交通运输工程学院轨道交通大数据湖南省重点实验室湖南长沙410075 中南大学土木工程学院湖南长沙410075

针对城市轨道交通高峰时段客流需求过饱和与分布不均衡情形下,车站乘客滞留集中效应明显和乘客候车时间过长等问题,提出一种考虑开行部分跨站停列车的多站客流协同控制优化方法。建立以车站与列车安全容量、列车跨站数量、列车追踪间隔... 详细信息

针对城市轨道交通高峰时段客流需求过饱和与分布不均衡情形下,车站乘客滞留集中效应明显和乘客候车时间过长等问题,提出一种考虑开行部分跨站停列车的多站客流协同控制优化方法。建立以车站与列车安全容量、列车跨站数量、列车追踪间隔等为约束,以车站乘客滞留率方差最小与线路乘客候车时间最小为优化目标的控制决策模型,设计自适应差分进化算法,求解列车跨站停车方案与车站进站客流限制比例。研究结果表明:在时变的城市轨道交通高峰客流需求下,采取本文的协同控制决策方法,能够有效降低案例线路车站乘客滞留率方差60.23%和乘客候车等待时间24.78%。

关键词：城市轨道交通跨站停车车站客流控制协同控制差分进化算法

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