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Chinese Chemical Letters 2024年第7期35卷 428-432页

作者： Yiyue Ding qiuxiang zhang Lei zhang Qilu Yao Gang Feng zhang-Hui Lu Key Laboratory of Energy Catalysis and Conversion of Nanchang College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

Formic acid(FA),which is obtainable through CO_(2)hydrogenation with green hydrogen or biomass conversion,has been used as a prospective liquid organic hydrogen carrier(LOHC)because of the abundant advantages of renewability,wide availability,stability,and high volumetric capacity(53 g H_(2)/L).The development of highly efficient catalytic systems to achieve enhanced catalytic activity is attractive but still ***,ultrafine and highly dispersed PdAu nanoclusters(NCs)anchored on amino-modified reduced graphene oxide(ArGO)were successfully synthesized via a facile impregnation-reduction method and applied as a catalyst toward formic acid dehydrogenation(FAD).Benefiting from the promoting effect of amino groups,the strain and ligand effect in the alloy,and the Mott–Schottky effect between PdAu NCs and ArGO,the resultant PdAu/ArGO affords an ultrahigh activity under visible light irradiation with an exceptional turnover frequency value of 10,699.5 h^(-1)at 298 K without any additives,more than 2.6times improvement than that under dark,which is the highest among all reported catalysts under the same *** study provides a green and convenient strategy for developing more efficient and sustainable FAD catalysts and promotes the effective utilization of FA as a prospective renewable LOHC.

关键词： Visible-light-enhanced Hydrogen production Formic acid Pd-Au Heterogeneous catalyst

Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

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Food Science and Human Wellness 2024年第2期13卷 709-720页

作者： Bingyong Mao Weiling Guo Shumao Cui qiuxiang zhang Jianxin Zhao Xin Tang Hao zhang State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and *** study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium(DSS)and to reveal the underlying *** showed that *** D4 intervention significantly relieved body weight loss,and suppressed the elevation of pro-inflammatory cytokines(including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β))and excessive oxidative stress(myeloperoxidease(MPO)activity,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity,and malondialdehyde(MDA)level)in colitis ***,the concentrations of tight junction proteins(occludin,claudin-1,and ZO-1)related to the intestinal barrier were obviously elevated,and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after *** D4 *** intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1,Bifidobacterium,GCA-900066225,Enterorhabdus,and reducing the relative abundance of Lachnospiraceae NK4A136 *** conclusion,oral administration of *** D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses,maintaining the intestinal barrier,inhibiting TLR4/NF-κB pathway,and regulating intestinal microbiota *** results are conducive to accelerate the development of *** D4 as a functional probiotic for colitis.

关键词： Blautia producta D4 Colitis Intestinal mechanical barrier TLR4/NF-κB pathway Intestinal microbiot

Prognostic ability of the neoadjuvant rectal(NAR)score in long-course concurrent chemoradiotherapy for patients with locally advanced rectal cancer:a retrospective cohort study

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Malignancy Spectrum 2024年第1期1卷 53-63页

作者： Siyi Lu Ran Peng Xianan Li Zhaoyu Chen Yi Zhou Ruize Qu Xin Zhou qiuxiang zhang Yuxia Wang Xuemin Li Tao Sun Hao Wang Wei Fu Cancer Center Peking University Third HospitalBeijingChina Department of General Surgery Peking University Third HospitalBeijingChina Department of Radiation Oncology Peking University Third HospitalBeijingChina Department of Radiation Oncology Peking University People's HospitalBeijingChina Department of Basic Medical Sciences Peking University Health Science CenterBeijingChina Shenzhen Health Development Research and Data Management Center ShenzhenChina Department of Clinical Nutrition Peking University Third HospitalBeijingChina

Background:The aims of this study were to evaluate the prognostic ability of the neoadjuvant rectal(NAR)score and to develop and validate a nomogram based on the NAR for patients with locally advanced rectal cancer(LARC)treated with neoadjuvant chemoradiotherapy(nCRT).Methods:In total,307 patients,including 230 patients from the primary cohort and 77 from the external cohort,were enrolled across the two *** associations of the NAR score with the tumor response,tumor control,and clinicopathological parameters were *** analysis was performed in the primary and external cohorts using Kaplan‒Meier *** and multivariate analyses were performed to evaluate the prognostic *** NAR-based nomogram was developed in the primary cohort and validated in the external cohort using the concordance index(C-index),calibration plots,and decision curve analyses(DCAs).Results:Kaplan‒Meier survival analysis revealed that the disease-free survival(DFS)and overall survival(OS)of the NAR>16 group were significantly lower than those of the NAR≤16 group(p<0.001).Multivariate Cox regression analysis identified the NAR score as an independent prognostic factor for both DFS(hazard ratio[HR]=2.484,95%confidence interval[CI]:1.159−5.323,p=0.019)and OS(HR=4.633,95%CI:1.076−19.941,p=0.04).Calibration plots and DCAs showed that NARbased nomograms for DFS and OS were consistent and useful in clinical ***,the C-indexes of the NAR-based nomograms were better than those of the other variables in both the primary and external ***:Our study validates the prognostic role of the NAR score for DFS and *** NAR-based nomogram for OS could accurately predict the outcome of LARC patients by stratifying the risk score accordingly.

关键词： NAR score rectal cancer prognosis nomogram

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耐高渗青春双歧杆菌的筛选及发酵工艺优化

食品与发酵工业 2024年第3期50卷 30-37页

作者：潘子怡毛丙永唐鑫张秋香赵建新崔树茂江南大学食品学院江苏无锡214122

为解决青春双歧杆菌在生产中发酵密度低的问题,该文测定了94株青春双歧杆菌的耐渗能力,同时评价了耐高渗菌株耐渗能力的遗传稳定性,最后通过解析培养基底物和发酵工艺探究了耐高渗菌株的最适发酵条件,从而提高其生产中的发酵活菌数。筛... 详细信息

为解决青春双歧杆菌在生产中发酵密度低的问题,该文测定了94株青春双歧杆菌的耐渗能力,同时评价了耐高渗菌株耐渗能力的遗传稳定性,最后通过解析培养基底物和发酵工艺探究了耐高渗菌株的最适发酵条件,从而提高其生产中的发酵活菌数。筛选得到两株最高可耐受1400 mOsm/kg的菌株CCFM1302和CCFM1066,其最优氮源为复合氮源(胰酪蛋白胨和酵母浸粉FM528以质量比1∶1复合),最优碳氮比分别为(2.71±0.23)∶1和(2.53±0.11)∶1。以达到完全抑制渗透压为发酵终点推算底物最适浓度,进一步优化微量元素的添加量,得到最优培养基:复合氮源21.0 g/L、葡萄糖57.0 g/L(CCFM1302),复合氮源22.4 g/L、葡萄糖56.5 g/L(CCFM1066);此外添加MgSO_(4)·7H_(2)O 0.25 g/L,半胱氨酸1 g/L、吐温801 mL/L。恒pH 5.5培养至稳定期发酵液活菌数可达(1.82±0.08)×10^(10)CFU/mL和(1.70±0.03)×10^(10)CFU/mL。该文筛选到可产业化的两株青春双歧杆菌,并优化其高密度发酵工艺,对生产和应用都具有重要意义。

关键词：青春双歧杆菌渗透压高密度培养碳氮比活菌数

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统计假设检验的模糊集描述

宁夏师范学院学报 2024年第1期45卷 18-26页

作者：章秋香魏立力宁夏大学数学统计学院宁夏银川750021

基于p值函数给出了零假设显著性检验的模糊集描述,为模糊集理论提供实际背景的同时,给p值一个新的解释.其中样本数据对零假设的支持程度用一个模糊集的隶属度函数表示,检验的拒绝域表示为该模糊集的截集,截集的水平表示显著性水平.具体... 详细信息

基于p值函数给出了零假设显著性检验的模糊集描述,为模糊集理论提供实际背景的同时,给p值一个新的解释.其中样本数据对零假设的支持程度用一个模糊集的隶属度函数表示,检验的拒绝域表示为该模糊集的截集,截集的水平表示显著性水平.具体例子表明此方法的可行性和有效性.

关键词：假设检验 p值函数模糊集

不同剂量长双歧杆菌联合西兰花种子水提物对结肠炎的缓解作用

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食品与发酵工业 2024年第12期50卷 92-100页

作者：徐何颖邬佳颖唐鑫张秋香崔树茂赵建新毛丙永江南大学食品学院江苏无锡214122

长双歧杆菌CCFM1206分离自健康成人粪便,可将萝卜硫苷转化成萝卜硫素(sulforaphane,SFN),该文研究了西兰花种子水提物(broccoli seed extract,BSE)以及其联合不同剂量的长双歧杆菌CCFM1206(10^(8)、10^(9)和10^(10)CFU)对小鼠肠内SFN水平的调控以及对右旋糖酐硫酸酯钠(dextran sulfate sodium,DSS)诱导结肠炎的缓解作用。研究发现,与BSE组相比,补充10^(9)和10^(10)CFU长双歧杆菌CCFM1206后,小鼠粪便中SFN和N-乙酰萝卜硫素(sulforaphane N-acetyl-L-cysteine,SFN-NAC)总量由30.84μmol/g分别提高至45.48和49.32μmol/g(P<0.05);仅摄入BSE(200 mg/kg小鼠体重),能有效缓解小鼠结肠缩短、降低炎症因子水平(IL-6、IL-1β和TNF-α)、增强抗氧化酶活力(GSH、SOD)、上调紧密连接蛋白的基因转录水平和蛋白表达水平,激活Nrf2信号通路并抑制NF-κB信号通路;补充10^(8)CFU长双歧杆菌CCFM1206效果与BSE无显著差异,而补充10^(9)和10^(10)CFU长双歧杆菌CCFM1206在激活Nrf2和抑制NF-κB信号通路方面更加优异,这可能与产生更多SFN有关。该研究可为开发缓解结肠炎的膳食制剂提供理论依据和剂量参考。

关键词：萝卜硫素长双歧杆菌西兰花种子水提物结肠炎紧密连接蛋白

新型简易移送垫在手术室围手术期过床转运的应用效果

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中国当代医药 2024年第13期31卷 127-130,134页

作者：郭小菊张秋香涂平花南昌市第一医院手术室江西南昌330008

目的探讨新型简易移送垫在手术室围手术期过床转运的应用效果。方法选取2022年8月至2023年2月南昌市第一医院100例手术患者为研究对象,按随机数字表法分为对照组(50例)和观察组(50例)。对照组使用传统搬运方法,观察组使用新型简易转运... 详细信息

目的探讨新型简易移送垫在手术室围手术期过床转运的应用效果。方法选取2022年8月至2023年2月南昌市第一医院100例手术患者为研究对象,按随机数字表法分为对照组(50例)和观察组(50例)。对照组使用传统搬运方法,观察组使用新型简易转运移送垫搬运,比较两组的不良事件发生率、患者舒适满意度、过床搬运时间及医护人员腰肌损伤发生率。结果观察组的不良事件总发生率低于对照组,差异有统计学意义(P<0.05);观察组患者舒适度高于对照组,差异有统计学意义(P<0.05);观察组过床搬运时间短于对照组,差异有统计学意义(P<0.05);观察组医护人员腰肌损伤总发生率低于对照组,差异有统计学意义(P<0.05)。结论通过新型简易转运移送垫在术后手术室与临床科室过床搬运的应用,从而避免搬运过程中坠落、管道脱落或牵扯等不良事件发生,给患者增加舒适及安全感,提高患者舒适满意度,降低临床医护人员搬运时导致的腰肌劳损的发生率,值得临床推广。

关键词：移送垫过床转运围手术期安全护理

体外受精-胚胎移植女性生育生活质量的相关因素分析

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中国性科学 2024年第8期33卷 53-58页

作者：吴靓王雅卉张颖张秋香陆梦银车晓艳江苏大学鼓楼临床医学院(南京鼓楼医院)生殖医学和妇产医学中心南京210008 南京大学医学院附属鼓楼医院男科南京210008 江苏大学医学院江苏镇江212000 江苏大学鼓楼临床医学院(南京鼓楼医院)男科南京210008

目的探究体外受精-胚胎移植(IVF-ET)女性生育生活质量的影响因素。方法采用便利抽样法选取南京鼓楼医院2021年12月至2023年2月620例行IVF-ET的女性作为研究对象,采用一般资料调查表、生育生活质量问卷(Ferti QoL)进行调查。通过单因素... 详细信息

目的探究体外受精-胚胎移植(IVF-ET)女性生育生活质量的影响因素。方法采用便利抽样法选取南京鼓楼医院2021年12月至2023年2月620例行IVF-ET的女性作为研究对象,采用一般资料调查表、生育生活质量问卷(Ferti QoL)进行调查。通过单因素分析和多元逐步线性回归分析探讨生育生活质量的影响因素。结果调查显示IVF-ET女性生育生活质量处于中等偏下水平;生育生活质量的单因素分析结果显示,年龄、职业、压力程度、就诊阶段、不孕年限、心理状态、婚姻满意度对IVF-ET女性生育生活质量有影响(P<0.05);多元逐步线性回归分析结果显示,压力程度、心理状态、婚姻满意度与IVF-ET女性生育生活质量相关(P<0.05)。结论IVF-ET女性存在生育生活质量低的现状,影响因素主要为压力程度、心理状态、婚姻满意度,因此医护人员需降低IVF-ET女性的生活压力,提高夫妻亲密关系,纠正其不良心理状况,促使其顺利渡过移植阶段。

关键词：体外受精-胚胎移植生育生活质量心理干预

智能信息平台的构建及在辅助生殖周期内患者中的应用

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护士进修杂志 2024年第1期39卷 32-35页

作者：张秋香黄雯婧周婷婷武颖李晓琴梅洁南京大学医学院附属鼓楼医院生殖医学和妇产医学中心江苏南京210008 新余学院公共卫生与健康学院江西新余338000

目的探讨智能信息平台的构建及在生殖中心周期内患者中的应用效果。方法构建智能信息平台。改变传统的周期内患者等候医嘱、护士发药及注射流程。并于2021年3月起逐步在我院生殖中心周期内患者中应用,比较应用前后患者等候用药时间、... 详细信息

目的探讨智能信息平台的构建及在生殖中心周期内患者中的应用效果。方法构建智能信息平台。改变传统的周期内患者等候医嘱、护士发药及注射流程。并于2021年3月起逐步在我院生殖中心周期内患者中应用,比较应用前后患者等候用药时间、耗材使用情况、护理人员工作负荷及护患满意度的相关指标。结果智能信息平台应用之后,周期内患者平均滞留时长、有效时长、无效时长均较之前缩短,差异有统计学意义(P<0.001)。处方无纸化墨盒硒鼓等更换频次减少,减少耗材浪费。护理人员工作负荷减少,患者对新流程满意度提高。结论智能信息平台的应用在优化周期内患者就诊流程,缩短患者等候时间,节约了人力物力取得了良好成效提高了护患满意度。

关键词：辅助生殖智能管理平台护理信息化护理管理

Effect of Dangfei Liganning capsule(当飞利肝宁胶囊) on liver X receptor α/steroid regulatory element binding protein-1/fatty acid synthase signal pathway in rats with metabolic-associated fatty liver disease

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Journal of Traditional Chinese Medicine 2022年第6期42卷 940-947页

作者： LI Xiaoling SUN Fengxia SHANG Zimeng zhang Yingxue LI Jie zhang qiuxiang Infections Department Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Infections Department Beijing Hospital of Traditional Chinese Medicine Shunyi BranchBeijing 101300China

OBJECTIVE: To study the mechanism of Dangfei Liganning capsule(当飞利肝宁胶囊) in the treatment of rats with metabolic associated fatty liver disease(MAFLD). METHODS: Totally 48 specific pathogen free SpragueDawley male rats were randomly divided into normal Group, model group, Dangfei Liganning high, moderate, and low-dose groups and Essentiale group which were fed with high fat diet for 8 weeks, and gavage and molding were carried out simultaneously. Dangfei Liganning high, middle and low-dose group were given 0.27, 0.135 and 0.0675 g·kg-1·d-1 respectively by gavage, Essentiale group was given 0.123 g·kg-1·d-1 by gavage, the same amount of distilled water was given by gavage in the normal group and the model group. The rats were weighed at the 0th week, 2nd week, 4th week, 6th week and 8th weekend respectively. The rats were sacrificed at the end of the 8th week. Serum levels of alanine aminotransferase(ALT), alanine aminotransferase(AST),triglyceride(TG), total cholesterol(CHO), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein (LDL-C), total protein(TP), albumin(Alb), globulin(GLB), total bilirubin(TBIL), direct bilirubin(DBIL), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were measured. The levels of liver tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and liver pathology [hematoxylin and eosin(HE) staining, oil red O staining] were detected. The expression levels of liver X receptor α(LXRα), steroid regulatory element binding protein-1(SREBP-1) and fatty acid synthase(FAS) were detected by immunohistochemistry, Western blot and reverse transcription-polymerase chain reaction reverse transcription-polymerase chain reaction. RESULTS: From the beginning to the 8th week, the growth rate of body weight in the Dangfei Liganning highdose group was slower than all other groups. There was no significant difference in ALB level in all groups(P > 0.05). Compared with the model group, the levels of ALT, AST, LDL-C, TG, CHO, TP, GLB, TBIL, DBIL,

关键词： metabolic associated fatty liver disease liver X receptors steroid regulatory element binding protein-1 fatty acid synthases signal transduction Dangfei Liganning capsule